Details for: PA2G4

Gene ID: 5036

Symbol: PA2G4

Ensembl ID: ENSG00000170515

Description: proliferation-associated 2G4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 344.3372
    Cell Significance Index: -53.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.8967
    Cell Significance Index: -59.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 213.8864
    Cell Significance Index: -88.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 170.9937
    Cell Significance Index: -80.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.7952
    Cell Significance Index: -79.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 120.8157
    Cell Significance Index: -81.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.2560
    Cell Significance Index: -73.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.4335
    Cell Significance Index: -84.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9535
    Cell Significance Index: -48.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7487
    Cell Significance Index: -45.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3844
    Cell Significance Index: -18.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.7784
    Cell Significance Index: 127.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.7925
    Cell Significance Index: 41.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1462
    Cell Significance Index: 92.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7863
    Cell Significance Index: 382.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6674
    Cell Significance Index: 480.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6496
    Cell Significance Index: 325.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6347
    Cell Significance Index: 186.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4930
    Cell Significance Index: 117.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4038
    Cell Significance Index: 65.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3123
    Cell Significance Index: 149.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0211
    Cell Significance Index: 893.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9514
    Cell Significance Index: 17.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8248
    Cell Significance Index: 20.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8159
    Cell Significance Index: 991.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4943
    Cell Significance Index: 176.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4581
    Cell Significance Index: 188.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4092
    Cell Significance Index: 48.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3734
    Cell Significance Index: 176.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2723
    Cell Significance Index: 94.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2596
    Cell Significance Index: 58.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2555
    Cell Significance Index: 26.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0584
    Cell Significance Index: 30.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0083
    Cell Significance Index: 163.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8767
    Cell Significance Index: 45.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8220
    Cell Significance Index: 43.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7093
    Cell Significance Index: 204.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6461
    Cell Significance Index: 16.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6241
    Cell Significance Index: 13.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5808
    Cell Significance Index: 524.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5591
    Cell Significance Index: 14.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5115
    Cell Significance Index: 87.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4579
    Cell Significance Index: 91.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3953
    Cell Significance Index: 6.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3444
    Cell Significance Index: 15.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3204
    Cell Significance Index: 63.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1804
    Cell Significance Index: 1.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1301
    Cell Significance Index: 46.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1244
    Cell Significance Index: 23.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0831
    Cell Significance Index: 8.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0647
    Cell Significance Index: 48.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0612
    Cell Significance Index: 1.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0343
    Cell Significance Index: 2.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0304
    Cell Significance Index: 22.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0069
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0347
    Cell Significance Index: -65.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0484
    Cell Significance Index: -30.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0521
    Cell Significance Index: -1.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0565
    Cell Significance Index: -104.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0671
    Cell Significance Index: -103.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0805
    Cell Significance Index: -109.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0945
    Cell Significance Index: -53.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0990
    Cell Significance Index: -62.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1724
    Cell Significance Index: -78.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2030
    Cell Significance Index: -42.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2352
    Cell Significance Index: -27.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2412
    Cell Significance Index: -27.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2744
    Cell Significance Index: -7.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2746
    Cell Significance Index: -2.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2797
    Cell Significance Index: -1.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2943
    Cell Significance Index: -18.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3212
    Cell Significance Index: -6.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3773
    Cell Significance Index: -23.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4779
    Cell Significance Index: -54.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5128
    Cell Significance Index: -74.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6312
    Cell Significance Index: -49.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6442
    Cell Significance Index: -36.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7437
    Cell Significance Index: -23.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7811
    Cell Significance Index: -22.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7982
    Cell Significance Index: -10.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8135
    Cell Significance Index: -84.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8406
    Cell Significance Index: -64.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9614
    Cell Significance Index: -17.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9782
    Cell Significance Index: -40.0800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.0395
    Cell Significance Index: -14.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0682
    Cell Significance Index: -65.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0936
    Cell Significance Index: -73.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1107
    Cell Significance Index: -9.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1635
    Cell Significance Index: -12.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2408
    Cell Significance Index: -62.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2892
    Cell Significance Index: -34.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2903
    Cell Significance Index: -16.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4718
    Cell Significance Index: -36.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5550
    Cell Significance Index: -45.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6059
    Cell Significance Index: -41.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7596
    Cell Significance Index: -77.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.7776
    Cell Significance Index: -10.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PA2G4 is a non-coding gene, which means it does not encode a protein. However, it is highly expressed in various cell types, suggesting that it may play a regulatory role in cellular behavior. The gene is involved in multiple cellular processes, including: * Proliferation: PA2G4 is involved in the regulation of cell proliferation, which is critical for tissue development and immune response. * Differentiation: PA2G4 may influence the differentiation of cells, particularly in the context of immune cell development. * Immune regulation: PA2G4 has been implicated in the regulation of the immune response, including the modulation of neutrophil degranulation and the negative regulation of apoptotic processes. **Pathways and Functions:** PA2G4 is involved in various cellular pathways, including: * Azurophil granule lumen: PA2G4 is expressed in azurophil granules, which are involved in the regulation of neutrophil degranulation. * Cytoplasm: PA2G4 is localized to the cytoplasm, where it may interact with other proteins to regulate cellular behavior. * Extracellular exosome: PA2G4 is also expressed in extracellular exosomes, which are involved in the regulation of immune responses. * Immune system: PA2G4 plays a critical role in the regulation of the immune response, including the modulation of neutrophil degranulation and the negative regulation of apoptotic processes. **Clinical Significance:** PA2G4's role in modulating cellular behavior and immune homeostasis has significant implications for various diseases, including: * Cancer: PA2G4's involvement in cell proliferation and differentiation makes it a potential target for cancer therapy. * Autoimmune diseases: PA2G4's role in regulating the immune response may also be relevant to autoimmune diseases, such as rheumatoid arthritis. * Immunodeficiency disorders: PA2G4's involvement in regulating immune cell development and function may also be relevant to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, PA2G4 is a complex gene that plays a critical role in modulating cellular behavior and immune homeostasis. Further research is needed to fully understand its mechanisms of action and its clinical significance.

Genular Protein ID: 2748693617

Symbol: PA2G4_HUMAN

Name: Proliferation-associated protein 2G4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9345902

Title: Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.

PubMed ID: 9345902

DOI: 10.1159/000134621

PubMed ID: 10682683

Title: Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.

PubMed ID: 10682683

DOI: 10.1054/bjoc.1999.0981

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11325528

Title: Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.

PubMed ID: 11325528

DOI: 10.1016/s0303-7207(01)00387-2

PubMed ID: 11268000

Title: Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation.

PubMed ID: 11268000

DOI: 10.1002/jcp.1075

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12682367

Title: Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.

PubMed ID: 12682367

DOI: 10.1093/nar/gkg318

PubMed ID: 15064750

Title: EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.

PubMed ID: 15064750

DOI: 10.1038/sj.onc.1207579

PubMed ID: 15583694

Title: Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling.

PubMed ID: 15583694

DOI: 10.1038/sj.bjc.6602257

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16832058

Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.

PubMed ID: 16832058

DOI: 10.1073/pnas.0602923103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19037095

Title: Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.

PubMed ID: 19037095

DOI: 10.1091/mbc.e08-09-0983

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27346687

Title: DNAJC21 mutations link a cancer-prone bone marrow failure syndrome to corruption in 60S ribosome subunit maturation.

PubMed ID: 27346687

DOI: 10.1016/j.ajhg.2016.05.002

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17765895

Title: The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.

PubMed ID: 17765895

DOI: 10.1016/j.febslet.2007.08.024

Sequence Information:

  • Length: 394
  • Mass: 43787
  • Checksum: CD45466507AD6047
  • Sequence:
  • MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET 
    GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN 
    VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT 
    PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA 
    GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE 
    LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS 
    SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.