Details for: ARL17A

Gene ID: 51326

Symbol: ARL17A

Ensembl ID: ENSG00000185829

Description: ARF like GTPase 17A

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.1153
    Cell Significance Index: -19.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.9908
    Cell Significance Index: -18.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6940
    Cell Significance Index: -19.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4249
    Cell Significance Index: -16.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6969
    Cell Significance Index: -17.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1702
    Cell Significance Index: -15.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9581
    Cell Significance Index: -19.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.6515
    Cell Significance Index: 63.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6556
    Cell Significance Index: 101.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2650
    Cell Significance Index: 27.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1365
    Cell Significance Index: 71.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8423
    Cell Significance Index: 168.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7642
    Cell Significance Index: 75.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7240
    Cell Significance Index: 8.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5506
    Cell Significance Index: 64.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5483
    Cell Significance Index: 495.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5050
    Cell Significance Index: 181.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4709
    Cell Significance Index: 93.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4134
    Cell Significance Index: 67.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3889
    Cell Significance Index: 42.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3614
    Cell Significance Index: 27.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3497
    Cell Significance Index: 22.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3115
    Cell Significance Index: 18.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3001
    Cell Significance Index: 54.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2158
    Cell Significance Index: 9.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2097
    Cell Significance Index: 3.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1988
    Cell Significance Index: 13.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1921
    Cell Significance Index: 8.5000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1895
    Cell Significance Index: 1.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1852
    Cell Significance Index: 10.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1769
    Cell Significance Index: 6.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1749
    Cell Significance Index: 3.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1682
    Cell Significance Index: 4.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1655
    Cell Significance Index: 31.4900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1497
    Cell Significance Index: 1.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1473
    Cell Significance Index: 18.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1209
    Cell Significance Index: 16.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1171
    Cell Significance Index: 180.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1084
    Cell Significance Index: 7.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0921
    Cell Significance Index: 169.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0738
    Cell Significance Index: 0.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0735
    Cell Significance Index: 3.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0713
    Cell Significance Index: 1.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0704
    Cell Significance Index: 2.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0677
    Cell Significance Index: 1.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0635
    Cell Significance Index: 119.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0622
    Cell Significance Index: 1.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0605
    Cell Significance Index: 82.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0559
    Cell Significance Index: 30.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0547
    Cell Significance Index: 1.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0506
    Cell Significance Index: 22.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0427
    Cell Significance Index: 2.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0427
    Cell Significance Index: 1.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0375
    Cell Significance Index: 23.7900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0264
    Cell Significance Index: 0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0145
    Cell Significance Index: 6.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0086
    Cell Significance Index: 0.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0084
    Cell Significance Index: 1.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0076
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0140
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0188
    Cell Significance Index: -13.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0218
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0312
    Cell Significance Index: -19.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0501
    Cell Significance Index: -0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0595
    Cell Significance Index: -2.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0723
    Cell Significance Index: -8.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0738
    Cell Significance Index: -9.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0826
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0897
    Cell Significance Index: -18.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1184
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1294
    Cell Significance Index: -2.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1341
    Cell Significance Index: -2.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1382
    Cell Significance Index: -10.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1416
    Cell Significance Index: -14.7500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1546
    Cell Significance Index: -2.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1554
    Cell Significance Index: -9.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1928
    Cell Significance Index: -2.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2010
    Cell Significance Index: -14.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2105
    Cell Significance Index: -16.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2420
    Cell Significance Index: -8.4100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2512
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2615
    Cell Significance Index: -8.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2963
    Cell Significance Index: -9.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3096
    Cell Significance Index: -9.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3144
    Cell Significance Index: -3.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3414
    Cell Significance Index: -3.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3515
    Cell Significance Index: -8.9800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3564
    Cell Significance Index: -5.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3609
    Cell Significance Index: -6.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3658
    Cell Significance Index: -11.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3720
    Cell Significance Index: -7.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3811
    Cell Significance Index: -4.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4057
    Cell Significance Index: -8.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4070
    Cell Significance Index: -14.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARL17A is a member of the ARF-like GTPase family, which is characterized by its ability to bind and hydrolyze GTP. This gene is primarily expressed in cells involved in hematopoiesis, immune response, and neural development. The significantly expressed cells of ARL17A include polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and various immune cells such as Langerhans cells, CD8-alpha-beta-positive intraepithelial T cells, and regulatory T cells. **Pathways and Functions:** ARL17A is involved in multiple signaling pathways that regulate cell growth, differentiation, and survival. These pathways include: 1. **MAPK/ERK pathway**: ARL17A regulates the activation of the MAPK/ERK pathway, which is crucial for cell proliferation, differentiation, and survival. 2. **PI3K/AKT pathway**: ARL17A modulates the PI3K/AKT pathway, which is involved in cell survival, proliferation, and metabolism. 3. **JAK/STAT pathway**: ARL17A influences the JAK/STAT pathway, which plays a key role in immune response and inflammation. The functions of ARL17A can be broadly categorized into: 1. **Cell proliferation and differentiation**: ARL17A regulates cell growth and differentiation in hematopoietic cells, immune cells, and neural cells. 2. **Apoptosis and survival**: ARL17A modulates apoptosis and survival pathways, influencing the lifespan of cells in various tissues. 3. **Immune regulation**: ARL17A plays a crucial role in regulating immune responses, including inflammation, immune cell activation, and tolerance. **Clinical Significance:** Dysregulation of ARL17A has been implicated in various immune-related disorders, including: 1. **Hematological malignancies**: ARL17A mutations have been associated with hematological malignancies, such as acute myeloid leukemia and lymphoma. 2. **Autoimmune diseases**: ARL17A dysfunction has been linked to autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. 3. **Neurological disorders**: ARL17A mutations have been associated with neurological disorders, such as schizophrenia, autism spectrum disorder, and neurodegenerative diseases. In conclusion, ARL17A is a multifunctional gene that plays a critical role in regulating cell growth, differentiation, survival, and immune responses. Further research is necessary to fully elucidate the mechanisms of ARL17A and its implications in human disease.

Genular Protein ID: 2168977254

Symbol: A0A087WVX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVX3

Database IDs:

ARBA 2 Antibodypedia 2 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 5 GO 2 Gene3D 1 GeneTree 1 HGNC 2 IntAct 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 141
  • Mass: 16132
  • Checksum: E9823AEEFC7297FC
  • Sequence:
    • MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG FCVETVEYKN 
NTFAVWDVGS HFKIRPLWQH FFQNTKGSCS IDQAGVQWRD LGSLQRPLPK LRFVSHTSPH 
TKLLHTRPRT ASRKCFFRGK I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.