Details for: LFNG

Gene ID: 3955

Symbol: LFNG

Ensembl ID: ENSG00000106003

Description: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.8546
    Cell Significance Index: -10.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.2641
    Cell Significance Index: -10.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 24.7362
    Cell Significance Index: -10.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.9719
    Cell Significance Index: -8.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.4322
    Cell Significance Index: -10.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 16.2141
    Cell Significance Index: -10.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.8770
    Cell Significance Index: -9.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6946
    Cell Significance Index: -10.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8860
    Cell Significance Index: -10.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8488
    Cell Significance Index: -8.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7344
    Cell Significance Index: -10.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6811
    Cell Significance Index: 273.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3957
    Cell Significance Index: 162.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3024
    Cell Significance Index: 78.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2712
    Cell Significance Index: 36.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1909
    Cell Significance Index: 129.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1267
    Cell Significance Index: 51.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8445
    Cell Significance Index: 762.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7625
    Cell Significance Index: 337.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7461
    Cell Significance Index: 52.7700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6136
    Cell Significance Index: 6.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6001
    Cell Significance Index: 31.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5854
    Cell Significance Index: 10.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5425
    Cell Significance Index: 13.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5378
    Cell Significance Index: 37.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4380
    Cell Significance Index: 15.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4293
    Cell Significance Index: 9.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3788
    Cell Significance Index: 68.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3076
    Cell Significance Index: 6.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2339
    Cell Significance Index: 28.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2225
    Cell Significance Index: 22.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2066
    Cell Significance Index: 13.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1793
    Cell Significance Index: 34.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0986
    Cell Significance Index: 2.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0731
    Cell Significance Index: 4.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0554
    Cell Significance Index: 2.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0422
    Cell Significance Index: 23.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0169
    Cell Significance Index: 2.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0165
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0075
    Cell Significance Index: 10.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0041
    Cell Significance Index: 6.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0018
    Cell Significance Index: 0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0136
    Cell Significance Index: -9.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0275
    Cell Significance Index: -9.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0487
    Cell Significance Index: -9.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0563
    Cell Significance Index: -11.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0636
    Cell Significance Index: -1.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0668
    Cell Significance Index: -9.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0673
    Cell Significance Index: -8.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0725
    Cell Significance Index: -8.5500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0796
    Cell Significance Index: -0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0819
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0868
    Cell Significance Index: -9.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1034
    Cell Significance Index: -10.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1063
    Cell Significance Index: -6.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1085
    Cell Significance Index: -5.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1107
    Cell Significance Index: -3.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1151
    Cell Significance Index: -1.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1224
    Cell Significance Index: -3.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1264
    Cell Significance Index: -9.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1317
    Cell Significance Index: -6.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1320
    Cell Significance Index: -10.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1325
    Cell Significance Index: -1.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1423
    Cell Significance Index: -2.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1432
    Cell Significance Index: -8.8000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1556
    Cell Significance Index: -1.5600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1565
    Cell Significance Index: -1.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1630
    Cell Significance Index: -4.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1641
    Cell Significance Index: -8.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1663
    Cell Significance Index: -11.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1669
    Cell Significance Index: -10.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1800
    Cell Significance Index: -5.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1851
    Cell Significance Index: -2.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1907
    Cell Significance Index: -10.0100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2017
    Cell Significance Index: -2.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2448
    Cell Significance Index: -10.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2566
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2623
    Cell Significance Index: -2.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2657
    Cell Significance Index: -2.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2708
    Cell Significance Index: -9.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2843
    Cell Significance Index: -9.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2855
    Cell Significance Index: -10.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2857
    Cell Significance Index: -11.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2901
    Cell Significance Index: -10.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2923
    Cell Significance Index: -4.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2944
    Cell Significance Index: -7.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2979
    Cell Significance Index: -5.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3015
    Cell Significance Index: -8.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3245
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosylation enzyme**: LFNG is a 3-beta-N-acetylglucosaminyltransferase that catalyzes the transfer of fucose to specific carbohydrate moieties, leading to the formation of O-fucosylated peptides. 2. **Cell-specific expression**: LFNG is highly expressed in various cell types, including immune cells, endothelial cells, and neural cells, suggesting its involvement in multiple biological processes. 3. **Functional specificity**: LFNG exhibits specificity for certain carbohydrate moieties, which are involved in cell-cell interactions and signaling pathways. **Pathways and Functions:** 1. **Notch signaling pathway**: LFNG is involved in the regulation of the Notch signaling pathway, which plays a critical role in cell fate decisions, cell differentiation, and tissue development. 2. **Cell differentiation**: LFNG is required for the proper differentiation of immune cells, including T cells and B cells, and neural cells, such as GABAergic interneurons. 3. **Cell signaling**: LFNG is involved in the regulation of various cell signaling pathways, including the Notch, Wnt, and PI3K/AKT pathways. 4. **Developmental biology**: LFNG is required for the proper development of various tissues and organs, including the kidney, heart, and brain. **Clinical Significance:** 1. **Diseases associated with O-fucosylation**: Mutations in the LFNG gene have been associated with several diseases, including scdo3, a developmental disorder characterized by abnormal somitogenesis and osteogenesis. 2. **Immune system dysfunction**: LFNG deficiency has been linked to impaired immune system function, including abnormal T cell and B cell development. 3. **Cancer**: LFNG has been implicated in the regulation of cancer cell behavior, including cell proliferation, migration, and invasion. 4. **Neurological disorders**: LFNG has been linked to various neurological disorders, including autism spectrum disorder and schizophrenia. In conclusion, the LFNG gene plays a crucial role in regulating various biological processes, including immunology, development, and disease. Further research is needed to fully elucidate the mechanisms by which LFNG influences these processes and to explore its potential therapeutic applications.

Genular Protein ID: 4095017052

Symbol: LFNG_HUMAN

Name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

Q8NES3 B3KTY6 B5MCR5 O00589 Q96C39 Q9UJW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 4 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 4 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 9187150

Title: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

PubMed ID: 9187150

DOI: 10.1242/dev.124.11.2245

PubMed ID: 12110169

Title: Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis.

PubMed ID: 12110169

DOI: 10.1016/s1534-5807(02)00212-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11346656

Title: Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.

PubMed ID: 11346656

DOI: 10.1074/jbc.m103473200

PubMed ID: 16385447

Title: Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype.

PubMed ID: 16385447

DOI: 10.1086/498879

PubMed ID: 18485326

Title: Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.

PubMed ID: 18485326

DOI: 10.1016/j.ajhg.2008.04.014

PubMed ID: 30531807

Title: Identification of novel LFNG mutations in spondylocostal dysostosis.

PubMed ID: 30531807

DOI: 10.1038/s10038-018-0548-2

Sequence Information:

  • Length: 379
  • Mass: 41773
  • Checksum: 4400ECA731B36B45
  • Sequence:
    • MLKRCGRRLL LALAGALLAC LLVLTADPPP PPLPAERGRR ALRSLAGPAG AAPAPGLGAA 
AAAPGALVRD VHSLSEYFSL LTRARRDAGP PPGAAPRPAD GHPRPLAEPL APRDVFIAVK 
TTKKFHRARL DLLLETWISR HKEMTFIFTD GEDEALARHT GNVVITNCSA AHSRQALSCK 
MAVEYDRFIE SGRKWFCHVD DDNYVNLRAL LRLLASYPHT RDVYVGKPSL DRPIQAMERV 
SENKVRPVHF WFATGGAGFC ISRGLALKMS PWASGGHFMN TAERIRLPDD CTIGYIVEAL 
LGVPLIRSGL FHSHLENLQQ VPTSELHEQV TLSYGMFENK RNAVHVKGPF SVEADPSRFR 
SIHCHLYPDT PWCPRTAIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.