Details for: PFDN1

Gene ID: 5201

Symbol: PFDN1

Ensembl ID: ENSG00000113068

Description: prefoldin subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.78
    Marker Score: 3724
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.78
    Marker Score: 1856
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.75
    Marker Score: 6871
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.72
    Marker Score: 22638
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.67
    Marker Score: 1772
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.65
    Marker Score: 1749
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.63
    Marker Score: 2762
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.61
    Marker Score: 1808
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.61
    Marker Score: 593
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.59
    Marker Score: 2303
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.57
    Marker Score: 3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.57
    Marker Score: 1046
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.54
    Marker Score: 1449.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.54
    Marker Score: 2263
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.53
    Marker Score: 1632
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.52
    Marker Score: 15319
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 829
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.49
    Marker Score: 1406
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.49
    Marker Score: 429
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.48
    Marker Score: 4041.5
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.47
    Marker Score: 3670
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.46
    Marker Score: 439
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.46
    Marker Score: 2957
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.45
    Marker Score: 16829
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.43
    Marker Score: 5310.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.43
    Marker Score: 36552
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.42
    Marker Score: 1432.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.38
    Marker Score: 9006
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.38
    Marker Score: 2123
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 666
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.37
    Marker Score: 388
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.37
    Marker Score: 1476
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.36
    Marker Score: 1461
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1685.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.34
    Marker Score: 738
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.34
    Marker Score: 907
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.33
    Marker Score: 698
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.32
    Marker Score: 5107
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.32
    Marker Score: 310
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.32
    Marker Score: 460
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5678.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.32
    Marker Score: 1809
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.32
    Marker Score: 1588
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.31
    Marker Score: 828.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.31
    Marker Score: 2982
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.31
    Marker Score: 11270
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3
    Marker Score: 14673
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.3
    Marker Score: 2090.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.3
    Marker Score: 437
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.3
    Marker Score: 3530
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.3
    Marker Score: 815
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.3
    Marker Score: 2437
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.3
    Marker Score: 2588
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.29
    Marker Score: 309
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.29
    Marker Score: 665.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.28
    Marker Score: 604.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.28
    Marker Score: 484
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.28
    Marker Score: 1144
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1321
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.27
    Marker Score: 408
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.26
    Marker Score: 759
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.26
    Marker Score: 1473
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.26
    Marker Score: 8035
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.25
    Marker Score: 9788
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.23
    Marker Score: 657
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.23
    Marker Score: 1214
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.23
    Marker Score: 613
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.23
    Marker Score: 501
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.23
    Marker Score: 27447
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.23
    Marker Score: 1108
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.22
    Marker Score: 1627
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.21
    Marker Score: 4965
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 298
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.21
    Marker Score: 1222.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.2
    Marker Score: 7143
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.2
    Marker Score: 5775
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.2
    Marker Score: 2130
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 578
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.2
    Marker Score: 1904
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.19
    Marker Score: 1717.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.19
    Marker Score: 1191
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.19
    Marker Score: 704
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.19
    Marker Score: 478
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.18
    Marker Score: 4208.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.18
    Marker Score: 1086.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.18
    Marker Score: 1467
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.18
    Marker Score: 737
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.17
    Marker Score: 2955
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.17
    Marker Score: 3468.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.16
    Marker Score: 1039
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.16
    Marker Score: 351
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18173.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.16
    Marker Score: 648
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.16
    Marker Score: 967
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.16
    Marker Score: 10138.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11925
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.15
    Marker Score: 280
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.15
    Marker Score: 1388
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.15
    Marker Score: 39909
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.15
    Marker Score: 379

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Other Information

**Key Characteristics:** PFDN1 is a small protein that belongs to the prefoldin family, which is involved in the folding of actin and tubulin into their native structures. PFDN1 is highly expressed in various cell types, including epithelial cells of the nephron, erythroid progenitor cells, and placental villous trophoblasts. It is also highly conserved across species, suggesting its importance in maintaining protein homeostasis. **Pathways and Functions:** PFDN1 is involved in several critical pathways that regulate protein folding and homeostasis. These include: 1. **Chaperone-mediated protein folding**: PFDN1 works in conjunction with chaperone proteins to facilitate the folding of actin and tubulin into their native structures. 2. **Chaperonin-mediated protein folding**: PFDN1 is also involved in the folding of proteins into their native structures through the action of chaperonins. 3. **Cooperation of prefoldin and tric/cct**: PFDN1 interacts with the tric/cct complex to facilitate the folding of actin and tubulin. 4. **Negative regulation of amyloid fibril formation**: PFDN1 has been shown to inhibit the formation of amyloid fibrils, which are associated with various neurodegenerative diseases. **Functions:** PFDN1 has several functional roles, including: 1. **Protein binding**: PFDN1 binds to unfolded proteins, helping to regulate their folding and aggregation. 2. **Protein folding**: PFDN1 facilitates the folding of actin and tubulin into their native structures. 3. **Unfolded protein binding**: PFDN1 binds to unfolded proteins, preventing their aggregation and promoting their folding. **Clinical Significance:** Dysregulation of PFDN1 has been implicated in various diseases, including: 1. **Amyloidosis**: PFDN1 has been shown to inhibit the formation of amyloid fibrils, and its dysregulation is associated with amyloidosis. 2. **Neurodegenerative diseases**: PFDN1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: PFDN1 has been shown to have anti-tumor effects, and its dysregulation is associated with cancer development. In conclusion, PFDN1 is a critical component of the prefoldin complex, which plays a vital role in maintaining protein homeostasis and preventing amyloid fibril formation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PFDN1 and its role in human disease.

Genular Protein ID: 3909225950

Symbol: PFD1_HUMAN

Name: Prefoldin subunit 1

UniProtKB Accession Codes:

O60925 B2RD02 Q53F95 Q96EX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 122
  • Mass: 14210
  • Checksum: 4C88216612864F87
  • Sequence:
    • MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE IMTLVDETNM 
YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR 
AQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.