Details for: NDUFS3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 256.0670
Cell Significance Index: -39.8300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 149.5407
Cell Significance Index: -37.9300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.5837
Cell Significance Index: -50.9100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 119.0871
Cell Significance Index: -48.3800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 115.5208
Cell Significance Index: -54.5400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.7914
Cell Significance Index: -52.3600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 81.4727
Cell Significance Index: -54.6700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 51.6160
Cell Significance Index: -49.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.1085
Cell Significance Index: -50.6900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.5887
Cell Significance Index: -41.7600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.4590
Cell Significance Index: -53.1100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.9199
Cell Significance Index: -33.5400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 7.5847
Cell Significance Index: 189.1400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.0861
Cell Significance Index: -13.3200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 3.3061
Cell Significance Index: 198.4800 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.8937
Cell Significance Index: 15.1200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6762
Cell Significance Index: 78.1500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.6256
Cell Significance Index: 56.4900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.4488
Cell Significance Index: 15.7500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3759
Cell Significance Index: 28.8000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3374
Cell Significance Index: 86.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1576
Cell Significance Index: 52.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1318
Cell Significance Index: 204.0300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1270
Cell Significance Index: 498.2600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1172
Cell Significance Index: 79.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0939
Cell Significance Index: 597.3800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.0915
Cell Significance Index: 28.7000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9906
Cell Significance Index: 51.4600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9444
Cell Significance Index: 20.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9179
Cell Significance Index: 112.8700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9142
Cell Significance Index: 125.5500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.8909
Cell Significance Index: 26.1700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8731
Cell Significance Index: 102.9600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8595
Cell Significance Index: 776.0300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8301
Cell Significance Index: 43.5900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.7077
Cell Significance Index: 16.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5085
Cell Significance Index: 23.9000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.5081
Cell Significance Index: 65.6400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4732
Cell Significance Index: 60.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4726
Cell Significance Index: 89.9300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3733
Cell Significance Index: 27.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3687
Cell Significance Index: 73.9600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3518
Cell Significance Index: 22.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3471
Cell Significance Index: 9.7000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2922
Cell Significance Index: 49.8900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2785
Cell Significance Index: 7.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2239
Cell Significance Index: 36.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2221
Cell Significance Index: 44.0800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1730
Cell Significance Index: 9.0100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1148
Cell Significance Index: 84.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0997
Cell Significance Index: 68.9300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0959
Cell Significance Index: 34.3800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0756
Cell Significance Index: 7.4800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0269
Cell Significance Index: 0.4500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0239
Cell Significance Index: 0.8400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0236
Cell Significance Index: 0.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0140
Cell Significance Index: 10.5900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0106
Cell Significance Index: 0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0155
Cell Significance Index: -29.2000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0171
Cell Significance Index: -12.6700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0248
Cell Significance Index: -2.5300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0281
Cell Significance Index: -0.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0292
Cell Significance Index: -18.2300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0337
Cell Significance Index: -62.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0400
Cell Significance Index: -61.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0464
Cell Significance Index: -63.1100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0557
Cell Significance Index: -35.3600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0644
Cell Significance Index: -36.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0967
Cell Significance Index: -43.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1211
Cell Significance Index: -25.5100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1548
Cell Significance Index: -44.5400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1824
Cell Significance Index: -4.6600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1869
Cell Significance Index: -14.8000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1889
Cell Significance Index: -6.0500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2077
Cell Significance Index: -23.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2524
Cell Significance Index: -29.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2899
Cell Significance Index: -42.1400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3108
Cell Significance Index: -6.6200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3753
Cell Significance Index: -28.8000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3947
Cell Significance Index: -45.0500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4355
Cell Significance Index: -4.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4663
Cell Significance Index: -28.6600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5070
Cell Significance Index: -52.7900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5285
Cell Significance Index: -7.2100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5439
Cell Significance Index: -30.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5657
Cell Significance Index: -38.0400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5970
Cell Significance Index: -8.9500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6293
Cell Significance Index: -18.5400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6303
Cell Significance Index: -11.6500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6349
Cell Significance Index: -10.8800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6602
Cell Significance Index: -17.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6893
Cell Significance Index: -42.2600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7603
Cell Significance Index: -52.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8227
Cell Significance Index: -36.3900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.8782
Cell Significance Index: -23.4900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9101
Cell Significance Index: -26.0900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.9189
Cell Significance Index: -12.8800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.9378
Cell Significance Index: -12.0100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.9661
Cell Significance Index: -27.8400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0389
Cell Significance Index: -39.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1849229606
Symbol: NDUS3_HUMAN
Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9647766
Title: cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed.
PubMed ID: 9647766
PubMed ID: 10967146
Title: Human NDUFS3 gene coding for the 30-kDa subunit of mitochondrial Complex I: genomic organization and expression.
PubMed ID: 10967146
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19892738
Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.
PubMed ID: 19892738
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 17209039
Title: Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.
PubMed ID: 17209039
PubMed ID: 18826940
Title: Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.
PubMed ID: 18826940
PubMed ID: 19463981
Title: Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.
PubMed ID: 19463981
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 31536960
Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.
PubMed ID: 31536960
PubMed ID: 14729820
Title: Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome.
PubMed ID: 14729820
PubMed ID: 22499348
Title: Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing.
PubMed ID: 22499348
PubMed ID: 24028823
Title: Human mitochondrial NDUFS3 protein bearing Leigh syndrome mutation is more prone to aggregation than its wild-type.
PubMed ID: 24028823
PubMed ID: 30140060
Title: A Novel NDUFS3 mutation in a Chinese patient with severe Leigh syndrome.
PubMed ID: 30140060
Sequence Information:
- Length: 264
- Mass: 30242
- Checksum: C058D62779BEF17B
- Sequence:
MAAAAVARLW WRGILGASAL TRGTGRPSVL LLPVRRESAG ADTRPTVRPR NDVAHKQLSA FGEYVAEILP KYVQQVQVSC FNELEVCIHP DGVIPVLTFL RDHTNAQFKS LVDLTAVDVP TRQNRFEIVY NLLSLRFNSR IRVKTYTDEL TPIESAVSVF KAANWYEREI WDMFGVFFAN HPDLRRILTD YGFEGHPFRK DFPLSGYVEL RYDDEVKRVV AEPVELAQEF RKFDLNSPWE AFPVYRQPPE SLKLEAGDKK PDAK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.