PPP2CA | ENSG00000113575 | NCBI 5515

Details for: PPP2CA

Gene ID: 5515

Symbol: PPP2CA

Ensembl ID: ENSG00000113575

Description: protein phosphatase 2 catalytic subunit alpha

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation by tp53
(R-HSA-3700989)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 279.0185
Cell Significance Index: -43.4000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 174.8124
Cell Significance Index: -44.3400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 134.1433
Cell Significance Index: -55.2600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 117.5754
Cell Significance Index: -55.5100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 114.8534
Cell Significance Index: -46.6600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.7853
Cell Significance Index: -53.9000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 82.9034
Cell Significance Index: -55.6300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.6050
Cell Significance Index: -47.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.0558
Cell Significance Index: -50.6200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.2345
Cell Significance Index: -43.4900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.8073
Cell Significance Index: -45.4800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.4286
Cell Significance Index: -52.9900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 2.2407
Cell Significance Index: 13.7900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1457
Cell Significance Index: 159.9200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.9094
Cell Significance Index: 66.3500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.7134
Cell Significance Index: 80.5300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6720
Cell Significance Index: 100.3800
Cell Name: lactocyte (CL0002325)
Fold Change: 1.5166
Cell Significance Index: 195.9300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4997
Cell Significance Index: 40.8200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4463
Cell Significance Index: 170.5700
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.4026
Cell Significance Index: 36.8800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3719
Cell Significance Index: 275.2000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2981
Cell Significance Index: 37.2100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2280
Cell Significance Index: 150.9900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1872
Cell Significance Index: 62.3300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0844
Cell Significance Index: 56.4900
Cell Name: kidney cell (CL1000497)
Fold Change: 1.0558
Cell Significance Index: 8.4300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9975
Cell Significance Index: 179.8100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.8930
Cell Significance Index: 15.7800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8660
Cell Significance Index: 382.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8538
Cell Significance Index: 44.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8436
Cell Significance Index: 460.6900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8233
Cell Significance Index: 8.9500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8167
Cell Significance Index: 112.1600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7617
Cell Significance Index: 42.7400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6803
Cell Significance Index: 14.2400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6801
Cell Significance Index: 18.1600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6791
Cell Significance Index: 43.8100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6643
Cell Significance Index: 30.1100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6426
Cell Significance Index: 230.5100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5444
Cell Significance Index: 41.7800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4981
Cell Significance Index: 35.2300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3934
Cell Significance Index: 38.9200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3885
Cell Significance Index: 49.8000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3775
Cell Significance Index: 261.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3658
Cell Significance Index: 10.5400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3182
Cell Significance Index: 9.3400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3168
Cell Significance Index: 21.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2991
Cell Significance Index: 6.4800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2880
Cell Significance Index: 13.4300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2039
Cell Significance Index: 12.5300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1800
Cell Significance Index: 30.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1579
Cell Significance Index: 30.0500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.1491
Cell Significance Index: 17.0200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1463
Cell Significance Index: 7.3900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1243
Cell Significance Index: 1.1500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1212
Cell Significance Index: 2.2400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0987
Cell Significance Index: 2.6500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0581
Cell Significance Index: 0.6600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0173
Cell Significance Index: 0.2900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0171
Cell Significance Index: 1.0800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0060
Cell Significance Index: -4.4700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0097
Cell Significance Index: -6.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0117
Cell Significance Index: -0.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0145
Cell Significance Index: -11.0100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0220
Cell Significance Index: -16.1500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0276
Cell Significance Index: -51.9500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0333
Cell Significance Index: -61.3300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0394
Cell Significance Index: -60.6100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0444
Cell Significance Index: -25.0300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0451
Cell Significance Index: -61.3300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0480
Cell Significance Index: -4.9000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0796
Cell Significance Index: -50.5700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1063
Cell Significance Index: -22.3900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1191
Cell Significance Index: -54.0600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1304
Cell Significance Index: -14.9400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1587
Cell Significance Index: -18.5000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1632
Cell Significance Index: -46.9500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1753
Cell Significance Index: -6.1600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1895
Cell Significance Index: -30.8200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1920
Cell Significance Index: -1.1600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1958
Cell Significance Index: -8.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2601
Cell Significance Index: -51.6200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3018
Cell Significance Index: -11.4300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3254
Cell Significance Index: -6.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3541
Cell Significance Index: -11.3400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3689
Cell Significance Index: -53.6200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4415
Cell Significance Index: -11.2800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5164
Cell Significance Index: -53.7700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5558
Cell Significance Index: -13.3300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5566
Cell Significance Index: -44.0800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6500
Cell Significance Index: -9.7400
Cell Name: peg cell (CL4033014)
Fold Change: -0.6830
Cell Significance Index: -15.7800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6888
Cell Significance Index: -18.4300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.7476
Cell Significance Index: -30.6300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7704
Cell Significance Index: -21.5300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8312
Cell Significance Index: -55.8900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8379
Cell Significance Index: -24.6800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8964
Cell Significance Index: -54.9600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.0354
Cell Significance Index: -38.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Serine/threonine phosphatase**: PPP2CA is a member of the PP2A family of phosphatases, which are involved in the dephosphorylation of serine and threonine residues on proteins. 2. **Catalytic subunit alpha**: The PPP2CA gene encodes for the catalytic subunit alpha, which is the catalytic domain of the PP2A enzyme. 3. **Highly expressed in immune cells**: PPP2CA is highly expressed in GABAergic neurons, myeloid dendritic cells, and CD14-low, CD16-positive monocytes, suggesting its involvement in immune responses. 4. **Involvement in multiple signaling pathways**: PPP2CA is involved in numerous signaling pathways, including those related to the adaptive immune system, cytokine signaling, and cell cycle regulation. **Pathways and Functions** 1. **Adaptive immune system**: PPP2CA is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 2. **Cytokine signaling**: PPP2CA is involved in the regulation of cytokine signaling pathways, including those related to interferon-gamma (IFN-γ) and interleukin-17 (IL-17). 3. **Cell cycle regulation**: PPP2CA is involved in the regulation of cell cycle progression, including the G1/S transition and the G2/M transition. 4. **Transcriptional control**: PPP2CA is involved in the regulation of transcriptional control, including the phosphorylation and dephosphorylation of transcription factors. 5. **Signaling by Wnt and GPCR**: PPP2CA is involved in the regulation of signaling pathways related to Wnt and G protein-coupled receptor (GPCR) signaling. **Clinical Significance** 1. **Cancer**: PPP2CA has been implicated in the development and progression of various cancers, including breast cancer, prostate cancer, and colon cancer. 2. **Autoimmune diseases**: PPP2CA has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and lupus. 3. **Immunodeficiency disorders**: PPP2CA has been implicated in immunodeficiency disorders, including severe combined immunodeficiency (SCID) and chronic granulomatous disease (CGD). 4. **Neurological disorders**: PPP2CA has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the PPP2CA gene plays a crucial role in various cellular processes, including signal transduction, cell cycle regulation, and transcriptional control. Its involvement in multiple signaling pathways and its expression in immune cells, epithelial cells, and progenitor cells suggest its importance in immune responses, tissue homeostasis, and development. Further research is needed to fully elucidate the clinical significance of PPP2CA in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Genular Protein ID: 4267947468

Symbol: PP2AA_HUMAN

Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

UniProtKB Accession Codes:

P67775 P05323 P13197

Database IDs:

Citations:

PubMed ID: 2849764

Title: The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.

PubMed ID: 2849764

DOI: 10.1093/nar/16.23.11365

PubMed ID: 2837763

Title: Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PubMed ID: 2837763

DOI: 10.1073/pnas.85.12.4252

PubMed ID: 1846293

Title: Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PubMed ID: 1846293

DOI: 10.1021/bi00215a014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1848668

Title: Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.

PubMed ID: 1848668

DOI: 10.1128/mcb.11.4.1996-2003.1991

PubMed ID: 8206937

Title: The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PubMed ID: 8206937

DOI: 10.1016/s0021-9258(17)34009-7

PubMed ID: 9647778

Title: Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PubMed ID: 9647778

DOI: 10.1006/bbrc.1998.8792

PubMed ID: 10191253

Title: Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit.

PubMed ID: 10191253

DOI: 10.1042/bj3390241

PubMed ID: 2555176

Title: Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PubMed ID: 2555176

DOI: 10.1002/j.1460-2075.1989.tb08568.x

PubMed ID: 9920888

Title: Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PubMed ID: 9920888

DOI: 10.1074/jbc.274.6.3439

PubMed ID: 10801873

Title: Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.

PubMed ID: 10801873

DOI: 10.1074/jbc.m003259200

PubMed ID: 16580887

Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

PubMed ID: 16580887

DOI: 10.1016/j.devcel.2006.03.010

PubMed ID: 16258073

Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

PubMed ID: 16258073

DOI: 10.1124/mol.105.018275

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 12473674

Title: Protein phosphatase 2A regulates the stability of Pim protein kinases.

PubMed ID: 12473674

DOI: 10.1074/jbc.m208246200

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17485487

Title: Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.

PubMed ID: 17485487

DOI: 10.1083/jcb.200701122

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 19818709

Title: Alpha4 is an essential regulator of PP2A phosphatase activity.

PubMed ID: 19818709

DOI: 10.1016/j.molcel.2009.09.025

PubMed ID: 20092282

Title: Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination.

PubMed ID: 20092282

DOI: 10.1021/bi901837h

PubMed ID: 20080667

Title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

PubMed ID: 20080667

DOI: 10.1073/pnas.0908133107

PubMed ID: 22167190

Title: Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit.

PubMed ID: 22167190

DOI: 10.1074/jbc.m111.283341

PubMed ID: 22613722

Title: Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation.

PubMed ID: 22613722

DOI: 10.1074/jbc.m112.368613

PubMed ID: 25803737

Title: AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation.

PubMed ID: 25803737

DOI: 10.1080/15384101.2015.1021526

PubMed ID: 25438055

Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

PubMed ID: 25438055

DOI: 10.1038/ncb3072

PubMed ID: 27588481

Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

PubMed ID: 27588481

DOI: 10.18632/oncotarget.11698

PubMed ID: 28609714

Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.

PubMed ID: 28609714

DOI: 10.1016/j.molimm.2017.06.017

PubMed ID: 30513302

Title: AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis.

PubMed ID: 30513302

DOI: 10.1016/j.devcel.2018.11.010

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 30115741

Title: Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.

PubMed ID: 30115741

DOI: 10.1084/jem.20180397

PubMed ID: 33108758

Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

PubMed ID: 33108758

DOI: 10.1016/j.molcel.2020.10.008

PubMed ID: 37761890

Title: Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.

PubMed ID: 37761890

DOI: 10.3390/genes14091750

PubMed ID: 17055435

Title: Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.

PubMed ID: 17055435

DOI: 10.1016/j.cell.2006.09.025

PubMed ID: 18394995

Title: Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

PubMed ID: 18394995

DOI: 10.1016/j.cell.2008.02.041

PubMed ID: 25003389

Title: Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.

PubMed ID: 25003389

DOI: 10.1515/hsz-2014-0106

PubMed ID: 33633399

Title: Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

PubMed ID: 33633399

DOI: 10.1038/s41594-021-00564-y

PubMed ID: 30595372

Title: De novo mutations affecting the catalytic C alpha subunit of PP2A, PPP2CA, cause syndromic intellectual disability resembling other PP2A-related neurodevelopmental disorders.

PubMed ID: 30595372

DOI: 10.1016/j.ajhg.2018.12.002

Sequence Information:

Length: 309
Mass: 35594
Checksum: C602291F78F34555
Sequence:

MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 
RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 
RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 
HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 
TRRTPDYFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPP2CA

Associated with

Cells (max top 100)

Other Information

The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit. PubMed ID: 2849764

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. PubMed ID: 2837763

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. PubMed ID: 1846293

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. PubMed ID: 1848668

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. PubMed ID: 8206937

Alpha 4 associates with protein phosphatases 2A, 4, and 6. PubMed ID: 9647778

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. PubMed ID: 10191253

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. PubMed ID: 2555176

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. PubMed ID: 9920888

Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. PubMed ID: 10801873

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. PubMed ID: 16580887

A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. PubMed ID: 16258073

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

Protein phosphatase 2A regulates the stability of Pim protein kinases. PubMed ID: 12473674

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PubMed ID: 17245430

Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. PubMed ID: 17485487

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Alpha4 is an essential regulator of PP2A phosphatase activity. PubMed ID: 19818709

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. PubMed ID: 20092282

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. PubMed ID: 20080667

Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aalpha catalytic subunit. PubMed ID: 22167190

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit alpha4, altering PP2A stability and microtubule-associated protein phosphorylation. PubMed ID: 22613722

AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation. PubMed ID: 25803737

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. PubMed ID: 25438055

FAM122A, a new endogenous inhibitor of protein phosphatase 2A. PubMed ID: 27588481

MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239. PubMed ID: 28609714

AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. PubMed ID: 30513302

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. PubMed ID: 30115741

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. PubMed ID: 33108758

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients. PubMed ID: 37761890

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. PubMed ID: 17055435

Structural mechanism of demethylation and inactivation of protein phosphatase 2A. PubMed ID: 18394995

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A. PubMed ID: 25003389

Cryo-EM structure of the Hippo signaling integrator human STRIPAK. PubMed ID: 33633399

De novo mutations affecting the catalytic C alpha subunit of PP2A, PPP2CA, cause syndromic intellectual disability resembling other PP2A-related neurodevelopmental disorders. PubMed ID: 30595372