Details for: MRPS2

Gene ID: 51116

Symbol: MRPS2

Ensembl ID: ENSG00000122140

Description: mitochondrial ribosomal protein S2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.4742
    Cell Significance Index: -23.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.8759
    Cell Significance Index: -20.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.3245
    Cell Significance Index: -28.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.3913
    Cell Significance Index: -28.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.2395
    Cell Significance Index: -27.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.7423
    Cell Significance Index: -28.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3366
    Cell Significance Index: -27.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4346
    Cell Significance Index: -22.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2908
    Cell Significance Index: -28.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8669
    Cell Significance Index: -18.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7864
    Cell Significance Index: 324.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1294
    Cell Significance Index: 127.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7914
    Cell Significance Index: 1617.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6640
    Cell Significance Index: 18.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1156
    Cell Significance Index: 609.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0508
    Cell Significance Index: 8.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9282
    Cell Significance Index: 64.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8339
    Cell Significance Index: 10.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8138
    Cell Significance Index: 18.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7853
    Cell Significance Index: 107.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7751
    Cell Significance Index: 54.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7709
    Cell Significance Index: 20.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7394
    Cell Significance Index: 95.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7379
    Cell Significance Index: 25.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7310
    Cell Significance Index: 21.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6585
    Cell Significance Index: 17.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6344
    Cell Significance Index: 13.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6058
    Cell Significance Index: 31.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5926
    Cell Significance Index: 16.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5522
    Cell Significance Index: 105.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5222
    Cell Significance Index: 24.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5168
    Cell Significance Index: 13.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5105
    Cell Significance Index: 225.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5069
    Cell Significance Index: 32.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5034
    Cell Significance Index: 49.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4765
    Cell Significance Index: 21.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4656
    Cell Significance Index: 21.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4595
    Cell Significance Index: 3.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4314
    Cell Significance Index: 50.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4210
    Cell Significance Index: 31.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4123
    Cell Significance Index: 52.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4038
    Cell Significance Index: 72.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3665
    Cell Significance Index: 7.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3613
    Cell Significance Index: 44.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3444
    Cell Significance Index: 56.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2461
    Cell Significance Index: 7.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1971
    Cell Significance Index: 5.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1935
    Cell Significance Index: 2.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1913
    Cell Significance Index: 37.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1855
    Cell Significance Index: 5.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1720
    Cell Significance Index: 9.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1535
    Cell Significance Index: 4.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1532
    Cell Significance Index: 1.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1257
    Cell Significance Index: 25.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1169
    Cell Significance Index: 7.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0962
    Cell Significance Index: 2.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0342
    Cell Significance Index: 12.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0303
    Cell Significance Index: 1.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0078
    Cell Significance Index: 5.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0049
    Cell Significance Index: 0.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0003
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0011
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0108
    Cell Significance Index: -20.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0180
    Cell Significance Index: -0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0189
    Cell Significance Index: -34.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0217
    Cell Significance Index: -2.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0217
    Cell Significance Index: -33.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0268
    Cell Significance Index: -36.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0308
    Cell Significance Index: -22.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0357
    Cell Significance Index: -22.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0439
    Cell Significance Index: -24.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0499
    Cell Significance Index: -31.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0584
    Cell Significance Index: -26.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0740
    Cell Significance Index: -21.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1092
    Cell Significance Index: -12.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1291
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1484
    Cell Significance Index: -31.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1624
    Cell Significance Index: -23.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1771
    Cell Significance Index: -1.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2055
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2428
    Cell Significance Index: -19.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2496
    Cell Significance Index: -4.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2742
    Cell Significance Index: -28.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2743
    Cell Significance Index: -2.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2975
    Cell Significance Index: -2.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3078
    Cell Significance Index: -18.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3125
    Cell Significance Index: -21.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3243
    Cell Significance Index: -24.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3276
    Cell Significance Index: -4.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3929
    Cell Significance Index: -22.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4127
    Cell Significance Index: -25.3000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4328
    Cell Significance Index: -6.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5385
    Cell Significance Index: -13.4600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5399
    Cell Significance Index: -3.3800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5744
    Cell Significance Index: -4.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5910
    Cell Significance Index: -26.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6128
    Cell Significance Index: -7.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6486
    Cell Significance Index: -26.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6543
    Cell Significance Index: -24.0200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.6727
    Cell Significance Index: -9.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRPS2 is a mitochondrial ribosomal protein that belongs to the S2 subunit of the 28S ribosomal subunit, which is responsible for the translation of mitochondrial mRNAs into proteins. This protein is specifically expressed in cells that require high levels of mitochondrial protein synthesis, such as hematopoietic cells, embryonic stem cells, and smooth muscle fibers. The expression of MRPS2 is tightly regulated and is significantly upregulated in response to cellular stress or energy demand. **Pathways and Functions** MRPS2 is involved in various mitochondrial translation pathways, including: 1. **Mitochondrial translation elongation**: MRPS2 plays a crucial role in the elongation phase of mitochondrial translation, facilitating the assembly of the mitochondrial ribosome and the translation of mitochondrial mRNAs into proteins. 2. **Mitochondrial translation initiation**: MRPS2 is involved in the initiation phase of mitochondrial translation, ensuring the accurate assembly of the mitochondrial ribosome and the translation of mitochondrial mRNAs into proteins. 3. **Mitochondrial translation termination**: MRPS2 is also involved in the termination phase of mitochondrial translation, ensuring the proper termination of protein synthesis and the release of the completed protein. **Clinical Significance** Dysregulation of MRPS2 has been implicated in various diseases, including: 1. **Mitochondrial myopathies**: Mutations in the MRPS2 gene have been associated with mitochondrial myopathies, such as MERRF syndrome, which is characterized by muscle weakness, ataxia, and peripheral neuropathy. 2. **Neurodegenerative disorders**: MRPS2 has also been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction plays a critical role in disease pathogenesis. 3. **Cancer**: MRPS2 has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer, where it may contribute to tumorigenesis and progression. In conclusion, MRPS2 is a critical component of the mitochondrial ribosome, playing a pivotal role in the translation of mitochondrial mRNAs into proteins essential for energy production and cellular homeostasis. Dysregulation of MRPS2 has been implicated in various diseases, highlighting the importance of this protein in maintaining mitochondrial function and overall cellular health. Further research is needed to fully elucidate the role of MRPS2 in human disease and to explore potential therapeutic strategies for targeting this protein.

Genular Protein ID: 1879582975

Symbol: RT02_HUMAN

Name: 28S ribosomal protein S2, mitochondrial

UniProtKB Accession Codes:

Q9Y399 Q5T899 Q9BSQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 41 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11402041

Title: Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit.

PubMed ID: 11402041

DOI: 10.1074/jbc.m103236200

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 29576219

Title: Bi-allelic mutations in the mitochondrial ribosomal protein MRPS2 cause sensorineural hearing loss, hypoglycemia, and multiple OXPHOS complex deficiencies.

PubMed ID: 29576219

DOI: 10.1016/j.ajhg.2018.02.012

Sequence Information:

  • Length: 296
  • Mass: 33249
  • Checksum: E05A248B09AA1A8B
  • Sequence:
    • MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR ESEDSTDFND 
KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR FMEPYIFGSR LDHDIIDLEQ 
TATHLQLALN FTAHMAYRKG IILFISRNRQ FSYLIENMAR DCGEYAHTRY FRGGMLTNAR 
LLFGPTVRLP DLIIFLHTLN NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND 
DSPLAVHLYC RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.