RPL10A | ENSG00000198755 | NCBI 4736

Details for: RPL10A

Gene ID: 4736

Symbol: RPL10A

Ensembl ID: ENSG00000198755

Description: ribosomal protein L10a

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Maturation of lsu-rrna
(GO:0000470)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.96
Marker Score: 29,266
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.56
Marker Score: 4,353
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.49
Marker Score: 11,515
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.44
Marker Score: 8,373
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.28
Marker Score: 6,871
Cell Name: malignant cell (CL0001064)
Fold Change: 5.23
Marker Score: 70,257
Cell Name: mature T cell (CL0002419)
Fold Change: 5.22
Marker Score: 51,674
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.2
Marker Score: 3,926
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.18
Marker Score: 2,918
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.05
Marker Score: 3,664
Cell Name: radial glial cell (CL0000681)
Fold Change: 5
Marker Score: 1,845
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.99
Marker Score: 8,555
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.98
Marker Score: 14,521
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.96
Marker Score: 2,548
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.91
Marker Score: 167,005
Cell Name: theca cell (CL0000503)
Fold Change: 4.9
Marker Score: 3,511
Cell Name: naive B cell (CL0000788)
Fold Change: 4.8
Marker Score: 4,287
Cell Name: naive T cell (CL0000898)
Fold Change: 4.78
Marker Score: 3,080
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.72
Marker Score: 14,906
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.67
Marker Score: 246,893
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.47
Marker Score: 58,986
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.46
Marker Score: 23,435
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.34
Marker Score: 2,241
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.33
Marker Score: 2,636
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.31
Marker Score: 3,668
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.3
Marker Score: 4,774
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.27
Marker Score: 1,021
Cell Name: chondrocyte (CL0000138)
Fold Change: 4.27
Marker Score: 1,922
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.24
Marker Score: 11,722
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.18
Marker Score: 1,358
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.17
Marker Score: 11,688
Cell Name: memory T cell (CL0000813)
Fold Change: 4.16
Marker Score: 1,788
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.16
Marker Score: 10,156
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.1
Marker Score: 24,915
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.09
Marker Score: 9,327
Cell Name: blood cell (CL0000081)
Fold Change: 4.09
Marker Score: 47,557
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.09
Marker Score: 2,397
Cell Name: acinar cell (CL0000622)
Fold Change: 4.08
Marker Score: 2,876
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.07
Marker Score: 3,473
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.05
Marker Score: 17,365
Cell Name: supporting cell (CL0000630)
Fold Change: 4.04
Marker Score: 7,597
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.01
Marker Score: 4,279
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.99
Marker Score: 3,133
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.98
Marker Score: 3,923
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.98
Marker Score: 3,844
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 3.95
Marker Score: 1,263
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.92
Marker Score: 219,309
Cell Name: club cell (CL0000158)
Fold Change: 3.92
Marker Score: 4,571
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.89
Marker Score: 2,077
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.85
Marker Score: 28,687
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.8
Marker Score: 24,756
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.79
Marker Score: 2,550
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.79
Marker Score: 10,150
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.76
Marker Score: 3,533
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.75
Marker Score: 9,145
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.75
Marker Score: 1,233
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.74
Marker Score: 858
Cell Name: reticular cell (CL0000432)
Fold Change: 3.73
Marker Score: 1,360
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.72
Marker Score: 1,701
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.7
Marker Score: 4,573
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7
Marker Score: 24,084
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.69
Marker Score: 2,623
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.68
Marker Score: 2,802
Cell Name: memory B cell (CL0000787)
Fold Change: 3.67
Marker Score: 2,780
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.67
Marker Score: 1,002
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.66
Marker Score: 2,020
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.65
Marker Score: 1,173
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.65
Marker Score: 3,243
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.65
Marker Score: 9,082
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.63
Marker Score: 1,030
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.62
Marker Score: 1,020
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.61
Marker Score: 5,323
Cell Name: immature B cell (CL0000816)
Fold Change: 3.61
Marker Score: 2,394
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.6
Marker Score: 3,982
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.6
Marker Score: 3,173
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.6
Marker Score: 5,720
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.59
Marker Score: 2,983
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.59
Marker Score: 2,941
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.59
Marker Score: 3,216
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.58
Marker Score: 3,196
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.58
Marker Score: 8,121
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.57
Marker Score: 2,094
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.57
Marker Score: 12,690
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.57
Marker Score: 2,053
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.57
Marker Score: 3,001
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.55
Marker Score: 1,840
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.55
Marker Score: 3,114
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.55
Marker Score: 5,815
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.54
Marker Score: 1,523
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.54
Marker Score: 931
Cell Name: stromal cell (CL0000499)
Fold Change: 3.54
Marker Score: 4,143
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.53
Marker Score: 3,331
Cell Name: paneth cell (CL0000510)
Fold Change: 3.53
Marker Score: 2,453
Cell Name: fibroblast (CL0000057)
Fold Change: 3.52
Marker Score: 3,398
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.51
Marker Score: 2,311
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.51
Marker Score: 3,661
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.51
Marker Score: 4,137
Cell Name: basal cell (CL0000646)
Fold Change: 3.5
Marker Score: 4,516
Cell Name: basophil (CL0000767)
Fold Change: 3.49
Marker Score: 1,658
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.49
Marker Score: 994

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Ribosomal protein**: RPL10A is a constituent of the 60S ribosomal subunit, which is responsible for the assembly and function of the ribosome. 2. **Conservation across species**: RPL10A is conserved across various species, including humans, indicating its essential role in ribosome biogenesis and function. 3. **Multiple isoforms**: RPL10A has multiple isoforms, which may contribute to its diverse roles in cellular processes. 4. **Expression in various cells**: RPL10A is expressed in a wide range of cells, including immune cells, stem cells, and cancer cells, highlighting its potential involvement in various diseases. **Pathways and Functions:** 1. **Translation initiation**: RPL10A is involved in the initiation of translation, working in conjunction with other ribosomal proteins to form the 60S subunit. 2. **Eukaryotic translation elongation**: RPL10A plays a role in the elongation phase of translation, ensuring the accurate assembly of the ribosome. 3. **Regulation of protein synthesis**: RPL10A can modulate protein synthesis by regulating the activity of translation initiation and elongation factors. 4. **Response to stress and starvation**: RPL10A is involved in the cellular response to stress and starvation, helping to maintain protein homeostasis. 5. **Viral replication**: RPL10A is essential for the replication of certain viruses, such as influenza, highlighting its role in viral infection pathways. **Clinical Significance:** 1. **Cancer**: Abnormal expression of RPL10A has been linked to various cancers, including breast, lung, and colon cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Autoimmune diseases**: RPL10A has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its role in immune regulation. 3. **Neurological disorders**: RPL10A has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential involvement in protein misfolding and aggregation. 4. **Infectious diseases**: RPL10A plays a critical role in the replication of certain viruses, such as influenza, emphasizing its importance in viral infection pathways. In conclusion, RPL10A is a vital component of the 60S ribosomal subunit, playing a crucial role in translation initiation, elongation, and regulation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully elucidate the mechanisms by which RPL10A regulates protein synthesis and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L10a

Genular Protein ID: 1982561275

Symbol: RL10A_HUMAN

Name: 60S ribosomal protein L10a

UniProtKB Accession Codes:

P62906 B2R801 P52859 P53025 Q5TZT6 Q8J013

Database IDs:

Citations:

PubMed ID: 7609734

Title: Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19.

PubMed ID: 7609734

DOI: 10.1016/0161-5890(95)00032-a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 217
Mass: 24831
Checksum: 38F1A31119A751D3
Sequence:

MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS GTVRLKSTPR 
PKFSVCVLGD QQHCDEAKAV DIPHMDIEAL KKLNKNKKLV KKLAKKYDAF LASESLIKQI 
PRILGPGLNK AGKFPSLLTH NENMVAKVDE VKSTIKFQMK KVLCLAVAVG HVKMTDDELV 
YNIHLAVNFL VSLLKKNWQN VRALYIKSTM GKPQRLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPL10A

Associated with

Cells (max top 100)

Other Information

Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. PubMed ID: 7609734

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. PubMed ID: 12962325

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547