Details for: PPIB

Gene ID: 5479

Symbol: PPIB

Ensembl ID: ENSG00000166794

Description: peptidylprolyl isomerase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.18
    Marker Score: 6433.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.14
    Marker Score: 2920
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.01
    Marker Score: 3142
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.92
    Marker Score: 12384
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.8
    Marker Score: 50124
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.79
    Marker Score: 37517.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.79
    Marker Score: 128878
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.72
    Marker Score: 43253
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.66
    Marker Score: 3118
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.56
    Marker Score: 23159
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.54
    Marker Score: 3421
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.46
    Marker Score: 14837
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.35
    Marker Score: 8174
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.35
    Marker Score: 2938
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.34
    Marker Score: 4916
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.32
    Marker Score: 9183
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.31
    Marker Score: 8063
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113629.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.28
    Marker Score: 19442
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.27
    Marker Score: 1471
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.23
    Marker Score: 7366
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.2
    Marker Score: 9349
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.15
    Marker Score: 2799
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.15
    Marker Score: 3799
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.14
    Marker Score: 165880.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.12
    Marker Score: 23236
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1
    Marker Score: 173523
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.09
    Marker Score: 8659
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.08
    Marker Score: 3293
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.08
    Marker Score: 15145
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.04
    Marker Score: 8158
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.02
    Marker Score: 968
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.01
    Marker Score: 4144
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.01
    Marker Score: 7657
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3
    Marker Score: 2357
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3
    Marker Score: 2556
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.96
    Marker Score: 39829
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.96
    Marker Score: 2423
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1222
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.93
    Marker Score: 32992
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.9
    Marker Score: 22649
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.9
    Marker Score: 3997
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.9
    Marker Score: 2458
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.88
    Marker Score: 1630
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.88
    Marker Score: 687
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.87
    Marker Score: 2910
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.86
    Marker Score: 2049
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.86
    Marker Score: 5370
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.85
    Marker Score: 12312
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.85
    Marker Score: 5098
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.85
    Marker Score: 18241
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.85
    Marker Score: 1626
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.85
    Marker Score: 4576
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.84
    Marker Score: 4875
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.84
    Marker Score: 7162
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.83
    Marker Score: 4003.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.82
    Marker Score: 4632
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.81
    Marker Score: 18299
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.8
    Marker Score: 2633
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.8
    Marker Score: 5484
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.79
    Marker Score: 7313
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.79
    Marker Score: 1715
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.78
    Marker Score: 2025
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.78
    Marker Score: 3177
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.78
    Marker Score: 5410
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.77
    Marker Score: 2090
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.77
    Marker Score: 1432
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.74
    Marker Score: 2561
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.73
    Marker Score: 1243
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.73
    Marker Score: 1598
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.71
    Marker Score: 7376
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.71
    Marker Score: 1393
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.7
    Marker Score: 1978
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.69
    Marker Score: 27118
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.68
    Marker Score: 2258
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.67
    Marker Score: 2385
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.67
    Marker Score: 2868
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.66
    Marker Score: 1668
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.64
    Marker Score: 4199
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.64
    Marker Score: 1138
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.62
    Marker Score: 1538
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.62
    Marker Score: 1762
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.62
    Marker Score: 3064
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.61
    Marker Score: 4328
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6
    Marker Score: 10024
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.6
    Marker Score: 5428
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.59
    Marker Score: 4719.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.58
    Marker Score: 5863
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.58
    Marker Score: 22266
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.58
    Marker Score: 3099.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2031
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.58
    Marker Score: 940
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.57
    Marker Score: 3323
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.57
    Marker Score: 1859
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.57
    Marker Score: 2795
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.56
    Marker Score: 2297
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.56
    Marker Score: 2126
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.56
    Marker Score: 45437
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.55
    Marker Score: 1695
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.54
    Marker Score: 628

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Other Information

**Key characteristics:** * PPIB is a serine protease that is involved in the regulation of the immune response. * It is expressed in a variety of cell types, including immune cells. * It is involved in the regulation of inflammation and tissue remodeling. * It is a key regulator of the inflammatory response to infection. **Pathways and functions:** * PPIB is involved in the regulation of the inflammatory response to infection. * It is a key regulator of the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha). * It is involved in the regulation of the migration and activation of immune cells. * It is a key regulator of the formation of new blood vessels. **Clinical significance:** * PPIB is a potential therapeutic target for inflammatory diseases. * Inhibition of PPIB has been shown to reduce inflammation and improve disease outcomes in animal models of inflammatory diseases. * PPIB is a promising target for the treatment of inflammatory diseases, such as rheumatoid arthritis, Crohn's disease, and psoriasis. **Additional information:** * PPIB is a highly conserved protein that is found in mammals. * It is expressed in high levels in tissues that are exposed to infection, such as the skin, lungs, and gut. * It is a key regulator of the immune response to infection.

Genular Protein ID: 4163192484

Symbol: PPIB_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase B

UniProtKB Accession Codes:

P23284 A8K534 Q6IBH5 Q9BVK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2040592

Title: A novel secreted cyclophilin-like protein (SCYLP).

PubMed ID: 2040592

DOI: 10.1016/s0021-9258(18)99078-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2000394

Title: Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

PubMed ID: 2000394

DOI: 10.1073/pnas.88.5.1903

PubMed ID: 1710767

Title: An endoplasmic reticulum-specific cyclophilin.

PubMed ID: 1710767

DOI: 10.1128/mcb.11.7.3484-3491.1991

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1530944

Title: S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.

PubMed ID: 1530944

DOI: 10.1083/jcb.116.1.113

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19781681

Title: PPIB mutations cause severe osteogenesis imperfecta.

PubMed ID: 19781681

DOI: 10.1016/j.ajhg.2009.09.001

PubMed ID: 20147391

Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

PubMed ID: 20147391

DOI: 10.1128/jvi.02168-09

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21280149

Title: Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development.

PubMed ID: 21280149

DOI: 10.1002/humu.21413

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8197205

Title: X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.

PubMed ID: 8197205

DOI: 10.1073/pnas.91.11.5183

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 20089953

Title: Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.

PubMed ID: 20089953

DOI: 10.1056/nejmoa0907705

Sequence Information:

  • Length: 216
  • Mass: 23743
  • Checksum: 2D0410A07AA9E420
  • Sequence:
    • MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL RIGDEDVGRV 
IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG 
ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR 
KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.