PPP2R1A | ENSG00000105568 | NCBI 5518

Details for: PPP2R1A

Gene ID: 5518

Symbol: PPP2R1A

Ensembl ID: ENSG00000105568

Description: protein phosphatase 2 scaffold subunit Aalpha

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation by tp53
(R-HSA-3700989)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 376.6750
Cell Significance Index: -58.5900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 196.4175
Cell Significance Index: -49.8200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 149.7885
Cell Significance Index: -61.7100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 139.7391
Cell Significance Index: -56.7700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 135.8016
Cell Significance Index: -64.1200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 122.7873
Cell Significance Index: -63.1600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 96.0102
Cell Significance Index: -64.4300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.9009
Cell Significance Index: -57.1900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 50.2289
Cell Significance Index: -61.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.7426
Cell Significance Index: -47.5300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.0668
Cell Significance Index: -52.4200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.9476
Cell Significance Index: -62.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.9797
Cell Significance Index: -24.0300
Cell Name: kidney cell (CL1000497)
Fold Change: 4.7807
Cell Significance Index: 38.1700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.6779
Cell Significance Index: 323.5000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.4592
Cell Significance Index: 119.4900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.1482
Cell Significance Index: 53.1300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.0788
Cell Significance Index: 161.6500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.0625
Cell Significance Index: 106.4200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4680
Cell Significance Index: 51.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.1175
Cell Significance Index: 23.0200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.0552
Cell Significance Index: 282.2400
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.8924
Cell Significance Index: 49.7600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.6993
Cell Significance Index: 200.4100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.6703
Cell Significance Index: 14.0300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.3845
Cell Significance Index: 40.6600
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3806
Cell Significance Index: 753.9600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1610
Cell Significance Index: 74.9000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1197
Cell Significance Index: 224.6200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0233
Cell Significance Index: 53.3000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0178
Cell Significance Index: 22.0500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9930
Cell Significance Index: 74.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9546
Cell Significance Index: 172.0800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9186
Cell Significance Index: 112.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9177
Cell Significance Index: 329.1500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8970
Cell Significance Index: 115.8900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8550
Cell Significance Index: 109.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7686
Cell Significance Index: 339.8100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6862
Cell Significance Index: 19.7700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6825
Cell Significance Index: 135.4400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6814
Cell Significance Index: 31.7700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.6241
Cell Significance Index: 17.8100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5540
Cell Significance Index: 15.0800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5353
Cell Significance Index: 25.1600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5112
Cell Significance Index: 461.5800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4227
Cell Significance Index: 41.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4003
Cell Significance Index: 28.3100
Cell Name: peg cell (CL4033014)
Fold Change: 0.3792
Cell Significance Index: 8.7600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3247
Cell Significance Index: 8.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3193
Cell Significance Index: 16.5900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3080
Cell Significance Index: 20.7100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3031
Cell Significance Index: 18.2000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.2982
Cell Significance Index: 1.8500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2748
Cell Significance Index: 21.0900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2601
Cell Significance Index: 2.4000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2544
Cell Significance Index: 43.4400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2152
Cell Significance Index: 13.2300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1741
Cell Significance Index: 7.8900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0945
Cell Significance Index: 1.6200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0874
Cell Significance Index: 3.0700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0556
Cell Significance Index: 0.9300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0180
Cell Significance Index: 12.4600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0113
Cell Significance Index: 8.5200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0070
Cell Significance Index: 13.0900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0086
Cell Significance Index: -0.2800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0186
Cell Significance Index: -13.6200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0249
Cell Significance Index: -45.9400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0253
Cell Significance Index: -18.7100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0298
Cell Significance Index: -45.8700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0364
Cell Significance Index: -49.4700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0399
Cell Significance Index: -4.0800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0424
Cell Significance Index: -26.9000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0461
Cell Significance Index: -8.7700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0499
Cell Significance Index: -22.6700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0547
Cell Significance Index: -34.1300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0706
Cell Significance Index: -39.8000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0770
Cell Significance Index: -4.8500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1347
Cell Significance Index: -3.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1498
Cell Significance Index: -31.5500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1806
Cell Significance Index: -51.9500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1902
Cell Significance Index: -22.1600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2474
Cell Significance Index: -28.3400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2487
Cell Significance Index: -4.4000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2766
Cell Significance Index: -40.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2834
Cell Significance Index: -7.9200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3032
Cell Significance Index: -34.6100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3447
Cell Significance Index: -9.8800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3635
Cell Significance Index: -20.4000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3784
Cell Significance Index: -5.6700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5781
Cell Significance Index: -60.1900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6322
Cell Significance Index: -50.0700
Cell Name: germ cell (CL0000586)
Fold Change: -0.6370
Cell Significance Index: -4.8100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6812
Cell Significance Index: -30.1300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6888
Cell Significance Index: -12.7300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.6915
Cell Significance Index: -5.3300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7469
Cell Significance Index: -10.1900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8335
Cell Significance Index: -19.9900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8461
Cell Significance Index: -18.0200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9018
Cell Significance Index: -34.1500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9359
Cell Significance Index: -57.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Scaffold subunit**: PPP2R1A is a scaffold subunit of PP2A, binding to the catalytic subunit (PP2A) to regulate its activity. 2. **Regulatory subunit**: PPP2R1A is a regulatory subunit, which interacts with PP2A to modulate its activity and specificity. 3. **Phosphatase activity**: PPP2R1A is involved in the phosphatase activity of PP2A, which is essential for dephosphorylating and regulating downstream targets. 4. **Cellular localization**: PPP2R1A is primarily localized to the cytoplasm and nucleus, where it interacts with various signaling proteins and transcription factors. **Pathways and Functions:** 1. **Adaptive immune system**: PPP2R1A plays a crucial role in regulating the adaptive immune response by modulating the activity of PP2A and its downstream targets, such as NF-κB and MAPK signaling pathways. 2. **Cell cycle regulation**: PPP2R1A is involved in regulating the cell cycle by dephosphorylating and activating key regulators, such as cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 3. **Signaling pathways**: PPP2R1A is involved in various signaling pathways, including Wnt/β-catenin, Notch, and TGF-β, which regulate cellular processes such as proliferation, differentiation, and apoptosis. 4. **Antiviral mechanisms**: PPP2R1A has been implicated in antiviral mechanisms by regulating the activity of PP2A and its downstream targets, such as interferons and cytokines. **Clinical Significance:** 1. **Cancer**: Alterations in PPP2R1A expression and function have been implicated in various cancers, including breast, lung, and colon cancer. 2. **Immunological disorders**: PPP2R1A dysfunction has been linked to immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: PPP2R1A has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Infectious diseases**: PPP2R1A has been shown to play a role in antiviral mechanisms, with implications for the treatment of infectious diseases. In conclusion, PPP2R1A is a crucial scaffold subunit of PP2A, playing a pivotal role in regulating various cellular processes, including immune regulation, cell cycle control, and signal transduction. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying PPP2R1A function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Genular Protein ID: 1523677888

Symbol: 2AAA_HUMAN

Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

UniProtKB Accession Codes:

P30153 Q13773 Q6ICQ3 Q96DH3

Database IDs:

Citations:

PubMed ID: 2554323

Title: Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.

PubMed ID: 2554323

DOI: 10.1073/pnas.86.22.8669

PubMed ID: 2159327

Title: Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.

PubMed ID: 2159327

DOI: 10.1021/bi00465a002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 8254721

Title: Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.

PubMed ID: 8254721

DOI: 10.1128/jvi.68.1.123-129.1994

PubMed ID: 12670497

Title: Interaction between protein phosphatase 2A and members of the importin beta superfamily.

PubMed ID: 12670497

DOI: 10.1016/s0006-291x(03)00434-0

PubMed ID: 15525651

Title: Galpha12 directly interacts with PP2A: evidence for Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

PubMed ID: 15525651

DOI: 10.1074/jbc.c400508200

PubMed ID: 16580887

Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

PubMed ID: 16580887

DOI: 10.1016/j.devcel.2006.03.010

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17374643

Title: Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells.

PubMed ID: 17374643

DOI: 10.1242/jcs.000018

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18353419

Title: Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen.

PubMed ID: 18353419

DOI: 10.1016/j.virol.2008.02.020

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20485545

Title: JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

PubMed ID: 20485545

DOI: 10.1371/journal.pone.0010606

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27588481

Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

PubMed ID: 27588481

DOI: 10.18632/oncotarget.11698

PubMed ID: 28982702

Title: Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.

PubMed ID: 28982702

DOI: 10.1242/bio.026930

PubMed ID: 28174209

Title: Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

PubMed ID: 28174209

DOI: 10.15252/embr.201642788

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 9989501

Title: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.

PubMed ID: 9989501

DOI: 10.1016/s0092-8674(00)80963-0

PubMed ID: 18394995

Title: Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

PubMed ID: 18394995

DOI: 10.1016/j.cell.2008.02.041

PubMed ID: 33633399

Title: Cryo-EM structure of the Hippo signaling integrator human STRIPAK.

PubMed ID: 33633399

DOI: 10.1038/s41594-021-00564-y

PubMed ID: 26168268

Title: B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.

PubMed ID: 26168268

DOI: 10.1172/jci79860

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 37761890

Title: Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.

PubMed ID: 37761890

DOI: 10.3390/genes14091750

Sequence Information:

Length: 589
Mass: 65309
Checksum: 5174EBE94D537836
Sequence:

MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY 
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS 
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM 
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL 
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA 
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN 
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR 
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA 
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV 
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PPP2R1A

Associated with

Cells (max top 100)

Other Information

Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein. PubMed ID: 2554323

Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. PubMed ID: 2159327

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. PubMed ID: 8694763

Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens. PubMed ID: 8254721

Interaction between protein phosphatase 2A and members of the importin beta superfamily. PubMed ID: 12670497

Galpha12 directly interacts with PP2A: evidence for Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. PubMed ID: 15525651

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. PubMed ID: 16580887

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. PubMed ID: 17245430

Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells. PubMed ID: 17374643

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen. PubMed ID: 18353419

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. PubMed ID: 18782753

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity. PubMed ID: 20485545

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

FAM122A, a new endogenous inhibitor of protein phosphatase 2A. PubMed ID: 27588481

Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores. PubMed ID: 28982702

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. PubMed ID: 28174209

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. PubMed ID: 9989501

Structural mechanism of demethylation and inactivation of protein phosphatase 2A. PubMed ID: 18394995

Cryo-EM structure of the Hippo signaling integrator human STRIPAK. PubMed ID: 33633399

B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. PubMed ID: 26168268

Large-scale discovery of novel genetic causes of developmental disorders. PubMed ID: 25533962

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients. PubMed ID: 37761890