Details for: MRPL35

Gene ID: 51318

Symbol: MRPL35

Ensembl ID: ENSG00000132313

Description: mitochondrial ribosomal protein L35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.0206
    Cell Significance Index: -14.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.2919
    Cell Significance Index: -18.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.4180
    Cell Significance Index: -21.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.7838
    Cell Significance Index: -18.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.6545
    Cell Significance Index: -18.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.7078
    Cell Significance Index: -20.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1971
    Cell Significance Index: -19.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5120
    Cell Significance Index: -16.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4916
    Cell Significance Index: -21.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8544
    Cell Significance Index: 216.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6227
    Cell Significance Index: 13.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3789
    Cell Significance Index: 62.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3260
    Cell Significance Index: 215.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1611
    Cell Significance Index: 73.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0105
    Cell Significance Index: 52.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8376
    Cell Significance Index: 12.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8334
    Cell Significance Index: 11.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7759
    Cell Significance Index: 53.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7196
    Cell Significance Index: 15.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6840
    Cell Significance Index: 123.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6237
    Cell Significance Index: 76.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5874
    Cell Significance Index: 16.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5658
    Cell Significance Index: 5.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5627
    Cell Significance Index: 39.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5446
    Cell Significance Index: 491.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5293
    Cell Significance Index: 62.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4866
    Cell Significance Index: 13.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4499
    Cell Significance Index: 61.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4425
    Cell Significance Index: 20.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4313
    Cell Significance Index: 190.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4170
    Cell Significance Index: 227.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4068
    Cell Significance Index: 81.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3665
    Cell Significance Index: 9.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3524
    Cell Significance Index: 10.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3138
    Cell Significance Index: 7.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2774
    Cell Significance Index: 52.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2558
    Cell Significance Index: 25.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2507
    Cell Significance Index: 8.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2423
    Cell Significance Index: 48.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2268
    Cell Significance Index: 4.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1782
    Cell Significance Index: 9.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1677
    Cell Significance Index: 60.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1388
    Cell Significance Index: 10.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1288
    Cell Significance Index: 3.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1221
    Cell Significance Index: 7.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1181
    Cell Significance Index: 15.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1121
    Cell Significance Index: 5.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0674
    Cell Significance Index: 2.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0502
    Cell Significance Index: 1.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0386
    Cell Significance Index: 1.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0285
    Cell Significance Index: 20.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0176
    Cell Significance Index: 2.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0027
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0163
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0240
    Cell Significance Index: -2.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0372
    Cell Significance Index: -23.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0461
    Cell Significance Index: -0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0478
    Cell Significance Index: -13.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0660
    Cell Significance Index: -0.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0739
    Cell Significance Index: -3.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0802
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0923
    Cell Significance Index: -10.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0970
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1108
    Cell Significance Index: -23.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1148
    Cell Significance Index: -9.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1423
    Cell Significance Index: -9.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1616
    Cell Significance Index: -4.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1727
    Cell Significance Index: -4.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1791
    Cell Significance Index: -7.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1981
    Cell Significance Index: -20.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2175
    Cell Significance Index: -8.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2198
    Cell Significance Index: -4.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2433
    Cell Significance Index: -13.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2763
    Cell Significance Index: -2.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2980
    Cell Significance Index: -18.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3112
    Cell Significance Index: -1.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3346
    Cell Significance Index: -5.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3360
    Cell Significance Index: -16.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3426
    Cell Significance Index: -10.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3545
    Cell Significance Index: -8.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3816
    Cell Significance Index: -9.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3827
    Cell Significance Index: -4.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4056
    Cell Significance Index: -6.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4139
    Cell Significance Index: -11.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4255
    Cell Significance Index: -7.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4341
    Cell Significance Index: -10.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4413
    Cell Significance Index: -16.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4536
    Cell Significance Index: -15.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4712
    Cell Significance Index: -10.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Mitochondrial localization**: MRPL35 is a mitochondrial ribosomal protein, specifically a large subunit ribosomal protein L35, which is essential for the assembly and function of the mitochondrial ribosome. 2. **Translation regulation**: MRPL35 is involved in the translation elongation process, ensuring the accurate translation of mitochondrial mRNAs into proteins. 3. **Cellular expression**: MRPL35 is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle cells, epithelial cells, and stromal cells of bone marrow. 4. **Protein binding**: MRPL35 interacts with other proteins, including ribosomal proteins and mitochondrial transcription factors, to regulate translation and mitochondrial function. **Pathways and Functions** 1. **Mitochondrial translation**: MRPL35 is a critical component of the mitochondrial ribosome, involved in the translation of mitochondrial mRNAs into proteins essential for energy production, cell signaling, and other cellular processes. 2. **Protein metabolism**: MRPL35 is involved in the regulation of protein metabolism, including translation elongation, initiation, and termination, ensuring the accurate synthesis of proteins. 3. **Mitochondrial function**: MRPL35 contributes to the maintenance of mitochondrial function, including the regulation of mitochondrial membrane potential, ATP production, and reactive oxygen species (ROS) production. 4. **Cellular homeostasis**: MRPL35 plays a role in maintaining cellular homeostasis, including the regulation of cell growth, differentiation, and survival. **Clinical Significance** 1. **Mitochondrial disorders**: Mutations in MRPL35 have been associated with mitochondrial disorders, including myopathies, neuropathies, and cardiomyopathies, highlighting the importance of this gene in maintaining mitochondrial function. 2. **Cancer**: Alterations in MRPL35 expression have been observed in various types of cancer, including leukemia, lymphoma, and breast cancer, suggesting its potential role in cancer development and progression. 3. **Neurological disorders**: MRPL35 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), highlighting its importance in maintaining mitochondrial function and cellular homeostasis. 4. **Pharmacological targets**: MRPL35 may serve as a potential therapeutic target for the treatment of diseases associated with mitochondrial dysfunction, including cancer and neurological disorders. In conclusion, MRPL35 is a crucial gene involved in mitochondrial translation, protein metabolism, and cellular homeostasis. Its dysregulation has been implicated in various diseases, including mitochondrial disorders, cancer, and neurological disorders, highlighting the importance of this gene in maintaining cellular health and function.

Genular Protein ID: 2368280759

Symbol: RM35_HUMAN

Name: 39S ribosomal protein L35, mitochondrial

UniProtKB Accession Codes:

Q9NZE8 A6NKV6 B2RB93 Q658U7 Q8WWA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 56 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 59 PDBsum 59 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551941

Title: The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.

PubMed ID: 11551941

DOI: 10.1074/jbc.m106510200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 188
  • Mass: 21514
  • Checksum: 3A44076927C5A54B
  • Sequence:
    • MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL 
TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR KGKRKTVKAV IDRFLRLHCG 
LWVRRKAGYK KKLWKKTPAR KKRLREFVFC NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY 
HDRTNLKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.