Details for: PFDN1

Gene ID: 5201

Symbol: PFDN1

Ensembl ID: ENSG00000113068

Description: prefoldin subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 285.7690
    Cell Significance Index: -44.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.3607
    Cell Significance Index: -45.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.4528
    Cell Significance Index: -51.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.1697
    Cell Significance Index: -53.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.1581
    Cell Significance Index: -43.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.6494
    Cell Significance Index: -49.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.3371
    Cell Significance Index: -44.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.4695
    Cell Significance Index: -51.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5771
    Cell Significance Index: -39.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4514
    Cell Significance Index: -53.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5515
    Cell Significance Index: -35.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0254
    Cell Significance Index: -24.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.7334
    Cell Significance Index: 14.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4871
    Cell Significance Index: 20.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4457
    Cell Significance Index: 30.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1772
    Cell Significance Index: 191.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0400
    Cell Significance Index: 142.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0209
    Cell Significance Index: 27.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9991
    Cell Significance Index: 34.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9708
    Cell Significance Index: 194.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9119
    Cell Significance Index: 112.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9055
    Cell Significance Index: 163.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8960
    Cell Significance Index: 396.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8784
    Cell Significance Index: 23.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8539
    Cell Significance Index: 169.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8322
    Cell Significance Index: 38.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7798
    Cell Significance Index: 40.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7483
    Cell Significance Index: 38.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7477
    Cell Significance Index: 19.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6515
    Cell Significance Index: 355.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6436
    Cell Significance Index: 47.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6185
    Cell Significance Index: 13.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6129
    Cell Significance Index: 78.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5931
    Cell Significance Index: 69.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5666
    Cell Significance Index: 6.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5507
    Cell Significance Index: 38.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5114
    Cell Significance Index: 33.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4808
    Cell Significance Index: 22.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4656
    Cell Significance Index: 35.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3917
    Cell Significance Index: 17.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3496
    Cell Significance Index: 45.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3478
    Cell Significance Index: 124.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3425
    Cell Significance Index: 17.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3111
    Cell Significance Index: 7.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2836
    Cell Significance Index: 8.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2640
    Cell Significance Index: 7.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2211
    Cell Significance Index: 1.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2094
    Cell Significance Index: 35.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1768
    Cell Significance Index: 11.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1766
    Cell Significance Index: 122.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1543
    Cell Significance Index: 29.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1051
    Cell Significance Index: 6.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1007
    Cell Significance Index: 3.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0815
    Cell Significance Index: 1.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0512
    Cell Significance Index: 5.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0387
    Cell Significance Index: 2.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0186
    Cell Significance Index: 35.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0150
    Cell Significance Index: 23.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0147
    Cell Significance Index: 19.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0078
    Cell Significance Index: 5.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0259
    Cell Significance Index: -11.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -18.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0441
    Cell Significance Index: -4.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0598
    Cell Significance Index: -33.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0657
    Cell Significance Index: -0.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0923
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1205
    Cell Significance Index: -25.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1506
    Cell Significance Index: -43.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1508
    Cell Significance Index: -2.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1862
    Cell Significance Index: -1.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1937
    Cell Significance Index: -1.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2032
    Cell Significance Index: -29.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2039
    Cell Significance Index: -23.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2438
    Cell Significance Index: -28.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3650
    Cell Significance Index: -24.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3852
    Cell Significance Index: -43.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3995
    Cell Significance Index: -17.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4069
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4394
    Cell Significance Index: -34.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4892
    Cell Significance Index: -50.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5147
    Cell Significance Index: -13.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5249
    Cell Significance Index: -19.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5323
    Cell Significance Index: -17.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5473
    Cell Significance Index: -14.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5587
    Cell Significance Index: -9.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5780
    Cell Significance Index: -12.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6236
    Cell Significance Index: -16.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6747
    Cell Significance Index: -12.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7086
    Cell Significance Index: -20.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7296
    Cell Significance Index: -19.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7447
    Cell Significance Index: -45.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8187
    Cell Significance Index: -23.4700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.8404
    Cell Significance Index: -13.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8990
    Cell Significance Index: -21.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8999
    Cell Significance Index: -11.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PFDN1 is a small protein that belongs to the prefoldin family, which is involved in the folding of actin and tubulin into their native structures. PFDN1 is highly expressed in various cell types, including epithelial cells of the nephron, erythroid progenitor cells, and placental villous trophoblasts. It is also highly conserved across species, suggesting its importance in maintaining protein homeostasis. **Pathways and Functions:** PFDN1 is involved in several critical pathways that regulate protein folding and homeostasis. These include: 1. **Chaperone-mediated protein folding**: PFDN1 works in conjunction with chaperone proteins to facilitate the folding of actin and tubulin into their native structures. 2. **Chaperonin-mediated protein folding**: PFDN1 is also involved in the folding of proteins into their native structures through the action of chaperonins. 3. **Cooperation of prefoldin and tric/cct**: PFDN1 interacts with the tric/cct complex to facilitate the folding of actin and tubulin. 4. **Negative regulation of amyloid fibril formation**: PFDN1 has been shown to inhibit the formation of amyloid fibrils, which are associated with various neurodegenerative diseases. **Functions:** PFDN1 has several functional roles, including: 1. **Protein binding**: PFDN1 binds to unfolded proteins, helping to regulate their folding and aggregation. 2. **Protein folding**: PFDN1 facilitates the folding of actin and tubulin into their native structures. 3. **Unfolded protein binding**: PFDN1 binds to unfolded proteins, preventing their aggregation and promoting their folding. **Clinical Significance:** Dysregulation of PFDN1 has been implicated in various diseases, including: 1. **Amyloidosis**: PFDN1 has been shown to inhibit the formation of amyloid fibrils, and its dysregulation is associated with amyloidosis. 2. **Neurodegenerative diseases**: PFDN1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: PFDN1 has been shown to have anti-tumor effects, and its dysregulation is associated with cancer development. In conclusion, PFDN1 is a critical component of the prefoldin complex, which plays a vital role in maintaining protein homeostasis and preventing amyloid fibril formation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of PFDN1 and its role in human disease.

Genular Protein ID: 3909225950

Symbol: PFD1_HUMAN

Name: Prefoldin subunit 1

UniProtKB Accession Codes:

O60925 B2RD02 Q53F95 Q96EX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 122
  • Mass: 14210
  • Checksum: 4C88216612864F87
  • Sequence:
    • MAAPVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE IMTLVDETNM 
YEGVGRMFIL QSKEAIHSQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR 
AQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.