PPP2CA | ENSG00000113575 | NCBI 5515

Details for: PPP2CA

Gene ID: 5515

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PPP2CA

Ensembl ID: ENSG00000113575

Description: protein phosphatase 2 catalytic subunit alpha

Cell Significance Landscape

Display Count:

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin d associated events in g1
(R-HSA-69231)
Cytokine signaling in immune system
(R-HSA-1280215)
Darpp-32 events
(R-HSA-180024)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f mediated regulation of dna replication
(R-HSA-113510)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Erk/mapk targets
(R-HSA-198753)
Erks are inactivated
(R-HSA-202670)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of rna
(R-HSA-8953854)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of mapk pathway
(R-HSA-5675221)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Pkr-mediated signaling
(R-HSA-9833482)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(R-HSA-9634600)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rna polymerase ii transcription
(R-HSA-73857)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Spry regulation of fgf signaling
(R-HSA-1295596)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)
Chromosome, centromeric region
(GO:0000775)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Far/sin/stripak complex
(GO:0090443)
Gaba receptor binding
(GO:0050811)
Intracellular signal transduction
(GO:0035556)
Meiotic cell cycle
(GO:0051321)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton
(GO:0015630)
Mitochondrion
(GO:0005739)
Mitotic cell cycle
(GO:0000278)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of glycolytic process through fructose-6-phosphate
(GO:1904539)
Negative regulation of hippo signaling
(GO:0035331)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Nucleus
(GO:0005634)
Peptidyl-serine dephosphorylation
(GO:0070262)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of microtubule binding
(GO:1904528)
Positive regulation of nlrp3 inflammasome complex assembly
(GO:1900227)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein heterodimerization activity
(GO:0046982)
Protein phosphatase type 2a complex
(GO:0000159)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein serine/threonine phosphatase complex
(GO:0008287)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of cell differentiation
(GO:0045595)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of growth
(GO:0040008)
Regulation of microtubule binding
(GO:1904526)
Regulation of protein phosphorylation
(GO:0001932)
Response to lead ion
(GO:0010288)
Spindle pole
(GO:0000922)
Synapse
(GO:0045202)
Tau protein binding
(GO:0048156)
T cell homeostasis
(GO:0043029)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

glutamatergic neuron CL0000679

CSI 25.17

rCSI 51.73%

PRS 22.05
placental villous trophoblast CL2000060

CSI 18.6

rCSI 28.74%

PRS 21.02
GABAergic neuron CL0000617

CSI 18.35

rCSI 61.47%

PRS 16.26
activated CD4-positive, alpha-beta T cell CL0000896

CSI 17.05

rCSI 15.76%

PRS 40.46
parietal epithelial cell CL1000452

CSI 16.2

rCSI 43.3%

PRS 18.73
ependymal cell CL0000065

CSI 15.73

rCSI 31.92%

PRS 11.9
keratinocyte CL0000312

CSI 15.17

rCSI 12.72%

PRS 26.64
alternatively activated macrophage CL0000890

CSI 14.19

rCSI 17.84%

PRS 34.39
megakaryocyte-erythroid progenitor cell CL0000050

CSI 13.73

rCSI 12.4%

PRS 20.45
respiratory hillock cell CL4030023

CSI 13.25

rCSI 23.64%

PRS 36.95
peripheral nervous system neuron CL2000032

CSI 11.41

rCSI 15.55%

PRS 19.73
pancreatic ductal cell CL0002079

CSI 11.26

rCSI 21.9%

PRS 23.11
germinal center B cell CL0000844

CSI 10.13

rCSI 30.22%

PRS 49.23
innate lymphoid cell CL0001065

CSI 9.76

rCSI 20.15%

PRS 33.4
muscle cell CL0000187

CSI 9.75

rCSI 20.01%

PRS 46.57
sst GABAergic cortical interneuron CL4023017

CSI 9.71

rCSI 12.51%

PRS 13.93
endothelial cell of lymphatic vessel CL0002138

CSI 9.56

rCSI 18.96%

PRS 56.17
adipocyte CL0000136

CSI 9.36

rCSI 12.02%

PRS 21.79
vascular associated smooth muscle cell CL0000359

CSI 9.09

rCSI 29.48%

PRS 26.92
cardiac muscle cell CL0000746

CSI 8.02

rCSI 11.51%

PRS 17.43
paneth cell CL0000510

CSI 7.57

rCSI 11.17%

PRS 34.97
lamp5 GABAergic cortical interneuron CL4023011

CSI 7.45

rCSI 12.51%

PRS 13.34
pulmonary capillary endothelial cell CL4028001

CSI 7.04

rCSI 13.43%

PRS 35.18
effector CD8-positive, alpha-beta T cell CL0001050

CSI 6.83

rCSI 5.2%

PRS 29.93
memory T cell CL0000813

CSI 6.8

rCSI 13.11%

PRS 50.04
radial glial cell CL0000681

CSI 6.79

rCSI 9.43%

PRS 22.77
granulocyte monocyte progenitor cell CL0000557

CSI 6.48

rCSI 5.61%

PRS 25.43
effector CD4-positive, alpha-beta T cell CL0001044

CSI 6.22

rCSI 17.85%

PRS 34
lung pericyte CL0009089

CSI 5.89

rCSI 15.54%

PRS 26.87
podocyte CL0000653

CSI 5.76

rCSI 25.61%

PRS 21.89
non-classical monocyte CL0000875

CSI 5.68

rCSI 9.11%

PRS 57.24
CD14-positive, CD16-positive monocyte CL0002397

CSI 5.61

rCSI 7.35%

PRS 32.21
kidney connecting tubule epithelial cell CL1000768

CSI 5.53

rCSI 14.04%

PRS 17.06
neural crest cell CL0011012

CSI 5.36

rCSI 4.24%

PRS 15.44
intestinal epithelial cell CL0002563

CSI 5.3

rCSI 5.54%

PRS 23.42
retina horizontal cell CL0000745

CSI 5.28

rCSI 8.05%

PRS 20.74
stem cell CL0000034

CSI 5.26

rCSI 5.07%

PRS 16.41
plasmablast CL0000980

CSI 5.11

rCSI 4.02%

PRS 27.37
L6b glutamatergic cortical neuron CL4023038

CSI 4.88

rCSI 15.25%

PRS 14.19
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 4.83

rCSI 15.1%

PRS 15.29
squamous epithelial cell CL0000076

CSI 4.73

rCSI 11.23%

PRS 27.83
myofibroblast cell CL0000186

CSI 4.72

rCSI 6.53%

PRS 31.14
retinal ganglion cell CL0000740

CSI 4.69

rCSI 10.37%

PRS 16.05
endothelial cell of placenta CL0009092

CSI 4.65

rCSI 22.92%

PRS 30.3
tracheobronchial smooth muscle cell CL0019019

CSI 4.52

rCSI 7.98%

PRS 29.26
blood vessel endothelial cell CL0000071

CSI 4.37

rCSI 9.06%

PRS 22.46
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 4.23

rCSI 4.15%

PRS 35.06
renal interstitial pericyte CL1001318

CSI 4.1

rCSI 11.31%

PRS 20.98
CD14-positive monocyte CL0001054

CSI 4.07

rCSI 5.07%

PRS 31.79
colon epithelial cell CL0011108

CSI 4.07

rCSI 4.26%

PRS 21.01
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 3.9

rCSI 2.92%

PRS 58.45
extravillous trophoblast CL0008036

CSI 3.79

rCSI 4.69%

PRS 19.73
myeloid lineage restricted progenitor cell CL0000839

CSI 3.66

rCSI 18.92%

PRS 43.27
secretory cell CL0000151

CSI 3.63

rCSI 3.79%

PRS 23.07
alpha-beta T cell CL0000789

CSI 3.42

rCSI 4.01%

PRS 31.46
medium spiny neuron CL1001474

CSI 3.41

rCSI 29.36%

PRS 12.15
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.37

rCSI 2.7%

PRS 39.98
CD14-low, CD16-positive monocyte CL0002396

CSI 3.37

rCSI 2.6%

PRS 21.08
enteric smooth muscle cell CL0002504

CSI 3.32

rCSI 4.74%

PRS 25.23
basal-myoepithelial cell of mammary gland CL0002324

CSI 3.26

rCSI 6.17%

PRS 46.36
basal cell of prostate epithelium CL0002341

CSI 3.24

rCSI 9.37%

PRS 45.84
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.21

rCSI 1.9%

PRS 31.78
cerebral cortex GABAergic interneuron CL0010011

CSI 3.2

rCSI 9.44%

PRS 26.45
endothelial cell of vascular tree CL0002139

CSI 3.19

rCSI 17.44%

PRS 33.9
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.11

rCSI 2.83%

PRS 34.42
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 3.04

rCSI 6.92%

PRS 23.13
pvalb GABAergic cortical interneuron CL4023018

CSI 3.01

rCSI 3.75%

PRS 12.49
epithelial cell of lower respiratory tract CL0002632

CSI 2.97

rCSI 2.3%

PRS 21.7
Mueller cell CL0000636

CSI 2.95

rCSI 6.73%

PRS 19.28
regular atrial cardiac myocyte CL0002129

CSI 2.95

rCSI 9.49%

PRS 23.36
ciliated cell CL0000064

CSI 2.93

rCSI 4.75%

PRS 22.67
IgA plasma cell CL0000987

CSI 2.91

rCSI 2.98%

PRS 40.66
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.79

rCSI 7.21%

PRS 20.92
immature B cell CL0000816

CSI 2.78

rCSI 2.06%

PRS 33.21
common myeloid progenitor CL0000049

CSI 2.71

rCSI 2.19%

PRS 22.7
pro-B cell CL0000826

CSI 2.7

rCSI 2.24%

PRS 22.93
respiratory goblet cell CL0002370

CSI 2.7

rCSI 29.35%

PRS 42.23
hematopoietic precursor cell CL0008001

CSI 2.66

rCSI 2.73%

PRS 36.15
pulmonary alveolar type 2 cell CL0002063

CSI 2.64

rCSI 4.1%

PRS 33.25
epithelial cell CL0000066

CSI 2.63

rCSI 4.04%

PRS 30.23
pulmonary ionocyte CL0017000

CSI 2.63

rCSI 3.2%

PRS 28.16
plasmacytoid dendritic cell, human CL0001058

CSI 2.58

rCSI 1.8%

PRS 24.11
conventional dendritic cell CL0000990

CSI 2.57

rCSI 2.15%

PRS 54.63
enteroendocrine cell CL0000164

CSI 2.53

rCSI 3.45%

PRS 25.04
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.49

rCSI 9.68%

PRS 36.89
intestine goblet cell CL0019031

CSI 2.47

rCSI 2.2%

PRS 22.69
mucus secreting cell CL0000319

CSI 2.46

rCSI 3.91%

PRS 28.88
activated type II NK T cell CL0000931

CSI 2.44

rCSI 2.74%

PRS 35.79
group 3 innate lymphoid cell CL0001071

CSI 2.43

rCSI 1.83%

PRS 24.16
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.43

rCSI 1.64%

PRS 27.97
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.42

rCSI 2.38%

PRS 57.22
double negative thymocyte CL0002489

CSI 2.41

rCSI 1.68%

PRS 27.25
unswitched memory B cell CL0000970

CSI 2.4

rCSI 2.02%

PRS 35.61
ciliated epithelial cell CL0000067

CSI 2.39

rCSI 2.1%

PRS 16.36
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.39

rCSI 3.38%

PRS 20.84
CD4-positive helper T cell CL0000492

CSI 2.35

rCSI 1.78%

PRS 31.01
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 2.34

rCSI 1.56%

PRS 51.62
mesenchymal cell CL0008019

CSI 2.34

rCSI 5.94%

PRS 22.44
astrocyte of the cerebral cortex CL0002605

CSI 2.34

rCSI 5.24%

PRS 13.95
retinal bipolar neuron CL0000748

CSI 2.33

rCSI 4.37%

PRS 16.21

chondrocyte CL0000138

CSI 0.1

rCSI 0.1%

PRS 19.0%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.1%

PRS 42.5%
pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 2.2%

PRS 61.2%
enterocyte of epithelium of small intestine CL1000334

CSI 0.2

rCSI 3.8%

PRS 51.9%
tracheobronchial serous cell CL0019001

CSI 0.2

rCSI 1.1%

PRS 40.4%
eosinophil CL0000771

CSI 0.3

rCSI 1.7%

PRS 54.4%
epithelial cell of urethra CL1000296

CSI 0.3

rCSI 6.4%

PRS 57.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.3

rCSI 0.6%

PRS 15.2%
group 2 innate lymphoid cell CL0001069

CSI 0.3

rCSI 1.4%

PRS 65.9%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 3.8%

PRS 17.7%
epithelial cell of nephron CL1000449

CSI 0.3

rCSI 3.0%

PRS 72.0%
stromal cell of ovary CL0002132

CSI 0.3

rCSI 0.9%

PRS 36.6%
pancreatic PP cell CL0002275

CSI 0.3

rCSI 1.3%

PRS 38.0%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.3

rCSI 1.7%

PRS 29.9%
myelocyte CL0002193

CSI 0.4

rCSI 2.3%

PRS 62.0%
glycinergic amacrine cell CL4030028

CSI 0.4

rCSI 1.1%

PRS 22.8%
retinal cone cell CL0000573

CSI 0.4

rCSI 0.7%

PRS 17.2%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.5

rCSI 2.7%

PRS 48.4%
bronchial goblet cell CL1000312

CSI 0.5

rCSI 1.9%

PRS 46.0%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.7%

PRS 33.0%
thymocyte CL0000893

CSI 0.5

rCSI 1.7%

PRS 62.9%
respiratory epithelial cell CL0002368

CSI 0.5

rCSI 3.0%

PRS 62.9%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.5

rCSI 2.2%

PRS 65.5%
megakaryocyte CL0000556

CSI 0.5

rCSI 2.2%

PRS 38.6%
late pro-B cell CL0002048

CSI 0.5

rCSI 1.3%

PRS 57.6%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.2%

PRS 20.8%
amacrine cell CL0000561

CSI 0.6

rCSI 1.6%

PRS 17.3%
lung goblet cell CL1000143

CSI 0.6

rCSI 6.3%

PRS 63.5%
pancreatic epsilon cell CL0005019

CSI 0.6

rCSI 2.6%

PRS 47.6%
basophil mast progenitor cell CL0002028

CSI 0.6

rCSI 3.1%

PRS 68.2%
transit amplifying cell of small intestine CL0009012

CSI 0.6

rCSI 2.6%

PRS 40.8%
mature alpha-beta T cell CL0000791

CSI 0.6

rCSI 2.2%

PRS 38.7%
type EC enteroendocrine cell CL0000577

CSI 0.6

rCSI 2.2%

PRS 36.2%
colon goblet cell CL0009039

CSI 0.6

rCSI 1.5%

PRS 33.3%
deuterosomal cell CL4033044

CSI 0.6

rCSI 2.1%

PRS 35.2%
basket cell CL0000118

CSI 0.7

rCSI 4.0%

PRS 16.2%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.7

rCSI 2.2%

PRS 15.1%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.7

rCSI 0.8%

PRS 38.9%
T-helper 17 cell CL0000899

CSI 0.7

rCSI 0.6%

PRS 40.2%
colon macrophage CL0009038

CSI 0.8

rCSI 3.5%

PRS 45.8%
syncytiotrophoblast cell CL0000525

CSI 0.8

rCSI 2.2%

PRS 40.6%
retinal pigment epithelial cell CL0002586

CSI 0.8

rCSI 1.6%

PRS 23.5%
primitive red blood cell CL0002355

CSI 0.8

rCSI 4.5%

PRS 37.8%
kidney epithelial cell CL0002518

CSI 0.8

rCSI 1.6%

PRS 47.4%
brain vascular cell CL4023072

CSI 0.9

rCSI 8.8%

PRS 25.6%
mesodermal cell CL0000222

CSI 0.9

rCSI 1.1%

PRS 21.9%
duct epithelial cell CL0000068

CSI 0.9

rCSI 1.3%

PRS 23.8%
Cajal-Retzius cell CL0000695

CSI 0.9

rCSI 7.2%

PRS 42.9%
enteroendocrine cell of small intestine CL0009006

CSI 0.9

rCSI 2.0%

PRS 33.9%
dendritic cell, human CL0001056

CSI 0.9

rCSI 1.4%

PRS 27.1%
cerebellar neuron CL1001611

CSI 0.9

rCSI 8.2%

PRS 16.4%
IgG plasma cell CL0000985

CSI 0.9

rCSI 1.1%

PRS 39.1%
cerebral cortex endothelial cell CL1001602

CSI 1.0

rCSI 1.7%

PRS 17.2%
sncg GABAergic cortical interneuron CL4023015

CSI 1.0

rCSI 1.5%

PRS 14.5%
prostate gland microvascular endothelial cell CL2000059

CSI 1.0

rCSI 23.3%

PRS 60.3%
dopaminergic neuron CL0000700

CSI 1.0

rCSI 5.7%

PRS 13.2%
mature B cell CL0000785

CSI 1.0

rCSI 0.9%

PRS 28.5%
pulmonary artery endothelial cell CL1001568

CSI 1.0

rCSI 1.4%

PRS 33.9%
luminal epithelial cell of mammary gland CL0002326

CSI 1.0

rCSI 1.8%

PRS 34.2%
small intestine goblet cell CL1000495

CSI 1.0

rCSI 2.2%

PRS 30.0%
intestinal tuft cell CL0019032

CSI 1.0

rCSI 1.6%

PRS 25.7%
transit amplifying cell CL0009010

CSI 1.0

rCSI 1.6%

PRS 36.1%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.0

rCSI 1.3%

PRS 27.7%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.1

rCSI 3.8%

PRS 12.6%
luminal cell of prostate epithelium CL0002340

CSI 1.1

rCSI 5.7%

PRS 38.9%
pancreatic D cell CL0000173

CSI 1.1

rCSI 1.1%

PRS 24.2%
type L enteroendocrine cell CL0002279

CSI 1.1

rCSI 2.0%

PRS 43.1%
epithelial cell of proximal tubule CL0002306

CSI 1.1

rCSI 2.7%

PRS 22.0%
small pre-B-II cell CL0000954

CSI 1.1

rCSI 1.1%

PRS 44.8%
acinar cell CL0000622

CSI 1.2

rCSI 1.7%

PRS 29.5%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.2

rCSI 1.6%

PRS 50.9%
erythroid progenitor cell CL0000038

CSI 1.2

rCSI 6.8%

PRS 33.2%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.2

rCSI 2.9%

PRS 13.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.2

rCSI 2.1%

PRS 13.2%
lung ciliated cell CL1000271

CSI 1.2

rCSI 1.4%

PRS 16.6%
epithelial cell of lung CL0000082

CSI 1.2

rCSI 1.0%

PRS 21.4%
mucous neck cell CL0000651

CSI 1.2

rCSI 1.7%

PRS 35.2%
fibroblast of lung CL0002553

CSI 1.2

rCSI 1.1%

PRS 22.6%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.2

rCSI 1.7%

PRS 43.3%
renal beta-intercalated cell CL0002201

CSI 1.2

rCSI 2.9%

PRS 25.5%
tracheal goblet cell CL1000329

CSI 1.2

rCSI 2.7%

PRS 42.8%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.2

rCSI 7.3%

PRS 14.0%
VIP GABAergic cortical interneuron CL4023016

CSI 1.2

rCSI 1.5%

PRS 13.2%
ventricular cardiac muscle cell CL2000046

CSI 1.3

rCSI 4.3%

PRS 67.5%
alveolar adventitial fibroblast CL4028006

CSI 1.3

rCSI 2.0%

PRS 22.6%
glioblast CL0000030

CSI 1.3

rCSI 2.1%

PRS 19.1%
BEST4+ enteroycte CL4030026

CSI 1.3

rCSI 1.6%

PRS 24.0%
alveolar macrophage CL0000583

CSI 1.3

rCSI 2.2%

PRS 26.7%
lung neuroendocrine cell CL1000223

CSI 1.3

rCSI 2.0%

PRS 25.7%
rod bipolar cell CL0000751

CSI 1.3

rCSI 2.4%

PRS 18.6%
ionocyte CL0005006

CSI 1.3

rCSI 1.4%

PRS 20.7%
club cell CL0000158

CSI 1.3

rCSI 2.0%

PRS 25.5%
progenitor cell CL0011026

CSI 1.3

rCSI 2.9%

PRS 33.6%
T-helper 1 cell CL0000545

CSI 1.4

rCSI 2.5%

PRS 52.5%
common lymphoid progenitor CL0000051

CSI 1.4

rCSI 1.8%

PRS 42.2%
enteric neuron CL0007011

CSI 1.4

rCSI 20.7%

PRS 50.3%
retinal blood vessel endothelial cell CL0002585

CSI 1.4

rCSI 2.3%

PRS 24.7%
helper T cell CL0000912

CSI 1.4

rCSI 2.0%

PRS 31.6%
inflammatory macrophage CL0000863

CSI 1.4

rCSI 2.5%

PRS 45.0%
colonocyte CL1000347

CSI 1.5

rCSI 2.1%

PRS 30.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PPP2CA](/details-gene/5515) encodes the alpha isoform of the catalytic subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase that plays a crucial role in a vast array of cellular processes. As a core component of the PP2A holoenzyme, it is responsible for dephosphorylating a wide range of protein substrates, thereby regulating fundamental pathways including cell cycle progression, signal transduction, and metabolism. Its broad and high expression across diverse tissues is consistent with a vital housekeeping function. **Overall**, the gene shows particularly high significance in cell types with high metabolic and signaling activity, such as [glutamatergic neurons](/details-cell/CL0000679), [placental villous trophoblasts](/details-cell/CL2000060), and [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896), underscoring its indispensable role in neuronal function, development, and immune regulation. Clinical associations for this gene are noted in OMIM ([176915](https://omim.org/entry/176915)). ## Cellular Roles and Expression Landscape The expression profile of [PPP2CA](/details-gene/5515) highlights its ubiquitous and essential nature. **Overall**, it demonstrates high significance across functionally distinct cell lineages, suggesting a central role in cellular physiology rather than being a marker for a specific cell type. Its highest significance is observed in [glutamatergic neurons](/details-cell/CL0000679) and [GABAergic neurons](/details-cell/CL0000617), indicating a critical function in the central nervous system, likely related to regulating synaptic transmission and neuronal signaling. The gene also shows high significance in various epithelial and specialized cell types, including [placental villous trophoblasts](/details-cell/CL2000060), [parietal epithelial cells](/details-cell/CL1000452), [ependymal cells](/details-cell/CL0000065), and [keratinocytes](/details-cell/CL0000312), pointing to its involvement in barrier function, transport, and tissue homeostasis. Furthermore, [PPP2CA](/details-gene/5515) is highly significant in the immune system, particularly in [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896), [alternatively activated macrophages](/details-cell/CL0000890), [germinal center B cells](/details-cell/CL0000844), and [innate lymphoid cells](/details-cell/CL0001065). This pattern suggests it is a key regulator of immune cell activation, differentiation, and effector function. Its prominence in progenitor cells, such as [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050), is consistent with its established role in cell cycle control and differentiation. ## Pathways and Molecular Function The functional annotations for [PPP2CA](/details-gene/5515) reflect its role as the catalytic core of the PP2A complex, a master regulator in cellular signaling. Its primary molecular functions are [protein serine/threonine phosphatase activity](/details-go/GO:0004722) and [phosphoprotein phosphatase activity](/details-go/GO:0004721). [PPP2CA](/details-gene/5515) is a component of the [protein phosphatase type 2A complex](/details-go/GO:0000159), which is localized to numerous cellular compartments including the [cytosol](/details-go/GO:0005829), [nucleus](/details-go/GO:0005634), [plasma membrane](/details-go/GO:0005886), and [mitochondrion](/details-go/GO:0005739). The gene's involvement in a vast number of biological processes is extensive: * **Cell Cycle Regulation:** [PPP2CA](/details-gene/5515) is integral to the [Cell cycle](/details-pathway/R-HSA-1640170), participating in the [G1/S transition](/details-pathway/R-HSA-69206), [mitotic spindle checkpoint](/details-pathway/R-HSA-69618), and [separation of sister chromatids](/details-pathway/R-HSA-2467813). This aligns with research showing its role in centromeric cohesion protection ([Link](https://doi.org/10.1038/nature04663), [Link](https://doi.org/10.1016/j.devcel.2006.03.010)). * **Signal Transduction:** It acts as a key negative regulator in multiple critical signaling cascades, including the [MAPK family signaling cascades](/details-pathway/R-HSA-5683057), [Signaling by Wnt](/details-pathway/R-HSA-195721), and the PI3K/AKT pathway ([Negative regulation of the PI3K/AKT network](/details-pathway/R-HSA-199418)). Its function in dephosphorylating key signaling components is crucial for terminating signals and maintaining cellular homeostasis. * **Immune System Modulation:** The gene is a participant in both the [Innate immune system](/details-pathway/R-HSA-168249) and [Adaptive immune system](/details-pathway/R-HSA-1280218). It is involved in [Toll-like receptor cascades](/details-pathway/R-HSA-168898) and pathways governing T cell function, such as [Costimulation by the CD28 family](/details-pathway/R-HSA-388841) and [T cell homeostasis](/details-go/GO:0043029). * **Metabolism:** [PPP2CA](/details-gene/5515) regulates metabolic pathways, including [Glycolysis](/details-pathway/R-HSA-70171), via [PP2A-mediated dephosphorylation of key metabolic factors](/details-pathway/R-HSA-163767). ## Research Directions The ubiquitous and fundamental nature of [PPP2CA](/details-gene/5515) presents numerous avenues for investigation, particularly in understanding how its activity is tailored to specific cellular contexts. **Proposed Hypotheses:** 1. Given its high significance in both [glutamatergic](/details-cell/CL0000679) and [GABAergic neurons](/details-cell/CL0000617) and its annotated function in [GABA receptor binding](/details-go/GO:0050811), we hypothesize that [PPP2CA](/details-gene/5515) activity is spatially and temporally regulated at the synapse to control the phosphorylation state of neurotransmitter receptors and associated scaffolding proteins, thereby modulating synaptic strength and plasticity. 2. Based on its high significance in [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896) and its role in [T cell homeostasis](/details-go/GO:0043029), we hypothesize that [PPP2CA](/details-gene/5515) is a critical component of a negative feedback loop that deactivates TCR signaling pathways. Its activity may increase post-activation to dephosphorylate kinases like LCK and ZAP70, thus preventing immune hyper-activation and promoting a return to quiescence. **Suggested Experimental Approach:** To test the second hypothesis regarding its role in T cell signaling, a conditional knockout of [PPP2CA](/details-gene/5515) in murine T cells (e.g., using a *Cd4-Cre* driver) would be highly informative. Primary T cells from these mice could be isolated and activated *in vitro* with anti-CD3/CD28 antibodies. A time-course analysis using phosphoproteomics or targeted Western blots would reveal the phosphorylation dynamics of key TCR signaling intermediates (e.g., LCK, ZAP70, SLP-76, AKT). Functional assays measuring IL-2 production (ELISA), proliferation (CFSE dilution), and expression of activation markers (flow cytometry) would determine if the loss of [PPP2CA](/details-gene/5515) leads to sustained, hyper-activated signaling and effector function. **Therapeutic Potential:** As a ubiquitous and essential phosphatase, global inhibition of [PPP2CA](/details-gene/5515) would likely be highly toxic. However, its function is often subverted in cancer, where it acts as a tumor suppressor by dephosphorylating oncoproteins. Therefore, therapeutic strategies are focused on **activation** rather than inhibition. The development of small-molecule activators of PP2A (SMAPs) that specifically stabilize the PP2A holoenzyme, restoring its tumor-suppressive functions, represents a promising approach for treating various malignancies. Targeting specific PP2A complexes by modulating its interaction with distinct regulatory subunits could offer a more precise and less toxic therapeutic window.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Genular Protein ID: 4267947468

Symbol: PP2AA_HUMAN

Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

UniProtKB Accession Codes:

P67775 P05323 P13197

Database IDs:

Citations:

PubMed ID: 2849764

Title: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.

PubMed ID: 2849764

DOI: 10.1093/nar/16.23.11365

PubMed ID: 2837763

Title: Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PubMed ID: 2837763

DOI: 10.1073/pnas.85.12.4252

PubMed ID: 1846293

Title: Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PubMed ID: 1846293

DOI: 10.1021/bi00215a014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1848668

Title: Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

PubMed ID: 1848668

DOI: 10.1128/mcb.11.4.1996-2003.1991

PubMed ID: 8206937

Title: The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PubMed ID: 8206937

DOI: 10.1016/s0021-9258(17)34009-7

PubMed ID: 9647778

Title: Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PubMed ID: 9647778

DOI: 10.1006/bbrc.1998.8792

PubMed ID: 10191253

Title: Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit.

PubMed ID: 10191253

DOI: 10.1042/bj3390241

PubMed ID: 2555176

Title: Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PubMed ID: 2555176

DOI: 10.1002/j.1460-2075.1989.tb08568.x

PubMed ID: 9920888

Title: Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PubMed ID: 9920888

DOI: 10.1074/jbc.274.6.3439

PubMed ID: 10801873

Title: Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.

PubMed ID: 10801873

DOI: 10.1074/jbc.m003259200

PubMed ID: 16580887

Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

PubMed ID: 16580887

DOI: 10.1016/j.devcel.2006.03.010

PubMed ID: 16258073

Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

PubMed ID: 16258073

DOI: 10.1124/mol.105.018275

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 12473674

Title: Protein phosphatase 2A regulates the stability of Pim protein kinases.

PubMed ID: 12473674

DOI: 10.1074/jbc.m208246200

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17485487

Title: Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.

PubMed ID: 17485487

DOI: 10.1083/jcb.200701122

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 19818709

Title: Alpha4 is an essential regulator of PP2A phosphatase activity.

PubMed ID: 19818709

DOI: 10.1016/j.molcel.2009.09.025

PubMed ID: 20092282

Title: Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

PubMed ID: 20092282

DOI: 10.1021/bi901837h

PubMed ID: 20080667

Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

PubMed ID: 20080667

DOI: 10.1073/pnas.0908133107

PubMed ID: 22167190

Title: Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit.

PubMed ID: 22167190

DOI: 10.1074/jbc.m111.283341

PubMed ID: 22613722

Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation.

PubMed ID: 22613722

DOI: 10.1074/jbc.m112.368613

PubMed ID: 25803737

Title: AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation.

PubMed ID: 25803737

DOI: 10.1080/15384101.2015.1021526

PubMed ID: 25438055

Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

PubMed ID: 25438055

DOI: 10.1038/ncb3072

PubMed ID: 27588481

Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

PubMed ID: 27588481

DOI: 10.18632/oncotarget.11698

PubMed ID: 28609714

Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.

PubMed ID: 28609714

DOI: 10.1016/j.molimm.2017.06.017

PubMed ID: 30513302

Title: AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis.

PubMed ID: 30513302

DOI: 10.1016/j.devcel.2018.11.010

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 30115741

Title: Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.

PubMed ID: 30115741

DOI: 10.1084/jem.20180397

PubMed ID: 33108758

Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

PubMed ID: 33108758

DOI: 10.1016/j.molcel.2020.10.008

PubMed ID: 37761890

Title: Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.

PubMed ID: 37761890

DOI: 10.3390/genes14091750

PubMed ID: 17055435

Title: Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.

PubMed ID: 17055435

DOI: 10.1016/j.cell.2006.09.025

PubMed ID: 18394995

Title: Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

PubMed ID: 18394995

DOI: 10.1016/j.cell.2008.02.041

PubMed ID: 25003389

Title: Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.

PubMed ID: 25003389

DOI: 10.1515/hsz-2014-0106

PubMed ID: 33633399

Title: Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

PubMed ID: 33633399

DOI: 10.1038/s41594-021-00564-y

PubMed ID: 30595372

Title: De novo mutations affecting the catalytic C alpha subunit of PP2A, PPP2CA, cause syndromic intellectual disability resembling other PP2A-related neurodevelopmental disorders.

PubMed ID: 30595372

DOI: 10.1016/j.ajhg.2018.12.002

Sequence Information:

Length: 309
Mass: 35594
Checksum: C602291F78F34555
Sequence:

MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 
TRRTPDYFL

Details for: PPP2CA

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit. PubMed ID: 2849764

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. PubMed ID: 2837763

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. PubMed ID: 1846293

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. PubMed ID: 1848668

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. PubMed ID: 8206937

Alpha 4 associates with protein phosphatases 2A, 4, and 6. PubMed ID: 9647778

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. PubMed ID: 10191253

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. PubMed ID: 2555176

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. PubMed ID: 9920888

Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. PubMed ID: 10801873

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. PubMed ID: 16580887

A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. PubMed ID: 16258073

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

Protein phosphatase 2A regulates the stability of Pim protein kinases. PubMed ID: 12473674

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PubMed ID: 17245430

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. PubMed ID: 17485487

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Alpha4 is an essential regulator of PP2A phosphatase activity. PubMed ID: 19818709

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. PubMed ID: 20092282

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. PubMed ID: 20080667

Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit. PubMed ID: 22167190

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. PubMed ID: 22613722

AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation. PubMed ID: 25803737

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. PubMed ID: 25438055

FAM122A, a new endogenous inhibitor of protein phosphatase 2A. PubMed ID: 27588481

MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239. PubMed ID: 28609714

AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. PubMed ID: 30513302

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. PubMed ID: 30115741

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. PubMed ID: 33108758

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients. PubMed ID: 37761890

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. PubMed ID: 17055435

Structural mechanism of demethylation and inactivation of protein phosphatase 2A. PubMed ID: 18394995

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A. PubMed ID: 25003389

Cryo-EM structure of the Hippo signaling integrator human STRIPAK. PubMed ID: 33633399

De novo mutations affecting the catalytic C alpha subunit of PP2A, PPP2CA, cause syndromic intellectual disability resembling other PP2A-related neurodevelopmental disorders. PubMed ID: 30595372