Details for: CRBN

Gene ID: 51185

Symbol: CRBN

Ensembl ID: ENSG00000113851

Description: cereblon

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 281.7187
    Cell Significance Index: -43.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.0535
    Cell Significance Index: -35.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 109.3100
    Cell Significance Index: -45.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.8228
    Cell Significance Index: -40.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.7455
    Cell Significance Index: -46.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.4077
    Cell Significance Index: -45.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.6698
    Cell Significance Index: -46.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.1635
    Cell Significance Index: -41.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.0468
    Cell Significance Index: -46.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5393
    Cell Significance Index: -36.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.5543
    Cell Significance Index: -38.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3212
    Cell Significance Index: -48.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0773
    Cell Significance Index: -22.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1038
    Cell Significance Index: 214.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8911
    Cell Significance Index: 379.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5545
    Cell Significance Index: 169.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9103
    Cell Significance Index: 326.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8963
    Cell Significance Index: 57.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8740
    Cell Significance Index: 45.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8288
    Cell Significance Index: 149.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7994
    Cell Significance Index: 158.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7640
    Cell Significance Index: 689.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7500
    Cell Significance Index: 103.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6849
    Cell Significance Index: 43.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6343
    Cell Significance Index: 38.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6095
    Cell Significance Index: 5.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5934
    Cell Significance Index: 262.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5745
    Cell Significance Index: 70.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5301
    Cell Significance Index: 67.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4914
    Cell Significance Index: 17.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4815
    Cell Significance Index: 21.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4330
    Cell Significance Index: 236.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4183
    Cell Significance Index: 28.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4182
    Cell Significance Index: 19.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4141
    Cell Significance Index: 15.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3921
    Cell Significance Index: 22.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3147
    Cell Significance Index: 14.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3140
    Cell Significance Index: 22.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2894
    Cell Significance Index: 7.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2284
    Cell Significance Index: 6.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2179
    Cell Significance Index: 16.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1956
    Cell Significance Index: 10.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1809
    Cell Significance Index: 3.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1735
    Cell Significance Index: 29.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1467
    Cell Significance Index: 27.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1454
    Cell Significance Index: 14.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1391
    Cell Significance Index: 17.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1259
    Cell Significance Index: 3.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1032
    Cell Significance Index: 1.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0933
    Cell Significance Index: 1.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0653
    Cell Significance Index: 7.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0536
    Cell Significance Index: 34.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0531
    Cell Significance Index: 0.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0527
    Cell Significance Index: 71.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0452
    Cell Significance Index: 69.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0448
    Cell Significance Index: 84.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0285
    Cell Significance Index: 52.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0010
    Cell Significance Index: 0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0051
    Cell Significance Index: -2.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0070
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0267
    Cell Significance Index: -1.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0307
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0325
    Cell Significance Index: -20.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0410
    Cell Significance Index: -31.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0581
    Cell Significance Index: -2.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0768
    Cell Significance Index: -7.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0898
    Cell Significance Index: -4.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1088
    Cell Significance Index: -5.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1093
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1159
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1165
    Cell Significance Index: -24.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1396
    Cell Significance Index: -40.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1563
    Cell Significance Index: -22.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1677
    Cell Significance Index: -19.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1858
    Cell Significance Index: -3.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2111
    Cell Significance Index: -5.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2410
    Cell Significance Index: -28.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2488
    Cell Significance Index: -7.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2915
    Cell Significance Index: -3.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3069
    Cell Significance Index: -8.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3104
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3636
    Cell Significance Index: -41.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3671
    Cell Significance Index: -4.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3814
    Cell Significance Index: -6.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4179
    Cell Significance Index: -13.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4215
    Cell Significance Index: -43.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4368
    Cell Significance Index: -34.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5214
    Cell Significance Index: -3.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5363
    Cell Significance Index: -12.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5480
    Cell Significance Index: -14.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6084
    Cell Significance Index: -17.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6555
    Cell Significance Index: -16.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6570
    Cell Significance Index: -6.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6787
    Cell Significance Index: -41.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7058
    Cell Significance Index: -14.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7726
    Cell Significance Index: -14.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8013
    Cell Significance Index: -11.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CRBN gene is a single-copy gene, primarily expressed in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and embryonic stem cells. Its expression is also observed in mucosal-type mast cells, smooth muscle fibers of the ileum, and peripheral blood mononuclear cells. The CRBN protein is a member of the E3 ubiquitin ligase complex, specifically interacting with the CUL4A-RING complex. This interaction enables the CRBN protein to regulate protein ubiquitination, a critical process involved in the degradation of proteins. **Pathways and Functions:** The CRBN gene is involved in several key pathways, including: 1. **CUL4a-RING Complex:** The CRBN protein interacts with the CUL4A-RING complex, facilitating the ubiquitination of target proteins. This interaction regulates the degradation of proteins involved in various signaling pathways. 2. **Protein Ubiquitination:** CRBN plays a crucial role in the regulation of protein ubiquitination, a process involved in the degradation of proteins. This process is essential for maintaining protein homeostasis and regulating signaling pathways. 3. **Negative Regulation of Large Conductance Calcium-Activated Potassium Channel Activity:** CRBN regulates the activity of large conductance calcium-activated potassium channels, which are essential for maintaining cellular homeostasis. 4. **Positive Regulation of Wnt Signaling Pathway:** CRBN also regulates the Wnt signaling pathway, a critical pathway involved in development, cell proliferation, and differentiation. **Clinical Significance:** The CRBN gene has significant implications in various diseases, including: 1. **Infectious Diseases:** CRBN has been implicated in the regulation of viral infections, including SARS-CoV. Its dysregulation may contribute to the development of severe respiratory diseases. 2. **Cancer:** CRBN has been shown to regulate the ubiquitination of tumor suppressor proteins, which may contribute to the development of cancer. 3. **Neurological Disorders:** CRBN has been implicated in the regulation of protein ubiquitination in the brain, which may contribute to the development of neurological disorders, such as Alzheimer's disease. In conclusion, the CRBN gene plays a crucial role in the regulation of protein ubiquitination and the negative regulation of various signaling pathways. Its dysregulation may contribute to the development of various diseases, highlighting the importance of further research into the molecular mechanisms underlying its functions.

Genular Protein ID: 3743563256

Symbol: CRBN_HUMAN

Name: Protein cereblon

UniProtKB Accession Codes:

Q96SW2 B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 7 EMDB 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 37 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15557513

Title: A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation.

PubMed ID: 15557513

DOI: 10.1212/01.wnl.0000146196.01316.a2

PubMed ID: 17380424

Title: Primary function analysis of human mental retardation related gene CRBN.

PubMed ID: 17380424

DOI: 10.1007/s11033-007-9077-3

PubMed ID: 18414909

Title: Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation.

PubMed ID: 18414909

DOI: 10.1007/s10048-008-0128-2

PubMed ID: 20223979

Title: Identification of a primary target of thalidomide teratogenicity.

PubMed ID: 20223979

DOI: 10.1126/science.1177319

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24328678

Title: Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

PubMed ID: 24328678

DOI: 10.1111/bjh.12708

PubMed ID: 25043012

Title: Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.

PubMed ID: 25043012

DOI: 10.1038/nature13527

PubMed ID: 26990986

Title: Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon.

PubMed ID: 26990986

DOI: 10.1016/j.molcel.2016.02.032

PubMed ID: 29530986

Title: Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.

PubMed ID: 29530986

DOI: 10.1523/jneurosci.2081-17.2018

PubMed ID: 33009960

Title: Cereblon Promotes the Ubiquitination and Proteasomal Degradation of Interleukin Enhancer-Binding Factor 2.

PubMed ID: 33009960

DOI: 10.1007/s10930-020-09918-9

PubMed ID: 25108355

Title: Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

PubMed ID: 25108355

DOI: 10.1038/nsmb.2874

PubMed ID: 28143899

Title: A missense mutation in the CRBN gene that segregates with intellectual disability and self-mutilating behaviour in a consanguineous Saudi family.

PubMed ID: 28143899

DOI: 10.1136/jmedgenet-2016-104117

PubMed ID: 31620128

Title: CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.

PubMed ID: 31620128

DOI: 10.3389/fimmu.2019.02203

Sequence Information:

  • Length: 442
  • Mass: 50546
  • Checksum: 90DF77D98A8BEAA8
  • Sequence:
    • MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL 
GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF 
AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA 
KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW 
PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK 
IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL 
TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS 
ALLPTIPDTE DEISPDKVIL CL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.