Details for: PPP2R1A

Gene ID: 5518

Symbol: PPP2R1A

Ensembl ID: ENSG00000105568

Description: protein phosphatase 2 scaffold subunit Aalpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.71
    Marker Score: 65921
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.77
    Marker Score: 18015
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.67
    Marker Score: 35156
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.57
    Marker Score: 5360
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.46
    Marker Score: 4999
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.43
    Marker Score: 6625
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.41
    Marker Score: 2908
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.31
    Marker Score: 2177.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.3
    Marker Score: 3913
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.29
    Marker Score: 23032
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.27
    Marker Score: 2417
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.26
    Marker Score: 2532
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.21
    Marker Score: 9517
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.21
    Marker Score: 1472
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.2
    Marker Score: 1380
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.16
    Marker Score: 18650
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.16
    Marker Score: 25125
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.14
    Marker Score: 2286
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.09
    Marker Score: 702
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.09
    Marker Score: 2207
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.06
    Marker Score: 2073
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.05
    Marker Score: 1933
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.04
    Marker Score: 3339
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.03
    Marker Score: 4782.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.03
    Marker Score: 7964
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.02
    Marker Score: 1687
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.01
    Marker Score: 2842.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2
    Marker Score: 1190
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2
    Marker Score: 943
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.98
    Marker Score: 5861
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.97
    Marker Score: 2118
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.97
    Marker Score: 2318.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.96
    Marker Score: 2360
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.96
    Marker Score: 6146
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.92
    Marker Score: 66505
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9
    Marker Score: 7757
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.89
    Marker Score: 1784
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.88
    Marker Score: 12028
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.88
    Marker Score: 1035
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.87
    Marker Score: 4728
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.85
    Marker Score: 20882
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.85
    Marker Score: 1789
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.84
    Marker Score: 636
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.83
    Marker Score: 1324
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.83
    Marker Score: 4340
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.81
    Marker Score: 728.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.8
    Marker Score: 518
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.79
    Marker Score: 4807
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.79
    Marker Score: 1304
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.77
    Marker Score: 6570
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.77
    Marker Score: 8502
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.77
    Marker Score: 13812
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.77
    Marker Score: 10471
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.75
    Marker Score: 2199.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.75
    Marker Score: 6211
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.74
    Marker Score: 4741
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.74
    Marker Score: 3037
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.73
    Marker Score: 3391
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.73
    Marker Score: 2134
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.71
    Marker Score: 2721
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.71
    Marker Score: 2835
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.71
    Marker Score: 842
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.71
    Marker Score: 400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.71
    Marker Score: 2626
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.7
    Marker Score: 420
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.7
    Marker Score: 2254
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.69
    Marker Score: 6535
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.69
    Marker Score: 22755
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.69
    Marker Score: 930
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.69
    Marker Score: 1711
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.68
    Marker Score: 477
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.68
    Marker Score: 3159
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.67
    Marker Score: 5285
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.67
    Marker Score: 819
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.66
    Marker Score: 2336
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.65
    Marker Score: 879
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.65
    Marker Score: 1593
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.65
    Marker Score: 1989
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.65
    Marker Score: 781
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.64
    Marker Score: 2364
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.64
    Marker Score: 12210
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.64
    Marker Score: 574
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.64
    Marker Score: 16604
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.63
    Marker Score: 567
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.62
    Marker Score: 1522
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.62
    Marker Score: 519
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.62
    Marker Score: 7479
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.62
    Marker Score: 386
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.61
    Marker Score: 2280
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.57
    Marker Score: 3060
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.57
    Marker Score: 82815
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.57
    Marker Score: 1835
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.57
    Marker Score: 6715
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.56
    Marker Score: 803
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.56
    Marker Score: 821
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.56
    Marker Score: 2779
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.55
    Marker Score: 584
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.55
    Marker Score: 1645
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.54
    Marker Score: 3772
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.54
    Marker Score: 1601

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Other Information

**Key Characteristics:** 1. **Scaffold subunit**: PPP2R1A is a scaffold subunit of PP2A, binding to the catalytic subunit (PP2A) to regulate its activity. 2. **Regulatory subunit**: PPP2R1A is a regulatory subunit, which interacts with PP2A to modulate its activity and specificity. 3. **Phosphatase activity**: PPP2R1A is involved in the phosphatase activity of PP2A, which is essential for dephosphorylating and regulating downstream targets. 4. **Cellular localization**: PPP2R1A is primarily localized to the cytoplasm and nucleus, where it interacts with various signaling proteins and transcription factors. **Pathways and Functions:** 1. **Adaptive immune system**: PPP2R1A plays a crucial role in regulating the adaptive immune response by modulating the activity of PP2A and its downstream targets, such as NF-κB and MAPK signaling pathways. 2. **Cell cycle regulation**: PPP2R1A is involved in regulating the cell cycle by dephosphorylating and activating key regulators, such as cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 3. **Signaling pathways**: PPP2R1A is involved in various signaling pathways, including Wnt/β-catenin, Notch, and TGF-β, which regulate cellular processes such as proliferation, differentiation, and apoptosis. 4. **Antiviral mechanisms**: PPP2R1A has been implicated in antiviral mechanisms by regulating the activity of PP2A and its downstream targets, such as interferons and cytokines. **Clinical Significance:** 1. **Cancer**: Alterations in PPP2R1A expression and function have been implicated in various cancers, including breast, lung, and colon cancer. 2. **Immunological disorders**: PPP2R1A dysfunction has been linked to immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: PPP2R1A has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Infectious diseases**: PPP2R1A has been shown to play a role in antiviral mechanisms, with implications for the treatment of infectious diseases. In conclusion, PPP2R1A is a crucial scaffold subunit of PP2A, playing a pivotal role in regulating various cellular processes, including immune regulation, cell cycle control, and signal transduction. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying PPP2R1A function.

Genular Protein ID: 1523677888

Symbol: 2AAA_HUMAN

Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

UniProtKB Accession Codes:

P30153 Q13773 Q6ICQ3 Q96DH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 EMDB 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 22 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 44 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2554323

Title: Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.

PubMed ID: 2554323

DOI: 10.1073/pnas.86.22.8669

PubMed ID: 2159327

Title: Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.

PubMed ID: 2159327

DOI: 10.1021/bi00465a002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 8254721

Title: Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.

PubMed ID: 8254721

DOI: 10.1128/jvi.68.1.123-129.1994

PubMed ID: 12670497

Title: Interaction between protein phosphatase 2A and members of the importin beta superfamily.

PubMed ID: 12670497

DOI: 10.1016/s0006-291x(03)00434-0

PubMed ID: 15525651

Title: Galpha12 directly interacts with PP2A: evidence for Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

PubMed ID: 15525651

DOI: 10.1074/jbc.c400508200

PubMed ID: 16580887

Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

PubMed ID: 16580887

DOI: 10.1016/j.devcel.2006.03.010

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17374643

Title: Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells.

PubMed ID: 17374643

DOI: 10.1242/jcs.000018

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18353419

Title: Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen.

PubMed ID: 18353419

DOI: 10.1016/j.virol.2008.02.020

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20485545

Title: JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.

PubMed ID: 20485545

DOI: 10.1371/journal.pone.0010606

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27588481

Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

PubMed ID: 27588481

DOI: 10.18632/oncotarget.11698

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 9989501

Title: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.

PubMed ID: 9989501

DOI: 10.1016/s0092-8674(00)80963-0

PubMed ID: 18394995

Title: Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

PubMed ID: 18394995

DOI: 10.1016/j.cell.2008.02.041

PubMed ID: 26168268

Title: B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.

PubMed ID: 26168268

DOI: 10.1172/jci79860

PubMed ID: 28174209

Title: Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

PubMed ID: 28174209

DOI: 10.15252/embr.201642788

Sequence Information:

  • Length: 589
  • Mass: 65309
  • Checksum: 5174EBE94D537836
  • Sequence:
    • MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY 
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS 
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM 
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL 
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA 
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN 
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR 
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA 
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV 
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.