Details for: RPL10A

Gene ID: 4736

Symbol: RPL10A

Ensembl ID: ENSG00000198755

Description: ribosomal protein L10a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 631.2210
    Cell Significance Index: -260.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 561.7871
    Cell Significance Index: -228.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 530.2012
    Cell Significance Index: -250.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 504.4857
    Cell Significance Index: -259.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 375.1292
    Cell Significance Index: -251.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 243.5106
    Cell Significance Index: -232.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.7950
    Cell Significance Index: -71.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.5743
    Cell Significance Index: 500.0600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 18.5225
    Cell Significance Index: 108.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.3597
    Cell Significance Index: 1466.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.0667
    Cell Significance Index: 376.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 12.1002
    Cell Significance Index: 279.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.9573
    Cell Significance Index: 561.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.7458
    Cell Significance Index: 408.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.4913
    Cell Significance Index: 147.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.3812
    Cell Significance Index: 201.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.5285
    Cell Significance Index: 276.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.3991
    Cell Significance Index: 217.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.1671
    Cell Significance Index: 1313.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.0778
    Cell Significance Index: 642.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.0412
    Cell Significance Index: 1241.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.8655
    Cell Significance Index: 96.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.7973
    Cell Significance Index: 252.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7452
    Cell Significance Index: 651.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.5470
    Cell Significance Index: 52.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.4407
    Cell Significance Index: 95.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.9462
    Cell Significance Index: 977.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.8646
    Cell Significance Index: 1417.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.7046
    Cell Significance Index: 3406.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.2418
    Cell Significance Index: 57.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.1845
    Cell Significance Index: 3923.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.0119
    Cell Significance Index: 452.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.9570
    Cell Significance Index: 324.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.7814
    Cell Significance Index: 799.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1982
    Cell Significance Index: 168.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.1561
    Cell Significance Index: 789.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.8247
    Cell Significance Index: 141.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.4127
    Cell Significance Index: 40.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.6573
    Cell Significance Index: 624.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.9017
    Cell Significance Index: 152.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.7395
    Cell Significance Index: 73.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.5465
    Cell Significance Index: 1927.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3723
    Cell Significance Index: 123.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2785
    Cell Significance Index: 2057.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1210
    Cell Significance Index: 420.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5028
    Cell Significance Index: 148.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1846
    Cell Significance Index: 61.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9984
    Cell Significance Index: 731.9900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.9915
    Cell Significance Index: 8.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9305
    Cell Significance Index: 64.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1525
    Cell Significance Index: 24.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1332
    Cell Significance Index: 10.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0958
    Cell Significance Index: 1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0694
    Cell Significance Index: -19.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0702
    Cell Significance Index: -132.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0964
    Cell Significance Index: -71.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1285
    Cell Significance Index: -237.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1407
    Cell Significance Index: -26.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1522
    Cell Significance Index: -234.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2016
    Cell Significance Index: -274.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2061
    Cell Significance Index: -116.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2245
    Cell Significance Index: -140.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2258
    Cell Significance Index: -45.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3164
    Cell Significance Index: -200.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3439
    Cell Significance Index: -123.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4562
    Cell Significance Index: -207.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4905
    Cell Significance Index: -103.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6151
    Cell Significance Index: -19.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7222
    Cell Significance Index: -44.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7813
    Cell Significance Index: -43.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8622
    Cell Significance Index: -39.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9797
    Cell Significance Index: -112.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0032
    Cell Significance Index: -114.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0305
    Cell Significance Index: -17.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1771
    Cell Significance Index: -19.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5295
    Cell Significance Index: -222.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9893
    Cell Significance Index: -125.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4150
    Cell Significance Index: -251.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.0949
    Cell Significance Index: -237.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.1824
    Cell Significance Index: -43.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.2407
    Cell Significance Index: -19.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.3528
    Cell Significance Index: -83.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.3905
    Cell Significance Index: -227.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.3923
    Cell Significance Index: -50.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.4773
    Cell Significance Index: -213.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.9045
    Cell Significance Index: -112.5000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -4.1919
    Cell Significance Index: -19.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.6156
    Cell Significance Index: -135.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.7967
    Cell Significance Index: -103.9200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.8745
    Cell Significance Index: -26.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -4.9144
    Cell Significance Index: -41.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.9810
    Cell Significance Index: -85.3600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.1794
    Cell Significance Index: -108.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -5.2370
    Cell Significance Index: -32.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -5.5242
    Cell Significance Index: -202.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7356
    Cell Significance Index: -253.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -5.9582
    Cell Significance Index: -76.7300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.9782
    Cell Significance Index: -42.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.2571
    Cell Significance Index: -219.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -6.5357
    Cell Significance Index: -175.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein**: RPL10A is a constituent of the 60S ribosomal subunit, which is responsible for the assembly and function of the ribosome. 2. **Conservation across species**: RPL10A is conserved across various species, including humans, indicating its essential role in ribosome biogenesis and function. 3. **Multiple isoforms**: RPL10A has multiple isoforms, which may contribute to its diverse roles in cellular processes. 4. **Expression in various cells**: RPL10A is expressed in a wide range of cells, including immune cells, stem cells, and cancer cells, highlighting its potential involvement in various diseases. **Pathways and Functions:** 1. **Translation initiation**: RPL10A is involved in the initiation of translation, working in conjunction with other ribosomal proteins to form the 60S subunit. 2. **Eukaryotic translation elongation**: RPL10A plays a role in the elongation phase of translation, ensuring the accurate assembly of the ribosome. 3. **Regulation of protein synthesis**: RPL10A can modulate protein synthesis by regulating the activity of translation initiation and elongation factors. 4. **Response to stress and starvation**: RPL10A is involved in the cellular response to stress and starvation, helping to maintain protein homeostasis. 5. **Viral replication**: RPL10A is essential for the replication of certain viruses, such as influenza, highlighting its role in viral infection pathways. **Clinical Significance:** 1. **Cancer**: Abnormal expression of RPL10A has been linked to various cancers, including breast, lung, and colon cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Autoimmune diseases**: RPL10A has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its role in immune regulation. 3. **Neurological disorders**: RPL10A has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential involvement in protein misfolding and aggregation. 4. **Infectious diseases**: RPL10A plays a critical role in the replication of certain viruses, such as influenza, emphasizing its importance in viral infection pathways. In conclusion, RPL10A is a vital component of the 60S ribosomal subunit, playing a crucial role in translation initiation, elongation, and regulation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which RPL10A regulates protein synthesis and its clinical significance.

Genular Protein ID: 1982561275

Symbol: RL10A_HUMAN

Name: 60S ribosomal protein L10a

UniProtKB Accession Codes:

P62906 B2R801 P52859 P53025 Q5TZT6 Q8J013

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 37 Ensembl 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7609734

Title: Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19.

PubMed ID: 7609734

DOI: 10.1016/0161-5890(95)00032-a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 38383789

Title: The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.

PubMed ID: 38383789

DOI: 10.1038/s41586-024-07093-w

Sequence Information:

  • Length: 217
  • Mass: 24831
  • Checksum: 38F1A31119A751D3
  • Sequence:
    • MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS GTVRLKSTPR 
PKFSVCVLGD QQHCDEAKAV DIPHMDIEAL KKLNKNKKLV KKLAKKYDAF LASESLIKQI 
PRILGPGLNK AGKFPSLLTH NENMVAKVDE VKSTIKFQMK KVLCLAVAVG HVKMTDDELV 
YNIHLAVNFL VSLLKKNWQN VRALYIKSTM GKPQRLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.