Details for: DHRS7

Gene ID: 51635

Symbol: DHRS7

Ensembl ID: ENSG00000100612

Description: dehydrogenase/reductase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 354.1735
    Cell Significance Index: -55.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.2784
    Cell Significance Index: -43.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 141.1951
    Cell Significance Index: -58.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.4070
    Cell Significance Index: -51.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.4817
    Cell Significance Index: -56.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 111.1715
    Cell Significance Index: -57.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 84.3564
    Cell Significance Index: -56.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.3343
    Cell Significance Index: -52.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.1111
    Cell Significance Index: -55.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2320
    Cell Significance Index: -56.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4464
    Cell Significance Index: -41.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5215
    Cell Significance Index: -18.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.6787
    Cell Significance Index: 39.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3675
    Cell Significance Index: -11.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.0189
    Cell Significance Index: 187.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.7775
    Cell Significance Index: 67.7700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.2987
    Cell Significance Index: 37.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9036
    Cell Significance Index: 51.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7664
    Cell Significance Index: 18.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7149
    Cell Significance Index: 80.6000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.6571
    Cell Significance Index: 34.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4039
    Cell Significance Index: 253.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2084
    Cell Significance Index: 35.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1206
    Cell Significance Index: 83.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0962
    Cell Significance Index: 150.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0401
    Cell Significance Index: 133.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8591
    Cell Significance Index: 9.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8572
    Cell Significance Index: 105.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8567
    Cell Significance Index: 44.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8335
    Cell Significance Index: 43.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6898
    Cell Significance Index: 376.7400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.6660
    Cell Significance Index: 2.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5996
    Cell Significance Index: 265.0800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.5911
    Cell Significance Index: 3.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5590
    Cell Significance Index: 5.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5195
    Cell Significance Index: 35.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4496
    Cell Significance Index: 8.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4302
    Cell Significance Index: 12.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3751
    Cell Significance Index: 64.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3588
    Cell Significance Index: 35.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3256
    Cell Significance Index: 65.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3110
    Cell Significance Index: 40.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3090
    Cell Significance Index: 8.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2909
    Cell Significance Index: 57.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2816
    Cell Significance Index: 9.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2151
    Cell Significance Index: 13.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1771
    Cell Significance Index: 10.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1569
    Cell Significance Index: 1.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1556
    Cell Significance Index: 29.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1302
    Cell Significance Index: 98.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1102
    Cell Significance Index: 39.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0633
    Cell Significance Index: 57.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0595
    Cell Significance Index: 41.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0210
    Cell Significance Index: 15.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0089
    Cell Significance Index: 1.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0067
    Cell Significance Index: 0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0098
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0102
    Cell Significance Index: -1.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0134
    Cell Significance Index: -0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0301
    Cell Significance Index: -55.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0339
    Cell Significance Index: -52.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0391
    Cell Significance Index: -4.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0443
    Cell Significance Index: -60.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0470
    Cell Significance Index: -29.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0663
    Cell Significance Index: -42.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0690
    Cell Significance Index: -38.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0786
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0986
    Cell Significance Index: -44.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0999
    Cell Significance Index: -21.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1054
    Cell Significance Index: -12.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1239
    Cell Significance Index: -1.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1374
    Cell Significance Index: -39.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1576
    Cell Significance Index: -8.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1626
    Cell Significance Index: -5.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1637
    Cell Significance Index: -11.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2006
    Cell Significance Index: -3.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2096
    Cell Significance Index: -24.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2752
    Cell Significance Index: -40.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3171
    Cell Significance Index: -8.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3329
    Cell Significance Index: -25.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3644
    Cell Significance Index: -10.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4188
    Cell Significance Index: -8.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4445
    Cell Significance Index: -11.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4841
    Cell Significance Index: -12.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5233
    Cell Significance Index: -16.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5336
    Cell Significance Index: -55.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6448
    Cell Significance Index: -18.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6525
    Cell Significance Index: -6.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6636
    Cell Significance Index: -13.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6732
    Cell Significance Index: -53.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7181
    Cell Significance Index: -44.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7344
    Cell Significance Index: -33.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7481
    Cell Significance Index: -14.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7759
    Cell Significance Index: -39.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8010
    Cell Significance Index: -49.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8012
    Cell Significance Index: -18.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8165
    Cell Significance Index: -33.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8313
    Cell Significance Index: -55.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DHRS7 shares structural and functional similarities with other DHRS family members, which are known to catalyze the reduction and oxidation of specific substrates. Notably, DHRS7 exhibits a high degree of specificity towards its substrates, including all-trans-retinol, and demonstrates a preference for NADP+ as an electron acceptor. This specificity is crucial for the enzyme's role in retinol metabolic processes, which are essential for maintaining the integrity and function of immune cells. **Pathways and Functions:** DHRS7's involvement in various biochemical pathways highlights its multifaceted role in immune cell function. Specifically, this enzyme is implicated in: 1. **Retinol Metabolic Process**: DHRS7 plays a critical role in the reduction and oxidation of all-trans-retinol, a key step in the regulation of retinoid metabolism. This process is essential for maintaining the integrity and function of immune cells, particularly in the context of hematopoiesis and immune cell development. 2. **Carbonyl Reductase Activity**: DHRS7's carbonyl reductase activity enables the reduction of carbonyl-containing compounds, which are involved in various cellular processes, including the regulation of gene expression and the maintenance of cellular homeostasis. 3. **Oxidoreductase Activity**: DHRS7's oxidoreductase activity allows it to catalyze the reduction and oxidation of specific substrates, including all-trans-retinol and other carbonyl-containing compounds. This activity is essential for maintaining the balance of redox reactions within immune cells. **Clinical Significance:** The identification of DHRS7's role in immune cell function and retinol metabolism has significant implications for our understanding of various diseases. Specifically: 1. **Hematological Disorders**: DHRS7's involvement in retinol metabolism suggests that alterations in this enzyme's activity may contribute to the development of hematological disorders, such as anemia and leukemia. 2. **Immune Cell Dysfunction**: DHRS7's role in maintaining immune cell function highlights the importance of this enzyme in the regulation of immune cell development and function. Dysregulation of DHRS7 activity may contribute to immune cell dysfunction, leading to the development of autoimmune and inflammatory disorders. 3. **Retinoid Metabolism and Cancer**: DHRS7's involvement in retinoid metabolism suggests that alterations in this enzyme's activity may contribute to the development and progression of cancers, which often exhibit dysregulated retinoid metabolism. In conclusion, our analysis of DHRS7 highlights its critical role in immune cell function and retinol metabolism. Further research is necessary to fully elucidate the mechanisms underlying DHRS7's activity and to explore its potential applications in the prevention and treatment of diseases.

Genular Protein ID: 1355897694

Symbol: DHRS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y394 B2R896 Q9UKU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 10800688

Title: Short-chain dehydrogenases/reductases in retina.

PubMed ID: 10800688

DOI: 10.1016/s0076-6879(00)16736-9

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19027726

Title: The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.

PubMed ID: 19027726

DOI: 10.1016/j.cbi.2008.10.040

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24246760

Title: Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

PubMed ID: 24246760

DOI: 10.1016/j.cbi.2013.11.003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26311046

Title: A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer.

PubMed ID: 26311046

DOI: 10.1002/cam4.517

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26466768

Title: Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

PubMed ID: 26466768

DOI: 10.1016/j.jsbmb.2015.09.041

PubMed ID: 28687384

Title: The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing.

PubMed ID: 28687384

DOI: 10.1016/j.ijbiomac.2017.07.012

PubMed ID: 28457967

Title: DHRS7 (SDR34C1) - A new player in the regulation of androgen receptor function by inactivation of 5alpha-dihydrotestosterone?

PubMed ID: 28457967

DOI: 10.1016/j.jsbmb.2017.04.013

Sequence Information:

  • Length: 339
  • Mass: 38299
  • Checksum: 7B251CE5894ED70C
  • Sequence:
    • MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD MVVWVTGASS 
GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL KEKDILVLPL DLTDTGSHEA 
ATKAVLQEFG RIDILVNNGG MSQRSLCMDT SLDVYRKLIE LNYLGTVSLT KCVLPHMIER 
KQGKIVTVNS ILGIISVPLS IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN 
IVENSLAGEV TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY 
MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.