Details for: MRPS33

Gene ID: 51650

Symbol: MRPS33

Ensembl ID: ENSG00000090263

Description: mitochondrial ribosomal protein S33

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.2318
    Cell Significance Index: -41.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.3137
    Cell Significance Index: -31.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 109.7955
    Cell Significance Index: -45.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.7712
    Cell Significance Index: -46.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.9387
    Cell Significance Index: -44.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.0141
    Cell Significance Index: -46.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.3047
    Cell Significance Index: -46.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8604
    Cell Significance Index: -37.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0956
    Cell Significance Index: -47.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5032
    Cell Significance Index: -32.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4162
    Cell Significance Index: 22.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1857
    Cell Significance Index: 99.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9248
    Cell Significance Index: 1051.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7343
    Cell Significance Index: 90.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6916
    Cell Significance Index: 78.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4383
    Cell Significance Index: 176.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2844
    Cell Significance Index: 231.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2520
    Cell Significance Index: 88.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1628
    Cell Significance Index: 159.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1567
    Cell Significance Index: 9.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0034
    Cell Significance Index: 13.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9499
    Cell Significance Index: 857.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9439
    Cell Significance Index: 121.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9363
    Cell Significance Index: 14.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9270
    Cell Significance Index: 409.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9076
    Cell Significance Index: 26.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8714
    Cell Significance Index: 23.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8631
    Cell Significance Index: 101.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8307
    Cell Significance Index: 22.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8193
    Cell Significance Index: 133.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8144
    Cell Significance Index: 38.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7389
    Cell Significance Index: 19.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7302
    Cell Significance Index: 15.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7009
    Cell Significance Index: 14.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6929
    Cell Significance Index: 20.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5792
    Cell Significance Index: 74.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5783
    Cell Significance Index: 13.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5400
    Cell Significance Index: 102.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5160
    Cell Significance Index: 38.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4919
    Cell Significance Index: 83.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4097
    Cell Significance Index: 117.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4066
    Cell Significance Index: 80.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3539
    Cell Significance Index: 22.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3464
    Cell Significance Index: 21.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3428
    Cell Significance Index: 18.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3293
    Cell Significance Index: 3.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3142
    Cell Significance Index: 8.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2638
    Cell Significance Index: 52.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2535
    Cell Significance Index: 2.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2446
    Cell Significance Index: 8.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1118
    Cell Significance Index: 3.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0793
    Cell Significance Index: 2.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0759
    Cell Significance Index: 57.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0662
    Cell Significance Index: 6.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0549
    Cell Significance Index: 19.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0521
    Cell Significance Index: 38.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0108
    Cell Significance Index: -6.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0178
    Cell Significance Index: -33.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0300
    Cell Significance Index: -55.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0329
    Cell Significance Index: -3.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0358
    Cell Significance Index: -55.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0418
    Cell Significance Index: -56.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0498
    Cell Significance Index: -28.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0571
    Cell Significance Index: -36.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0891
    Cell Significance Index: -18.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0951
    Cell Significance Index: -43.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1023
    Cell Significance Index: -11.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1146
    Cell Significance Index: -3.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1442
    Cell Significance Index: -16.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1538
    Cell Significance Index: -3.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2780
    Cell Significance Index: -22.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2855
    Cell Significance Index: -41.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3582
    Cell Significance Index: -40.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3729
    Cell Significance Index: -6.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3744
    Cell Significance Index: -28.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3745
    Cell Significance Index: -23.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4038
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4611
    Cell Significance Index: -48.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4939
    Cell Significance Index: -33.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5938
    Cell Significance Index: -33.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7539
    Cell Significance Index: -46.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7551
    Cell Significance Index: -22.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7826
    Cell Significance Index: -11.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8707
    Cell Significance Index: -21.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8817
    Cell Significance Index: -39.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9842
    Cell Significance Index: -36.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9998
    Cell Significance Index: -25.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0001
    Cell Significance Index: -17.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.0090
    Cell Significance Index: -20.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0587
    Cell Significance Index: -40.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0589
    Cell Significance Index: -17.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0703
    Cell Significance Index: -30.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0864
    Cell Significance Index: -20.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1484
    Cell Significance Index: -40.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1996
    Cell Significance Index: -39.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2099
    Cell Significance Index: -15.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2143
    Cell Significance Index: -10.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2336
    Cell Significance Index: -39.2900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2347
    Cell Significance Index: -50.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** MRPS33 is a mitochondrial protein, specifically localized to the mitochondrial small ribosomal subunit. 2. **Function:** MRPS33 is involved in the translation of mitochondrial mRNAs into functional proteins, ensuring the proper functioning of the mitochondria. 3. **Expression:** MRPS33 is widely expressed across various cell types, including hematopoietic progenitor cells, embryonic stem cells, and smooth muscle fibers. 4. **Protein Structure:** The protein consists of a single subunit, with a molecular weight of approximately 28 kDa. **Pathways and Functions:** 1. **Mitochondrial Translation:** MRPS33 is a key component of the mitochondrial translation machinery, responsible for translating mitochondrial mRNAs into functional proteins. 2. **Mitochondrial Inner Membrane:** MRPS33 is localized to the mitochondrial inner membrane, where it plays a crucial role in maintaining mitochondrial homeostasis. 3. **Mitochondrial Translation Elongation:** MRPS33 is involved in the elongation phase of mitochondrial translation, ensuring the proper assembly of ribosomal subunits. 4. **Mitochondrial Translation Initiation and Termination:** MRPS33 also plays a role in the initiation and termination phases of mitochondrial translation, ensuring the proper functioning of the mitochondrial translation machinery. **Clinical Significance:** 1. **Mitochondrial Disorders:** Mutations or abnormalities in MRPS33 have been implicated in various mitochondrial disorders, including neurodegenerative diseases such as Parkinson's disease and mitochondrial myopathies. 2. **Metabolic Disorders:** MRPS33 dysfunction has also been linked to metabolic disorders, including type 2 diabetes and obesity. 3. **Cancer:** Abnormal expression of MRPS33 has been observed in certain types of cancer, including leukemia and lymphoma. 4. **Neurological Disorders:** MRPS33 dysfunction has also been implicated in various neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In conclusion, MRPS33 is a crucial protein involved in mitochondrial translation and cellular homeostasis. Its dysfunction has been implicated in various diseases, including mitochondrial disorders, metabolic disorders, cancer, and neurological disorders. Further research is necessary to fully elucidate the role of MRPS33 in human health and disease.

Genular Protein ID: 3894585794

Symbol: RT33_HUMAN

Name: 28S ribosomal protein S33, mitochondrial

UniProtKB Accession Codes:

Q9Y291

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 41 Ensembl 4 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 106
  • Mass: 12629
  • Checksum: E755EDAFB6AF6A46
  • Sequence:
    • MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD WYPNHHTYAE 
LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK RAAKRK

Genular Protein ID: 621700303

Symbol: Q3KRB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3KRB4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 IntAct 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 112
  • Mass: 13371
  • Checksum: C6245374F7B017E2
  • Sequence:
    • MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD WYPNHHTYAE 
LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG EEKPKKGEGK RAAKKKKKKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.