Details for: TRMT6

Gene ID: 51605

Symbol: TRMT6

Ensembl ID: ENSG00000089195

Description: tRNA methyltransferase 6 non-catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 127.3585
    Cell Significance Index: -19.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.4496
    Cell Significance Index: -18.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 52.0151
    Cell Significance Index: -21.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.9777
    Cell Significance Index: -17.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3871
    Cell Significance Index: -17.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.4053
    Cell Significance Index: -21.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6568
    Cell Significance Index: -17.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5194
    Cell Significance Index: -21.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7376
    Cell Significance Index: -11.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8313
    Cell Significance Index: 181.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1308
    Cell Significance Index: 30.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0129
    Cell Significance Index: 60.8100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8377
    Cell Significance Index: 6.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7846
    Cell Significance Index: 85.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6881
    Cell Significance Index: 621.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5628
    Cell Significance Index: 65.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5601
    Cell Significance Index: 91.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4541
    Cell Significance Index: 11.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4404
    Cell Significance Index: 22.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3686
    Cell Significance Index: 25.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3466
    Cell Significance Index: 24.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3375
    Cell Significance Index: 60.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3216
    Cell Significance Index: 64.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3062
    Cell Significance Index: 135.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2767
    Cell Significance Index: 34.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2725
    Cell Significance Index: 54.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2412
    Cell Significance Index: 45.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2316
    Cell Significance Index: 126.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2165
    Cell Significance Index: 5.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2029
    Cell Significance Index: 23.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1664
    Cell Significance Index: 22.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1428
    Cell Significance Index: 3.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1334
    Cell Significance Index: 2.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1204
    Cell Significance Index: 7.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1188
    Cell Significance Index: 3.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1184
    Cell Significance Index: 81.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0909
    Cell Significance Index: 2.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0882
    Cell Significance Index: 2.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0802
    Cell Significance Index: 28.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0754
    Cell Significance Index: 3.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0615
    Cell Significance Index: 3.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0593
    Cell Significance Index: 7.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0372
    Cell Significance Index: 2.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0218
    Cell Significance Index: 2.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0146
    Cell Significance Index: 0.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0101
    Cell Significance Index: 0.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0066
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0136
    Cell Significance Index: -10.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0158
    Cell Significance Index: -24.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0233
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0350
    Cell Significance Index: -19.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0387
    Cell Significance Index: -24.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0408
    Cell Significance Index: -1.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0427
    Cell Significance Index: -19.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0549
    Cell Significance Index: -15.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0607
    Cell Significance Index: -0.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0819
    Cell Significance Index: -1.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0947
    Cell Significance Index: -13.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0970
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1037
    Cell Significance Index: -11.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1132
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1142
    Cell Significance Index: -24.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1233
    Cell Significance Index: -6.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1368
    Cell Significance Index: -2.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1437
    Cell Significance Index: -3.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1668
    Cell Significance Index: -8.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1699
    Cell Significance Index: -13.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1742
    Cell Significance Index: -5.5800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2023
    Cell Significance Index: -2.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2042
    Cell Significance Index: -1.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2080
    Cell Significance Index: -4.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2086
    Cell Significance Index: -21.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2138
    Cell Significance Index: -16.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2298
    Cell Significance Index: -4.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2383
    Cell Significance Index: -13.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2441
    Cell Significance Index: -15.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2512
    Cell Significance Index: -7.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2656
    Cell Significance Index: -11.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2705
    Cell Significance Index: -3.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2985
    Cell Significance Index: -15.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3031
    Cell Significance Index: -7.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3145
    Cell Significance Index: -4.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3183
    Cell Significance Index: -3.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3298
    Cell Significance Index: -12.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3494
    Cell Significance Index: -21.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4167
    Cell Significance Index: -3.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4256
    Cell Significance Index: -17.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4258
    Cell Significance Index: -8.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4458
    Cell Significance Index: -10.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4480
    Cell Significance Index: -9.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4846
    Cell Significance Index: -8.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of tRNA methyltransferase 6**: TRMT6 is a non-catalytic subunit of the tRNA methyltransferase 6 complex, which is responsible for the methylation of adenine residues in tRNA. 2. **Restricted expression**: TRMT6 is highly expressed in specific cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, embryonic stem cell, mucosal type mast cell, and certain types of epithelial cells. 3. **RNA binding and modification**: TRMT6 interacts with tRNA and facilitates the methylation of adenine residues, which is essential for tRNA stability, translation efficiency, and protein synthesis. **Pathways and Functions:** 1. **Metabolism of RNA**: TRMT6 is involved in the regulation of RNA metabolism, particularly in the context of tRNA modification, which is essential for protein synthesis and cellular function. 2. **mRNA processing**: TRMT6 has been implicated in the regulation of mRNA processing, including the splicing and polyadenylation of mRNA. 3. **Protein binding and regulation**: TRMT6 interacts with various proteins, including transcription factors and RNA-binding proteins, which are involved in the regulation of gene expression and cellular differentiation. 4. **Cellular differentiation and proliferation**: TRMT6 is highly expressed in specific cell types, suggesting its involvement in cellular differentiation and proliferation. **Clinical Significance:** 1. **Hematological disorders**: Alterations in TRMT6 expression have been linked to hematological disorders, such as leukemia and lymphoma. 2. **Cancer**: TRMT6 has been implicated in the regulation of cancer cell proliferation and survival, suggesting its potential as a therapeutic target. 3. **Neurological disorders**: TRMT6 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in the regulation of cellular differentiation and survival. 4. **Epithelial disorders**: TRMT6 has been implicated in the regulation of epithelial cell differentiation and proliferation, suggesting its potential role in the development of epithelial disorders, such as cancer. In conclusion, TRMT6 is a multifaceted gene that plays a crucial role in the regulation of RNA metabolism, cellular differentiation, and proliferation. Its restricted expression and involvement in various cellular processes make it an attractive target for the development of therapeutic strategies for various diseases.

Genular Protein ID: 413941540

Symbol: TRM6_HUMAN

Name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

UniProtKB Accession Codes:

Q9UJA5 B4DUV6 Q76P92 Q9BQV5 Q9ULR7 Q9Y2Z8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16043508

Title: The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans.

PubMed ID: 16043508

DOI: 10.1261/rna.5040605

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29107537

Title: Base-resolution mapping reveals distinct m1A methylome in nuclear- and mitochondrial-encoded transcripts.

PubMed ID: 29107537

DOI: 10.1016/j.molcel.2017.10.019

PubMed ID: 29072297

Title: The m(1)A landscape on cytosolic and mitochondrial mRNA at single-base resolution.

PubMed ID: 29072297

DOI: 10.1038/nature24456

PubMed ID: 26470919

Title: Crystal structure of the human tRNA m(1)A58 methyltransferase-tRNA(3)(Lys) complex: refolding of substrate tRNA allows access to the methylation target.

PubMed ID: 26470919

DOI: 10.1016/j.jmb.2015.10.005

Sequence Information:

  • Length: 497
  • Mass: 55799
  • Checksum: 920800D0722A6CBB
  • Sequence:
    • MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ WFYLDNVIGH 
SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD GKSQKLTQDD IKALKDKGIK 
GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK KKKYEAIITV VKPSTRILSI MYYAREPGKI 
NHMRYDTLAQ MLTLGNIRAG NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA 
TACFGFPKSF LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ 
ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ EEQRKRHLEA 
AALLSERNAD GLIVASRFHP TPLLLSLLDF VAPSRPFVVY CQYKEPLLEC YTKLRERGGV 
INLRLSETWL RNYQVLPDRS HPKLLMSGGG GYLLSGFTVA MDNLKADTSL KSNASTLESH 
ETEEPAAKKR KCPESDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.