Details for: LSS

Gene ID: 4047

Symbol: LSS

Ensembl ID: ENSG00000160285

Description: lanosterol synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.9687
    Cell Significance Index: -27.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.8035
    Cell Significance Index: -27.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.7572
    Cell Significance Index: -25.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1135
    Cell Significance Index: -27.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9536
    Cell Significance Index: -20.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9721
    Cell Significance Index: -24.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 7.8092
    Cell Significance Index: 194.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9867
    Cell Significance Index: -27.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0953
    Cell Significance Index: -13.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.5484
    Cell Significance Index: 95.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7746
    Cell Significance Index: 337.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2899
    Cell Significance Index: 255.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9574
    Cell Significance Index: 94.7100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.8534
    Cell Significance Index: 8.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7840
    Cell Significance Index: 157.2700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.7687
    Cell Significance Index: 6.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7554
    Cell Significance Index: 9.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7312
    Cell Significance Index: 20.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7130
    Cell Significance Index: 27.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6938
    Cell Significance Index: 19.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6804
    Cell Significance Index: 244.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6406
    Cell Significance Index: 38.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6027
    Cell Significance Index: 65.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5720
    Cell Significance Index: 25.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5502
    Cell Significance Index: 24.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5361
    Cell Significance Index: 87.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5092
    Cell Significance Index: 14.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4403
    Cell Significance Index: 9.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.4018
    Cell Significance Index: 5.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3044
    Cell Significance Index: 54.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3042
    Cell Significance Index: 413.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3022
    Cell Significance Index: 20.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2913
    Cell Significance Index: 22.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2405
    Cell Significance Index: 452.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2372
    Cell Significance Index: 5.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2250
    Cell Significance Index: 10.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1777
    Cell Significance Index: 9.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1775
    Cell Significance Index: 24.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1736
    Cell Significance Index: 267.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1706
    Cell Significance Index: 93.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1558
    Cell Significance Index: 140.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1418
    Cell Significance Index: 17.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1249
    Cell Significance Index: 55.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1145
    Cell Significance Index: 72.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1036
    Cell Significance Index: 190.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0858
    Cell Significance Index: 3.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0845
    Cell Significance Index: 5.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0643
    Cell Significance Index: 3.3400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0547
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0341
    Cell Significance Index: 5.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0240
    Cell Significance Index: 1.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0239
    Cell Significance Index: 0.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0210
    Cell Significance Index: 0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0089
    Cell Significance Index: 6.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0003
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0112
    Cell Significance Index: -1.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0123
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0210
    Cell Significance Index: -15.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0591
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0651
    Cell Significance Index: -7.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0677
    Cell Significance Index: -19.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0788
    Cell Significance Index: -10.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0800
    Cell Significance Index: -9.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0912
    Cell Significance Index: -10.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1043
    Cell Significance Index: -10.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1086
    Cell Significance Index: -2.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1133
    Cell Significance Index: -2.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1213
    Cell Significance Index: -8.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1319
    Cell Significance Index: -1.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1324
    Cell Significance Index: -6.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1325
    Cell Significance Index: -8.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1403
    Cell Significance Index: -8.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1760
    Cell Significance Index: -13.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1895
    Cell Significance Index: -4.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1959
    Cell Significance Index: -20.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2105
    Cell Significance Index: -24.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2342
    Cell Significance Index: -15.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2587
    Cell Significance Index: -8.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2604
    Cell Significance Index: -20.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2656
    Cell Significance Index: -6.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2719
    Cell Significance Index: -8.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3017
    Cell Significance Index: -5.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3363
    Cell Significance Index: -20.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3409
    Cell Significance Index: -8.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3482
    Cell Significance Index: -5.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3569
    Cell Significance Index: -7.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3870
    Cell Significance Index: -20.1600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3983
    Cell Significance Index: -5.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4071
    Cell Significance Index: -11.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4433
    Cell Significance Index: -12.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4562
    Cell Significance Index: -9.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4626
    Cell Significance Index: -6.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4762
    Cell Significance Index: -4.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4818
    Cell Significance Index: -14.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4868
    Cell Significance Index: -7.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4976
    Cell Significance Index: -12.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme classification:** LSS belongs to the cytochrome P450 superfamily, specifically in the subclass of 3α-hydroxysteroid dehydrogenases. 2. **Substrate specificity:** LSS catalyzes the conversion of squalene to lanosterol, a key intermediate in cholesterol biosynthesis. 3. **Regulation by SREBP:** LSS is activated by SREBP, which binds to the promoter region of the LSS gene, inducing its transcription and subsequent expression. 4. **Cellular localization:** LSS is primarily expressed in cells involved in cholesterol synthesis, such as hepatocytes, lens epithelial cells, and adrenal cortical cells. **Pathways and Functions:** 1. **Cholesterol biosynthesis:** LSS is a critical enzyme in the biosynthesis of cholesterol, specifically in the conversion of squalene to lanosterol. 2. **Steroidal biosynthesis:** LSS is also involved in the synthesis of other steroidal compounds, such as pregnenolone and progesterone. 3. **Regulation of cholesterol synthesis:** LSS plays a key role in regulating cholesterol synthesis in response to changes in SREBP activity. 4. **Endoplasmic reticulum membrane:** LSS is anchored to the endoplasmic reticulum membrane, where it catalyzes the conversion of squalene to lanosterol. **Clinical Significance:** 1. **Hypercholesterolemia:** Dysregulation of LSS has been implicated in hypercholesterolemia, a condition characterized by elevated levels of cholesterol in the blood. 2. **Atherosclerosis:** The overexpression of LSS has been linked to atherosclerosis, a condition characterized by the buildup of cholesterol-rich plaques in arteries. 3. **Lanosterol synthase deficiency:** A rare genetic disorder, lanosterol synthase deficiency, has been reported to cause severe hypercholesterolemia and other metabolic abnormalities. 4. **Cancer research:** LSS has been identified as a potential target for cancer therapy, as its overexpression has been linked to the development of various types of cancer. In conclusion, lanosterol synthase is a critical enzyme involved in the biosynthesis of cholesterol and other steroidal compounds. Its dysregulation has been implicated in various diseases, including hypercholesterolemia, atherosclerosis, and cancer. Further research on LSS and its role in disease pathogenesis will provide valuable insights into the development of novel therapeutic strategies.

Genular Protein ID: 1753128708

Symbol: LSS_HUMAN

Name: Lanosterol synthase

UniProtKB Accession Codes:

P48449 B4DJZ9 D3DSN0 E9PEI9 G5E9Q9 Q8IYL6 Q9UEZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 24 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 Rhea 2 SFLD 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7639730

Title: Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.

PubMed ID: 7639730

DOI: 10.1006/bbrc.1995.2110

PubMed ID: 8593458

Title: Molecular cloning of cDNA encoding human lanosterol synthase.

PubMed ID: 8593458

DOI: 10.1248/bpb.18.1459

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10598817

Title: Structure of the human lanosterol synthase gene and its analysis as a candidate for holoprosencephaly.

PubMed ID: 10598817

DOI: 10.1007/s004390051135

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14766201

Title: The monotopic membrane protein human oxidosqualene cyclase is active as monomer.

PubMed ID: 14766201

DOI: 10.1016/j.bbrc.2004.01.052

PubMed ID: 8655142

Title: The human lanosterol synthase gene maps to chromosome 21q22.3.

PubMed ID: 8655142

DOI: 10.1007/bf02281872

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26200341

Title: Lanosterol reverses protein aggregation in cataracts.

PubMed ID: 26200341

DOI: 10.1038/nature14650

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29016354

Title: Congenital cataract with LSS gene mutations: a new case report.

PubMed ID: 29016354

DOI: 10.1515/jpem-2017-0101

PubMed ID: 30401459

Title: Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex.

PubMed ID: 30401459

DOI: 10.1016/j.ajhg.2018.09.011

PubMed ID: 30723320

Title: Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome.

PubMed ID: 30723320

DOI: 10.1038/s41436-019-0445-x

PubMed ID: 15525992

Title: Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.

PubMed ID: 15525992

DOI: 10.1038/nature02993

Sequence Information:

  • Length: 732
  • Mass: 83309
  • Checksum: E4708A5AE53585ED
  • Sequence:
    • MTEGTCLRRR GGPYKTEPAT DLGRWRLNCE RGRQTWTYLQ DERAGREQTG LEAYALGLDT 
KNYFKDLPKA HTAFEGALNG MTFYVGLQAE DGHWTGDYGG PLFLLPGLLI TCHVARIPLP 
AGYREEIVRY LRSVQLPDGG WGLHIEDKST VFGTALNYVS LRILGVGPDD PDLVRARNIL 
HKKGGAVAIP SWGKFWLAVL NVYSWEGLNT LFPEMWLFPD WAPAHPSTLW CHCRQVYLPM 
SYCYAVRLSA AEDPLVQSLR QELYVEDFAS IDWLAQRNNV APDELYTPHS WLLRVVYALL 
NLYEHHHSAH LRQRAVQKLY EHIVADDRFT KSISIGPISK TINMLVRWYV DGPASTAFQE 
HVSRIPDYLW MGLDGMKMQG TNGSQIWDTA FAIQALLEAG GHHRPEFSSC LQKAHEFLRL 
SQVPDNPPDY QKYYRQMRKG GFSFSTLDCG WIVSDCTAEA LKAVLLLQEK CPHVTEHIPR 
ERLCDAVAVL LNMRNPDGGF ATYETKRGGH LLELLNPSEV FGDIMIDYTY VECTSAVMQA 
LKYFHKRFPE HRAAEIRETL TQGLEFCRRQ QRADGSWEGS WGVCFTYGTW FGLEAFACMG 
QTYRDGTACA EVSRACDFLL SRQMADGGWG EDFESCEERR YLQSAQSQIH NTCWAMMGLM 
AVRHPDIEAQ ERGVRCLLEK QLPNGDWPQE NIAGVFNKSC AISYTSYRNI FPIWALGRFS 
QLYPERALAG HP

Genular Protein ID: 3474049963

Symbol: B2R694_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R694

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 2 RuleBase 1 SFLD 1 SUPFAM 1

Sequence Information:

  • Length: 732
  • Mass: 83424
  • Checksum: 19279807FC7334F6
  • Sequence:
    • MTEGTCLRRR GGPYKTEPAT DLGRWRLNCE RGRQTWTYLQ DERAGREQTG LEAYALGLDT 
KNYFKDLPKA HTAFEGALNG MTFYVGLQAE DGHWTGDYGG PLFLLPGLLI TCHVARIPLP 
AGYREEIVRY LRSVQLPDGG WGLHIEDKST VFGTALNYVS LRILGVGPDD PDLVRARNIL 
HKKGGAVAIP SWGKFWLAVL NVYSWEGLNT LFPEMWLFPD WAPAHPSTLW CHCRQVYLPM 
SYCYAVRLSA AEDPLVQSLR QELYVEDFAS IDWLAQRNNV APDELYTPHS WLLRVVYALL 
NLYEHHHSAH LRQRAVQKLY EHIVADDRFT KSISIGPISK TINMLVRWYV DWPASTAFQE 
HVSRIPDYLW MGLDGMKMQG TNGSQIWDTA FAIQALLEAG GHHRPEFSSC LQKAHEFLRL 
SQVPDNPPDY QKYYRQMRKG GFSFSTLDCG WIVSDCTAEA LKAVLLLQEK CPHVTEHIPR 
ERLCDAVAVL LNMRNPDGGF ATYETKRGGH LLELLNPSEV FGDIMIDYTY VECTSAVMQA 
LKYFHKRFPE HRAAEIRETL TQGLEFCRRQ QRADGSWEGS WGVCFTYGTW FGLEAFACMG 
QTYRDGTACA EVSRACDFLL SRQMADGGWG EDFESCEERR YVQSAQSQIH NTCWAMMGLM 
AVRHPDIEAQ ERGVRCLLEK QLPNGDWPQE NIAGVFNKSC AISYTSYRNI FPIWALGRFS 
QLYPERALAG HP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.