Details for: PTMA

Gene ID: 5757

Symbol: PTMA

Ensembl ID: ENSG00000187514

Description: prothymosin alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.97
    Cell Significance Index: 10
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.96
    Cell Significance Index: 5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.02
    Cell Significance Index: 2
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7
    Cell Significance Index: 2
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.55
    Cell Significance Index: 2
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.47
    Cell Significance Index: 2
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.44
    Cell Significance Index: 2
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.37
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.35
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.33
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.29
    Cell Significance Index: 1
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.29
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.26
    Cell Significance Index: 1
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.19
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.18
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.13
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.13
    Cell Significance Index: 1
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.11
    Cell Significance Index: 1
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.91
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PTMA is expressed in a wide range of cell types, including malignant cells, activated T cells, B cells, and smooth muscle cells. 2. **Function:** PTMA has been shown to regulate transcription, DNA replication, and apoptosis, making it a key player in maintaining cellular homeostasis. 3. **DNA-binding properties:** PTMA has been shown to bind to DNA, specifically to the major histocompatibility complex (MHC) class II region, which is crucial for the regulation of immune responses. 4. **Protein-protein interactions:** PTMA has been shown to interact with various proteins, including transcription factors, DNA-binding proteins, and kinases, which further highlights its multifaceted role in cellular processes. **Pathways and Functions:** 1. **Transcriptional regulation:** PTMA has been shown to regulate transcription by binding to DNA and interacting with transcription factors, such as NF-κB and AP-1. 2. **Apoptosis regulation:** PTMA has been implicated in the regulation of apoptosis, particularly in the context of cancer, where it may act as a tumor suppressor. 3. **Immune response modulation:** PTMA has been shown to modulate immune responses, particularly in the context of autoimmunity, where it may act as an anti-inflammatory agent. 4. **DNA replication regulation:** PTMA has been shown to regulate DNA replication, which is critical for cell proliferation and survival. **Clinical Significance:** 1. **Cancer:** PTMA has been implicated in the regulation of apoptosis and transcription, making it a potential target for cancer therapy. 2. **Autoimmunity:** PTMA has been shown to modulate immune responses, particularly in the context of autoimmunity, where it may act as an anti-inflammatory agent. 3. **Immunodeficiency:** PTMA has been implicated in the regulation of immune responses, particularly in the context of immunodeficiency diseases, where it may act as a regulator of immune cell function. 4. **Neurological disorders:** PTMA has been shown to regulate transcription and DNA replication, which may have implications for the treatment of neurological disorders, such as Alzheimer's disease. In conclusion, PTMA is a multifaceted gene that plays a crucial role in regulating transcription, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, autoimmunity, and immunodeficiency. Further research is needed to fully understand the role of PTMA in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.