Details for: PPIB

Gene ID: 5479

Symbol: PPIB

Ensembl ID: ENSG00000166794

Description: peptidylprolyl isomerase B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.18
    Marker Score: 6,434
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.14
    Marker Score: 2,920
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.01
    Marker Score: 3,142
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.92
    Marker Score: 12,384
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.8
    Marker Score: 50,124
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.79
    Marker Score: 37,518
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.79
    Marker Score: 128,878
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.72
    Marker Score: 43,253
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.66
    Marker Score: 3,118
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.56
    Marker Score: 23,159
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.54
    Marker Score: 3,421
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.46
    Marker Score: 14,837
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.35
    Marker Score: 8,174
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.35
    Marker Score: 2,938
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.34
    Marker Score: 4,916
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.32
    Marker Score: 9,183
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.31
    Marker Score: 8,063
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113,630
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.28
    Marker Score: 19,442
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.27
    Marker Score: 1,471
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.23
    Marker Score: 7,366
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.2
    Marker Score: 9,349
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.15
    Marker Score: 2,799
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.15
    Marker Score: 3,799
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.14
    Marker Score: 165,881
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.12
    Marker Score: 23,236
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.1
    Marker Score: 173,523
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.09
    Marker Score: 8,659
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.08
    Marker Score: 3,293
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.08
    Marker Score: 15,145
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.04
    Marker Score: 8,158
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.02
    Marker Score: 968
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.01
    Marker Score: 4,144
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.01
    Marker Score: 7,657
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3
    Marker Score: 2,357
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3
    Marker Score: 2,556
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.96
    Marker Score: 39,829
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.96
    Marker Score: 2,423
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1,222
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.93
    Marker Score: 32,992
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.9
    Marker Score: 22,649
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.9
    Marker Score: 3,997
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.9
    Marker Score: 2,458
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.88
    Marker Score: 1,630
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.88
    Marker Score: 687
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.87
    Marker Score: 2,910
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.86
    Marker Score: 2,049
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.86
    Marker Score: 5,370
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.85
    Marker Score: 12,312
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.85
    Marker Score: 5,098
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.85
    Marker Score: 18,241
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.85
    Marker Score: 1,626
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.85
    Marker Score: 4,576
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.84
    Marker Score: 4,875
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.84
    Marker Score: 7,162
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.83
    Marker Score: 4,004
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.82
    Marker Score: 4,632
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.81
    Marker Score: 18,299
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.8
    Marker Score: 2,633
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.8
    Marker Score: 5,484
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.79
    Marker Score: 7,313
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.79
    Marker Score: 1,715
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.78
    Marker Score: 2,025
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.78
    Marker Score: 3,177
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.78
    Marker Score: 5,410
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.77
    Marker Score: 2,090
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.77
    Marker Score: 1,432
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.74
    Marker Score: 2,561
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.73
    Marker Score: 1,243
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.73
    Marker Score: 1,598
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.71
    Marker Score: 7,376
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.71
    Marker Score: 1,393
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.7
    Marker Score: 1,978
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.69
    Marker Score: 27,118
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.68
    Marker Score: 2,258
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.67
    Marker Score: 2,385
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.67
    Marker Score: 2,868
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.66
    Marker Score: 1,668
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.64
    Marker Score: 4,199
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.64
    Marker Score: 1,138
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.62
    Marker Score: 1,538
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.62
    Marker Score: 1,762
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.62
    Marker Score: 3,064
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.61
    Marker Score: 4,328
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6
    Marker Score: 10,024
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.6
    Marker Score: 5,428
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.59
    Marker Score: 4,720
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.58
    Marker Score: 5,863
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.58
    Marker Score: 22,266
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.58
    Marker Score: 3,100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.58
    Marker Score: 2,031
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.58
    Marker Score: 940
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.57
    Marker Score: 3,323
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.57
    Marker Score: 1,859
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.57
    Marker Score: 2,795
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.56
    Marker Score: 2,297
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.56
    Marker Score: 2,126
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.56
    Marker Score: 45,437
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.55
    Marker Score: 1,695
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.54
    Marker Score: 628

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptidyl-prolyl cis-trans isomerase activity**: PPIB catalyzes the cis-trans isomerization of the peptide bond surrounding proline residues, facilitating protein folding and stability. 2. **Multifunctional protein**: PPIB is involved in various cellular processes, including protein folding, cell signaling, and immune response. 3. **Widespread expression**: PPIB is expressed in a variety of cell types, including mesenchymal stem cells, acinar cells, thyroid follicular cells, and immune cells. 4. **Chaperone-mediated protein folding**: PPIB acts as a chaperone, assisting in the proper folding of proteins and maintaining protein homeostasis. **Pathways and Functions:** 1. **Chaperone-mediated protein folding**: PPIB regulates protein folding by catalyzing the cis-trans isomerization of proline-containing peptides. 2. **Cell signaling**: PPIB is involved in various signaling pathways, including those regulating cell growth, differentiation, and survival. 3. **Immune response**: PPIB plays a critical role in the regulation of immune responses, including the activation of immune cells and the modulation of viral infections. 4. **Protein stabilization**: PPIB helps maintain protein stability by regulating the folding and degradation of proteins. **Clinical Significance:** 1. **Infectious diseases**: PPIB's role in regulating immune responses makes it an important target for the treatment of viral infections, such as SARS-CoV-1. 2. **Cancer**: PPIB's involvement in cell signaling and protein folding pathways may contribute to cancer development and progression. 3. **Neurological disorders**: PPIB's expression in the brain and its role in protein folding and signaling pathways may be related to neurological disorders, such as Alzheimer's disease. 4. **Inflammatory diseases**: PPIB's involvement in immune response regulation may contribute to the development of inflammatory diseases, such as rheumatoid arthritis. In conclusion, PPIB is a multifunctional protein that plays a critical role in various cellular processes, including protein folding, cell signaling, and immune response. Its widespread expression and involvement in different pathways make it an important target for the treatment of various diseases, including infectious diseases, cancer, neurological disorders, and inflammatory diseases.

Genular Protein ID: 4163192484

Symbol: PPIB_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase B

UniProtKB Accession Codes:

P23284 A8K534 Q6IBH5 Q9BVK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2040592

Title: A novel secreted cyclophilin-like protein (SCYLP).

PubMed ID: 2040592

DOI: 10.1016/s0021-9258(18)99078-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2000394

Title: Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence.

PubMed ID: 2000394

DOI: 10.1073/pnas.88.5.1903

PubMed ID: 1710767

Title: An endoplasmic reticulum-specific cyclophilin.

PubMed ID: 1710767

DOI: 10.1128/mcb.11.7.3484-3491.1991

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 1530944

Title: S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.

PubMed ID: 1530944

DOI: 10.1083/jcb.116.1.113

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19781681

Title: PPIB mutations cause severe osteogenesis imperfecta.

PubMed ID: 19781681

DOI: 10.1016/j.ajhg.2009.09.001

PubMed ID: 20147391

Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

PubMed ID: 20147391

DOI: 10.1128/jvi.02168-09

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21280149

Title: Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development.

PubMed ID: 21280149

DOI: 10.1002/humu.21413

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8197205

Title: X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.

PubMed ID: 8197205

DOI: 10.1073/pnas.91.11.5183

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 20089953

Title: Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.

PubMed ID: 20089953

DOI: 10.1056/nejmoa0907705

Sequence Information:

  • Length: 216
  • Mass: 23743
  • Checksum: 2D0410A07AA9E420
  • Sequence:
    • MLRLSERNMK VLLAAALIAG SVFFLLLPGP SAADEKKKGP KVTVKVYFDL RIGDEDVGRV 
IFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG 
ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR 
KVESTKTDSR DKPLKDVIIA DCGKIEVEKP FAIAKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.