Details for: PTX3

Gene ID: 5806

Symbol: PTX3

Ensembl ID: ENSG00000163661

Description: pentraxin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 68.2760
    Cell Significance Index: -10.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.6924
    Cell Significance Index: -10.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5972
    Cell Significance Index: -10.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1662
    Cell Significance Index: 90.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5798
    Cell Significance Index: -10.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8589
    Cell Significance Index: 38.9100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.5359
    Cell Significance Index: 8.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1801
    Cell Significance Index: 151.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9455
    Cell Significance Index: 15.5800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.5568
    Cell Significance Index: 3.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3071
    Cell Significance Index: 5.1400
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.1767
    Cell Significance Index: 1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1700
    Cell Significance Index: 92.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0912
    Cell Significance Index: 1.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0557
    Cell Significance Index: 34.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0377
    Cell Significance Index: 4.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0164
    Cell Significance Index: 1.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0161
    Cell Significance Index: 1.8800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0069
    Cell Significance Index: 0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0045
    Cell Significance Index: 0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -6.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0112
    Cell Significance Index: -4.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0170
    Cell Significance Index: -6.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0175
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0199
    Cell Significance Index: -4.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0233
    Cell Significance Index: -0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0249
    Cell Significance Index: -5.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0253
    Cell Significance Index: -3.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0281
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0285
    Cell Significance Index: -4.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0402
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0407
    Cell Significance Index: -4.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0426
    Cell Significance Index: -8.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0530
    Cell Significance Index: -1.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0619
    Cell Significance Index: -7.6100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0625
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0672
    Cell Significance Index: -4.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0728
    Cell Significance Index: -7.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0748
    Cell Significance Index: -1.4600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0775
    Cell Significance Index: -0.4600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0784
    Cell Significance Index: -0.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0798
    Cell Significance Index: -3.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0823
    Cell Significance Index: -2.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0905
    Cell Significance Index: -1.4000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0963
    Cell Significance Index: -0.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0969
    Cell Significance Index: -2.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0996
    Cell Significance Index: -10.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1045
    Cell Significance Index: -4.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1191
    Cell Significance Index: -9.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1246
    Cell Significance Index: -9.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1249
    Cell Significance Index: -9.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1283
    Cell Significance Index: -7.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1314
    Cell Significance Index: -8.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1580
    Cell Significance Index: -7.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1611
    Cell Significance Index: -10.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1687
    Cell Significance Index: -8.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1813
    Cell Significance Index: -5.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1844
    Cell Significance Index: -11.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2017
    Cell Significance Index: -3.2000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2037
    Cell Significance Index: -1.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2116
    Cell Significance Index: -10.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2348
    Cell Significance Index: -8.6200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2375
    Cell Significance Index: -1.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2430
    Cell Significance Index: -6.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2530
    Cell Significance Index: -11.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2658
    Cell Significance Index: -3.0200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2718
    Cell Significance Index: -2.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2792
    Cell Significance Index: -4.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2912
    Cell Significance Index: -10.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2950
    Cell Significance Index: -6.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2976
    Cell Significance Index: -11.2700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2998
    Cell Significance Index: -3.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3155
    Cell Significance Index: -4.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3213
    Cell Significance Index: -10.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3272
    Cell Significance Index: -10.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3368
    Cell Significance Index: -9.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3393
    Cell Significance Index: -9.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3536
    Cell Significance Index: -8.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3611
    Cell Significance Index: -7.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3702
    Cell Significance Index: -9.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3705
    Cell Significance Index: -9.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3714
    Cell Significance Index: -8.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3724
    Cell Significance Index: -9.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3754
    Cell Significance Index: -9.8700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3788
    Cell Significance Index: -3.5200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3810
    Cell Significance Index: -2.3900
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3974
    Cell Significance Index: -3.8900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.4010
    Cell Significance Index: -2.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4089
    Cell Significance Index: -11.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4102
    Cell Significance Index: -10.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4110
    Cell Significance Index: -13.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTX3 is a secreted protein that belongs to the pentraxin superfamily, which also includes C-reactive protein (CRP) and serum amyloid P (SAP). Unlike CRP and SAP, PTX3 is not produced by the liver but by various cells, including endothelial cells, fibroblasts, and immune cells. Its expression is induced by inflammatory signals, such as the presence of pathogens, cytokines, or chemokines. PTX3 has a unique structure, consisting of three domains: the pentraxin domain, the collagen-like domain, and the collagen domain. This structure allows PTX3 to bind to a wide range of ligands, including carbohydrates, proteins, and nucleic acids. **Pathways and Functions:** PTX3 plays a central role in the innate immune response, particularly in the recognition and elimination of pathogens. Its primary function is to bind to pathogens, such as bacteria, viruses, and fungi, and to facilitate their clearance by immune cells, such as neutrophils and macrophages. PTX3 also modulates the inflammatory response by regulating the production of cytokines and chemokines, which are essential for the recruitment of immune cells to the site of infection. In addition to its immune-related functions, PTX3 is involved in various other biological processes, including: 1. **Inflammation**: PTX3 is produced in response to inflammatory signals and contributes to the regulation of the inflammatory response. 2. **Immune regulation**: PTX3 modulates the activity of immune cells, such as neutrophils and macrophages, and regulates the production of cytokines and chemokines. 3. **Tissue repair**: PTX3 is involved in the repair of damaged tissues by promoting the migration and proliferation of fibroblasts and endothelial cells. 4. **Angiogenesis**: PTX3 is a potent angiogenic factor, promoting the formation of new blood vessels. **Clinical Significance:** PTX3 has been implicated in various diseases, including: 1. **Infectious diseases**: PTX3 is elevated in response to bacterial, viral, and fungal infections, making it a potential biomarker for the diagnosis of these conditions. 2. **Inflammatory disorders**: PTX3 is involved in the pathogenesis of inflammatory diseases, such as atherosclerosis, rheumatoid arthritis, and multiple sclerosis. 3. **Cancer**: PTX3 has been associated with tumor progression and metastasis, suggesting its potential role in cancer development and treatment. 4. **Neurological disorders**: PTX3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PTX3 is a multifunctional protein that plays a crucial role in the innate immune response and beyond. Its widespread expression and involvement in various biological processes make it a potential target for the diagnosis and treatment of various diseases. Further research is needed to fully elucidate the functions and clinical significance of PTX3.

Genular Protein ID: 3011729651

Symbol: PTX3_HUMAN

Name: Pentaxin-related protein PTX3

UniProtKB Accession Codes:

P26022 B2R6T6 Q38M82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1429570

Title: Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.

PubMed ID: 1429570

DOI: 10.1016/s0021-9258(18)41653-5

PubMed ID: 8131794

Title: IL-1 inducible genes in human umbilical vein endothelial cells.

PubMed ID: 8131794

PubMed ID: 7679696

Title: TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins.

PubMed ID: 7679696

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7523502

Title: Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins.

PubMed ID: 7523502

PubMed ID: 12763682

Title: Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity.

PubMed ID: 12763682

DOI: 10.1016/s0264-410x(03)00199-3

PubMed ID: 18223257

Title: Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization.

PubMed ID: 18223257

DOI: 10.1074/jbc.m708535200

PubMed ID: 35102342

Title: Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.

PubMed ID: 35102342

DOI: 10.1038/s41590-021-01114-w

Sequence Information:

  • Length: 381
  • Mass: 41976
  • Checksum: 09BCE02E2A62D62A
  • Sequence:
    • MHLLAILFCA LWSAVLAENS DDYDLMYVNL DNEIDNGLHP TEDPTPCACG QEHSEWDKLF 
IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL 
LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE 
TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL 
SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH 
IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR 
GNIVGWGVTE IQPHGGAQYV S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.