Details for: NARS1

Gene ID: 4677

Symbol: NARS1

Ensembl ID: ENSG00000134440

Description: asparaginyl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 258.7993
    Cell Significance Index: -40.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 169.4899
    Cell Significance Index: -42.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.4481
    Cell Significance Index: -52.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.7489
    Cell Significance Index: -44.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.2981
    Cell Significance Index: -51.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.5424
    Cell Significance Index: -49.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.3611
    Cell Significance Index: -51.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.9969
    Cell Significance Index: -44.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.3047
    Cell Significance Index: -46.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5949
    Cell Significance Index: -49.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6920
    Cell Significance Index: -32.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7780
    Cell Significance Index: -21.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3983
    Cell Significance Index: 22.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9781
    Cell Significance Index: 243.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8899
    Cell Significance Index: 340.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6165
    Cell Significance Index: 44.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5307
    Cell Significance Index: 80.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3964
    Cell Significance Index: 96.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3765
    Cell Significance Index: 10.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3171
    Cell Significance Index: 180.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2122
    Cell Significance Index: 197.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2021
    Cell Significance Index: 656.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1872
    Cell Significance Index: 34.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1628
    Cell Significance Index: 60.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0879
    Cell Significance Index: 76.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0607
    Cell Significance Index: 212.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9547
    Cell Significance Index: 422.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9351
    Cell Significance Index: 43.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8894
    Cell Significance Index: 46.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8839
    Cell Significance Index: 175.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7942
    Cell Significance Index: 37.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7613
    Cell Significance Index: 47.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6263
    Cell Significance Index: 46.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5941
    Cell Significance Index: 76.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4860
    Cell Significance Index: 62.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4720
    Cell Significance Index: 10.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4659
    Cell Significance Index: 12.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4624
    Cell Significance Index: 29.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4599
    Cell Significance Index: 15.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4547
    Cell Significance Index: 163.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4203
    Cell Significance Index: 379.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4102
    Cell Significance Index: 4.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3393
    Cell Significance Index: 9.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3049
    Cell Significance Index: 13.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3013
    Cell Significance Index: 29.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2944
    Cell Significance Index: 8.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2691
    Cell Significance Index: 51.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2484
    Cell Significance Index: 5.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1635
    Cell Significance Index: 8.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1410
    Cell Significance Index: 103.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1322
    Cell Significance Index: 4.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1282
    Cell Significance Index: 15.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0596
    Cell Significance Index: 4.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0414
    Cell Significance Index: 31.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0237
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0155
    Cell Significance Index: 28.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0066
    Cell Significance Index: 10.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0061
    Cell Significance Index: 3.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0197
    Cell Significance Index: -13.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0507
    Cell Significance Index: -5.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0534
    Cell Significance Index: -24.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0615
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0636
    Cell Significance Index: -47.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0775
    Cell Significance Index: -13.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0831
    Cell Significance Index: -46.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0845
    Cell Significance Index: -52.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0893
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1446
    Cell Significance Index: -16.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1470
    Cell Significance Index: -42.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1496
    Cell Significance Index: -21.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1514
    Cell Significance Index: -1.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1601
    Cell Significance Index: -8.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1832
    Cell Significance Index: -12.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2555
    Cell Significance Index: -53.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2883
    Cell Significance Index: -4.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2990
    Cell Significance Index: -3.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3009
    Cell Significance Index: -6.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3358
    Cell Significance Index: -10.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3527
    Cell Significance Index: -15.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3767
    Cell Significance Index: -5.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4133
    Cell Significance Index: -3.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4243
    Cell Significance Index: -11.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4296
    Cell Significance Index: -10.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4458
    Cell Significance Index: -46.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4469
    Cell Significance Index: -8.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4509
    Cell Significance Index: -18.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4724
    Cell Significance Index: -17.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5180
    Cell Significance Index: -31.1000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5280
    Cell Significance Index: -4.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5418
    Cell Significance Index: -13.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5705
    Cell Significance Index: -12.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6174
    Cell Significance Index: -17.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6818
    Cell Significance Index: -41.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6827
    Cell Significance Index: -20.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7030
    Cell Significance Index: -20.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7540
    Cell Significance Index: -14.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7983
    Cell Significance Index: -20.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NARS1 is a cytoplasmic enzyme that catalyzes the aminoacylation of asparagine to its corresponding tRNA molecule. This process is a critical step in protein synthesis, ensuring that amino acids are accurately incorporated into proteins. NARS1 is a member of the aminoacyl-tRNA synthetase family, which is responsible for the accurate loading of amino acids onto their corresponding tRNA molecules. **Pathways and Functions:** NARS1 is involved in several key pathways, including: 1. **Asparagine-trna ligase activity**: NARS1 catalyzes the aminoacylation of asparagine to its corresponding tRNA molecule, a process essential for protein synthesis. 2. **Protein synthesis**: NARS1 is involved in the translation of mRNA into proteins, ensuring that amino acids are accurately incorporated into proteins. 3. **Cell migration**: NARS1 has been implicated in the regulation of cell migration, a process critical for various physiological and pathological processes, including cancer metastasis. 4. **Cerebral cortex development**: NARS1 is expressed in the developing cerebral cortex, suggesting a role in the regulation of neural development and function. **Clinical Significance:** NARS1 has been implicated in several disease states, including: 1. **Cancer**: NARS1 is overexpressed in various types of cancer, including breast cancer, suggesting a role in tumorigenesis and cancer progression. 2. **Neurological disorders**: NARS1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting a role in the regulation of protein synthesis and aggregation. 3. **Cardiac disease**: NARS1 has been implicated in cardiac disease, including heart failure and cardiac arrhythmias, suggesting a role in the regulation of protein synthesis and cardiac function. **Significantly Expressed Cells:** NARS1 is expressed in a variety of cell types, including: 1. **Extravillous trophoblast**: NARS1 is expressed in extravillous trophoblast cells, which are involved in placental development and function. 2. **Kidney loop of Henle thick ascending limb epithelial cell**: NARS1 is expressed in kidney cells, suggesting a role in the regulation of electrolyte balance and kidney function. 3. **Malignant cell**: NARS1 is overexpressed in malignant cells, suggesting a role in tumorigenesis and cancer progression. **Conclusion:** NARS1 is a critical enzyme involved in protein synthesis and cellular migration. Its expression in various cell types and its implication in disease states highlight its importance in understanding the regulation of protein synthesis and cellular function. Further research is needed to elucidate the mechanisms by which NARS1 regulates protein synthesis and cellular migration, and to explore its potential as a therapeutic target in disease states.

Genular Protein ID: 3101700658

Symbol: SYNC_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9421509

Title: Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen.

PubMed ID: 9421509

DOI: 10.1093/nar/26.2.521

PubMed ID: 9801298

Title: Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family.

PubMed ID: 9801298

DOI: 10.1093/nar/26.22.5045

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9973509

Title: Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease.

PubMed ID: 9973509

PubMed ID: 12235211

Title: Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.

PubMed ID: 12235211

DOI: 10.1084/jem.20020186

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30171954

Title: Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.

PubMed ID: 30171954

DOI: 10.1016/j.ijbiomac.2018.08.171

PubMed ID: 32738225

Title: De novo and bi-allelic pathogenic variants in NARS1 cause neurodevelopmental delay due to toxic gain-of-function and partial loss-of-function effects.

PubMed ID: 32738225

DOI: 10.1016/j.ajhg.2020.06.016

PubMed ID: 32788587

Title: Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly.

PubMed ID: 32788587

DOI: 10.1038/s41467-020-17454-4

PubMed ID: 33589599

Title:

PubMed ID: 33589599

DOI: 10.1038/s41467-021-21448-1

Sequence Information:

  • Length: 548
  • Mass: 62943
  • Checksum: CDD442C4E962CDDB
  • Sequence:
  • MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK ENERWNVISK 
    SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK ITIKNDPSLP EPKCVKIGAL 
    EGYRGQRVKV FGWVHRLRRQ GKNLMFLVLR DGTGYLQCVL ADELCQCYNG VLLSTESSVA 
    VYGMLNLTPK GKQAPGGHEL SCDFWELIGL APAGGADNLI NEESDVDVQL NNRHMMIRGE 
    NMSKILKARS MVTRCFRDHF FDRGYYEVTP PTLVQTQVEG GATLFKLDYF GEEAFLTQSS 
    QLYLETCLPA LGDVFCIAQS YRAEQSRTRR HLAEYTHVEA ECPFLTFDDL LNRLEDLVCD 
    VVDRILKSPA GSIVHELNPN FQPPKRPFKR MNYSDAIVWL KEHDVKKEDG TFYEFGEDIP 
    EAPERLMTDT INEPILLCRF PVEIKSFYMQ RCPEDSRLTE SVDVLMPNVG EIVGGSMRIF 
    DSEEILAGYK REGIDPTPYY WYTDQRKYGT CPHGGYGLGL ERFLTWILNR YHIRDVCLYP 
    RFVQRCTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.