Details for: GPN3

Gene ID: 51184

Symbol: GPN3

Ensembl ID: ENSG00000111231

Description: GPN-loop GTPase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.0715
    Cell Significance Index: -16.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.8869
    Cell Significance Index: -17.9800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.8054
    Cell Significance Index: -22.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.8342
    Cell Significance Index: -24.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.3930
    Cell Significance Index: -19.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0528
    Cell Significance Index: -20.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1515
    Cell Significance Index: -22.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7529
    Cell Significance Index: -18.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8920
    Cell Significance Index: -23.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9618
    Cell Significance Index: -15.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1801
    Cell Significance Index: -6.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1643
    Cell Significance Index: 18.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.1327
    Cell Significance Index: 45.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6257
    Cell Significance Index: 189.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5085
    Cell Significance Index: 41.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0274
    Cell Significance Index: 111.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9816
    Cell Significance Index: 61.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9681
    Cell Significance Index: 874.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8739
    Cell Significance Index: 142.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6955
    Cell Significance Index: 36.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6633
    Cell Significance Index: 9.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5194
    Cell Significance Index: 63.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5164
    Cell Significance Index: 93.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4948
    Cell Significance Index: 67.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4820
    Cell Significance Index: 33.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4819
    Cell Significance Index: 22.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4758
    Cell Significance Index: 259.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4590
    Cell Significance Index: 4.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4375
    Cell Significance Index: 20.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4258
    Cell Significance Index: 188.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4146
    Cell Significance Index: 29.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3929
    Cell Significance Index: 25.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3688
    Cell Significance Index: 8.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3657
    Cell Significance Index: 46.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3607
    Cell Significance Index: 18.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3604
    Cell Significance Index: 18.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3318
    Cell Significance Index: 63.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3291
    Cell Significance Index: 38.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3099
    Cell Significance Index: 8.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3080
    Cell Significance Index: 61.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2808
    Cell Significance Index: 9.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2582
    Cell Significance Index: 19.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2078
    Cell Significance Index: 4.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1913
    Cell Significance Index: 5.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1676
    Cell Significance Index: 33.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1622
    Cell Significance Index: 4.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1167
    Cell Significance Index: 1.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1131
    Cell Significance Index: 14.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1047
    Cell Significance Index: 3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0976
    Cell Significance Index: 35.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0886
    Cell Significance Index: 1.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0707
    Cell Significance Index: 7.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0158
    Cell Significance Index: 11.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0101
    Cell Significance Index: 7.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0049
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0099
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0112
    Cell Significance Index: -7.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0159
    Cell Significance Index: -10.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0180
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -21.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0308
    Cell Significance Index: -0.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0325
    Cell Significance Index: -1.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0364
    Cell Significance Index: -16.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0404
    Cell Significance Index: -22.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0407
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0418
    Cell Significance Index: -26.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0474
    Cell Significance Index: -1.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0487
    Cell Significance Index: -14.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0503
    Cell Significance Index: -1.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0643
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0746
    Cell Significance Index: -8.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0875
    Cell Significance Index: -2.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1217
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1263
    Cell Significance Index: -26.6000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1403
    Cell Significance Index: -2.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1599
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1621
    Cell Significance Index: -12.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1810
    Cell Significance Index: -13.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2077
    Cell Significance Index: -2.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2097
    Cell Significance Index: -21.8300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2202
    Cell Significance Index: -2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2338
    Cell Significance Index: -13.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2360
    Cell Significance Index: -14.4700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2555
    Cell Significance Index: -2.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2745
    Cell Significance Index: -18.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3078
    Cell Significance Index: -9.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3112
    Cell Significance Index: -8.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3208
    Cell Significance Index: -5.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3238
    Cell Significance Index: -3.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3745
    Cell Significance Index: -11.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4142
    Cell Significance Index: -18.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4268
    Cell Significance Index: -3.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4684
    Cell Significance Index: -2.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5016
    Cell Significance Index: -19.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5312
    Cell Significance Index: -12.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPN3 is a GTPase, which is an enzyme that plays a crucial role in the regulation of cellular processes such as signal transduction, cell growth, and differentiation. The protein encoded by GPN3 contains an ATP-binding domain, which is a characteristic feature of GTPases. This domain is essential for the binding of GTP and the hydrolysis of ATP, which drives the conformational changes necessary for GTPase activity. The expression of GPN3 is significantly high in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. This suggests that GPN3 plays a critical role in the regulation of hematopoiesis, the process by which blood cells are produced. **Pathways and Functions** GPN3 is involved in several signaling pathways, including the GTPase activity pathway and the GTP binding pathway. These pathways are essential for the regulation of cellular processes such as cell growth, differentiation, and survival. The GTPase activity pathway is involved in the regulation of signaling cascades, including the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are critical for the regulation of cell growth, differentiation, and survival. The GTP binding pathway is involved in the regulation of protein-protein interactions, including the interaction between GTPases and their regulatory proteins. This pathway is essential for the regulation of cellular processes such as signal transduction and cell growth. **Clinical Significance** GPN3 has been implicated in several diseases, including cancer and autoimmune disorders. For example, studies have shown that GPN3 is overexpressed in certain types of cancer, such as breast cancer and lung cancer. This suggests that GPN3 may play a role in tumorigenesis, the process by which cancer cells are formed. GPN3 has also been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Studies have shown that GPN3 is overexpressed in the synovial fluid of patients with rheumatoid arthritis, suggesting that GPN3 may play a role in the regulation of immune responses. In addition, GPN3 has been shown to have anti-inflammatory properties, which may be beneficial in the treatment of autoimmune disorders. **Conclusion** In conclusion, GPN3 is a gene that encodes a protein with a wide range of cellular functions, including the regulation of hematopoiesis, cell growth, differentiation, and survival. The expression of GPN3 is significant in various cell types, including hematopoietic cells and non-hematopoietic cells. The involvement of GPN3 in several signaling pathways, including the GTPase activity pathway and the GTP binding pathway, suggests that it plays a critical role in the regulation of cellular processes. The clinical significance of GPN3 has been demonstrated in several diseases, including cancer and autoimmune disorders. Further research is needed to fully understand the role of GPN3 in human disease and to explore its potential as a therapeutic target. **Future Directions** Future research should focus on the following areas: 1. Elucidating the mechanisms by which GPN3 regulates cellular processes, including the regulation of hematopoiesis and cell growth. 2. Investigating the role of GPN3 in human disease, including cancer and autoimmune disorders. 3. Developing therapeutic strategies based on the modulation of GPN3 activity. 4. Exploring the potential of GPN3 as a biomarker for disease diagnosis and prognosis. By advancing our understanding of GPN3, we may uncover new insights into the regulation of cellular processes and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1276928459

Symbol: GPN3_HUMAN

Name: ATP-binding domain 1 family member C

UniProtKB Accession Codes:

Q9UHW5 B2RC54 D4YWV1 F5H759 Q53FS3 Q6UVZ6 Q7Z3D3 Q8NEI2 Q96HK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16533400

Title: NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.

PubMed ID: 16533400

DOI: 10.1186/1471-2164-7-48

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20864038

Title: HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II.

PubMed ID: 20864038

DOI: 10.1016/j.molcel.2010.08.023

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21768307

Title: Human GTPases associate with RNA polymerase II to mediate its nuclear import.

PubMed ID: 21768307

DOI: 10.1128/mcb.05442-11

Sequence Information:

  • Length: 284
  • Mass: 32761
  • Checksum: 8E604ECB5C1DE3B5
  • Sequence:
    • MPRYAQLVMG PAGSGKSTYC ATMVQHCEAL NRSVQVVNLD PAAEHFNYSV MADIRELIEV 
DDVMEDDSLR FGPNGGLVFC MEYFANNFDW LENCLGHVED DYILFDCPGQ IELYTHLPVM 
KQLVQQLEQW EFRVCGVFLV DSQFMVESFK FISGILAALS AMISLEIPQV NIMTKMDLLS 
KKAKKEIEKF LDPDMYSLLE DSTSDLRSKK FKKLTKAICG LIDDYSMVRF LPYDQSDEES 
MNIVLQHIDF AIQYGEDLEF KEPKEREDES SSMFDEYFQE CQDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.