Gene POU4F1 - ENSG00000152192 | NCBI Gene ID: 5457

Details for: POU4F1

Gene ID: 5457

Symbol: POU4F1

Ensembl ID: ENSG00000152192

Description: POU class 4 homeobox 1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through association with co-factors
(R-HSA-6804759)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by tp53
(R-HSA-3700989)
Axonogenesis
(GO:0007409)
Cell migration in hindbrain
(GO:0021535)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to estradiol stimulus
(GO:0071392)
Central nervous system neuron differentiation
(GO:0021953)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Gtpase binding
(GO:0051020)
Habenula development
(GO:0021986)
Heart development
(GO:0007507)
Innervation
(GO:0060384)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Mesoderm development
(GO:0007498)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of programmed cell death
(GO:0043069)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron apoptotic process
(GO:0051402)
Neuron fate specification
(GO:0048665)
Neuron migration
(GO:0001764)
Neuron projection
(GO:0043005)
Neuron projection development
(GO:0031175)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peripheral nervous system neuron development
(GO:0048935)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription regulatory region dna binding
(GO:2000679)
Proprioception involved in equilibrioception
(GO:0051355)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of dna-binding transcription factor activity
(GO:0051090)
Regulation of neurogenesis
(GO:0050767)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sensory system development
(GO:0048880)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Single-stranded dna binding
(GO:0003697)
Suckling behavior
(GO:0001967)
Synapse assembly
(GO:0007416)
Trigeminal nerve development
(GO:0021559)
Ventricular compact myocardium morphogenesis
(GO:0003223)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 4.37
Marker Score: 12757
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 2.59
Marker Score: 10022
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.38
Marker Score: 2393
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1178
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 862
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4826
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.14
Marker Score: 723
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.13
Marker Score: 1408
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.11
Marker Score: 508
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.08
Marker Score: 448
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.02
Marker Score: 539
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71838
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48063
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 514
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 467
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 378
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5354
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.88
Marker Score: 672
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.85
Marker Score: 343
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.79
Marker Score: 329
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.78
Marker Score: 236
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 401
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181
Cell Name: pericyte (CL0000669)
Fold Change: 0.68
Marker Score: 398
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.67
Marker Score: 1269
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.66
Marker Score: 425
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.64
Marker Score: 511
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.62
Marker Score: 1264
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.6
Marker Score: 233
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 150
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 176
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 228
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.51
Marker Score: 7968
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.5
Marker Score: 299
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.5
Marker Score: 531
Cell Name: mast cell (CL0000097)
Fold Change: 0.48
Marker Score: 281
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 281
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.43
Marker Score: 1798
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 244
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.4
Marker Score: 423.5
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.35
Marker Score: 690
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.33
Marker Score: 460
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.33
Marker Score: 680.5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.32
Marker Score: 516
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.31
Marker Score: 149
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.29
Marker Score: 76
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.29
Marker Score: 195
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.27
Marker Score: 118
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.27
Marker Score: 85
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.27
Marker Score: 78
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.26
Marker Score: 314
Cell Name: centroblast (CL0009112)
Fold Change: 0.25
Marker Score: 124
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.24
Marker Score: 102
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.23
Marker Score: 120
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.22
Marker Score: 69
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.17
Marker Score: 115
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.16
Marker Score: 42
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.15
Marker Score: 181
Cell Name: oocyte (CL0000023)
Fold Change: 0.14
Marker Score: 35
Cell Name: germ cell (CL0000586)
Fold Change: 0.14
Marker Score: 236
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.13
Marker Score: 380
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.12
Marker Score: 33
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.12
Marker Score: 119
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.11
Marker Score: 77
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.1
Marker Score: 44
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.1
Marker Score: 142
Cell Name: male germ cell (CL0000015)
Fold Change: 0.09
Marker Score: 27
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.09
Marker Score: 71
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.09
Marker Score: 268
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.09
Marker Score: 142
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.08
Marker Score: 62
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.08
Marker Score: 44
Cell Name: astrocyte (CL0000127)
Fold Change: 0.08
Marker Score: 68
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.08
Marker Score: 43
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.08
Marker Score: 25
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.07
Marker Score: 18
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.07
Marker Score: 23
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.07
Marker Score: 73
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.07
Marker Score: 53
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.07
Marker Score: 158
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.06
Marker Score: 22
Cell Name: glial cell (CL0000125)
Fold Change: 0.06
Marker Score: 65
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 14
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.06
Marker Score: 21
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.06
Marker Score: 55
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.06
Marker Score: 169
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.05
Marker Score: 1145
Cell Name: Unknown (CL0002371)
Fold Change: 0.05
Marker Score: 55
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.05
Marker Score: 51

Hover over a box to see details here...

**Key characteristics:** * It is a protein of the POU class 4 family of transcription factors. * It is expressed in high levels in neurons, endothelial cells, and stem cells. * It is a key regulator of gene expression in these cells. * It has been shown to play a role in neuron migration, cell cycle regulation, and tumor growth. **Pathways and functions:** * POU4F1 is a key regulator of gene expression in neurons. * It is expressed in high levels in neurons and is required for the expression of genes involved in neuron migration, growth, and differentiation. * It is also required for the regulation of cell cycle progression and apoptosis. * In endothelial cells, POU4F1 is essential for the formation of new blood vessels and the maintenance of vascular integrity. * In stem cells, POU4F1 is required for the maintenance of stem cell identity and for the differentiation of stem cells into other cell types. **Clinical significance:** * Mutations in POU4F1 have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * In some cases, POU4F1 mutations can lead to the loss of neural function. * Therefore, POU4F1 is a promising target for the treatment of neurological disorders. **Additional notes:** * POU4F1 is a highly conserved protein, with a similar protein found in other vertebrates. * It is a well-known target for cancer immunotherapy, and several drugs that target POU4F1 are currently in clinical development.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Brain-specific homeobox/POU domain protein 3A

Genular Protein ID: 2083912646

Symbol: PO4F1_HUMAN

Name: Brain-specific homeobox/POU domain protein 3A

UniProtKB Accession Codes:

Q01851 Q14986 Q15318 Q5T227

Database IDs:

Citations:

PubMed ID: 1357630

Title: A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.

PubMed ID: 1357630

DOI: 10.1093/nar/20.18.4919

PubMed ID: 8234287

Title: Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.

PubMed ID: 8234287

DOI: 10.1073/pnas.90.21.10260

PubMed ID: 7623109

Title: The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.

PubMed ID: 7623109

DOI: 10.1523/jneurosci.15-07-04762.1995

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 12934100

Title: Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.

PubMed ID: 12934100

DOI: 10.1038/sj.onc.1206635

PubMed ID: 33783914

Title: Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.

PubMed ID: 33783914

DOI: 10.1002/humu.24201

Sequence Information:

Length: 419
Mass: 42697
Checksum: 6EDC2A2082F95F23
Sequence:

MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA 
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI 
SSPSLALMAG AGGAGAAAGG GGAHDGPGGG GGPGGGGGPG GGPGGGGGGG PGGGGGGPGG 
GLLGGSAHPH PHMHSLGHLS HPAAAAAMNM PSGLPHPGLV AAAAHHGAAA AAAAAAAGQV 
AAASAAAAVV GAAGLASICD SDTDPRELEA FAERFKQRRI KLGVTQADVG SALANLKIPG 
VGSLSQSTIC RFESLTLSHN NMIALKPILQ AWLEEAEGAQ REKMNKPELF NGGEKKRKRT 
SIAAPEKRSL EAYFAVQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ KRMKFSATY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: POU4F1

Associated with

Cells (max top 100)

Other Information

A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. PubMed ID: 1357630

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. PubMed ID: 8234287

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. PubMed ID: 7623109

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. PubMed ID: 12934100