Details for: ODC1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 270.8858
Cell Significance Index: -42.1400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 209.2702
Cell Significance Index: -53.0800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 117.3636
Cell Significance Index: -55.4100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 108.5766
Cell Significance Index: -44.1100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 98.5545
Cell Significance Index: -50.7000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 82.1731
Cell Significance Index: -55.1400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.9865
Cell Significance Index: -44.8600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.8385
Cell Significance Index: -51.5900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.6530
Cell Significance Index: -47.2900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.7527
Cell Significance Index: -58.2200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 9.8357
Cell Significance Index: -30.2100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.9487
Cell Significance Index: 64.6700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.2893
Cell Significance Index: 149.0500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.3584
Cell Significance Index: 232.2500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4145
Cell Significance Index: 50.5400 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.4122
Cell Significance Index: 19.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.2974
Cell Significance Index: 1254.6800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.2432
Cell Significance Index: 275.8200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2384
Cell Significance Index: 30.5400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.1651
Cell Significance Index: 255.3300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.5156
Cell Significance Index: 78.7300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4374
Cell Significance Index: 92.7400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3717
Cell Significance Index: 247.2800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3641
Cell Significance Index: 64.1100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2129
Cell Significance Index: 34.7700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2080
Cell Significance Index: 32.8800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1876
Cell Significance Index: 53.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1511
Cell Significance Index: 33.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0699
Cell Significance Index: 146.9300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9164
Cell Significance Index: 90.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6435
Cell Significance Index: 104.6700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5735
Cell Significance Index: 113.8100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5225
Cell Significance Index: 13.7400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5076
Cell Significance Index: 96.6000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4824
Cell Significance Index: 5.4800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4645
Cell Significance Index: 10.0600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.4460
Cell Significance Index: 128.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3953
Cell Significance Index: 174.7900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3873
Cell Significance Index: 49.6500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3864
Cell Significance Index: 5.7900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.3450
Cell Significance Index: 44.5700 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.3002
Cell Significance Index: 1.4600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1488
Cell Significance Index: 3.1700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1009
Cell Significance Index: 5.6600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0860
Cell Significance Index: 0.8900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0611
Cell Significance Index: 46.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0409
Cell Significance Index: 8.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0306
Cell Significance Index: 1.9300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0050
Cell Significance Index: 0.2300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0037
Cell Significance Index: -6.9800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0120
Cell Significance Index: -8.8200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0243
Cell Significance Index: -16.8100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0299
Cell Significance Index: -55.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0300
Cell Significance Index: -46.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0416
Cell Significance Index: -26.4000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0456
Cell Significance Index: -16.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0474
Cell Significance Index: -64.4100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0601
Cell Significance Index: -44.5500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0771
Cell Significance Index: -1.2900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0825
Cell Significance Index: -8.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0834
Cell Significance Index: -14.2500 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0846
Cell Significance Index: -1.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0922
Cell Significance Index: -52.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1021
Cell Significance Index: -46.3500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1043
Cell Significance Index: -65.1100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1049
Cell Significance Index: -7.4200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1241
Cell Significance Index: -7.6300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1347
Cell Significance Index: -19.5800 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2313
Cell Significance Index: -3.2500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2541
Cell Significance Index: -29.6200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2742
Cell Significance Index: -31.4100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2810
Cell Significance Index: -9.0000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2986
Cell Significance Index: -62.9000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3339
Cell Significance Index: -8.5300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3416
Cell Significance Index: -25.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3754
Cell Significance Index: -10.4900 - Cell Name: glioblast (CL0000030)
Fold Change: -0.3870
Cell Significance Index: -2.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4211
Cell Significance Index: -33.3600 - Cell Name: sensory neuron (CL0000101)
Fold Change: -0.5331
Cell Significance Index: -3.0300 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.5342
Cell Significance Index: -4.5900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5478
Cell Significance Index: -57.0400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5814
Cell Significance Index: -44.6200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6007
Cell Significance Index: -15.4400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.6040
Cell Significance Index: -7.7400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6171
Cell Significance Index: -10.9100 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.6380
Cell Significance Index: -5.8000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6540
Cell Significance Index: -34.0700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6542
Cell Significance Index: -17.5000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7815
Cell Significance Index: -52.5500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8504
Cell Significance Index: -44.6500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8901
Cell Significance Index: -54.5700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9026
Cell Significance Index: -26.5900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.1082
Cell Significance Index: -13.2100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1163
Cell Significance Index: -40.9800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.1408
Cell Significance Index: -46.7400 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -1.2235
Cell Significance Index: -7.9600 - Cell Name: radial glial cell (CL0000681)
Fold Change: -1.2268
Cell Significance Index: -7.2800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2385
Cell Significance Index: -54.7800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.2439
Cell Significance Index: -11.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.3147
Cell Significance Index: -46.2000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1242724124
Symbol: DCOR_HUMAN
Name: Ornithine decarboxylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3595418
Title: Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA.
PubMed ID: 3595418
PubMed ID: 2693021
Title: Characterization and sequence analysis of the human ornithine decarboxylase gene.
PubMed ID: 2693021
PubMed ID: 2587220
Title: Nucleotide sequence of the human ornithine decarboxylase gene.
PubMed ID: 2587220
PubMed ID: 2227439
Title: Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene.
PubMed ID: 2227439
PubMed ID: 2318872
Title: Isolation and expression of a human ornithine decarboxylase gene.
PubMed ID: 2318872
PubMed ID: 1598217
Title: Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.
PubMed ID: 1598217
PubMed ID: 8519686
Title: Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element.
PubMed ID: 8519686
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2317811
Title: Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells.
PubMed ID: 2317811
PubMed ID: 3308908
Title: Cell-cycle-dependent expression of human ornithine decarboxylase.
PubMed ID: 3308908
PubMed ID: 10462479
Title: Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.
PubMed ID: 10462479
PubMed ID: 11461922
Title: Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
PubMed ID: 11461922
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 17900240
Title: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.
PubMed ID: 17900240
DOI: 10.1042/bj20071004
PubMed ID: 10623504
Title: Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.
PubMed ID: 10623504
PubMed ID: 17407445
Title: A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.
PubMed ID: 17407445
DOI: 10.1042/bj20070188
PubMed ID: 26305948
Title: Structural basis of antizyme-mediated regulation of polyamine homeostasis.
PubMed ID: 26305948
PubMed ID: 26443277
Title: Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor antizyme1.
PubMed ID: 26443277
DOI: 10.1038/srep14738
PubMed ID: 30239107
Title: Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features.
PubMed ID: 30239107
DOI: 10.1002/ajmg.a.40523
PubMed ID: 30475435
Title: Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities.
PubMed ID: 30475435
DOI: 10.1002/ajmg.a.60677
Sequence Information:
- Length: 461
- Mass: 51148
- Checksum: 8CCB88CE80E823C5
- Sequence:
MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK KHLRWLKALP RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLRTSRLL LERAKELNID VVGVSFHVGS GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG SEDVKLKFEE ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY YSSSIWGPTC DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPTIYYVMS GPAWQLMQQF QNPDFPPEVE EQDASTLPVS CAWESGMKRH RAACASASIN V
Genular Protein ID: 2393474890
Symbol: B4DXF8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 308
- Mass: 34156
- Checksum: D02B4B4A075F6E1D
- Sequence:
MMTFDSEVGL MKVARAHPKA KLVLRIATDD SKAVCRLSVK FGATLRTSRL LLERAKELNI DVVGVSFHVG SGCTDPETFV QAISDARCVF DMGAEVGFSM YLLDIGGGFP GSEDVKLKFE EITGVINPAL DKYFPSDSGV RIIAEPGRYY VASAFTLAVN IIAKKIVLKE QTGSDDEDES SEQTFMYYVN DGVYGSFNCI LYDHAHVKPL LQKRPKPDEK YYSSSIWGPT CDGLDRIVER CDLPEMHVGD WMLFENKGAY TVAAASTFNG FQRPTIYYVM SGPAWQLMQQ FQNPDFPPCL CLVPGRVG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.