Details for: P4HA1

Gene ID: 5033

Symbol: P4HA1

Ensembl ID: ENSG00000122884

Description: prolyl 4-hydroxylase subunit alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 358.2238
    Cell Significance Index: -55.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.8579
    Cell Significance Index: -53.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 147.5794
    Cell Significance Index: -60.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.1415
    Cell Significance Index: -58.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 115.6410
    Cell Significance Index: -46.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.6819
    Cell Significance Index: -55.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.5083
    Cell Significance Index: -58.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.3641
    Cell Significance Index: -47.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.5653
    Cell Significance Index: -56.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.1601
    Cell Significance Index: -56.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.3181
    Cell Significance Index: -56.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3282
    Cell Significance Index: -29.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.3825
    Cell Significance Index: 131.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.2064
    Cell Significance Index: 82.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.5476
    Cell Significance Index: 195.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3359
    Cell Significance Index: 463.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5046
    Cell Significance Index: 301.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4216
    Cell Significance Index: 776.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2835
    Cell Significance Index: 21.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1443
    Cell Significance Index: 64.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0988
    Cell Significance Index: 29.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0497
    Cell Significance Index: 54.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9034
    Cell Significance Index: 1701.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8998
    Cell Significance Index: 1385.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8949
    Cell Significance Index: 122.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8742
    Cell Significance Index: 313.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.7161
    Cell Significance Index: 973.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6548
    Cell Significance Index: 17.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6508
    Cell Significance Index: 450.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5720
    Cell Significance Index: 56.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5178
    Cell Significance Index: 63.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5147
    Cell Significance Index: 233.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5088
    Cell Significance Index: 82.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4903
    Cell Significance Index: 53.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4640
    Cell Significance Index: 855.7400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4152
    Cell Significance Index: 2.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3568
    Cell Significance Index: 64.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3172
    Cell Significance Index: 286.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2995
    Cell Significance Index: 38.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2871
    Cell Significance Index: 182.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2466
    Cell Significance Index: 3.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1982
    Cell Significance Index: 37.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1942
    Cell Significance Index: 3.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1362
    Cell Significance Index: 2.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1092
    Cell Significance Index: 7.3400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1008
    Cell Significance Index: 1.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0782
    Cell Significance Index: 34.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0743
    Cell Significance Index: 3.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0677
    Cell Significance Index: 2.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0329
    Cell Significance Index: 2.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0172
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0128
    Cell Significance Index: 2.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0041
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0301
    Cell Significance Index: -22.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0304
    Cell Significance Index: -23.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0428
    Cell Significance Index: -26.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0476
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0502
    Cell Significance Index: -36.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0745
    Cell Significance Index: -42.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1111
    Cell Significance Index: -11.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1548
    Cell Significance Index: -2.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1623
    Cell Significance Index: -46.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1705
    Cell Significance Index: -1.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1733
    Cell Significance Index: -25.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1898
    Cell Significance Index: -22.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2023
    Cell Significance Index: -8.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2076
    Cell Significance Index: -43.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2168
    Cell Significance Index: -5.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2517
    Cell Significance Index: -13.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2639
    Cell Significance Index: -3.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2836
    Cell Significance Index: -19.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2857
    Cell Significance Index: -10.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3122
    Cell Significance Index: -23.2700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3135
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3166
    Cell Significance Index: -36.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3270
    Cell Significance Index: -15.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3373
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3435
    Cell Significance Index: -39.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3523
    Cell Significance Index: -22.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3563
    Cell Significance Index: -46.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3767
    Cell Significance Index: -17.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3886
    Cell Significance Index: -44.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3963
    Cell Significance Index: -5.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4353
    Cell Significance Index: -22.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4900
    Cell Significance Index: -14.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5052
    Cell Significance Index: -35.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5377
    Cell Significance Index: -14.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5398
    Cell Significance Index: -9.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5466
    Cell Significance Index: -34.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5936
    Cell Significance Index: -16.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6232
    Cell Significance Index: -31.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6468
    Cell Significance Index: -51.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6516
    Cell Significance Index: -18.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6786
    Cell Significance Index: -41.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6965
    Cell Significance Index: -15.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7318
    Cell Significance Index: -16.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7560
    Cell Significance Index: -26.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8045
    Cell Significance Index: -23.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.8253
    Cell Significance Index: -11.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8780
    Cell Significance Index: -8.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of prolyl 4-dioxygenase:** P4HA1 is a subunit of the prolyl 4-dioxygenase complex, which is responsible for the hydroxylation of proline residues in procollagen. 2. **Collagen biosynthesis:** P4HA1 is involved in the biosynthesis of collagen, a critical ECM protein that provides structural support and tissue integrity. 3. **Protein binding:** P4HA1 interacts with other proteins, including collagen, fibronectin, and integrins, to regulate ECM organization and cell signaling. 4. **Expression in various tissues:** P4HA1 is expressed in lens epithelial cells, skeletal muscle fibers, cardiac myocytes, and fibroblasts, highlighting its role in tissue regeneration and ECM maintenance. **Pathways and Functions:** 1. **Collagen biosynthesis pathway:** P4HA1 is involved in the hydroxylation of proline residues in procollagen, which is essential for collagen's triple-helix structure and ECM integrity. 2. **Endoplasmic reticulum (ER) pathway:** P4HA1 is localized to the ER, where it interacts with other proteins to regulate collagen biosynthesis and ECM organization. 3. **Protein binding and interaction:** P4HA1 interacts with other proteins to regulate ECM organization, cell signaling, and tissue regeneration. 4. **Iron ion binding and L-ascorbic acid binding:** P4HA1 binds to iron ions and L-ascorbic acid, which are essential cofactors for the prolyl 4-dioxygenase reaction. **Clinical Significance:** 1. **Collagen-related disorders:** P4HA1 mutations have been implicated in collagen-related disorders, such as osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS). 2. **Tissue regeneration:** P4HA1 plays a critical role in tissue regeneration, particularly in the context of wound healing and ECM maintenance. 3. **Cancer and fibrosis:** P4HA1 has been implicated in cancer progression and fibrosis, highlighting its potential as a therapeutic target. 4. **Immunological disorders:** P4HA1 has been linked to immunological disorders, such as autoimmune diseases and inflammation, suggesting its potential as a therapeutic target. In conclusion, P4HA1 is a critical component of the prolyl 4-dioxygenase complex, essential for collagen biosynthesis and ECM organization. Its dysregulation has been implicated in various immunological and tissue-related disorders, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the role of P4HA1 in human health and disease.

Genular Protein ID: 1362491801

Symbol: P4HA1_HUMAN

Name: Prolyl 4-hydroxylase subunit alpha-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2543975

Title: Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts.

PubMed ID: 2543975

DOI: 10.1073/pnas.86.12.4392

PubMed ID: 7961714

Title: Structure and expression of the human gene for the alpha subunit of prolyl 4-hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues.

PubMed ID: 7961714

DOI: 10.1016/s0021-9258(18)46864-0

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9211872

Title: Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer.

PubMed ID: 9211872

DOI: 10.1074/jbc.272.28.17342

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15456751

Title: The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues.

PubMed ID: 15456751

DOI: 10.1074/jbc.m410007200

Sequence Information:

  • Length: 534
  • Mass: 61049
  • Checksum: EBAFA8CCF09A1DDB
  • Sequence:
  • MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA 
    EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY 
    FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS FLTAEDCFEL GKVAYTEADY 
    YHTELWMEQA LRQLDEGEIS TIDKVSVLDY LSYAVYQQGD LDKALLLTKK LLELDPEHQR 
    ANGNLKYFEY IMAKEKDVNK SASDDQSDQK TTPKKKGVAV DYLPERQKYE MLCRGEGIKM 
    TPRRQKKLFC RYHDGNRNPK FILAPAKQED EWDKPRIIRF HDIISDAEIE IVKDLAKPRL 
    RRATISNPIT GDLETVHYRI SKSAWLSGYE NPVVSRINMR IQDLTGLDVS TAEELQVANY 
    GVGGQYEPHF DFARKDEPDA FKELGTGNRI ATWLFYMSDV SAGGATVFPE VGASVWPKKG 
    TAVFWYNLFA SGEGDYSTRH AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE

Genular Protein ID: 3935894727

Symbol: Q5VSQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 534
  • Mass: 60967
  • Checksum: 5FE1B10A8AC5E792
  • Sequence:
  • MIWYILIIGI LLPQSLAHPG FFTSIGQMTD LIHTEKDLVT SLKDYIKAEE DKLEQIKKWA 
    EKLDRLTSTA TKDPEGFVGH PVNAFKLMKR LNTEWSELEN LVLKDMSDGF ISNLTIQRQY 
    FPNDEDQVGA AKALLRLQDT YNLDTDTISK GNLPGVKHKS FLTAEDCFEL GKVAYTEADY 
    YHTELWMEQA LRQLDEGEIS TIDKVSVLDY LSYAVYQQGD LDKALLLTKK LLELDPEHQR 
    ANGNLKYFEY IMAKEKDVNK SASDDQSDQK TTPKKKGVAV DYLPERQKYE MLCRGEGIKM 
    TPRRQKKLFC RYHDGNRNPK FILAPAKQED EWDKPRIIRF HDIISDAEIE IVKDLAKPRL 
    SRATVHDPET GKLTTAQYRV SKSAWLSGYE NPVVSRINMR IQDLTGLDVS TAEELQVANY 
    GVGGQYEPHF DFARKDEPDA FKELGTGNRI ATWLFYMSDV SAGGATVFPE VGASVWPKKG 
    TAVFWYNLFA SGEGDYSTRH AACPVLVGNK WVSNKWLHER GQEFRRPCTL SELE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.