Details for: PPIB

Gene ID: 5479

Symbol: PPIB

Ensembl ID: ENSG00000166794

Description: peptidylprolyl isomerase B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 752.1928
    Cell Significance Index: -117.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 415.2681
    Cell Significance Index: -105.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 323.2814
    Cell Significance Index: -133.1800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 287.6257
    Cell Significance Index: -116.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 273.7848
    Cell Significance Index: -129.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 252.5539
    Cell Significance Index: -129.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 193.6151
    Cell Significance Index: -129.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 124.6723
    Cell Significance Index: -119.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 100.7579
    Cell Significance Index: -124.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.1179
    Cell Significance Index: -101.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 32.3564
    Cell Significance Index: -127.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.6922
    Cell Significance Index: -82.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.6585
    Cell Significance Index: -34.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.4464
    Cell Significance Index: 108.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.9389
    Cell Significance Index: 183.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.8603
    Cell Significance Index: 66.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.9008
    Cell Significance Index: 173.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3206
    Cell Significance Index: 139.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.2964
    Cell Significance Index: 727.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.8773
    Cell Significance Index: 102.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.8562
    Cell Significance Index: 226.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.7462
    Cell Significance Index: 126.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.7381
    Cell Significance Index: 135.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.6357
    Cell Significance Index: 217.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.5285
    Cell Significance Index: 2473.1200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.3598
    Cell Significance Index: 34.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.0844
    Cell Significance Index: 35.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0595
    Cell Significance Index: 551.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.8436
    Cell Significance Index: 349.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5710
    Cell Significance Index: 69.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.4125
    Cell Significance Index: 14.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3946
    Cell Significance Index: 306.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3316
    Cell Significance Index: 173.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0852
    Cell Significance Index: 269.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9571
    Cell Significance Index: 68.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9438
    Cell Significance Index: 17.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8878
    Cell Significance Index: 133.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8759
    Cell Significance Index: 829.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8603
    Cell Significance Index: 96.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8524
    Cell Significance Index: 218.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7375
    Cell Significance Index: 296.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6636
    Cell Significance Index: 107.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4013
    Cell Significance Index: 25.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3566
    Cell Significance Index: 269.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1811
    Cell Significance Index: 12.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1198
    Cell Significance Index: 32.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9837
    Cell Significance Index: 68.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8644
    Cell Significance Index: 85.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8063
    Cell Significance Index: 610.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7060
    Cell Significance Index: 114.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4127
    Cell Significance Index: 21.4400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.3863
    Cell Significance Index: 2.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1892
    Cell Significance Index: 36.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1825
    Cell Significance Index: 3.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1407
    Cell Significance Index: 0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0982
    Cell Significance Index: 71.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0784
    Cell Significance Index: 54.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0544
    Cell Significance Index: 49.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0167
    Cell Significance Index: 1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0062
    Cell Significance Index: 1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0061
    Cell Significance Index: -2.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0329
    Cell Significance Index: -61.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0419
    Cell Significance Index: -31.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0829
    Cell Significance Index: -152.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0982
    Cell Significance Index: -151.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1145
    Cell Significance Index: -155.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1396
    Cell Significance Index: -87.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1753
    Cell Significance Index: -98.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1759
    Cell Significance Index: -111.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2725
    Cell Significance Index: -123.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3529
    Cell Significance Index: -101.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3768
    Cell Significance Index: -79.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4797
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5925
    Cell Significance Index: -67.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6322
    Cell Significance Index: -16.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6570
    Cell Significance Index: -17.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7265
    Cell Significance Index: -84.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8012
    Cell Significance Index: -44.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8356
    Cell Significance Index: -121.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9611
    Cell Significance Index: -26.8600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -1.0482
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0943
    Cell Significance Index: -124.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1621
    Cell Significance Index: -89.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2469
    Cell Significance Index: -129.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3715
    Cell Significance Index: -62.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3733
    Cell Significance Index: -86.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4473
    Cell Significance Index: -114.6300
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.4485
    Cell Significance Index: -8.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4993
    Cell Significance Index: -26.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.5306
    Cell Significance Index: -80.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7972
    Cell Significance Index: -26.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8440
    Cell Significance Index: -123.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8969
    Cell Significance Index: -116.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.9114
    Cell Significance Index: -117.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.9209
    Cell Significance Index: -19.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.0507
    Cell Significance Index: -103.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0861
    Cell Significance Index: -61.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.1229
    Cell Significance Index: -56.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.1348
    Cell Significance Index: -87.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.2544
    Cell Significance Index: -44.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptidyl-prolyl cis-trans isomerase activity**: PPIB catalyzes the cis-trans isomerization of the peptide bond surrounding proline residues, facilitating protein folding and stability. 2. **Multifunctional protein**: PPIB is involved in various cellular processes, including protein folding, cell signaling, and immune response. 3. **Widespread expression**: PPIB is expressed in a variety of cell types, including mesenchymal stem cells, acinar cells, thyroid follicular cells, and immune cells. 4. **Chaperone-mediated protein folding**: PPIB acts as a chaperone, assisting in the proper folding of proteins and maintaining protein homeostasis. **Pathways and Functions:** 1. **Chaperone-mediated protein folding**: PPIB regulates protein folding by catalyzing the cis-trans isomerization of proline-containing peptides. 2. **Cell signaling**: PPIB is involved in various signaling pathways, including those regulating cell growth, differentiation, and survival. 3. **Immune response**: PPIB plays a critical role in the regulation of immune responses, including the activation of immune cells and the modulation of viral infections. 4. **Protein stabilization**: PPIB helps maintain protein stability by regulating the folding and degradation of proteins. **Clinical Significance:** 1. **Infectious diseases**: PPIB's role in regulating immune responses makes it an important target for the treatment of viral infections, such as SARS-CoV-1. 2. **Cancer**: PPIB's involvement in cell signaling and protein folding pathways may contribute to cancer development and progression. 3. **Neurological disorders**: PPIB's expression in the brain and its role in protein folding and signaling pathways may be related to neurological disorders, such as Alzheimer's disease. 4. **Inflammatory diseases**: PPIB's involvement in immune response regulation may contribute to the development of inflammatory diseases, such as rheumatoid arthritis. In conclusion, PPIB is a multifunctional protein that plays a critical role in various cellular processes, including protein folding, cell signaling, and immune response. Its widespread expression and involvement in different pathways make it an important target for the treatment of various diseases, including infectious diseases, cancer, neurological disorders, and inflammatory diseases.

Genular Protein ID: 4163192484

Symbol: PPIB_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase B

UniProtKB Accession Codes:

P23284 A8K534 Q6IBH5 Q9BVK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2040592

Title: A novel secreted cyclophilin-like protein (SCYLP).

PubMed ID: 2040592

DOI: 10.1016/s0021-9258(18)99078-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2000394

Title: Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

PubMed ID: 2000394

DOI: 10.1073/pnas.88.5.1903

PubMed ID: 1710767

Title: An endoplasmic reticulum-specific cyclophilin.

PubMed ID: 1710767

DOI: 10.1128/mcb.11.7.3484-3491.1991

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1530944

Title: S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.

PubMed ID: 1530944

DOI: 10.1083/jcb.116.1.113

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19781681

Title: PPIB mutations cause severe osteogenesis imperfecta.

PubMed ID: 19781681

DOI: 10.1016/j.ajhg.2009.09.001

PubMed ID: 20147391

Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

PubMed ID: 20147391

DOI: 10.1128/jvi.02168-09

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21280149

Title: Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development.

PubMed ID: 21280149

DOI: 10.1002/humu.21413

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8197205

Title: X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.

PubMed ID: 8197205

DOI: 10.1073/pnas.91.11.5183

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 20089953

Title: Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.

PubMed ID: 20089953

DOI: 10.1056/nejmoa0907705

Sequence Information:

  • Length: 216
  • Mass: 23743
  • Checksum: 2D0410A07AA9E420
  • Sequence:
    • MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL RIGDEDVGRV 
IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG 
ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR 
KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.