Details for: NARS1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 258.7993
Cell Significance Index: -40.2600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 169.4899
Cell Significance Index: -42.9900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 126.4481
Cell Significance Index: -52.0900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 108.7489
Cell Significance Index: -44.1800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 108.2981
Cell Significance Index: -51.1300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 96.5424
Cell Significance Index: -49.6600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 76.3611
Cell Significance Index: -51.2400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.9969
Cell Significance Index: -44.8700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 37.3047
Cell Significance Index: -46.0000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.5949
Cell Significance Index: -49.7000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.6920
Cell Significance Index: -32.8400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.7780
Cell Significance Index: -21.4000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3983
Cell Significance Index: 22.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.9781
Cell Significance Index: 243.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8899
Cell Significance Index: 340.6900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.6165
Cell Significance Index: 44.0000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.5307
Cell Significance Index: 80.3700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.3964
Cell Significance Index: 96.5700 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.3765
Cell Significance Index: 10.9900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3171
Cell Significance Index: 180.8700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2122
Cell Significance Index: 197.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2021
Cell Significance Index: 656.5200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1872
Cell Significance Index: 34.2100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1628
Cell Significance Index: 60.4100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.0879
Cell Significance Index: 76.9400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0607
Cell Significance Index: 212.7700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9547
Cell Significance Index: 422.0900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9351
Cell Significance Index: 43.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.8894
Cell Significance Index: 46.3300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8839
Cell Significance Index: 175.4200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7942
Cell Significance Index: 37.3300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7613
Cell Significance Index: 47.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6263
Cell Significance Index: 46.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5941
Cell Significance Index: 76.1600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4860
Cell Significance Index: 62.7900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.4720
Cell Significance Index: 10.9100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4659
Cell Significance Index: 12.2500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4624
Cell Significance Index: 29.8300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4599
Cell Significance Index: 15.9800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4547
Cell Significance Index: 163.0900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4203
Cell Significance Index: 379.5000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.4102
Cell Significance Index: 4.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3393
Cell Significance Index: 9.0600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3049
Cell Significance Index: 13.8200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3013
Cell Significance Index: 29.8100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2944
Cell Significance Index: 8.4400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2691
Cell Significance Index: 51.2200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.2484
Cell Significance Index: 5.2000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1635
Cell Significance Index: 8.2600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1410
Cell Significance Index: 103.3900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1322
Cell Significance Index: 4.6500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1282
Cell Significance Index: 15.1200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0596
Cell Significance Index: 4.5700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0414
Cell Significance Index: 31.3200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0237
Cell Significance Index: 0.2500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0226
Cell Significance Index: 42.4800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0155
Cell Significance Index: 28.5500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0066
Cell Significance Index: 10.1700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0061
Cell Significance Index: 3.8800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0021
Cell Significance Index: 0.0600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0158
Cell Significance Index: -21.4800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0197
Cell Significance Index: -13.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0507
Cell Significance Index: -5.1800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0534
Cell Significance Index: -24.2300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0615
Cell Significance Index: -4.8700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0636
Cell Significance Index: -47.1000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0775
Cell Significance Index: -13.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0831
Cell Significance Index: -46.8700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0845
Cell Significance Index: -52.7800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0893
Cell Significance Index: -1.5000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1446
Cell Significance Index: -16.5700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1470
Cell Significance Index: -42.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1496
Cell Significance Index: -21.7500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1514
Cell Significance Index: -1.7200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1601
Cell Significance Index: -8.9900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1832
Cell Significance Index: -12.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2555
Cell Significance Index: -53.8200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2883
Cell Significance Index: -4.9400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2990
Cell Significance Index: -3.2500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3009
Cell Significance Index: -6.5200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3358
Cell Significance Index: -10.7600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3527
Cell Significance Index: -15.6000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3767
Cell Significance Index: -5.1400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4133
Cell Significance Index: -3.3700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4243
Cell Significance Index: -11.3500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4296
Cell Significance Index: -10.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4458
Cell Significance Index: -46.4200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4469
Cell Significance Index: -8.2600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4509
Cell Significance Index: -18.4800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4724
Cell Significance Index: -17.8900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5180
Cell Significance Index: -31.1000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.5280
Cell Significance Index: -4.0700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5418
Cell Significance Index: -13.8400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5705
Cell Significance Index: -12.1500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6174
Cell Significance Index: -17.6200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6818
Cell Significance Index: -41.8000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6827
Cell Significance Index: -20.0500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7030
Cell Significance Index: -20.7100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7540
Cell Significance Index: -14.7200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7983
Cell Significance Index: -20.5200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3101700658
Symbol: SYNC_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9421509
Title: Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen.
PubMed ID: 9421509
DOI: 10.1093/nar/26.2.521
PubMed ID: 9801298
Title: Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family.
PubMed ID: 9801298
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9973509
Title: Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease.
PubMed ID: 9973509
PubMed ID: 12235211
Title: Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.
PubMed ID: 12235211
DOI: 10.1084/jem.20020186
PubMed ID: 19892738
Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.
PubMed ID: 19892738
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30171954
Title: Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.
PubMed ID: 30171954
PubMed ID: 32738225
Title: De novo and bi-allelic pathogenic variants in NARS1 cause neurodevelopmental delay due to toxic gain-of-function and partial loss-of-function effects.
PubMed ID: 32738225
PubMed ID: 32788587
Title: Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly.
PubMed ID: 32788587
PubMed ID: 33589599
Sequence Information:
- Length: 548
- Mass: 62943
- Checksum: CDD442C4E962CDDB
- Sequence:
MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK ENERWNVISK SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK ITIKNDPSLP EPKCVKIGAL EGYRGQRVKV FGWVHRLRRQ GKNLMFLVLR DGTGYLQCVL ADELCQCYNG VLLSTESSVA VYGMLNLTPK GKQAPGGHEL SCDFWELIGL APAGGADNLI NEESDVDVQL NNRHMMIRGE NMSKILKARS MVTRCFRDHF FDRGYYEVTP PTLVQTQVEG GATLFKLDYF GEEAFLTQSS QLYLETCLPA LGDVFCIAQS YRAEQSRTRR HLAEYTHVEA ECPFLTFDDL LNRLEDLVCD VVDRILKSPA GSIVHELNPN FQPPKRPFKR MNYSDAIVWL KEHDVKKEDG TFYEFGEDIP EAPERLMTDT INEPILLCRF PVEIKSFYMQ RCPEDSRLTE SVDVLMPNVG EIVGGSMRIF DSEEILAGYK REGIDPTPYY WYTDQRKYGT CPHGGYGLGL ERFLTWILNR YHIRDVCLYP RFVQRCTP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.