Details for: MOCS2

Gene ID: 4338

Symbol: MOCS2

Ensembl ID: ENSG00000164172

Description: molybdenum cofactor synthesis 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.3398
    Cell Significance Index: -26.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.4740
    Cell Significance Index: -24.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.0480
    Cell Significance Index: -29.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.8785
    Cell Significance Index: -28.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.1990
    Cell Significance Index: -24.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.2633
    Cell Significance Index: -24.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.5474
    Cell Significance Index: -27.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3659
    Cell Significance Index: -25.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0944
    Cell Significance Index: -28.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8306
    Cell Significance Index: -20.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0974
    Cell Significance Index: 214.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8690
    Cell Significance Index: 25.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.6827
    Cell Significance Index: 12.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4207
    Cell Significance Index: 165.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2625
    Cell Significance Index: 58.8700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.0603
    Cell Significance Index: 4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9563
    Cell Significance Index: 50.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8253
    Cell Significance Index: 22.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7992
    Cell Significance Index: 50.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7175
    Cell Significance Index: 19.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6344
    Cell Significance Index: 87.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6251
    Cell Significance Index: 125.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6175
    Cell Significance Index: 4.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5962
    Cell Significance Index: 76.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5716
    Cell Significance Index: 15.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5416
    Cell Significance Index: 295.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5339
    Cell Significance Index: 65.6500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4907
    Cell Significance Index: 3.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4829
    Cell Significance Index: 87.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4167
    Cell Significance Index: 12.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4152
    Cell Significance Index: 8.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4029
    Cell Significance Index: 20.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3826
    Cell Significance Index: 8.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3705
    Cell Significance Index: 163.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3513
    Cell Significance Index: 3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3437
    Cell Significance Index: 15.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2899
    Cell Significance Index: 104.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2873
    Cell Significance Index: 13.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2174
    Cell Significance Index: 43.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2109
    Cell Significance Index: 20.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1772
    Cell Significance Index: 129.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1716
    Cell Significance Index: 12.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1335
    Cell Significance Index: 10.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1299
    Cell Significance Index: 15.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1193
    Cell Significance Index: 8.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1042
    Cell Significance Index: 19.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1023
    Cell Significance Index: 70.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0956
    Cell Significance Index: 12.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0696
    Cell Significance Index: 0.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0290
    Cell Significance Index: 0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0200
    Cell Significance Index: 15.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0115
    Cell Significance Index: 0.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0039
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0169
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0181
    Cell Significance Index: -24.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0184
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0269
    Cell Significance Index: -19.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0364
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0401
    Cell Significance Index: -6.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0418
    Cell Significance Index: -18.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0499
    Cell Significance Index: -31.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0604
    Cell Significance Index: -1.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0610
    Cell Significance Index: -3.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0749
    Cell Significance Index: -21.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1067
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1261
    Cell Significance Index: -4.0400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1302
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1411
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1441
    Cell Significance Index: -30.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1448
    Cell Significance Index: -16.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1576
    Cell Significance Index: -12.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1712
    Cell Significance Index: -4.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1937
    Cell Significance Index: -10.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2122
    Cell Significance Index: -5.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2179
    Cell Significance Index: -6.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2182
    Cell Significance Index: -2.8000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.2189
    Cell Significance Index: -1.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2615
    Cell Significance Index: -16.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2631
    Cell Significance Index: -27.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2684
    Cell Significance Index: -11.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3238
    Cell Significance Index: -18.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3247
    Cell Significance Index: -19.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3272
    Cell Significance Index: -12.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3392
    Cell Significance Index: -9.6800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4136
    Cell Significance Index: -3.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4802
    Cell Significance Index: -14.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5229
    Cell Significance Index: -8.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5250
    Cell Significance Index: -4.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5382
    Cell Significance Index: -9.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5399
    Cell Significance Index: -13.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5487
    Cell Significance Index: -5.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6000
    Cell Significance Index: -14.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MOCS2 gene is a human gene that encodes two proteins, MOC2A (MOCO1-A) and MOC2B (MOCO1-B), which are involved in the biosynthesis of molybdenum cofactors. These proteins are part of the Molybdenum Cofactor Synthesis Complex (MCSC), a multi-enzyme complex that catalyzes the formation of molybdenum cofactors from molybdenum, carbon monoxide, and ribose-5-phosphate. The MOCS2 gene is highly expressed in various tissues, including the kidney, lung, and placenta, where it plays a critical role in maintaining molybdenum cofactor homeostasis. **Pathways and Functions:** The MOCS2 gene is involved in the biosynthesis of molybdenum cofactors through the following pathways: 1. **Molybdenum Cofactor Biosynthesis:** The MOCS2 gene encodes proteins that participate in the biosynthesis of molybdenum cofactors, which are essential for the functioning of numerous enzymes involved in metabolism. 2. **Molybdopterin Biosynthesis:** The MOCS2 gene is also involved in the biosynthesis of molybdopterin, a compound that serves as a precursor for the formation of molybdenum cofactors. 3. **Metabolism of Water-Soluble Vitamins and Cofactors:** The MOCS2 gene plays a critical role in the metabolism of water-soluble vitamins, including vitamin B12, which requires molybdenum cofactors for its metabolism. The MOCS2 gene has several functions, including: 1. **Maintenance of Molybdenum Cofactor Homeostasis:** The MOCS2 gene helps maintain molybdenum cofactor homeostasis by regulating the biosynthesis and degradation of molybdenum cofactors. 2. **Regulation of Enzyme Activity:** The MOCS2 gene regulates the activity of enzymes that require molybdenum cofactors, including those involved in the metabolism of sulfur-containing amino acids and the detoxification of xenobiotics. 3. **Cellular Protection:** The MOCS2 gene helps protect cells from oxidative damage by regulating the activity of enzymes involved in antioxidant defenses. **Clinical Significance:** Dysregulation of the MOCS2 gene has been implicated in various diseases, including: 1. **Molybdenum Deficiency:** Molybdenum deficiency can lead to impaired molybdenum cofactor biosynthesis, resulting in impaired enzyme activity and increased risk of oxidative damage. 2. **Molybdenum-Responsive Anemia:** Molybdenum-responsive anemia is a rare genetic disorder characterized by impaired molybdenum cofactor biosynthesis, leading to impaired enzyme activity and anemia. 3. **Neurological Disorders:** Dysregulation of the MOCS2 gene has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, which are characterized by impaired enzyme activity and oxidative damage. In conclusion, the MOCS2 gene plays a critical role in the biosynthesis of molybdenum cofactors, which are essential molecules that facilitate various enzymatic reactions in the body. Dysregulation of the MOCS2 gene has been implicated in various diseases, highlighting the importance of maintaining molybdenum cofactor homeostasis for optimal cellular function and overall health.

Genular Protein ID: 1867225908

Symbol: MOC2B_HUMAN

Name: MOCO1-B

UniProtKB Accession Codes:

O96007 Q6IAI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10053003

Title: Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames.

PubMed ID: 10053003

DOI: 10.1086/302295

PubMed ID: 9889283

Title: The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames.

PubMed ID: 9889283

DOI: 10.1093/nar/27.3.854

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732628

Title: Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.

PubMed ID: 12732628

DOI: 10.1074/jbc.m303092200

PubMed ID: 15073332

Title: Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.

PubMed ID: 15073332

DOI: 10.1073/pnas.0308191101

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10053004

Title: Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B.

PubMed ID: 10053004

DOI: 10.1086/302296

PubMed ID: 16021469

Title: Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.

PubMed ID: 16021469

DOI: 10.1007/s00439-005-1341-9

PubMed ID: 16737835

Title: A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.

PubMed ID: 16737835

DOI: 10.1016/j.ymgme.2006.04.008

Sequence Information:

  • Length: 188
  • Mass: 20944
  • Checksum: F405256D85621146
  • Sequence:
    • MSSLEISSSC FSLETKLPLS PPLVEDSAFE PSRKDMDEVE EKSKDVINFT AEKLSVDEVS 
QLVISPLCGA ISLFVGTTRN NFEGKKVISL EYEAYLPMAE NEVRKICSDI RQKWPVKHIA 
VFHRLGLVPV SEASIIIAVS SAHRAASLEA VSYAIDTLKA KVPIWKKEIY EESSTWKGNK 
ECFWASNS

Genular Protein ID: 197226208

Symbol: MOC2A_HUMAN

Name: MOCO1-A

UniProtKB Accession Codes:

O96033

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 6 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HPA 1 IntAct 1 InterPro 5 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 1 Pumba 1 Reactome 1 RefSeq 1 SMR 1 SUPFAM 1 SignaLink 1 UCSC 1 UniPathway 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10053003

Title: Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames.

PubMed ID: 10053003

DOI: 10.1086/302295

PubMed ID: 9889283

Title: The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames.

PubMed ID: 9889283

DOI: 10.1093/nar/27.3.854

PubMed ID: 12732628

Title: Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency.

PubMed ID: 12732628

DOI: 10.1074/jbc.m303092200

PubMed ID: 15073332

Title: Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans.

PubMed ID: 15073332

DOI: 10.1073/pnas.0308191101

PubMed ID: 15910006

Title: Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry.

PubMed ID: 15910006

DOI: 10.1021/bi0503448

PubMed ID: 17459099

Title: Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs.

PubMed ID: 17459099

DOI: 10.1111/j.1742-4658.2007.05811.x

PubMed ID: 18491921

Title: The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.

PubMed ID: 18491921

DOI: 10.1021/bi800477u

PubMed ID: 10053004

Title: Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B.

PubMed ID: 10053004

DOI: 10.1086/302296

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11746050

Title: Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency.

PubMed ID: 11746050

DOI: 10.1002/1096-8628(20011122)104:2<169::aid-ajmg1603>3.0.co;2-8

PubMed ID: 16021469

Title: Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.

PubMed ID: 16021469

DOI: 10.1007/s00439-005-1341-9

PubMed ID: 16737835

Title: A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.

PubMed ID: 16737835

DOI: 10.1016/j.ymgme.2006.04.008

Sequence Information:

  • Length: 88
  • Mass: 9755
  • Checksum: BD08B374B615E7BE
  • Sequence:
    • MVPLCQVEVL YFAKSAEITG VRSETISVPQ EIKALQLWKE IETRHPGLAD VRNQIIFAVR 
QEYVELGDQL LVLQPGDEIA VIPPISGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.