Details for: NDUFB7

Gene ID: 4713

Symbol: NDUFB7

Ensembl ID: ENSG00000099795

Description: NADH:ubiquinone oxidoreductase subunit B7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 441.8651
    Cell Significance Index: -68.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 286.3469
    Cell Significance Index: -72.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 221.1689
    Cell Significance Index: -91.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 187.4089
    Cell Significance Index: -88.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 167.5981
    Cell Significance Index: -86.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 132.7229
    Cell Significance Index: -89.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 68.9238
    Cell Significance Index: -84.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.0636
    Cell Significance Index: -91.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6104
    Cell Significance Index: -60.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.7622
    Cell Significance Index: -63.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.4927
    Cell Significance Index: -29.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.7030
    Cell Significance Index: 265.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.1407
    Cell Significance Index: 95.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1123
    Cell Significance Index: 28.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7063
    Cell Significance Index: 21.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6899
    Cell Significance Index: 484.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.6782
    Cell Significance Index: 71.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.5131
    Cell Significance Index: 131.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5037
    Cell Significance Index: 343.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4723
    Cell Significance Index: 304.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4649
    Cell Significance Index: 1346.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4328
    Cell Significance Index: 172.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3941
    Cell Significance Index: 112.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1994
    Cell Significance Index: 972.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1358
    Cell Significance Index: 56.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9659
    Cell Significance Index: 53.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6907
    Cell Significance Index: 218.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6492
    Cell Significance Index: 122.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6310
    Cell Significance Index: 34.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6251
    Cell Significance Index: 1467.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5556
    Cell Significance Index: 80.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5446
    Cell Significance Index: 23.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4368
    Cell Significance Index: 142.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3913
    Cell Significance Index: 178.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3663
    Cell Significance Index: 88.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2614
    Cell Significance Index: 148.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0479
    Cell Significance Index: 11.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8257
    Cell Significance Index: 52.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6956
    Cell Significance Index: 24.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6844
    Cell Significance Index: 20.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6026
    Cell Significance Index: 16.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4571
    Cell Significance Index: 335.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4522
    Cell Significance Index: 73.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4312
    Cell Significance Index: 5.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3300
    Cell Significance Index: 65.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2894
    Cell Significance Index: 22.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2634
    Cell Significance Index: 50.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2068
    Cell Significance Index: 156.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1508
    Cell Significance Index: 30.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1282
    Cell Significance Index: 2.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0520
    Cell Significance Index: 0.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0490
    Cell Significance Index: 8.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0470
    Cell Significance Index: 1.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0172
    Cell Significance Index: -6.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0234
    Cell Significance Index: -43.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0515
    Cell Significance Index: -95.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0617
    Cell Significance Index: -94.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0745
    Cell Significance Index: -101.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0754
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0913
    Cell Significance Index: -67.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0972
    Cell Significance Index: -67.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1072
    Cell Significance Index: -68.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1202
    Cell Significance Index: -0.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1288
    Cell Significance Index: -72.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1487
    Cell Significance Index: -67.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1850
    Cell Significance Index: -115.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2233
    Cell Significance Index: -64.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3522
    Cell Significance Index: -40.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3872
    Cell Significance Index: -17.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4015
    Cell Significance Index: -46.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4018
    Cell Significance Index: -12.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4271
    Cell Significance Index: -10.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4519
    Cell Significance Index: -9.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4616
    Cell Significance Index: -97.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4925
    Cell Significance Index: -13.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5110
    Cell Significance Index: -74.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5929
    Cell Significance Index: -8.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7648
    Cell Significance Index: -47.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8009
    Cell Significance Index: -23.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8590
    Cell Significance Index: -65.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8711
    Cell Significance Index: -90.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9363
    Cell Significance Index: -16.5500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.9706
    Cell Significance Index: -8.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0256
    Cell Significance Index: -8.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0319
    Cell Significance Index: -13.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0595
    Cell Significance Index: -59.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0796
    Cell Significance Index: -31.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1550
    Cell Significance Index: -77.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.3800
    Cell Significance Index: -28.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4244
    Cell Significance Index: -40.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4342
    Cell Significance Index: -87.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4598
    Cell Significance Index: -31.0900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.6347
    Cell Significance Index: -12.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7516
    Cell Significance Index: -46.9400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.9281
    Cell Significance Index: -12.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.9314
    Cell Significance Index: -27.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9577
    Cell Significance Index: -33.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9905
    Cell Significance Index: -73.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0374
    Cell Significance Index: -52.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Complex I**: NDUFB7 is a beta subunit of Complex I, a multi-subunit enzyme that catalyzes the transfer of electrons from NADH to ubiquinone, generating a proton gradient that drives ATP synthesis. 2. **Mitochondrial localization**: NDUFB7 is exclusively localized to the mitochondrial inner membrane, where it plays a critical role in the electron transport chain. 3. **Regulation of energy metabolism**: NDUFB7 is involved in the regulation of energy metabolism, particularly in the context of the citric acid cycle and respiratory electron transport. 4. **Significant expression in various tissues**: NDUFB7 is expressed in multiple tissues, including the kidney, pancreas, salivary glands, and enterocytes, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Aerobic respiration**: NDUFB7 is essential for aerobic respiration, the process by which cells generate energy from the breakdown of glucose. 2. **Mitochondrial electron transport**: NDUFB7 plays a critical role in the mitochondrial electron transport chain, generating a proton gradient that drives ATP synthesis. 3. **Proton motive force-driven ATP synthesis**: NDUFB7 is involved in the regulation of proton motive force-driven ATP synthesis, a process that is essential for maintaining cellular energy homeostasis. 4. **Heat production by uncoupling proteins**: NDUFB7 has been implicated in the regulation of heat production by uncoupling proteins, which can lead to thermogenesis and energy metabolism. **Clinical Significance:** 1. **Neurodegenerative disorders**: Dysregulation of NDUFB7 has been implicated in neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 2. **Metabolic disorders**: NDUFB7 has been linked to metabolic disorders, including type 2 diabetes, metabolic syndrome, and obesity. 3. **Cardiovascular diseases**: NDUFB7 has been implicated in cardiovascular diseases, including hypertension, atherosclerosis, and cardiac arrhythmias. 4. **Cancer**: NDUFB7 has been found to be overexpressed in certain types of cancer, including lung, breast, and colon cancer. In conclusion, NDUFB7 is a critical gene that plays a pivotal role in mitochondrial function and energy metabolism. Dysregulation of NDUFB7 has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms underlying NDUFB7 dysregulation and its role in disease pathogenesis.

Genular Protein ID: 2554262705

Symbol: NDUB7_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

UniProtKB Accession Codes:

P17568 Q6ICN9 Q9UI16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2302251

Title: cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells.

PubMed ID: 2302251

DOI: 10.1016/0006-291x(90)90908-6

PubMed ID: 10830904

Title: Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients.

PubMed ID: 10830904

DOI: 10.1007/s004390000278

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21310150

Title: NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.

PubMed ID: 21310150

DOI: 10.1016/j.febslet.2011.01.046

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

PubMed ID: 33502047

Title: Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7.

PubMed ID: 33502047

DOI: 10.1002/humu.24173

Sequence Information:

  • Length: 137
  • Mass: 16402
  • Checksum: 2743716544288776
  • Sequence:
    • MGAHLVRRYL GDASVEPDPL QMPTFPPDYG FPERKEREMV ATQQEMMDAQ LRLQLRDYCA 
HHLIRLLKCK RDSFPNFLAC KQERHDWDYC EHRDYVMRMK EFERERRLLQ RKKRREKKAA 
ELAKGQGPGE VDPKVAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.