Details for: PTGIR

Gene ID: 5739

Symbol: PTGIR

Ensembl ID: ENSG00000160013

Description: prostaglandin I2 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.0755
    Cell Significance Index: -9.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.5617
    Cell Significance Index: -9.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 15.5331
    Cell Significance Index: -7.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7456
    Cell Significance Index: -9.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.3318
    Cell Significance Index: -7.0000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 3.1501
    Cell Significance Index: 36.2800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.9676
    Cell Significance Index: 18.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4277
    Cell Significance Index: -9.5800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.9127
    Cell Significance Index: 15.6800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5173
    Cell Significance Index: 7.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4144
    Cell Significance Index: 7.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2270
    Cell Significance Index: 3.2600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.2079
    Cell Significance Index: 0.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1247
    Cell Significance Index: 2.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1167
    Cell Significance Index: 5.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0987
    Cell Significance Index: 3.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0956
    Cell Significance Index: 34.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0912
    Cell Significance Index: 1.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0874
    Cell Significance Index: 1.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0524
    Cell Significance Index: 1.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0506
    Cell Significance Index: 0.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0474
    Cell Significance Index: 6.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0405
    Cell Significance Index: 7.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0286
    Cell Significance Index: 5.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0236
    Cell Significance Index: 1.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0141
    Cell Significance Index: 12.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0069
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0097
    Cell Significance Index: -13.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0158
    Cell Significance Index: -4.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0168
    Cell Significance Index: -1.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0170
    Cell Significance Index: -9.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0182
    Cell Significance Index: -9.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0317
    Cell Significance Index: -5.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0352
    Cell Significance Index: -6.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0365
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0410
    Cell Significance Index: -5.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0429
    Cell Significance Index: -6.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0462
    Cell Significance Index: -1.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0480
    Cell Significance Index: -6.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0507
    Cell Significance Index: -6.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0550
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0554
    Cell Significance Index: -11.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0589
    Cell Significance Index: -10.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0630
    Cell Significance Index: -6.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0634
    Cell Significance Index: -8.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0635
    Cell Significance Index: -6.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0656
    Cell Significance Index: -7.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0923
    Cell Significance Index: -9.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0931
    Cell Significance Index: -6.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0973
    Cell Significance Index: -11.1500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1009
    Cell Significance Index: -0.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1031
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1031
    Cell Significance Index: -7.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1070
    Cell Significance Index: -7.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1117
    Cell Significance Index: -5.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1121
    Cell Significance Index: -3.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1188
    Cell Significance Index: -5.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1291
    Cell Significance Index: -7.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1345
    Cell Significance Index: -8.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1346
    Cell Significance Index: -6.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1399
    Cell Significance Index: -9.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1403
    Cell Significance Index: -5.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1432
    Cell Significance Index: -3.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1435
    Cell Significance Index: -6.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1574
    Cell Significance Index: -4.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1579
    Cell Significance Index: -4.0600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1597
    Cell Significance Index: -1.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1630
    Cell Significance Index: -5.1900
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -0.1709
    Cell Significance Index: -0.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1753
    Cell Significance Index: -6.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1796
    Cell Significance Index: -3.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1796
    Cell Significance Index: -10.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1806
    Cell Significance Index: -4.8300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1857
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1905
    Cell Significance Index: -10.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1949
    Cell Significance Index: -6.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2044
    Cell Significance Index: -8.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2054
    Cell Significance Index: -10.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2181
    Cell Significance Index: -7.5800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2279
    Cell Significance Index: -2.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2357
    Cell Significance Index: -3.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2366
    Cell Significance Index: -6.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2412
    Cell Significance Index: -10.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2440
    Cell Significance Index: -6.0900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2488
    Cell Significance Index: -2.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2515
    Cell Significance Index: -3.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2571
    Cell Significance Index: -6.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2612
    Cell Significance Index: -9.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2706
    Cell Significance Index: -7.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2720
    Cell Significance Index: -3.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PTGIR is a member of the G protein-coupled receptor family, which is characterized by its ability to bind to prostaglandin I2 (PGI2) and other prostaglandin analogs. The receptor is activated by PGI2, leading to the activation of Gs-proteins, which in turn stimulate adenylate cyclase activity and increase cyclic AMP (cAMP) levels. This signaling cascade has been shown to have anti-inflammatory and anti-thrombotic effects, making PTGIR an important regulator of immune responses. **Pathways and Functions:** The PTGIR is involved in several signaling pathways that regulate immune responses and homeostasis. These include: 1. **Adenylate cyclase-activating G protein-coupled receptor signaling pathway**: Activation of PTGIR leads to the activation of Gs-proteins, which stimulate adenylate cyclase activity and increase cAMP levels. 2. **Cell-cell signaling**: PTGIR is involved in intercellular communication between cells, particularly in the context of immune responses. 3. **Inflammatory response**: PTGIR has been shown to have anti-inflammatory effects, particularly in the context of inflammatory responses mediated by PGI2. 4. **Platelet homeostasis**: PTGIR plays a role in regulating platelet function and preventing platelet aggregation. 5. **Smooth muscle cell proliferation**: PTGIR has been shown to inhibit smooth muscle cell proliferation, which is important in the context of vascular diseases. **Clinical Significance:** The PTGIR has been implicated in several clinical conditions, including: 1. **Inflammatory bowel disease**: PTGIR has been shown to have anti-inflammatory effects in the context of inflammatory bowel disease. 2. **Cardiovascular disease**: PTGIR has been implicated in the regulation of platelet function and preventing thrombosis, making it a potential target for the treatment of cardiovascular disease. 3. **Cancer**: PTGIR has been shown to have anti-proliferative effects on smooth muscle cells, which may have implications for the treatment of cancer. 4. **Neurological disorders**: PTGIR has been implicated in the regulation of GABAergic signaling in the cerebral cortex, making it a potential target for the treatment of neurological disorders such as epilepsy. In conclusion, the Prostaglandin I2 Receptor (PTGIR) is an important regulator of immune responses and homeostasis, and its dysregulation has been implicated in several clinical conditions. Further research is needed to fully understand the role of PTGIR in human disease and to develop therapeutic strategies that target this receptor.

Genular Protein ID: 2583911810

Symbol: PI2R_HUMAN

Name: Prostacyclin receptor

UniProtKB Accession Codes:

P43119

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 6 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7512962

Title: Cloning and expression of a cDNA for the human prostanoid IP receptor.

PubMed ID: 7512962

DOI: 10.1016/s0021-9258(17)32697-2

PubMed ID: 7514139

Title: Cloning and expression of a cDNA for the human prostacyclin receptor.

PubMed ID: 7514139

DOI: 10.1016/0014-5793(94)00355-6

PubMed ID: 7923647

Title: Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.

PubMed ID: 7923647

DOI: 10.1161/01.cir.90.4.1643

PubMed ID: 7665161

Title: Structural organization and chromosomal assignment of the human prostacyclin receptor gene.

PubMed ID: 7665161

DOI: 10.1006/geno.1995.1016

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11895442

Title: Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.

PubMed ID: 11895442

DOI: 10.1046/j.1432-1327.2002.02817.x

PubMed ID: 12488443

Title: Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.

PubMed ID: 12488443

DOI: 10.1074/jbc.m210637200

PubMed ID: 27613955

Title:

PubMed ID: 27613955

DOI: 10.1074/jbc.a116.210637

PubMed ID: 15194446

Title: Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor.

PubMed ID: 15194446

DOI: 10.1016/j.ejphar.2004.04.041

Sequence Information:

  • Length: 386
  • Mass: 40956
  • Checksum: 2B6B0CDBACED1608
  • Sequence:
    • MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD 
LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA 
LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG 
GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL 
LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF 
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL 
PPTQQSSGSA VGTSSKAEAS VACSLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.