Details for: POU4F1

Gene ID: 5457

Symbol: POU4F1

Ensembl ID: ENSG00000152192

Description: POU class 4 homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.7084
    Cell Significance Index: -2.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.5911
    Cell Significance Index: -2.9400
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 5.4267
    Cell Significance Index: 44.4300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.5932
    Cell Significance Index: 14.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4292
    Cell Significance Index: 87.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3716
    Cell Significance Index: 34.2900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6336
    Cell Significance Index: 6.6000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.3472
    Cell Significance Index: 0.8100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3400
    Cell Significance Index: 3.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3309
    Cell Significance Index: 62.9800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3108
    Cell Significance Index: 4.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2631
    Cell Significance Index: 26.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2325
    Cell Significance Index: 209.9300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1324
    Cell Significance Index: 1.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1168
    Cell Significance Index: 2.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0951
    Cell Significance Index: 4.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0819
    Cell Significance Index: 8.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0693
    Cell Significance Index: 11.2700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0691
    Cell Significance Index: 0.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0519
    Cell Significance Index: 0.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0499
    Cell Significance Index: 3.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0491
    Cell Significance Index: 1.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0408
    Cell Significance Index: 4.8100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0363
    Cell Significance Index: 0.4600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0263
    Cell Significance Index: 0.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0253
    Cell Significance Index: 1.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0245
    Cell Significance Index: 0.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0209
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0182
    Cell Significance Index: 2.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0157
    Cell Significance Index: 0.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0102
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0083
    Cell Significance Index: 0.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0022
    Cell Significance Index: 0.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0033
    Cell Significance Index: -0.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0041
    Cell Significance Index: -1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0043
    Cell Significance Index: -2.3600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0055
    Cell Significance Index: -1.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0074
    Cell Significance Index: -2.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0104
    Cell Significance Index: -1.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0108
    Cell Significance Index: -0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0109
    Cell Significance Index: -1.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0125
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0126
    Cell Significance Index: -2.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0133
    Cell Significance Index: -0.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0137
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0146
    Cell Significance Index: -1.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0177
    Cell Significance Index: -1.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0197
    Cell Significance Index: -2.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0202
    Cell Significance Index: -0.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0211
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0255
    Cell Significance Index: -1.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0257
    Cell Significance Index: -0.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0283
    Cell Significance Index: -0.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0289
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0319
    Cell Significance Index: -1.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0326
    Cell Significance Index: -0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0370
    Cell Significance Index: -2.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0385
    Cell Significance Index: -2.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0388
    Cell Significance Index: -0.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0405
    Cell Significance Index: -2.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0432
    Cell Significance Index: -1.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0455
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0492
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0497
    Cell Significance Index: -0.8500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0555
    Cell Significance Index: -2.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0581
    Cell Significance Index: -1.8600
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: -0.0600
    Cell Significance Index: -0.4100
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0621
    Cell Significance Index: -0.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0622
    Cell Significance Index: -2.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0649
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0678
    Cell Significance Index: -1.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0683
    Cell Significance Index: -1.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0690
    Cell Significance Index: -0.7500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0710
    Cell Significance Index: -1.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0722
    Cell Significance Index: -2.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0724
    Cell Significance Index: -2.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0730
    Cell Significance Index: -0.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0731
    Cell Significance Index: -2.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0745
    Cell Significance Index: -2.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0748
    Cell Significance Index: -1.0200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0749
    Cell Significance Index: -0.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0771
    Cell Significance Index: -1.8800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0781
    Cell Significance Index: -0.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0788
    Cell Significance Index: -2.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0801
    Cell Significance Index: -1.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0815
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0818
    Cell Significance Index: -1.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0853
    Cell Significance Index: -1.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0858
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **POU domain:** The POU4F1 gene contains a POU domain, a conserved DNA-binding motif characteristic of POU transcription factors. 2. **Transcriptional regulation:** POU4F1 acts as a transcriptional regulator, controlling the expression of target genes involved in various cellular processes. 3. **Cell-type specificity:** POU4F1 is highly expressed in specific cell types, including neural progenitor cells, retinal ganglion cells, and blood vessel endothelial cells. 4. **Antisense expression:** POU4F1 is also expressed in antisense orientation in certain tissues, suggesting a potential role in regulating gene expression. **Pathways and Functions:** 1. **Axonogenesis:** POU4F1 is involved in regulating axonogenesis, the process of axon formation and guidance. 2. **Neuronal differentiation:** POU4F1 plays a crucial role in the differentiation of neural progenitor cells into neurons. 3. **Cell migration:** POU4F1 regulates cell migration in the hindbrain and other tissues. 4. **Apoptosis regulation:** POU4F1 modulates the intrinsic apoptotic signaling pathway by p53 class mediators. 5. **Transcriptional regulation:** POU4F1 interacts with RNA polymerase II to regulate gene expression. **Clinical Significance:** 1. **Neurological disorders:** Alterations in POU4F1 expression have been linked to various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 2. **Cancer:** POU4F1 has been implicated in the development and progression of certain cancers, including glioblastoma and osteosarcoma. 3. **Non-neurological disorders:** POU4F1 dysregulation has also been associated with non-neurological conditions, such as inflammatory bowel disease and cardiovascular disease. 4. **Regenerative medicine:** POU4F1's role in regulating neural stem cell self-renewal and differentiation makes it a potential target for regenerative medicine applications. In conclusion, the POU4F1 gene plays a critical role in regulating various cellular processes, including gene expression, cell cycle, and apoptosis. Its dysregulation has been implicated in numerous neurological and non-neurological disorders, highlighting the need for further research into the molecular mechanisms underlying POU4F1's functions.

Genular Protein ID: 2083912646

Symbol: PO4F1_HUMAN

Name: Brain-specific homeobox/POU domain protein 3A

UniProtKB Accession Codes:

Q01851 Q14986 Q15318 Q5T227

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 51 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1357630

Title: A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.

PubMed ID: 1357630

DOI: 10.1093/nar/20.18.4919

PubMed ID: 8234287

Title: Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.

PubMed ID: 8234287

DOI: 10.1073/pnas.90.21.10260

PubMed ID: 7623109

Title: The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.

PubMed ID: 7623109

DOI: 10.1523/jneurosci.15-07-04762.1995

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 12934100

Title: Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.

PubMed ID: 12934100

DOI: 10.1038/sj.onc.1206635

PubMed ID: 33783914

Title: Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor.

PubMed ID: 33783914

DOI: 10.1002/humu.24201

Sequence Information:

  • Length: 419
  • Mass: 42697
  • Checksum: 6EDC2A2082F95F23
  • Sequence:
    • MMSMNSKQPH FAMHPTLPEH KYPSLHSSSE AIRRACLPTP PLQSNLFASL DETLLARAEA 
LAAVDIAVSQ GKSHPFKPDA TYHTMNSVPC TSTSTVPLAH HHHHHHHHQA LEPGDLLDHI 
SSPSLALMAG AGGAGAAAGG GGAHDGPGGG GGPGGGGGPG GGPGGGGGGG PGGGGGGPGG 
GLLGGSAHPH PHMHSLGHLS HPAAAAAMNM PSGLPHPGLV AAAAHHGAAA AAAAAAAGQV 
AAASAAAAVV GAAGLASICD SDTDPRELEA FAERFKQRRI KLGVTQADVG SALANLKIPG 
VGSLSQSTIC RFESLTLSHN NMIALKPILQ AWLEEAEGAQ REKMNKPELF NGGEKKRKRT 
SIAAPEKRSL EAYFAVQPRP SSEKIAAIAE KLDLKKNVVR VWFCNQRQKQ KRMKFSATY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.