Details for: PTMA
Gene ID: 5757
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PTMA
Ensembl ID: ENSG00000187514
Description: prothymosin alpha
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 152.25rCSI 100%PRS 1.03
-
CSI 150.96rCSI 100%PRS 0.43
-
CSI 149.25rCSI 88.14%PRS 0.51
-
CSI 148.43rCSI 100%PRS 0.44
-
CSI 139.83rCSI 100%PRS 0.54
-
CSI 135.68rCSI 100%PRS 0.37
-
CSI 134.62rCSI 99.7%PRS 0.34
-
CSI 132.07rCSI 100%PRS 0.36
-
CSI 127.33rCSI 95.48%PRS 1.1
-
CSI 127.25rCSI 98.04%PRS 0.33
-
CSI 125.74rCSI 100%PRS 0.36
-
CSI 125.59rCSI 88.2%PRS 1.11
-
CSI 124.79rCSI 87.13%PRS 0.38
-
CSI 124.54rCSI 92.97%PRS 0.62
-
CSI 124.23rCSI 86.45%PRS 0.53
-
CSI 122.33rCSI 95.15%PRS 0.5
-
CSI 122.04rCSI 91.33%PRS 0.6
-
CSI 121.72rCSI 96.65%PRS 0.65
-
CSI 119.66rCSI 91.01%PRS 0.48
-
CSI 118.99rCSI 85.42%PRS 0.5
-
CSI 118.31rCSI 99.17%PRS 0.44
-
CSI 117.76rCSI 100%PRS 0.41
-
CSI 117.64rCSI 88.99%PRS 0.51
-
CSI 116.65rCSI 93.44%PRS 0.68
-
CSI 116.45rCSI 96.54%PRS 0.34
-
CSI 115.9rCSI 93.65%PRS 0.96
-
CSI 115.41rCSI 100%PRS 0.27
-
CSI 115.35rCSI 100%PRS 0.49
-
CSI 114.74rCSI 88.95%PRS 0.32
-
CSI 113.25rCSI 100%PRS 0.32
-
CSI 112.98rCSI 91.8%PRS 0.38
-
CSI 110.9rCSI 97.4%PRS 0.41
-
CSI 110.35rCSI 95.93%PRS 0.45
-
CSI 110.05rCSI 86.99%PRS 0.25
-
CSI 109.84rCSI 86.4%PRS 0.43
-
CSI 107.62rCSI 92.31%PRS 1.19
-
CSI 107.42rCSI 92.6%PRS 0.61
-
CSI 103.88rCSI 100%PRS 0.38
-
CSI 103.55rCSI 91.91%PRS 0.37
-
CSI 102.4rCSI 93.26%PRS 0.57
-
CSI 102.09rCSI 98.17%PRS 0.8
-
CSI 100.4rCSI 84.47%PRS 0.61
-
CSI 99.53rCSI 92.01%PRS 0.67
-
CSI 98.82rCSI 91.97%PRS 0.36
-
CSI 97.39rCSI 67.71%PRS 0.43
-
CSI 96.6rCSI 91.28%PRS 0.38
-
CSI 95.75rCSI 100%PRS 1.18
-
CSI 95.25rCSI 87.45%PRS 0.39
-
CSI 94.86rCSI 93.68%PRS 1.62
-
CSI 94.78rCSI 96.6%PRS 0.53
-
CSI 94.2rCSI 90.83%PRS 0.11
-
CSI 93.58rCSI 96.28%PRS 0.41
-
CSI 91.56rCSI 95.91%PRS 0.34
-
CSI 89.5rCSI 100%PRS 0.34
-
CSI 89.15rCSI 87.56%PRS 0.58
-
CSI 88.89rCSI 92.08%PRS 0.43
-
CSI 88.52rCSI 100%PRS 0.76
-
CSI 88.21rCSI 92.2%PRS 0.39
-
CSI 87.38rCSI 100%PRS 0.43
-
CSI 85.49rCSI 90.84%PRS 0.67
-
CSI 85.24rCSI 85.07%PRS 0.31
-
CSI 84.95rCSI 100%PRS 0.63
-
CSI 84.35rCSI 82.91%PRS 1.09
-
CSI 83.1rCSI 100%PRS 0.42
-
CSI 82.6rCSI 97.02%PRS 3.71
-
CSI 82.48rCSI 96.87%PRS 0.45
-
CSI 81.62rCSI 100%PRS 0.46
-
CSI 81.08rCSI 98.7%PRS 0.46
-
CSI 80.59rCSI 84.09%PRS 0.37
-
CSI 80.37rCSI 74.15%PRS 0.37
-
CSI 80.29rCSI 78.97%PRS 0.4
-
CSI 79.73rCSI 100%PRS 0.37
-
CSI 79.52rCSI 81.41%PRS 0.69
-
CSI 77.54rCSI 100%PRS 0.7
-
CSI 76.45rCSI 97.83%PRS 8.12
-
CSI 75.79rCSI 96.94%PRS 1.7
-
CSI 74.9rCSI 100%PRS 0.56
-
CSI 74.63rCSI 100%PRS 0.33
-
CSI 73.72rCSI 100%PRS 0.53
-
CSI 72.74rCSI 96.67%PRS 0.4
-
CSI 72.7rCSI 100%PRS 0.39
-
CSI 72.57rCSI 89.77%PRS 0.32
-
CSI 72.56rCSI 91.22%PRS 0.56
-
CSI 72.29rCSI 86.77%PRS 0.36
-
CSI 71.83rCSI 83.06%PRS 0.26
-
CSI 70.89rCSI 59.17%PRS 1.46
-
CSI 70.83rCSI 89.01%PRS 2.01
-
CSI 70.73rCSI 97.17%PRS 0.78
-
CSI 69.92rCSI 89.68%PRS 0.42
-
CSI 69.86rCSI 95.45%PRS 0.4
-
CSI 69.32rCSI 100%PRS 0.46
-
CSI 69.27rCSI 100%PRS 4.29
-
CSI 68.82rCSI 99.7%PRS 0.54
-
CSI 68.77rCSI 99.19%PRS 0.51
-
CSI 68.74rCSI 91.97%PRS 2.24
-
CSI 68.15rCSI 84.88%PRS 0.54
-
CSI 68.06rCSI 97.13%PRS 0.42
-
CSI 66.74rCSI 90.91%PRS 0.92
-
CSI 66.14rCSI 90.41%PRS 0.42
-
CSI 66.04rCSI 100%PRS 0.53
-
CSI -50.7rCSI -60.5%PRS 0.3%
-
CSI -49.0rCSI -62.9%PRS 0.5%
-
CSI -45.1rCSI -79.1%PRS 0.3%
-
CSI -43.6rCSI -70.1%PRS 0.3%
-
CSI -35.9rCSI -63.5%PRS 0.2%
-
CSI -33.1rCSI -42.7%PRS 0.3%
-
CSI -31.6rCSI -100.0%PRS 1.2%
-
CSI -30.8rCSI -69.1%PRS 0.3%
-
CSI -30.7rCSI -100.0%PRS 0.6%
-
CSI -27.9rCSI -64.3%PRS 0.4%
-
CSI -27.2rCSI -63.9%PRS 0.7%
-
CSI -24.9rCSI -100.0%PRS 3.6%
-
CSI -24.3rCSI -87.6%PRS 0.2%
-
CSI -24.0rCSI -40.3%PRS 0.2%
-
CSI -24.0rCSI -76.7%PRS 0.5%
-
CSI -23.3rCSI -72.7%PRS 0.3%
-
CSI -22.2rCSI -86.8%PRS 2.4%
-
CSI -21.7rCSI -52.6%PRS 0.2%
-
CSI -19.6rCSI -76.4%PRS 0.6%
-
CSI -18.5rCSI -57.7%PRS 0.2%
-
CSI -17.4rCSI -89.1%PRS 1.2%
-
CSI -17.3rCSI -83.0%PRS 0.4%
-
CSI -16.7rCSI -63.3%PRS 0.3%
-
CSI -16.5rCSI -68.7%PRS 2.2%
-
CSI -16.2rCSI -81.8%PRS 2.5%
-
CSI -14.8rCSI -18.5%PRS 0.2%
-
CSI -14.0rCSI -46.9%PRS 0.4%
-
CSI -13.6rCSI -35.6%PRS 0.5%
-
CSI -12.7rCSI -81.6%PRS 1.1%
-
CSI -12.2rCSI -39.7%PRS 0.8%
-
CSI -11.4rCSI -67.3%PRS 0.3%
-
CSI -10.4rCSI -52.6%PRS 1.8%
-
CSI -10.4rCSI -39.2%PRS 0.9%
-
CSI -10.3rCSI -100.0%PRS 1.8%
-
CSI -8.7rCSI -100.0%PRS 2.1%
-
CSI -7.4rCSI -25.6%PRS 1.3%
-
CSI -7.3rCSI -52.0%PRS 1.7%
-
CSI -7.2rCSI -10.6%PRS 0.4%
-
CSI -7.0rCSI -43.9%PRS 0.3%
-
CSI -6.9rCSI -15.1%PRS 0.2%
-
CSI -6.0rCSI -44.3%PRS 0.2%
-
CSI -5.9rCSI -14.0%PRS 0.4%
-
CSI -5.8rCSI -11.8%PRS 0.4%
-
CSI -4.9rCSI -70.6%PRS 5.5%
-
CSI -4.5rCSI -8.2%PRS 0.5%
-
CSI -4.4rCSI -88.5%PRS 0.6%
-
CSI -3.8rCSI -77.9%PRS 0.5%
-
CSI -3.6rCSI -18.0%PRS 2.1%
-
CSI -3.3rCSI -23.2%PRS 1.2%
-
CSI -3.0rCSI -9.8%PRS 0.4%
-
CSI -2.9rCSI -20.7%PRS 1.6%
-
CSI -2.8rCSI -31.6%PRS 1.9%
-
CSI -2.5rCSI -10.8%PRS 0.9%
-
CSI -2.4rCSI -13.9%PRS 1.2%
-
CSI -2.3rCSI -10.6%PRS 1.3%
-
CSI -2.1rCSI -10.1%PRS 0.7%
-
CSI -1.9rCSI -10.2%PRS 1.4%
-
CSI -1.3rCSI -3.6%PRS 0.3%
-
CSI -1.2rCSI -3.4%PRS 0.7%
-
CSI -0.9rCSI -2.7%PRS 0.5%
-
CSI -0.6rCSI -2.5%PRS 1.8%
-
CSI -0.4rCSI -3.7%PRS 2.6%
-
CSI -0.4rCSI -3.4%PRS 1.4%
-
CSI -0.2rCSI -3.3%PRS 2.1%
-
CSI -0.1rCSI -0.4%PRS 0.7%
-
CSI 0.3rCSI 8.2%PRS 7.2%
-
CSI 0.4rCSI 1.8%PRS 0.4%
-
CSI 0.4rCSI 0.7%PRS 0.6%
-
CSI 0.5rCSI 3.7%PRS 1.4%
-
CSI 0.8rCSI 3.0%PRS 0.5%
-
CSI 0.8rCSI 1.1%PRS 0.4%
-
CSI 1.0rCSI 6.0%PRS 0.7%
-
CSI 1.2rCSI 23.2%PRS 9.6%
-
CSI 1.2rCSI 27.9%PRS 0.3%
-
CSI 1.4rCSI 3.7%PRS 0.8%
-
CSI 1.4rCSI 20.4%PRS 7.6%
-
CSI 1.5rCSI 35.0%PRS 0.3%
-
CSI 1.5rCSI 24.6%PRS 8.7%
-
CSI 2.6rCSI 59.9%PRS 0.3%
-
CSI 2.6rCSI 9.0%PRS 1.2%
-
CSI 2.7rCSI 21.1%PRS 5.5%
-
CSI 2.7rCSI 36.5%PRS 5.3%
-
CSI 2.7rCSI 23.2%PRS 1.0%
-
CSI 2.7rCSI 7.1%PRS 0.6%
-
CSI 2.9rCSI 89.2%PRS 5.5%
-
CSI 3.0rCSI 74.0%PRS 3.4%
-
CSI 3.2rCSI 33.8%PRS 0.7%
-
CSI 3.2rCSI 96.9%PRS 0.9%
-
CSI 3.4rCSI 26.4%PRS 1.3%
-
CSI 3.5rCSI 78.6%PRS 2.2%
-
CSI 3.5rCSI 12.1%PRS 0.6%
-
CSI 3.5rCSI 46.3%PRS 2.6%
-
CSI 3.5rCSI 93.1%PRS 2.1%
-
CSI 3.6rCSI 93.1%PRS 2.4%
-
CSI 3.6rCSI 8.0%PRS 0.3%
-
CSI 3.6rCSI 76.5%PRS 2.7%
-
CSI 3.7rCSI 39.7%PRS 5.8%
-
CSI 3.8rCSI 94.5%PRS 1.3%
-
CSI 3.9rCSI 14.5%PRS 0.3%
-
CSI 4.0rCSI 6.5%PRS 0.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4066477721
Symbol: PTMA_HUMAN
Name: Prothymosin alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3467312
Title: The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA.
PubMed ID: 3467312
PubMed ID: 3466166
Title: Molecular cloning of cDNA for human prothymosin alpha.
PubMed ID: 3466166
PubMed ID: 2708378
Title: Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products.
PubMed ID: 2708378
PubMed ID: 2785990
Title: The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation.
PubMed ID: 2785990
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7916742
Title: Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2.
PubMed ID: 7916742
DOI: 10.1007/bf00202480
PubMed ID: 3532956
Title: Human prothymosin alpha: amino acid sequence and immunologic properties.
PubMed ID: 3532956
PubMed ID: 8485135
Title: Phosphorylation of human and bovine prothymosin alpha in vivo.
PubMed ID: 8485135
DOI: 10.1021/bi00068a015
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16478804
Title: Regulation of apoptosis by the p8/prothymosin alpha complex.
PubMed ID: 16478804
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 22115779
Sequence Information:
- Length: 111
- Mass: 12203
- Checksum: 910BBF9D8D14B8E7
- Sequence:
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV DTKKQKTDED D
Genular Protein ID: 86522470
Symbol: Q53S24_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8125298
Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
PubMed ID: 8125298
PubMed ID: 9373149
Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
PubMed ID: 9373149
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 110
- Mass: 12074
- Checksum: 3A76436E79930993
- Sequence:
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAN EENGEQEADN EVDEEEEEGG EEEEEEEEGD GEEEDGDEDE EAESATGKRA AEDDEDDDVD TKKQKTDEDD