Details for: LCK

Gene ID: 3932

Symbol: LCK

Ensembl ID: ENSG00000182866

Description: LCK proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.67
    Marker Score: 36383
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.56
    Marker Score: 11221
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.48
    Marker Score: 3363
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.32
    Marker Score: 8096
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.27
    Marker Score: 9183
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.17
    Marker Score: 167517
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.12
    Marker Score: 13358
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.94
    Marker Score: 5255
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.93
    Marker Score: 1716
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.88
    Marker Score: 4244
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.85
    Marker Score: 18219
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.75
    Marker Score: 5395.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.75
    Marker Score: 3053
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.74
    Marker Score: 1367
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.72
    Marker Score: 1962
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.69
    Marker Score: 4609
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.67
    Marker Score: 2344
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.59
    Marker Score: 3663
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.53
    Marker Score: 7391.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.51
    Marker Score: 1619
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.48
    Marker Score: 2206
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.48
    Marker Score: 1424
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.46
    Marker Score: 2307
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.45
    Marker Score: 2062
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.38
    Marker Score: 738
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.34
    Marker Score: 1694
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.32
    Marker Score: 1281
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.28
    Marker Score: 1667
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.23
    Marker Score: 1748
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.22
    Marker Score: 722
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.22
    Marker Score: 1140
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.21
    Marker Score: 671
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.2
    Marker Score: 947
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.13
    Marker Score: 2939
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.11
    Marker Score: 24517
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.08
    Marker Score: 727
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.07
    Marker Score: 8462
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.02
    Marker Score: 1245
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.99
    Marker Score: 529
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.95
    Marker Score: 601
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.91
    Marker Score: 1448
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.86
    Marker Score: 410
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.86
    Marker Score: 2011.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.86
    Marker Score: 4195
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.74
    Marker Score: 441
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.73
    Marker Score: 571
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.73
    Marker Score: 1912
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.62
    Marker Score: 4804
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1149
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.5
    Marker Score: 1246
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.48
    Marker Score: 337
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.43
    Marker Score: 1212
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.39
    Marker Score: 845
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.38
    Marker Score: 2253
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.36
    Marker Score: 324
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.35
    Marker Score: 581
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2528
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.32
    Marker Score: 1380
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.2
    Marker Score: 672
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.11
    Marker Score: 811
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.07
    Marker Score: 525
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 1.05
    Marker Score: 286
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251746.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.03
    Marker Score: 232
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.02
    Marker Score: 1323
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.01
    Marker Score: 824
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 678
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71765.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47990
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.96
    Marker Score: 648
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.94
    Marker Score: 368
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.93
    Marker Score: 456
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5308
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.92
    Marker Score: 319
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.92
    Marker Score: 808.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 537
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.79
    Marker Score: 361
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.79
    Marker Score: 2173
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3201
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.76
    Marker Score: 824
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.76
    Marker Score: 1320
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.74
    Marker Score: 375
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.7
    Marker Score: 666
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.69
    Marker Score: 537
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.66
    Marker Score: 274
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.66
    Marker Score: 499
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.65
    Marker Score: 274

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Other Information

**Key characteristics:** * LCK is a tyrosine kinase that is highly expressed in immune cells. * It is a key regulator of T cell activation and differentiation. * It is involved in the regulation of inflammation and immune responses. * Mutations in the LCK gene have been linked to the development of several human cancers. **Pathways and functions:** * LCK is a key regulator of adaptive immune responses. It is involved in the activation of T cells and the regulation of immune responses to pathogens. * It is also involved in the regulation of inflammation and immune responses. * Mutations in the LCK gene have been linked to the development of several human cancers. **Clinical significance:** * LCK is a potential target for cancer immunotherapy. * Inhibition of LCK has been shown to be effective in tumor regression in preclinical models. * Development of LCK inhibitors is an active area of research for the treatment of cancer.

Genular Protein ID: 1504754112

Symbol: LCK_HUMAN

Name: Tyrosine-protein kinase Lck

UniProtKB Accession Codes:

P06239 D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 17 DrugCentral 1 EC 2 ELM 1 EMBL 18 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 68 PDBsum 56 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 23 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3493153

Title: A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.

PubMed ID: 3493153

DOI: 10.1002/eji.1830161229

PubMed ID: 3265417

Title: Structure and expression of lck transcripts in human lymphoid cells.

PubMed ID: 3265417

DOI: 10.1002/jcb.240380206

PubMed ID: 2558056

Title: Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons.

PubMed ID: 2558056

DOI: 10.1016/0378-1119(89)90144-3

PubMed ID: 8139546

Title: Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.

PubMed ID: 8139546

DOI: 10.1128/mcb.14.4.2429-2437.1994

PubMed ID: 7495859

Title: An aberrant lck mRNA in two human T-cell lines.

PubMed ID: 7495859

DOI: 10.1016/0167-4781(95)00162-a

PubMed ID: 12401726

Title: No association between lck gene polymorphisms and protein level in type 1 diabetes.

PubMed ID: 12401726

DOI: 10.2337/diabetes.51.11.3326

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2850479

Title: Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.

PubMed ID: 2850479

DOI: 10.1128/mcb.8.8.3058-3064.1988

PubMed ID: 2787474

Title: Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.

PubMed ID: 2787474

DOI: 10.1128/mcb.9.5.2173-2180.1989

PubMed ID: 11009097

Title: Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects.

PubMed ID: 11009097

DOI: 10.1002/1521-4141(200009)30:9<2632::aid-immu2632>3.0.co;2-c

PubMed ID: 2835736

Title: Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines.

PubMed ID: 2835736

PubMed ID: 3489486

Title: Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.

PubMed ID: 3489486

DOI: 10.1016/0167-4889(86)90228-4

PubMed ID: 1639064

Title: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

PubMed ID: 1639064

DOI: 10.1002/j.1460-2075.1992.tb05361.x

PubMed ID: 7504174

Title: The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.

PubMed ID: 7504174

DOI: 10.1128/mcb.13.12.7408-7417.1993

PubMed ID: 7852312

Title: p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes.

PubMed ID: 7852312

DOI: 10.1074/jbc.270.6.2506

PubMed ID: 8618896

Title: Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

PubMed ID: 8618896

DOI: 10.1073/pnas.92.26.12338

PubMed ID: 8631775

Title: Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394.

PubMed ID: 8631775

DOI: 10.1074/jbc.271.13.7465

PubMed ID: 8794306

Title: Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity.

PubMed ID: 8794306

DOI: 10.1128/jvi.70.10.6701-6708.1996

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 10848956

Title: Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.

PubMed ID: 10848956

DOI: 10.1046/j.1432-1327.2000.01412.x

PubMed ID: 12007789

Title: The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling.

PubMed ID: 12007789

DOI: 10.1016/s0167-4889(02)00165-9

PubMed ID: 11978774

Title: BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.

PubMed ID: 11978774

DOI: 10.1093/intimm/14.5.445

PubMed ID: 12218089

Title: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.

PubMed ID: 12218089

DOI: 10.4049/jimmunol.169.6.2813

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 14610046

Title: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

PubMed ID: 14610046

DOI: 10.1084/jem.20031484

PubMed ID: 14610044

Title: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.

PubMed ID: 14610044

DOI: 10.1084/jem.20030232

PubMed ID: 12837766

Title: Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.

PubMed ID: 12837766

DOI: 10.1074/jbc.m300648200

PubMed ID: 14757743

Title: Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.

PubMed ID: 14757743

DOI: 10.1084/jem.20030589

PubMed ID: 16339550

Title: T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.

PubMed ID: 16339550

DOI: 10.4049/jimmunol.175.12.8123

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16461343

Title: Identification of substrates of human protein-tyrosine phosphatase PTPN22.

PubMed ID: 16461343

DOI: 10.1074/jbc.m600498200

PubMed ID: 16709819

Title: Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.

PubMed ID: 16709819

DOI: 10.4049/jimmunol.176.11.6615

PubMed ID: 17634955

Title: Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes.

PubMed ID: 17634955

DOI: 10.1002/eji.200737111

PubMed ID: 18424730

Title: Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.

PubMed ID: 18424730

DOI: 10.4049/jimmunol.180.9.6085

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20028775

Title: The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

PubMed ID: 20028775

DOI: 10.1189/jlb.0409227

PubMed ID: 20851766

Title: RhoH modulates pre-TCR and TCR signalling by regulating LCK.

PubMed ID: 20851766

DOI: 10.1016/j.cellsig.2010.09.009

PubMed ID: 22080863

Title: T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.

PubMed ID: 22080863

DOI: 10.1172/jci59492

PubMed ID: 22034844

Title: DHHC2 is a protein S-acyltransferase for Lck.

PubMed ID: 22034844

DOI: 10.3109/09687688.2011.630682

PubMed ID: 21269457

Title: Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.

PubMed ID: 21269457

DOI: 10.1186/1750-1326-6-12

PubMed ID: 21917715

Title: Feedback circuits monitor and adjust Basal lck-dependent events in T cell receptor signaling.

PubMed ID: 21917715

DOI: 10.1126/scisignal.2001893

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23946459

Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

PubMed ID: 23946459

DOI: 10.1128/jvi.01702-13

PubMed ID: 27335501

Title: ARAP, a novel adaptor protein, is required for TCR signaling and integrin-mediated adhesion.

PubMed ID: 27335501

DOI: 10.4049/jimmunol.1501913

PubMed ID: 7512222

Title: Structure of the regulatory domains of the Src-family tyrosine kinase Lck.

PubMed ID: 7512222

DOI: 10.1038/368764a0

PubMed ID: 7532720

Title: The crystal structures of the SH2 domain of p56lck complexed with two phosphonopeptides suggest a gated peptide binding site.

PubMed ID: 7532720

DOI: 10.1006/jmbi.1994.0089

PubMed ID: 8604142

Title: Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0-A and 1.8-A resolution.

PubMed ID: 8604142

DOI: 10.1006/jmbi.1996.0112

PubMed ID: 8945479

Title: Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.

PubMed ID: 8945479

DOI: 10.1038/384484a0

PubMed ID: 9685372

Title: Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.

PubMed ID: 9685372

DOI: 10.1074/jbc.273.32.20238

PubMed ID: 22985903

Title: Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency.

PubMed ID: 22985903

DOI: 10.1016/j.jaci.2012.07.029

Sequence Information:

  • Length: 509
  • Mass: 58001
  • Checksum: 44BFF0D43FFB420D
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 
YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV 
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY 
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER 
PEDRPTFDYL RSVLEDFFTA TEGQYQPQP

Genular Protein ID: 2511444841

Symbol: E9PJ92_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJ92 A0A0S2Z3Y4

Database IDs:

ARBA 15 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 EPD 1 Ensembl 2 GO 5 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 11 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 7 PROSITE-ProRule 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 458
  • Mass: 52130
  • Checksum: 444FF288EADAE292
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 
YKIRNLDNGG FYISPRITFP GLHELVRHYT RYYNGHTKVA VKSLKQGSMS PDAFLAEANL 
MKQLQHQRLV RLYAVVTQEP IYIITEYMEN GSLVDFLKTP SGIKLTINKL LDMAAQIAEG 
MAFIEERNYI HRDLRAANIL VSDTLSCKIA DFGLARLIED NEYTAREGAK FPIKWTAPEA 
INYGTFTIKS DVWSFGILLT EIVTHGRIPY PGMTNPEVIQ NLERGYRMVR PDNCPEELYQ 
LMRLCWKERP EDRPTFDYLR SVLEDFFTAT EGQYQPQP

Genular Protein ID: 967588506

Symbol: Q573B4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q573B4

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 3 GenomeRNAi 1 IntAct 1 InterPro 11 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 4 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 2 Rhea 3 RuleBase 1 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16107303

Title: A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions.

PubMed ID: 16107303

DOI: 10.1016/j.gene.2005.06.018

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 516
  • Mass: 58333
  • Checksum: EB9A52D4EBDF14D2
  • Sequence:
    • MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 
LQGDPRQQGL KDKACGSLAV GFHLSPTYFL PGLAFLVPHP VTPGFLPIPA RFSLMPLVFT 
DNLVIALHSY EPSHDGDLGF EKGEQLRILE QSGEWWKAQS LTTGQEGFIP FNFVAKANSL 
EPEPWFFKNL SRKDAERQLL APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK 
IRNLDNGGFY ISPRITFPGL HELVRHYTRY YNGHTKVAVK SLKQGSMSPD AFLAEANLMK 
QLQHQRLVRL YAVVTQEPIY IITEYMENGS LVDFLKTPSG IKLTINKLLD MAAQIAEGMA 
FIEERNYIHR DLRAANILVS DTLSCKIADF GLARLIEDNE YTAREGAKFP IKWTAPEAIN 
YGTFTIKSDV WSFGILLTEI VTHGRIPYPG MTNPEVIQNL ERGYRMVRPD NCPEELYQLM 
RLCWKERPED RPTFDYLRSV LEDFFTATEG QYQPQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.