Details for: PA2G4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 344.3372
Cell Significance Index: -53.5600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 234.8967
Cell Significance Index: -59.5800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 213.8864
Cell Significance Index: -88.1100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 170.9937
Cell Significance Index: -80.7300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 153.7952
Cell Significance Index: -79.1100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 120.8157
Cell Significance Index: -81.0700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 59.2560
Cell Significance Index: -73.0600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 21.4335
Cell Significance Index: -84.5800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.9535
Cell Significance Index: -48.1000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.7487
Cell Significance Index: -45.3000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.3844
Cell Significance Index: -18.3500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 4.7784
Cell Significance Index: 127.8200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 3.7925
Cell Significance Index: 41.2300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.1462
Cell Significance Index: 92.4000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.7863
Cell Significance Index: 382.6300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.6674
Cell Significance Index: 480.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.6496
Cell Significance Index: 325.7900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.6347
Cell Significance Index: 186.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.4930
Cell Significance Index: 117.1700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4038
Cell Significance Index: 65.4300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.3123
Cell Significance Index: 149.1800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.0211
Cell Significance Index: 893.5700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.9514
Cell Significance Index: 17.9700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.8248
Cell Significance Index: 20.7300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.8159
Cell Significance Index: 991.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4943
Cell Significance Index: 176.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.4581
Cell Significance Index: 188.3700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4092
Cell Significance Index: 48.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.3734
Cell Significance Index: 176.0600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2723
Cell Significance Index: 94.8200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.2596
Cell Significance Index: 58.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.2555
Cell Significance Index: 26.2800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0584
Cell Significance Index: 30.3400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0083
Cell Significance Index: 163.9900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8767
Cell Significance Index: 45.5400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8220
Cell Significance Index: 43.1600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.7093
Cell Significance Index: 204.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.6461
Cell Significance Index: 16.9900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6241
Cell Significance Index: 13.5200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5808
Cell Significance Index: 524.4200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5591
Cell Significance Index: 14.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5115
Cell Significance Index: 87.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4579
Cell Significance Index: 91.8500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.3953
Cell Significance Index: 6.9900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3444
Cell Significance Index: 15.6100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3204
Cell Significance Index: 63.5800 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.1804
Cell Significance Index: 1.4400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1301
Cell Significance Index: 46.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1244
Cell Significance Index: 23.6700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0831
Cell Significance Index: 8.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0647
Cell Significance Index: 48.9700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0612
Cell Significance Index: 1.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0343
Cell Significance Index: 2.3700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0304
Cell Significance Index: 22.3100 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0069
Cell Significance Index: 0.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0129
Cell Significance Index: -9.5700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0215
Cell Significance Index: -0.3600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0347
Cell Significance Index: -65.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0437
Cell Significance Index: -4.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0484
Cell Significance Index: -30.2500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0521
Cell Significance Index: -1.8300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0565
Cell Significance Index: -104.1600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0671
Cell Significance Index: -103.2300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0805
Cell Significance Index: -109.4200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0945
Cell Significance Index: -53.3000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0990
Cell Significance Index: -62.8600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1724
Cell Significance Index: -78.2300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2030
Cell Significance Index: -42.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2352
Cell Significance Index: -27.4200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2412
Cell Significance Index: -27.6300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2744
Cell Significance Index: -7.0100 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.2746
Cell Significance Index: -2.3600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2797
Cell Significance Index: -1.6900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2943
Cell Significance Index: -18.5500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3212
Cell Significance Index: -6.8400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3773
Cell Significance Index: -23.1900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4779
Cell Significance Index: -54.5600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5128
Cell Significance Index: -74.5400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6312
Cell Significance Index: -49.9900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6442
Cell Significance Index: -36.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7437
Cell Significance Index: -23.8200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7811
Cell Significance Index: -22.5100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7982
Cell Significance Index: -10.8900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8135
Cell Significance Index: -84.7100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8406
Cell Significance Index: -64.5100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9614
Cell Significance Index: -17.7700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.9782
Cell Significance Index: -40.0800 - Cell Name: helper T cell (CL0000912)
Fold Change: -1.0395
Cell Significance Index: -14.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0682
Cell Significance Index: -65.4900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0936
Cell Significance Index: -73.5400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.1107
Cell Significance Index: -9.3300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.1635
Cell Significance Index: -12.0500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.2408
Cell Significance Index: -62.7100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.2892
Cell Significance Index: -34.5500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -1.2903
Cell Significance Index: -16.5300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.4718
Cell Significance Index: -36.7900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.5550
Cell Significance Index: -45.8000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.6059
Cell Significance Index: -41.2800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.7596
Cell Significance Index: -77.8300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.7776
Cell Significance Index: -10.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2748693617
Symbol: PA2G4_HUMAN
Name: Proliferation-associated protein 2G4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9345902
Title: Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.
PubMed ID: 9345902
DOI: 10.1159/000134621
PubMed ID: 10682683
Title: Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin.
PubMed ID: 10682683
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11325528
Title: Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
PubMed ID: 11325528
PubMed ID: 11268000
Title: Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation.
PubMed ID: 11268000
DOI: 10.1002/jcp.1075
PubMed ID: 12429849
Title: Functional proteomic analysis of human nucleolus.
PubMed ID: 12429849
PubMed ID: 12682367
Title: Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases.
PubMed ID: 12682367
DOI: 10.1093/nar/gkg318
PubMed ID: 15064750
Title: EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.
PubMed ID: 15064750
PubMed ID: 15583694
Title: Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling.
PubMed ID: 15583694
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16832058
Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.
PubMed ID: 16832058
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19037095
Title: Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
PubMed ID: 19037095
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27346687
Title: DNAJC21 mutations link a cancer-prone bone marrow failure syndrome to corruption in 60S ribosome subunit maturation.
PubMed ID: 27346687
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 17765895
Title: The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions.
PubMed ID: 17765895
Sequence Information:
- Length: 394
- Mass: 43787
- Checksum: CD45466507AD6047
- Sequence:
MSGEDEQQEQ TIAEDLVVTK YKMGGDIANR VLRSLVEASS SGVSVLSLCE KGDAMIMEET GKIFKKEKEM KKGIAFPTSI SVNNCVCHFS PLKSDQDYIL KEGDLVKIDL GVHVDGFIAN VAHTFVVDVA QGTQVTGRKA DVIKAAHLCA EAALRLVKPG NQNTQVTEAW NKVAHSFNCT PIEGMLSHQL KQHVIDGEKT IIQNPTDQQK KDHEKAEFEV HEVYAVDVLV SSGEGKAKDA GQRTTIYKRD PSKQYGLKMK TSRAFFSEVE RRFDAMPFTL RAFEDEKKAR MGVVECAKHE LLQPFNVLYE KEGEFVAQFK FTVLLMPNGP MRITSGPFEP DLYKSEMEVQ DAELKALLQS SASRKTQKKK KKKASKTAEN ATSGETLEEN EAGD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.