Details for: CIAO2B

Gene ID: 51647

Symbol: CIAO2B

Ensembl ID: ENSG00000166595

Description: cytosolic iron-sulfur assembly component 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 398.2122
    Cell Significance Index: -61.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 230.7571
    Cell Significance Index: -58.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 171.9636
    Cell Significance Index: -70.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 159.8249
    Cell Significance Index: -64.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.6266
    Cell Significance Index: -70.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 137.8928
    Cell Significance Index: -70.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 105.6746
    Cell Significance Index: -70.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.0500
    Cell Significance Index: -65.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.3386
    Cell Significance Index: -68.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9116
    Cell Significance Index: -70.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.2468
    Cell Significance Index: -46.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6070
    Cell Significance Index: -39.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8716
    Cell Significance Index: 84.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.5393
    Cell Significance Index: 66.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3626
    Cell Significance Index: 1290.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8358
    Cell Significance Index: 252.1100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.8014
    Cell Significance Index: 8.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6918
    Cell Significance Index: 46.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6020
    Cell Significance Index: 188.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4513
    Cell Significance Index: 93.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4145
    Cell Significance Index: 173.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3026
    Cell Significance Index: 234.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2679
    Cell Significance Index: 26.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2532
    Cell Significance Index: 58.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1961
    Cell Significance Index: 9.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1453
    Cell Significance Index: 85.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0723
    Cell Significance Index: 56.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0683
    Cell Significance Index: 116.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0397
    Cell Significance Index: 459.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0281
    Cell Significance Index: 47.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0031
    Cell Significance Index: 28.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9350
    Cell Significance Index: 48.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8403
    Cell Significance Index: 59.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8209
    Cell Significance Index: 105.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7773
    Cell Significance Index: 8.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7680
    Cell Significance Index: 99.2300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7026
    Cell Significance Index: 5.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5189
    Cell Significance Index: 9.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5091
    Cell Significance Index: 35.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5084
    Cell Significance Index: 96.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5013
    Cell Significance Index: 10.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4629
    Cell Significance Index: 24.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4371
    Cell Significance Index: 15.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3830
    Cell Significance Index: 76.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2856
    Cell Significance Index: 3.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2660
    Cell Significance Index: 52.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2407
    Cell Significance Index: 7.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2339
    Cell Significance Index: 6.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2184
    Cell Significance Index: 21.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1797
    Cell Significance Index: 162.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1444
    Cell Significance Index: 23.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1397
    Cell Significance Index: 105.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1281
    Cell Significance Index: 21.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0745
    Cell Significance Index: 26.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0701
    Cell Significance Index: 1.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0544
    Cell Significance Index: 1.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0434
    Cell Significance Index: 2.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0404
    Cell Significance Index: 1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0335
    Cell Significance Index: 24.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0084
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0251
    Cell Significance Index: -38.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0267
    Cell Significance Index: -2.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0364
    Cell Significance Index: -49.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0441
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0457
    Cell Significance Index: -33.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0608
    Cell Significance Index: -2.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0686
    Cell Significance Index: -43.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0994
    Cell Significance Index: -56.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1195
    Cell Significance Index: -54.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1317
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1400
    Cell Significance Index: -16.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1436
    Cell Significance Index: -89.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1628
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2000
    Cell Significance Index: -57.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3062
    Cell Significance Index: -2.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3182
    Cell Significance Index: -46.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3379
    Cell Significance Index: -20.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3509
    Cell Significance Index: -73.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3524
    Cell Significance Index: -5.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3793
    Cell Significance Index: -9.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4643
    Cell Significance Index: -27.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4941
    Cell Significance Index: -57.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4978
    Cell Significance Index: -38.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5460
    Cell Significance Index: -43.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5492
    Cell Significance Index: -9.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5821
    Cell Significance Index: -7.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6041
    Cell Significance Index: -14.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6540
    Cell Significance Index: -68.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7001
    Cell Significance Index: -4.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7046
    Cell Significance Index: -47.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7750
    Cell Significance Index: -43.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7860
    Cell Significance Index: -9.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8800
    Cell Significance Index: -23.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8937
    Cell Significance Index: -54.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9404
    Cell Significance Index: -9.7400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.0345
    Cell Significance Index: -17.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1153
    Cell Significance Index: -6.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1337
    Cell Significance Index: -28.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CIAO2B is a small protein (18 kDa) that belongs to the cytosolic iron-sulfur assembly component family (CIA). It interacts with other proteins, such as MSS19, to facilitate the assembly of iron-sulfur clusters. CIAO2B is specifically localized to the cytosol and exhibits a high degree of expression in various cell types, including those involved in hematopoiesis, embryonic development, and tissue repair. **Pathways and Functions:** CIAO2B is involved in the assembly of [4fe-4s] clusters, which are essential for the maturation of proteins containing iron-sulfur clusters. These clusters play critical roles in various cellular processes, including: 1. **Protein maturation**: CIAO2B facilitates the assembly of iron-sulfur clusters in proteins, enabling their proper folding and function. 2. **Metabolism**: Iron-sulfur clusters are involved in the regulation of various metabolic pathways, including energy metabolism and redox reactions. 3. **Cell cycle regulation**: Iron-sulfur clusters have been implicated in the regulation of cell cycle progression and apoptosis. 4. **Chromosome segregation**: CIAO2B has been shown to interact with components of the spindle apparatus, highlighting its role in maintaining proper chromosome segregation during cell division. **Clinical Significance:** Dysregulation of iron-sulfur cluster assembly has been implicated in various diseases, including: 1. **Anemia**: Defects in iron-sulfur cluster assembly have been linked to anemia, a condition characterized by reduced red blood cell production. 2. **Neurodegenerative diseases**: Mutations in proteins involved in iron-sulfur cluster assembly have been associated with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. 3. **Cancer**: Dysregulation of iron-sulfur cluster assembly has been implicated in cancer progression and metastasis. In conclusion, CIAO2B is a critical protein involved in the assembly of iron-sulfur clusters within the cytosol. Its dysregulation has been linked to various diseases, highlighting the importance of this protein in maintaining cellular homeostasis. Further studies are necessary to elucidate the precise mechanisms by which CIAO2B regulates iron-sulfur cluster assembly and its role in disease pathogenesis.

Genular Protein ID: 4020383265

Symbol: CIA2B_HUMAN

Name: MSS19-interacting protein of 18 kDa

UniProtKB Accession Codes:

Q9Y3D0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20797633

Title: MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.

PubMed ID: 20797633

DOI: 10.1016/j.molcel.2010.07.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22678362

Title: MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

PubMed ID: 22678362

DOI: 10.1126/science.1219723

PubMed ID: 22678361

Title: MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

PubMed ID: 22678361

DOI: 10.1126/science.1219664

PubMed ID: 23891004

Title: Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

PubMed ID: 23891004

DOI: 10.1016/j.cmet.2013.06.015

PubMed ID: 29320706

Title: Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.

PubMed ID: 29320706

DOI: 10.1016/j.cmet.2017.12.009

PubMed ID: 23585563

Title: IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.

PubMed ID: 23585563

DOI: 10.1074/jbc.m112.416602

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29848660

Title: Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis.

PubMed ID: 29848660

DOI: 10.1242/jcs.211433

PubMed ID: 30742009

Title: Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation.

PubMed ID: 30742009

DOI: 10.1038/s41598-019-39078-5

Sequence Information:

  • Length: 163
  • Mass: 17663
  • Checksum: 323004BAB92B1486
  • Sequence:
    • MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI RSINDPEHPL 
TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG LSIKVKLLRS LPQRFKMDVH 
ITPGTHASEH AVNKQLADKE RVAAALENTH LLEVVNQCLS ARS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.