Details for: AHSP

Gene ID: 51327

Symbol: AHSP

Ensembl ID: ENSG00000169877

Description: alpha hemoglobin stabilizing protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 205.5747
    Cell Significance Index: 93.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.4083
    Cell Significance Index: -2.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.2521
    Cell Significance Index: -4.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.7673
    Cell Significance Index: 147.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.3572
    Cell Significance Index: -4.1600
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.0271
    Cell Significance Index: 8.9700
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 1.9960
    Cell Significance Index: 10.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.0635
    Cell Significance Index: 12.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.8566
    Cell Significance Index: -3.3800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.8324
    Cell Significance Index: 7.2000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1176
    Cell Significance Index: 1.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0834
    Cell Significance Index: 1.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0364
    Cell Significance Index: 0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0205
    Cell Significance Index: 0.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0066
    Cell Significance Index: 1.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0057
    Cell Significance Index: 3.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0013
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0019
    Cell Significance Index: -0.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0096
    Cell Significance Index: -4.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0195
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0213
    Cell Significance Index: -4.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0217
    Cell Significance Index: -3.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0221
    Cell Significance Index: -2.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0223
    Cell Significance Index: -0.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0236
    Cell Significance Index: -0.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0246
    Cell Significance Index: -1.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0251
    Cell Significance Index: -1.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0262
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0320
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0330
    Cell Significance Index: -4.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0365
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0398
    Cell Significance Index: -4.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0452
    Cell Significance Index: -0.7800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0458
    Cell Significance Index: -0.5100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0469
    Cell Significance Index: -0.4900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0507
    Cell Significance Index: -0.6900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0508
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0528
    Cell Significance Index: -4.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0559
    Cell Significance Index: -3.7600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0569
    Cell Significance Index: -0.6700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0610
    Cell Significance Index: -0.4700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0620
    Cell Significance Index: -0.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0662
    Cell Significance Index: -4.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0690
    Cell Significance Index: -1.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0703
    Cell Significance Index: -0.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0738
    Cell Significance Index: -4.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0762
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0796
    Cell Significance Index: -3.7100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0799
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0802
    Cell Significance Index: -0.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0809
    Cell Significance Index: -2.1600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0845
    Cell Significance Index: -0.8300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0856
    Cell Significance Index: -0.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0901
    Cell Significance Index: -2.3700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0904
    Cell Significance Index: -1.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1051
    Cell Significance Index: -4.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1113
    Cell Significance Index: -5.7800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1131
    Cell Significance Index: -1.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1132
    Cell Significance Index: -1.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1150
    Cell Significance Index: -4.0000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1158
    Cell Significance Index: -0.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1184
    Cell Significance Index: -2.8400
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.1191
    Cell Significance Index: -0.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1200
    Cell Significance Index: -3.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1256
    Cell Significance Index: -4.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1274
    Cell Significance Index: -1.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1287
    Cell Significance Index: -4.5100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1307
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1341
    Cell Significance Index: -4.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1355
    Cell Significance Index: -3.9900
  • Cell Name: deuterosomal cell (CL4033044)
    Fold Change: -0.1421
    Cell Significance Index: -1.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1431
    Cell Significance Index: -3.5700
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1459
    Cell Significance Index: -0.9100
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.1513
    Cell Significance Index: -0.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1554
    Cell Significance Index: -1.9900
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: -0.1566
    Cell Significance Index: -0.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1585
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1617
    Cell Significance Index: -4.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1641
    Cell Significance Index: -4.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1646
    Cell Significance Index: -4.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1664
    Cell Significance Index: -4.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1664
    Cell Significance Index: -4.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1678
    Cell Significance Index: -2.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1700
    Cell Significance Index: -2.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** AHSP is widely expressed in various cell types, including hematopoietic progenitor cells, basophilic erythroblasts, reticulocytes, and stromal cells of the bone marrow. 2. **Protein Structure:** AHSP is a small, cytoplasmic protein consisting of approximately 92 amino acids, with a molecular weight of approximately 10 kDa. 3. **Function:** AHSP's primary function is to stabilize the hemoglobin complex, preventing its denaturation and aggregation, which is essential for maintaining the structural integrity and function of red blood cells. 4. **Cellular Localization:** AHSP is primarily localized to the cytoplasm of red blood cells, where it interacts with hemoglobin to prevent its denaturation. **Pathways and Functions:** 1. **Hemoglobin Metabolic Process:** AHSP plays a critical role in regulating the metabolic process of hemoglobin, preventing its denaturation and aggregation, which is essential for maintaining the structural integrity and function of red blood cells. 2. **Protein Binding:** AHSP interacts with hemoglobin, preventing its denaturation and aggregation, which is essential for maintaining the structural integrity and function of red blood cells. 3. **Protein Folding:** AHSP helps to maintain the correct folding of hemoglobin, preventing its denaturation and aggregation. 4. **Unfolded Protein Binding:** AHSP binds to unfolded proteins, preventing their aggregation and promoting their correct folding. **Clinical Significance:** Dysregulation of AHSP expression has been implicated in various hematological disorders, including beta-thalassemia and sickle cell disease. These disorders are characterized by impaired hemoglobin production and function, leading to anemia, oxidative stress, and tissue damage. Understanding the role of AHSP in maintaining the structural integrity and function of red blood cells is essential for developing novel therapeutic strategies for these disorders. In conclusion, AHSP is a critical component in the development and function of red blood cells, playing a key role in stabilizing the hemoglobin complex and preventing its denaturation and aggregation. Further research is necessary to fully elucidate the mechanisms by which AHSP regulates hemoglobin metabolism and function, and to explore its potential as a therapeutic target for hematological disorders.

Genular Protein ID: 4141901859

Symbol: AHSP_HUMAN

Name: Alpha-hemoglobin-stabilizing protein

UniProtKB Accession Codes:

Q9NZD4 Q8TD01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11231637

Title: A novel erythroid-specific marker of transmissible spongiform encephalopathies.

PubMed ID: 11231637

DOI: 10.1038/85515

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12066189

Title: An abundant erythroid protein that stabilizes free alpha-haemoglobin.

PubMed ID: 12066189

DOI: 10.1038/nature00803

PubMed ID: 12192002

Title: Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.

PubMed ID: 12192002

DOI: 10.1074/jbc.m206084200

PubMed ID: 15550245

Title: Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.

PubMed ID: 15550245

DOI: 10.1016/j.cell.2004.11.025

PubMed ID: 15178680

Title: NMR structure of the alpha-hemoglobin stabilizing protein: insights into conformational heterogeneity and binding.

PubMed ID: 15178680

DOI: 10.1074/jbc.m405016200

PubMed ID: 15931225

Title: Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.

PubMed ID: 15931225

DOI: 10.1038/nature03609

Sequence Information:

  • Length: 102
  • Mass: 11840
  • Checksum: 275DDF8BC670EF20
  • Sequence:
    • MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP 
QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.