Details for: LCK

Gene ID: 3932

Symbol: LCK

Ensembl ID: ENSG00000182866

Description: LCK proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.4700
    Cell Significance Index: -13.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.9053
    Cell Significance Index: -14.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.4022
    Cell Significance Index: -20.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.2057
    Cell Significance Index: -21.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.6655
    Cell Significance Index: -14.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7465
    Cell Significance Index: -13.2500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.6612
    Cell Significance Index: 28.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.5876
    Cell Significance Index: 222.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.1458
    Cell Significance Index: 128.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.0350
    Cell Significance Index: 77.9000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.6855
    Cell Significance Index: 14.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6986
    Cell Significance Index: -11.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6923
    Cell Significance Index: -14.5700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.2164
    Cell Significance Index: 32.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1710
    Cell Significance Index: -6.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5451
    Cell Significance Index: 55.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6017
    Cell Significance Index: 188.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9913
    Cell Significance Index: 98.0600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.9818
    Cell Significance Index: 10.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8518
    Cell Significance Index: 769.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5098
    Cell Significance Index: 82.9100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4603
    Cell Significance Index: 2.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3757
    Cell Significance Index: 40.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2759
    Cell Significance Index: 5.8800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.2081
    Cell Significance Index: 1.8200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.1886
    Cell Significance Index: 0.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1628
    Cell Significance Index: 11.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1382
    Cell Significance Index: 26.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1044
    Cell Significance Index: 12.1700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0746
    Cell Significance Index: 0.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0346
    Cell Significance Index: 2.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0300
    Cell Significance Index: 16.4000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0287
    Cell Significance Index: 0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0139
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0061
    Cell Significance Index: -4.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0083
    Cell Significance Index: -0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.4100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0107
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0148
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0163
    Cell Significance Index: -2.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0184
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0214
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0232
    Cell Significance Index: -1.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0275
    Cell Significance Index: -15.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0293
    Cell Significance Index: -10.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0303
    Cell Significance Index: -22.2200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0317
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0330
    Cell Significance Index: -20.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0414
    Cell Significance Index: -18.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0449
    Cell Significance Index: -8.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0490
    Cell Significance Index: -9.8300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0551
    Cell Significance Index: -0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0552
    Cell Significance Index: -15.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0574
    Cell Significance Index: -0.9900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0736
    Cell Significance Index: -9.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0752
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0833
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0845
    Cell Significance Index: -14.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0950
    Cell Significance Index: -1.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0987
    Cell Significance Index: -4.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0995
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1040
    Cell Significance Index: -1.0000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1046
    Cell Significance Index: -1.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1073
    Cell Significance Index: -14.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1178
    Cell Significance Index: -15.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1223
    Cell Significance Index: -5.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1256
    Cell Significance Index: -8.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1283
    Cell Significance Index: -15.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1291
    Cell Significance Index: -18.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1364
    Cell Significance Index: -15.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1394
    Cell Significance Index: -14.5100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1399
    Cell Significance Index: -2.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1460
    Cell Significance Index: -5.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1502
    Cell Significance Index: -10.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1630
    Cell Significance Index: -10.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1718
    Cell Significance Index: -17.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1736
    Cell Significance Index: -2.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1767
    Cell Significance Index: -5.6600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1831
    Cell Significance Index: -1.5600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1880
    Cell Significance Index: -2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2151
    Cell Significance Index: -16.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2213
    Cell Significance Index: -13.9500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2251
    Cell Significance Index: -1.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2265
    Cell Significance Index: -6.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2388
    Cell Significance Index: -17.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2389
    Cell Significance Index: -6.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2415
    Cell Significance Index: -3.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2734
    Cell Significance Index: -16.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2868
    Cell Significance Index: -17.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2931
    Cell Significance Index: -16.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3170
    Cell Significance Index: -14.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LCK is a non-receptor tyrosine kinase that belongs to the Src family of kinases. It is a small cytoplasmic protein that contains a catalytic domain and a SH2 (Src Homology 2) domain, which is involved in protein-protein interactions. LCK is specifically expressed in lymphoid cells, including T cells, B cells, and natural killer cells. It is known to be involved in various signaling pathways that regulate cell proliferation, differentiation, and survival. **Pathways and Functions** LCK is involved in several signaling pathways that regulate the function of immune cells. Some of the key pathways include: 1. T cell receptor signaling pathway: LCK is a key component of the TCR signaling complex, where it mediates the activation of downstream signaling molecules, including PI3K/AKT and MAPK/ERK pathways. 2. CD28 co-stimulation pathway: LCK is involved in the CD28 co-stimulation pathway, where it mediates the activation of PI3K/AKT and MAPK/ERK pathways in response to CD28 co-stimulation. 3. PI3K/AKT signaling pathway: LCK is involved in the PI3K/AKT signaling pathway, where it mediates the activation of PI3K and AKT, leading to cell survival and proliferation. 4. MAPK/ERK signaling pathway: LCK is involved in the MAPK/ERK signaling pathway, where it mediates the activation of MAPK and ERK, leading to cell proliferation and differentiation. **Clinical Significance** Dysregulation of LCK has been implicated in several autoimmune and inflammatory disorders, including: 1. T cell leukemia and lymphoma: Overexpression of LCK has been observed in T cell leukemia and lymphoma, where it contributes to the development and progression of the disease. 2. Autoimmune diseases: LCK has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, where it contributes to the activation and proliferation of autoreactive T cells. 3. Inflammatory disorders: LCK has been implicated in the pathogenesis of inflammatory disorders, including inflammatory bowel disease and asthma, where it contributes to the activation and proliferation of inflammatory cells. In conclusion, LCK is a critical gene that plays a key role in the regulation of immune cell function, and its dysregulation has been implicated in several autoimmune and inflammatory disorders. Further research is needed to fully understand the mechanisms by which LCK regulates immune cell function and to develop therapeutic strategies to target LCK in the treatment of these diseases.

Genular Protein ID: 1504754112

Symbol: LCK_HUMAN

Name: Tyrosine-protein kinase Lck

UniProtKB Accession Codes:

P06239 D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 17 DrugCentral 1 EC 2 ELM 1 EMBL 18 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 57 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 23 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3493153

Title: A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.

PubMed ID: 3493153

DOI: 10.1002/eji.1830161229

PubMed ID: 3265417

Title: Structure and expression of lck transcripts in human lymphoid cells.

PubMed ID: 3265417

DOI: 10.1002/jcb.240380206

PubMed ID: 2558056

Title: Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons.

PubMed ID: 2558056

DOI: 10.1016/0378-1119(89)90144-3

PubMed ID: 8139546

Title: Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.

PubMed ID: 8139546

DOI: 10.1128/mcb.14.4.2429-2437.1994

PubMed ID: 7495859

Title: An aberrant lck mRNA in two human T-cell lines.

PubMed ID: 7495859

DOI: 10.1016/0167-4781(95)00162-a

PubMed ID: 12401726

Title: No association between lck gene polymorphisms and protein level in type 1 diabetes.

PubMed ID: 12401726

DOI: 10.2337/diabetes.51.11.3326

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850479

Title: Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.

PubMed ID: 2850479

DOI: 10.1128/mcb.8.8.3058-3064.1988

PubMed ID: 2787474

Title: Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.

PubMed ID: 2787474

DOI: 10.1128/mcb.9.5.2173-2180.1989

PubMed ID: 11009097

Title: Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects.

PubMed ID: 11009097

DOI: 10.1002/1521-4141(200009)30:9<2632::aid-immu2632>3.0.co;2-c

PubMed ID: 2835736

Title: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines.

PubMed ID: 2835736

PubMed ID: 3489486

Title: Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.

PubMed ID: 3489486

DOI: 10.1016/0167-4889(86)90228-4

PubMed ID: 1639064

Title: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

PubMed ID: 1639064

DOI: 10.1002/j.1460-2075.1992.tb05361.x

PubMed ID: 7504174

Title: The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.

PubMed ID: 7504174

DOI: 10.1128/mcb.13.12.7408-7417.1993

PubMed ID: 7852312

Title: p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes.

PubMed ID: 7852312

DOI: 10.1074/jbc.270.6.2506

PubMed ID: 8618896

Title: Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

PubMed ID: 8618896

DOI: 10.1073/pnas.92.26.12338

PubMed ID: 8631775

Title: Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394.

PubMed ID: 8631775

DOI: 10.1074/jbc.271.13.7465

PubMed ID: 8794306

Title: Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity.

PubMed ID: 8794306

DOI: 10.1128/jvi.70.10.6701-6708.1996

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 10848956

Title: Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.

PubMed ID: 10848956

DOI: 10.1046/j.1432-1327.2000.01412.x

PubMed ID: 12007789

Title: The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.

PubMed ID: 12007789

DOI: 10.1016/s0167-4889(02)00165-9

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 14610046

Title: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

PubMed ID: 14610046

DOI: 10.1084/jem.20031484

PubMed ID: 14610044

Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.

PubMed ID: 14610044

DOI: 10.1084/jem.20030232

PubMed ID: 12837766

Title: Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.

PubMed ID: 12837766

DOI: 10.1074/jbc.m300648200

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 16339550

Title: T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.

PubMed ID: 16339550

DOI: 10.4049/jimmunol.175.12.8123

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16461343

Title: Identification of substrates of human protein-tyrosine phosphatase PTPN22.

PubMed ID: 16461343

DOI: 10.1074/jbc.m600498200

PubMed ID: 16709819

Title: Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.

PubMed ID: 16709819

DOI: 10.4049/jimmunol.176.11.6615

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 18424730

Title: Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.

PubMed ID: 18424730

DOI: 10.4049/jimmunol.180.9.6085

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20851766

Title: RhoH modulates pre-TCR and TCR signalling by regulating LCK.

PubMed ID: 20851766

DOI: 10.1016/j.cellsig.2010.09.009

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 22034844

Title: DHHC2 is a protein S-acyltransferase for Lck.

PubMed ID: 22034844

DOI: 10.3109/09687688.2011.630682

PubMed ID: 21269457

Title: Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.

PubMed ID: 21269457

DOI: 10.1186/1750-1326-6-12

PubMed ID: 21917715

Title: Feedback circuits monitor and adjust Basal lck-dependent events in T cell receptor signaling.

PubMed ID: 21917715

DOI: 10.1126/scisignal.2001893

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23946459

Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

PubMed ID: 23946459

DOI: 10.1128/jvi.01702-13

PubMed ID: 24714587

Title: The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.

PubMed ID: 24714587

DOI: 10.1038/ncomms4618

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 38225265

Title: The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling.

PubMed ID: 38225265

DOI: 10.1038/s41467-024-44843-w

PubMed ID: 7512222

Title: Structure of the regulatory domains of the Src-family tyrosine kinase Lck.

PubMed ID: 7512222

DOI: 10.1038/368764a0

PubMed ID: 7532720

Title: The crystal structures of the SH2 domain of p56lck complexed with two phosphonopeptides suggest a gated peptide binding site.

PubMed ID: 7532720

DOI: 10.1006/jmbi.1994.0089

PubMed ID: 8604142

Title: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0-A and 1.8-A resolution.

PubMed ID: 8604142

DOI: 10.1006/jmbi.1996.0112

PubMed ID: 8945479

Title: Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.

PubMed ID: 8945479

DOI: 10.1038/384484a0

PubMed ID: 9685372

Title: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.

PubMed ID: 9685372

DOI: 10.1074/jbc.273.32.20238

PubMed ID: 22985903

Title: Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

PubMed ID: 22985903

DOI: 10.1016/j.jaci.2012.07.029

Sequence Information:

  • Length: 509
  • Mass: 58001
  • Checksum: 44BFF0D43FFB420D
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 
YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY 
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER 
PEDRPTFDYL RSVLEDFFTA TEGQYQPQP

Genular Protein ID: 967588506

Symbol: Q573B4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q573B4

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 9 Gene3D 3 IntAct 1 InterPro 12 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 4 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 2 Rhea 3 RuleBase 1 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16107303

Title: A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions.

PubMed ID: 16107303

DOI: 10.1016/j.gene.2005.06.018

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 516
  • Mass: 58333
  • Checksum: EB9A52D4EBDF14D2
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQGDPRQQGL KDKACGSLAV GFHLSPTYFL PGLAFLVPHP VTPGFLPIPA RFSLMPLVFT 
DNLVIALHSY EPSHDGDLGF EKGEQLRILE QSGEWWKAQS LTTGQEGFIP FNFVAKANSL 
EPEPWFFKNL SRKDAERQLL APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK 
IRNLDNGGFY ISPRITFPGL HELVRHYTRY YNGHTKVAVK SLKQGSMSPD AFLAEANLMK 
QLQHQRLVRL YAVVTQEPIY IITEYMENGS LVDFLKTPSG IKLTINKLLD MAAQIAEGMA 
FIEERNYIHR DLRAANILVS DTLSCKIADF GLARLIEDNE YTAREGAKFP IKWTAPEAIN 
YGTFTIKSDV WSFGILLTEI VTHGRIPYPG MTNPEVIQNL ERGYRMVRPD NCPEELYQLM 
RLCWKERPED RPTFDYLRSV LEDFFTATEG QYQPQP

Genular Protein ID: 2511444841

Symbol: E9PJ92_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJ92 A0A0S2Z3Y4

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 458
  • Mass: 52130
  • Checksum: 444FF288EADAE292
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 
YKIRNLDNGG FYISPRITFP GLHELVRHYT RYYNGHTKVA VKSLKQGSMS PDAFLAEANL 
MKQLQHQRLV RLYAVVTQEP IYIITEYMEN GSLVDFLKTP SGIKLTINKL LDMAAQIAEG 
MAFIEERNYI HRDLRAANIL VSDTLSCKIA DFGLARLIED NEYTAREGAK FPIKWTAPEA 
INYGTFTIKS DVWSFGILLT EIVTHGRIPY PGMTNPEVIQ NLERGYRMVR PDNCPEELYQ 
LMRLCWKERP EDRPTFDYLR SVLEDFFTAT EGQYQPQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.