Details for: PTMA

Gene ID: 5757

Symbol: PTMA

Ensembl ID: ENSG00000187514

Description: prothymosin alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.78
    Marker Score: 77603
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.67
    Marker Score: 4114
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.67
    Marker Score: 11881
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.57
    Marker Score: 10161
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.46
    Marker Score: 2807
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.45
    Marker Score: 7097
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.44
    Marker Score: 15884
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.43
    Marker Score: 13794
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.35
    Marker Score: 52943
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.28
    Marker Score: 1945
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.25
    Marker Score: 8081
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.13
    Marker Score: 4107
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.05
    Marker Score: 3620
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.03
    Marker Score: 3241
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.96
    Marker Score: 168861
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.88
    Marker Score: 3686
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.84
    Marker Score: 15269.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.84
    Marker Score: 4120
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.77
    Marker Score: 252059
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.73
    Marker Score: 2035
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.7
    Marker Score: 3560
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.66
    Marker Score: 24495
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.65
    Marker Score: 5162
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.6
    Marker Score: 1098
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.57
    Marker Score: 12248
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.53
    Marker Score: 5476
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.5
    Marker Score: 59415
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.47
    Marker Score: 249782
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.46
    Marker Score: 4212.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.43
    Marker Score: 1441
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.42
    Marker Score: 28226
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.39
    Marker Score: 7531
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.38
    Marker Score: 50920
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.38
    Marker Score: 2663
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.35
    Marker Score: 3093
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.35
    Marker Score: 1957
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.34
    Marker Score: 6285
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.33
    Marker Score: 5346
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.33
    Marker Score: 11955
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.29
    Marker Score: 3827
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.24
    Marker Score: 10366
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.24
    Marker Score: 11890
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.23
    Marker Score: 10659
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.21
    Marker Score: 2471
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.18
    Marker Score: 4038
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.17
    Marker Score: 31027
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 4.16
    Marker Score: 3733
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.15
    Marker Score: 6032
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.11
    Marker Score: 3222
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.1
    Marker Score: 7703
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.1
    Marker Score: 14548
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 4.09
    Marker Score: 1083
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.09
    Marker Score: 17517
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.08
    Marker Score: 6013
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 4.08
    Marker Score: 1308
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3471
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 4.06
    Marker Score: 4368.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 4.05
    Marker Score: 26430
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.05
    Marker Score: 3488
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.04
    Marker Score: 926
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.04
    Marker Score: 4313
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 4.01
    Marker Score: 3566
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3932
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.96
    Marker Score: 1081
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.9
    Marker Score: 1106
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.87
    Marker Score: 3739
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.85
    Marker Score: 4500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.85
    Marker Score: 4188
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.85
    Marker Score: 3904
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.85
    Marker Score: 3392
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.83
    Marker Score: 1399
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.82
    Marker Score: 1006.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.81
    Marker Score: 3210
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.81
    Marker Score: 3632
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.81
    Marker Score: 1972
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.8
    Marker Score: 985
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.8
    Marker Score: 1704
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.79
    Marker Score: 15813
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.79
    Marker Score: 1322
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.79
    Marker Score: 2510
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 3.78
    Marker Score: 917
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.78
    Marker Score: 3207.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.77
    Marker Score: 4309
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.76
    Marker Score: 1072
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.75
    Marker Score: 1057
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.75
    Marker Score: 994
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.75
    Marker Score: 2195
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.74
    Marker Score: 3106
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.74
    Marker Score: 2107
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.74
    Marker Score: 2298
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.73
    Marker Score: 927
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.71
    Marker Score: 24127
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.7
    Marker Score: 2574
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.69
    Marker Score: 1110
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.68
    Marker Score: 4433
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.68
    Marker Score: 1590
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.67
    Marker Score: 2592
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.67
    Marker Score: 1036
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.67
    Marker Score: 6022
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.67
    Marker Score: 4298

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Other Information

## Summary PTMA, also known as prothymosin alpha, is a protein that plays a crucial role in the regulation of cell growth, differentiation, and apoptosis. It is a key regulator of the immune response and is highly expressed in malignant cells and immune cells. ## Key characteristics * PTMA is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the immunoglobulin superfamily and shares structural similarities with other members of the immunoglobulin family. * PTMA is expressed in a variety of cell types, including malignant cells, activated immune cells, and normal cells. * It is involved in a variety of cellular processes, including cell cycle regulation, cell adhesion, migration, and apoptosis. ## Pathways and functions PTMA plays a critical role in the regulation of cell growth, differentiation, and apoptosis. It is involved in the negative regulation of apoptosis by binding to the Bcl-2 family of proteins and inhibiting their activity. This prevents the initiation of apoptosis and promotes cell survival. PTMA also plays a role in cell cycle regulation by binding to the cyclin-dependent kinase inhibitor protein (CDK4) and inhibiting its activity. This prevents the progression of cells through the G1/S transition and promotes cell cycle arrest. In addition to its role in cell growth, differentiation, and apoptosis, PTMA is also involved in the regulation of inflammation and immune responses. It is expressed in inflammatory cells, such as macrophages and dendritic cells, and it plays a role in the regulation of inflammation by interacting with other immune molecules. ## Clinical significance PTMA is a promising target for cancer therapy. It is frequently overexpressed in cancer cells, and its overexpression is associated with poor prognosis. Inhibition of PTMA has been shown to inhibit cancer cell growth and metastasis, and it is currently being investigated as a potential therapeutic agent for cancer.

Genular Protein ID: 4066477721

Symbol: PTMA_HUMAN

Name: Prothymosin alpha

UniProtKB Accession Codes:

P06454 Q15249 Q15592

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 14 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 3 PDBsum 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3467312

Title: The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA.

PubMed ID: 3467312

DOI: 10.1073/pnas.83.24.9403

PubMed ID: 3466166

Title: Molecular cloning of cDNA for human prothymosin alpha.

PubMed ID: 3466166

DOI: 10.1073/pnas.83.23.8926

PubMed ID: 2708378

Title: Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products.

PubMed ID: 2708378

DOI: 10.1016/s0021-9258(18)83269-0

PubMed ID: 2785990

Title: The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation.

PubMed ID: 2785990

DOI: 10.1016/s0021-9258(18)81807-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7916742

Title: Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2.

PubMed ID: 7916742

DOI: 10.1007/bf00202480

PubMed ID: 3532956

Title: Human prothymosin alpha: amino acid sequence and immunologic properties.

PubMed ID: 3532956

DOI: 10.1016/0003-9861(86)90717-4

PubMed ID: 8485135

Title: Phosphorylation of human and bovine prothymosin alpha in vivo.

PubMed ID: 8485135

DOI: 10.1021/bi00068a015

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16478804

Title: Regulation of apoptosis by the p8/prothymosin alpha complex.

PubMed ID: 16478804

DOI: 10.1073/pnas.0508955103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22115779

Title: NMR structure of human thymosin alpha-1.

PubMed ID: 22115779

DOI: 10.1016/j.bbrc.2011.11.041

Sequence Information:

  • Length: 111
  • Mass: 12203
  • Checksum: 910BBF9D8D14B8E7
  • Sequence:
    • MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD NEVDEEEEEG 
GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV DTKKQKTDED D

Genular Protein ID: 86522470

Symbol: Q53S24_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53S24

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 12 ExpressionAtlas 1 GO 2 GeneCards 1 GenomeRNAi 1 HOGENOM 1 InterPro 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 110
  • Mass: 12074
  • Checksum: 3A76436E79930993
  • Sequence:
    • MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAN EENGEQEADN EVDEEEEEGG 
EEEEEEEEGD GEEEDGDEDE EAESATGKRA AEDDEDDDVD TKKQKTDEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.