Details for: TRAPPC2L

Gene ID: 51693

Symbol: TRAPPC2L

Ensembl ID: ENSG00000167515

Description: trafficking protein particle complex subunit 2L

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.0512
    Cell Significance Index: -36.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.9352
    Cell Significance Index: -35.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.3229
    Cell Significance Index: -39.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.2821
    Cell Significance Index: -41.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.3848
    Cell Significance Index: -40.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.4272
    Cell Significance Index: -41.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.2983
    Cell Significance Index: -36.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.6265
    Cell Significance Index: -41.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9629
    Cell Significance Index: -43.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4153
    Cell Significance Index: -31.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4476
    Cell Significance Index: -22.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7154
    Cell Significance Index: -10.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3923
    Cell Significance Index: 22.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9554
    Cell Significance Index: 91.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6602
    Cell Significance Index: 34.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5809
    Cell Significance Index: 863.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3908
    Cell Significance Index: 250.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3876
    Cell Significance Index: 190.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2473
    Cell Significance Index: 13.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2437
    Cell Significance Index: 9.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2072
    Cell Significance Index: 148.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1874
    Cell Significance Index: 61.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1846
    Cell Significance Index: 34.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1267
    Cell Significance Index: 26.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1265
    Cell Significance Index: 1017.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1165
    Cell Significance Index: 8.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0428
    Cell Significance Index: 27.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9474
    Cell Significance Index: 111.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9312
    Cell Significance Index: 24.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7244
    Cell Significance Index: 8.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7169
    Cell Significance Index: 316.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7163
    Cell Significance Index: 91.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6936
    Cell Significance Index: 44.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6895
    Cell Significance Index: 47.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6345
    Cell Significance Index: 29.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6023
    Cell Significance Index: 42.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5551
    Cell Significance Index: 15.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5533
    Cell Significance Index: 41.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4880
    Cell Significance Index: 13.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4802
    Cell Significance Index: 62.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4452
    Cell Significance Index: 9.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3550
    Cell Significance Index: 18.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3289
    Cell Significance Index: 11.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2383
    Cell Significance Index: 68.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1973
    Cell Significance Index: 5.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1497
    Cell Significance Index: 28.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1201
    Cell Significance Index: 11.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1046
    Cell Significance Index: 20.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0994
    Cell Significance Index: 2.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0783
    Cell Significance Index: 59.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0568
    Cell Significance Index: 0.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0362
    Cell Significance Index: 2.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0340
    Cell Significance Index: 6.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0248
    Cell Significance Index: 18.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0232
    Cell Significance Index: 8.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0022
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0096
    Cell Significance Index: -1.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0148
    Cell Significance Index: -27.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0231
    Cell Significance Index: -2.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0262
    Cell Significance Index: -48.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0311
    Cell Significance Index: -47.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0374
    Cell Significance Index: -50.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0428
    Cell Significance Index: -31.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0483
    Cell Significance Index: -30.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0582
    Cell Significance Index: -32.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0737
    Cell Significance Index: -46.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0783
    Cell Significance Index: -35.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1031
    Cell Significance Index: -2.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1040
    Cell Significance Index: -12.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1414
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1617
    Cell Significance Index: -18.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1949
    Cell Significance Index: -4.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1956
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2151
    Cell Significance Index: -45.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2289
    Cell Significance Index: -3.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2436
    Cell Significance Index: -35.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2476
    Cell Significance Index: -19.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2751
    Cell Significance Index: -8.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2901
    Cell Significance Index: -13.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3147
    Cell Significance Index: -9.0200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3482
    Cell Significance Index: -3.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3890
    Cell Significance Index: -23.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4125
    Cell Significance Index: -42.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4247
    Cell Significance Index: -5.8000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4313
    Cell Significance Index: -2.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4653
    Cell Significance Index: -9.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4873
    Cell Significance Index: -5.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5065
    Cell Significance Index: -30.4100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5155
    Cell Significance Index: -9.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5281
    Cell Significance Index: -40.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5738
    Cell Significance Index: -4.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5751
    Cell Significance Index: -35.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5769
    Cell Significance Index: -38.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6153
    Cell Significance Index: -34.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6335
    Cell Significance Index: -18.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7042
    Cell Significance Index: -36.6800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.7793
    Cell Significance Index: -3.7900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.9075
    Cell Significance Index: -7.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9127
    Cell Significance Index: -22.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9544
    Cell Significance Index: -35.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAPPC2L is a member of the TRAPP complex, which is composed of multiple subunits that interact to facilitate protein transport between the ER and the Golgi apparatus. The TRAPP complex is involved in various cellular processes, including protein modification, protein degradation, and vesicle-mediated transport. TRAPPC2L is a unique subunit of the TRAPP complex, which is distinct from other TRAPP subunits in its expression pattern and functional role. One of the key characteristics of TRAPPC2L is its involvement in the regulation of asparagine n-linked glycosylation, a post-translational modification process that is essential for protein function and stability. TRAPPC2L is also involved in the regulation of copii-mediated vesicle transport, a process that is critical for the transport of proteins and lipids between the ER and the Golgi apparatus. **Pathways and Functions** The TRAPPC2L gene is involved in several cellular pathways, including: 1. **Asparagine n-linked glycosylation**: TRAPPC2L is involved in the regulation of asparagine n-linked glycosylation, a post-translational modification process that is essential for protein function and stability. 2. **Copii-mediated vesicle transport**: TRAPPC2L is involved in the regulation of copii-mediated vesicle transport, a process that is critical for the transport of proteins and lipids between the ER and the Golgi apparatus. 3. **Endoplasmic reticulum to Golgi vesicle-mediated transport**: TRAPPC2L is involved in the regulation of endoplasmic reticulum to Golgi vesicle-mediated transport, a process that is essential for the transport of proteins and lipids between the ER and the Golgi apparatus. 4. **Rab regulation of trafficking**: TRAPPC2L is involved in the regulation of Rab-mediated trafficking, a process that is critical for the regulation of vesicle transport and protein modification. **Clinical Significance** The TRAPPC2L gene has been implicated in several diseases, including: 1. **Cancer**: TRAPPC2L has been shown to be overexpressed in several types of cancer, including breast cancer and colon cancer. 2. **Neurodegenerative diseases**: TRAPPC2L has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: TRAPPC2L has been implicated in several immunological disorders, including autoimmune diseases and immunodeficiency disorders. Overall, the TRAPPC2L gene plays a critical role in the regulation of membrane trafficking and protein modification, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the functional role of TRAPPC2L and its implications for human disease.

Genular Protein ID: 4205648070

Symbol: TPC2L_HUMAN

Name: Trafficking protein particle complex subunit 2-like protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19416478

Title: TRAPPC2L is a novel, highly conserved TRAPP-interacting protein.

PubMed ID: 19416478

DOI: 10.1111/j.1600-0854.2009.00906.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21525244

Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.

PubMed ID: 21525244

DOI: 10.1091/mbc.e10-11-0873

PubMed ID: 30120216

Title: Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts.

PubMed ID: 30120216

DOI: 10.1136/jmedgenet-2018-105441

Sequence Information:

  • Length: 140
  • Mass: 16146
  • Checksum: 4549BCA7CE9566DC
  • Sequence:
  • MAVCIAVIAK ENYPLYIRST PTENELKFHY MVHTSLDVVD EKISAMGKAL VDQRELYLGL 
    LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF RKLHNSYTDV MCNPFYNPGD 
    RIQSSRAFDN MVTSMMIQVC

Genular Protein ID: 2374641899

Symbol: H3BUK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 109
  • Mass: 12561
  • Checksum: 6872BF1231DD15CC
  • Sequence:
  • MVHTSLDVVD EKISAMGKAL VDQRELYLGL LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA 
    LRDNEIRSMF RKLHNSYTDV MCNPFYNPGD RIQSRAFDNM VTSMMIQVC

Genular Protein ID: 4051781705

Symbol: H3BQQ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 129
  • Mass: 14820
  • Checksum: 7E68F616335D772D
  • Sequence:
  • MRRSPQWGRP WSTRGSCTWA CSTPRRTTRL PHFSKVRAHR GPSTGSPCVT SAFPNQLCRY 
    GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF RKLHNSYTDV MCNPFYNPGD RIQSRAFDNM 
    VTSMMIQVC

Genular Protein ID: 3604350109

Symbol: A0A0B4J294_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 146
  • Mass: 16676
  • Checksum: 48D827091E625A47
  • Sequence:
  • MAVCIAVIAK ENYPLYIRST PTENELKFHY MVHTSLDVVD EKISAMGKAL VDQRELYLGL 
    LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF RKLHNSYTDV MCNPFYNPGD 
    RIQSSGSVSL SRAFDNMVTS MMIQVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.