Details for: MRPL37

Gene ID: 51253

Symbol: MRPL37

Ensembl ID: ENSG00000116221

Description: mitochondrial ribosomal protein L37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9703
    Cell Significance Index: -14.1500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 74.8396
    Cell Significance Index: -30.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.4890
    Cell Significance Index: -18.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.8984
    Cell Significance Index: -30.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.1866
    Cell Significance Index: -25.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.7400
    Cell Significance Index: -30.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.8107
    Cell Significance Index: -30.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1068
    Cell Significance Index: -25.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.0470
    Cell Significance Index: -25.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1643
    Cell Significance Index: -24.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3874
    Cell Significance Index: -22.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1755
    Cell Significance Index: -28.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.5267
    Cell Significance Index: 573.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.3413
    Cell Significance Index: 389.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4639
    Cell Significance Index: 15.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3705
    Cell Significance Index: 40.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0463
    Cell Significance Index: 13.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0198
    Cell Significance Index: 120.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0089
    Cell Significance Index: 8.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8214
    Cell Significance Index: 52.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7385
    Cell Significance Index: 34.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7133
    Cell Significance Index: 14.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6920
    Cell Significance Index: 89.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6880
    Cell Significance Index: 47.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6575
    Cell Significance Index: 593.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6544
    Cell Significance Index: 46.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6511
    Cell Significance Index: 355.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6267
    Cell Significance Index: 16.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5841
    Cell Significance Index: 80.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5720
    Cell Significance Index: 252.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5631
    Cell Significance Index: 29.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5596
    Cell Significance Index: 15.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4828
    Cell Significance Index: 91.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4728
    Cell Significance Index: 93.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4519
    Cell Significance Index: 15.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4438
    Cell Significance Index: 12.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4415
    Cell Significance Index: 20.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4029
    Cell Significance Index: 18.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3971
    Cell Significance Index: 79.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3919
    Cell Significance Index: 8.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3764
    Cell Significance Index: 28.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3763
    Cell Significance Index: 67.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3347
    Cell Significance Index: 41.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2966
    Cell Significance Index: 8.5500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2642
    Cell Significance Index: 2.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2513
    Cell Significance Index: 6.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1981
    Cell Significance Index: 71.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1577
    Cell Significance Index: 20.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1349
    Cell Significance Index: 93.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1278
    Cell Significance Index: 12.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1174
    Cell Significance Index: 3.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0222
    Cell Significance Index: 0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0214
    Cell Significance Index: 3.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0133
    Cell Significance Index: 10.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0117
    Cell Significance Index: -1.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0139
    Cell Significance Index: -25.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -28.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0243
    Cell Significance Index: -0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0295
    Cell Significance Index: -18.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0371
    Cell Significance Index: -0.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0429
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0437
    Cell Significance Index: -19.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0568
    Cell Significance Index: -0.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0698
    Cell Significance Index: -3.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0838
    Cell Significance Index: -24.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0969
    Cell Significance Index: -6.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1082
    Cell Significance Index: -15.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1094
    Cell Significance Index: -1.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1145
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1276
    Cell Significance Index: -14.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1612
    Cell Significance Index: -33.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1761
    Cell Significance Index: -13.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1990
    Cell Significance Index: -12.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2294
    Cell Significance Index: -2.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2418
    Cell Significance Index: -13.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2623
    Cell Significance Index: -4.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2655
    Cell Significance Index: -27.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2915
    Cell Significance Index: -23.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2942
    Cell Significance Index: -19.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3218
    Cell Significance Index: -19.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3831
    Cell Significance Index: -7.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3951
    Cell Significance Index: -5.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4098
    Cell Significance Index: -12.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4301
    Cell Significance Index: -11.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4379
    Cell Significance Index: -19.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4415
    Cell Significance Index: -3.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4550
    Cell Significance Index: -4.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4709
    Cell Significance Index: -13.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4731
    Cell Significance Index: -10.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4799
    Cell Significance Index: -8.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5113
    Cell Significance Index: -19.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5190
    Cell Significance Index: -7.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5526
    Cell Significance Index: -9.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5573
    Cell Significance Index: -13.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRPL37 is a mitochondrial ribosomal protein that belongs to the L37 family of ribosomal proteins. It is composed of 39 amino acids and is highly conserved across various species, suggesting its essential role in mitochondrial translation. The protein is localized to the mitochondrial large ribosomal subunit and is involved in the translation elongation process. MRPL37 is also known to interact with other mitochondrial proteins, including ribosomal RNA and translation initiation factors. **Pathways and Functions** MRPL37 is involved in several key pathways, including: 1. **Mitochondrial translation**: MRPL37 plays a crucial role in the translation of mitochondrial mRNAs, which are essential for the production of essential proteins involved in energy metabolism, cell signaling, and cellular homeostasis. 2. **Mitochondrial inner membrane**: MRPL37 is localized to the mitochondrial inner membrane and is involved in the regulation of mitochondrial function and biogenesis. 3. **Mitochondrial large ribosomal subunit**: MRPL37 is a component of the mitochondrial large ribosomal subunit and is involved in the translation elongation process. 4. **Mitochondrial translation elongation**: MRPL37 interacts with other mitochondrial proteins, including ribosomal RNA and translation initiation factors, to facilitate the translation elongation process. 5. **Mitochondrial translation initiation**: MRPL37 is involved in the translation initiation process, where it interacts with translation initiation factors to facilitate the recruitment of ribosomes to the mitochondrial mRNA. **Clinical Significance** Dysregulation of MRPL37 has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the MRPL37 gene have been associated with mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Cancer**: Overexpression of MRPL37 has been observed in various types of cancer, including breast cancer and lung cancer. 3. **Neurodegenerative diseases**: MRPL37 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, MRPL37 is a critical component of the mitochondrial ribosome and plays a vital role in mitochondrial translation and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and regulation of MRPL37.

Genular Protein ID: 1775236399

Symbol: RM37_HUMAN

Name: 39S ribosomal protein L2, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 423
  • Mass: 48117
  • Checksum: 9556DAF4349F6EEB
  • Sequence:
  • MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF 
    AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK DQACYIFHHR CRLLEGVKQA 
    LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ DECVLNVISH ARLWQTTEEI PKRETYCPVI 
    VDNLIQLCKS QILKHPSLAR RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA 
    SREEIEATKN HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 
    PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR VFHFLVFQLN 
    TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVEP VGPVGFKPET FRKFLALYLH 
    GAA

Genular Protein ID: 3901392391

Symbol: S4R369_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 483
  • Mass: 54953
  • Checksum: F6A2AD9F7077D4CA
  • Sequence:
  • MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF 
    AGKMHFVPWL ARPIFPPWDR GYKDPRFYRS PPLHEHPLYK DQACYIFHHR CRLLEGVKQA 
    LWLTKTKLIE GLPEKVLSLV DDPRNHIENQ DECVLNVISH ARLWQTTEEI PKRETYCPVI 
    VDNLIQLCKS QILKHPSLAR RICVQNSTFS ATWNRESLLL QVRGSGGARL STKDPLPTIA 
    SREEIEATKN HVLETFYPIS PIIDLHECNI YDVKNDTGFQ EGYPYPYPHT LYLLDKANLR 
    PHRLQPDQLR AKMILFAFGS ALAQARLLYG NDAKVLEQPV VVQSVGTDGR VFHFLVFQLN 
    TTDLDCNEGV KNLAWVDSDQ LLYQHFWCLP VIKKRVVVKN KRHSSGPKCV CKTRNGKWLL 
    DGPQIFKVRW IPSLPTHLPP RPSRLHKNTE FAGPGKEGRR LKHKTSCYAP GTKTVPKKSP 
    CIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.