Details for: RARA

Gene ID: 5914

Symbol: RARA

Ensembl ID: ENSG00000131759

Description: retinoic acid receptor alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.8027
    Cell Significance Index: -22.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.0657
    Cell Significance Index: -21.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.1160
    Cell Significance Index: -20.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.8582
    Cell Significance Index: -22.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.7231
    Cell Significance Index: -20.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7922
    Cell Significance Index: -23.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0893
    Cell Significance Index: -21.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8641
    Cell Significance Index: -23.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5093
    Cell Significance Index: -13.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5542
    Cell Significance Index: -5.5900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 2.3377
    Cell Significance Index: 14.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2444
    Cell Significance Index: 23.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1304
    Cell Significance Index: 1020.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1121
    Cell Significance Index: 12.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7959
    Cell Significance Index: 86.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6811
    Cell Significance Index: 110.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6666
    Cell Significance Index: 19.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5544
    Cell Significance Index: 11.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5097
    Cell Significance Index: 59.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4993
    Cell Significance Index: 26.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4706
    Cell Significance Index: 35.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4590
    Cell Significance Index: 63.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4528
    Cell Significance Index: 12.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4487
    Cell Significance Index: 31.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4434
    Cell Significance Index: 12.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3823
    Cell Significance Index: 76.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3618
    Cell Significance Index: 4.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3569
    Cell Significance Index: 70.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3319
    Cell Significance Index: 63.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3224
    Cell Significance Index: 6.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2293
    Cell Significance Index: 29.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2061
    Cell Significance Index: 91.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1967
    Cell Significance Index: 10.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1924
    Cell Significance Index: 3.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1784
    Cell Significance Index: 17.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1740
    Cell Significance Index: 8.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1622
    Cell Significance Index: 11.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1612
    Cell Significance Index: 19.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1491
    Cell Significance Index: 9.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1434
    Cell Significance Index: 6.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1410
    Cell Significance Index: 18.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1358
    Cell Significance Index: 74.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1055
    Cell Significance Index: 1.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1053
    Cell Significance Index: 2.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0804
    Cell Significance Index: 14.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0623
    Cell Significance Index: 22.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0511
    Cell Significance Index: 78.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0448
    Cell Significance Index: 1.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0410
    Cell Significance Index: 1.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0338
    Cell Significance Index: 63.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0245
    Cell Significance Index: 16.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0245
    Cell Significance Index: 33.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0227
    Cell Significance Index: 1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0077
    Cell Significance Index: 0.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0044
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0002
    Cell Significance Index: 0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0154
    Cell Significance Index: -2.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0218
    Cell Significance Index: -0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0245
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0289
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0336
    Cell Significance Index: -2.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0355
    Cell Significance Index: -2.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0415
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0424
    Cell Significance Index: -26.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0447
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0532
    Cell Significance Index: -2.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0570
    Cell Significance Index: -16.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0682
    Cell Significance Index: -2.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0945
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0977
    Cell Significance Index: -16.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1034
    Cell Significance Index: -1.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1104
    Cell Significance Index: -13.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1178
    Cell Significance Index: -24.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1367
    Cell Significance Index: -3.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1450
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1472
    Cell Significance Index: -16.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1607
    Cell Significance Index: -4.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1692
    Cell Significance Index: -17.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1749
    Cell Significance Index: -11.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1754
    Cell Significance Index: -4.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1802
    Cell Significance Index: -5.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1850
    Cell Significance Index: -2.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2464
    Cell Significance Index: -3.1600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2591
    Cell Significance Index: -4.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2606
    Cell Significance Index: -20.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2899
    Cell Significance Index: -8.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3287
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3378
    Cell Significance Index: -14.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3503
    Cell Significance Index: -2.7000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3542
    Cell Significance Index: -2.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3737
    Cell Significance Index: -22.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4087
    Cell Significance Index: -20.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4306
    Cell Significance Index: -8.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RARA gene exhibits the following characteristics: 1. **Retinoic acid responsiveness**: RARA is a target gene for retinoic acid, a derivative of vitamin A, which plays a crucial role in cell differentiation, proliferation, and apoptosis. 2. **Nuclear receptor activity**: RARA belongs to the nuclear receptor superfamily, which regulates gene expression by binding to specific DNA sequences. 3. **Anterior hox gene activation**: RARA is involved in the activation of anterior hox genes during hindbrain development in early embryogenesis. 4. **Apoptotic cell clearance**: RARA regulates the clearance of apoptotic cells, which is essential for maintaining tissue homeostasis. **Pathways and Functions** The RARA gene is involved in various biological pathways, including: 1. **Cell differentiation**: RARA regulates the differentiation of neural crest cells, kidney cells, and immune cells. 2. **Apoptosis**: RARA promotes the clearance of apoptotic cells, which is crucial for maintaining tissue homeostasis. 3. **Immune response**: RARA is expressed in immune cells and regulates the production of cytokines, such as IL-4, IL-5, and IL-13. 4. **Developmental biology**: RARA is involved in the development of various organs, including the kidney, liver, and prostate gland. 5. **Signaling pathways**: RARA interacts with other signaling molecules, such as protein kinases and transcription factors, to regulate gene expression. **Clinical Significance** The RARA gene has been implicated in several diseases, including: 1. **Acute promyelocytic leukemia (APL)**: Mutations in the RARA gene are associated with APL, a subtype of acute myeloid leukemia. 2. **Cancer**: RARA dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. 3. **Autoimmune disorders**: RARA is involved in the regulation of immune responses and has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurological disorders**: RARA has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the RARA gene plays a crucial role in immune response, development, and cell differentiation. Its dysregulation has been implicated in several diseases, highlighting the importance of understanding its function and regulation. Further research is necessary to elucidate the mechanisms by which RARA influences biological processes and to develop therapeutic strategies for diseases associated with RARA dysregulation.

Genular Protein ID: 1401737839

Symbol: RARA_HUMAN

Name: Retinoic acid receptor alpha

UniProtKB Accession Codes:

P10276 B8Y636 P78456 Q13440 Q13441 Q96S41 Q9NQS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EMBL 20 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 89 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 6 RefSeq 7 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2825036

Title: Identification of a receptor for the morphogen retinoic acid.

PubMed ID: 2825036

DOI: 10.1038/330624a0

PubMed ID: 8302850

Title: PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

PubMed ID: 8302850

DOI: 10.1073/pnas.91.3.1178

PubMed ID: 10337631

Title: Genomic structure of the human retinoic acid receptor-alpha1 gene.

PubMed ID: 10337631

DOI: 10.1007/s003359901036

PubMed ID: 11812818

Title: Retinoic acid receptor alpha1 variants, RARalpha1DeltaB and RARalpha1DeltaBC, define a new class of nuclear receptor isoforms.

PubMed ID: 11812818

DOI: 10.1093/nar/29.24.4901

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2175878

Title: Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).

PubMed ID: 2175878

DOI: 10.1093/nar/18.23.6799

PubMed ID: 2825025

Title: A human retinoic acid receptor which belongs to the family of nuclear receptors.

PubMed ID: 2825025

DOI: 10.1038/330444a0

PubMed ID: 8562957

Title: The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.

PubMed ID: 8562957

PubMed ID: 12691149

Title: Cytogenetics, FISH and RT-PCR analysis of acute promyelocytic leukemia: structure of the fusion point in a case lacking classic t(15;17) translocation.

PubMed ID: 12691149

DOI: 10.1080/1042819021000040305

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 11971969

Title: ERAP140, a conserved tissue-specific nuclear receptor coactivator.

PubMed ID: 11971969

DOI: 10.1128/mcb.22.10.3358-3372.2002

PubMed ID: 15509776

Title: Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.

PubMed ID: 15509776

DOI: 10.1128/mcb.24.22.9705-9725.2004

PubMed ID: 15809060

Title: Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.

PubMed ID: 15809060

DOI: 10.1016/j.bbrc.2005.03.052

PubMed ID: 16179254

Title: The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.

PubMed ID: 16179254

DOI: 10.1016/j.cell.2005.07.003

PubMed ID: 16417524

Title: Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.

PubMed ID: 16417524

DOI: 10.1042/bj20051794

PubMed ID: 16606617

Title: Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.

PubMed ID: 16606617

DOI: 10.1074/jbc.m512616200

PubMed ID: 17455211

Title: RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix.

PubMed ID: 17455211

DOI: 10.1002/jcb.21340

PubMed ID: 19850744

Title: Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity.

PubMed ID: 19850744

DOI: 10.1210/en.2009-0868

PubMed ID: 19398580

Title: ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription.

PubMed ID: 19398580

DOI: 10.1128/mcb.00362-09

PubMed ID: 19377461

Title: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 19377461

DOI: 10.1038/nature07954

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 24336203

Title: Retraction: GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.

PubMed ID: 24336203

DOI: 10.1038/nature12896

PubMed ID: 20215566

Title: Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.

PubMed ID: 20215566

DOI: 10.1210/en.2009-1338

PubMed ID: 22351778

Title: Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.

PubMed ID: 22351778

DOI: 10.1074/jbc.m112.345421

PubMed ID: 26463675

Title: Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

PubMed ID: 26463675

DOI: 10.1093/brain/awv289

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

PubMed ID: 30468856

Title: Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.

PubMed ID: 30468856

DOI: 10.1016/j.jsbmb.2018.11.008

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 10698945

Title: Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.

PubMed ID: 10698945

DOI: 10.1093/emboj/19.5.1045

PubMed ID: 10882070

Title: Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.

PubMed ID: 10882070

DOI: 10.1016/s1097-2765(00)80424-4

PubMed ID: 20543827

Title: A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.

PubMed ID: 20543827

DOI: 10.1038/nsmb.1855

PubMed ID: 21152046

Title: The 'phantom effect' of the rexinoid LG100754: structural and functional insights.

PubMed ID: 21152046

DOI: 10.1371/journal.pone.0015119

Sequence Information:

  • Length: 462
  • Mass: 50771
  • Checksum: E8D1CF9A1E57CB99
  • Sequence:
    • MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTTLQHQLPV SGYSTPSPAT 
IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM 
VYTCHRDKNC IINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKEVP KPECSESYTL 
TPEVGELIEK VRKAHQETFP ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV 
EFAKQLPGFT TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDRVDM LQEPLLEALK 
VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGL 
DTLSGQPGGG GRDGGGLAPP PGSCSPSLSP SSNRSSPATH SP

Genular Protein ID: 2526090745

Symbol: A8K840_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K840

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 462
  • Mass: 50785
  • Checksum: 77F01D8EB5A374D2
  • Sequence:
    • MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTTLQHQLPV SGYSTPSPAT 
IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM 
VYTCHRDKNC IINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKEVP KPECSESYTL 
TPEVGELIEK VRKAHQETFP ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV 
EFAKQLPGFT TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 
GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDRVDM LQEPLLEALK 
VYLRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGL 
DTLSGQPGGG GRDGGGLAPP PGSCSPSLSP SSNRSSPATH SP

Genular Protein ID: 3048387466

Symbol: F1D8N9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1D8N9

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 10 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 457
  • Mass: 50742
  • Checksum: 1E328ED7945D1F95
  • Sequence:
    • MYESVEVGGP TPNPFLVVDF YNQNRACLLP EKGLPAPGPY STPLRTPLWN GSNHSIETQS 
SSSEEIVPSP PSPPPLPRIY KPCFVCQDKS SGYHYGVSAC EGCKGFFRRS IQKNMVYTCH 
RDKNCIINKV TRNRCQYCRL QKCFEVGMSK ESVRNDRNKK KKEVPKPECS ESYTLTPEVG 
ELIEKVRKAH QETFPALCQL GKYTTNNSSE QRVSLDIDLW DKFSELSTKC IIKTVEFAKQ 
LPGFTTLTIA DQITLLKAAC LDILILRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL 
TDLVFAFANQ LLPLEMDDAE TGLLSAICLI CGDRQDLEQP DRVDMLQEPL LEALKVYVRK 
RRPSRPHMFP KMLMKITDLR SISAKGAERV ITLKMEIPGS MPPLIQEMLE NSEGLDTLSG 
QPGGGGRDGG GLAPPPGSCS PSLSPSSNRS SPATHSP

Genular Protein ID: 1080251280

Symbol: A8MUP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MUP8

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 7 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 478
  • Mass: 52907
  • Checksum: 82F4371E70732E59
  • Sequence:
    • MMSQTMTQAG VSFRHSVRAA QCHTRVPNTW PRATRPYASC RRSPRLRGRW PGSAGQGAGG 
RAPRAGWRAG DVTGSAIETQ SSSSEEIVPS PPSPPPLPRI YKPCFVCQDK SSGYHYGVSA 
CEGCKGFFRR SIQKNMVYTC HRDKNCIINK VTRNRCQYCR LQKCFEVGMS KESVRNDRNK 
KKKEVPKPEC SESYTLTPEV GELIEKVRKA HQETFPALCQ LGKYTTNNSS EQRVSLDIDL 
WDKFSELSTK CIIKTVEFAK QLPGFTTLTI ADQITLLKAA CLDILILRIC TRYTPEQDTM 
TFSDGLTLNR TQMHNAGFGP LTDLVFAFAN QLLPLEMDDA ETGLLSAICL ICGDRQDLEQ 
PDRVDMLQEP LLEALKVYVR KRRPSRPHMF PKMLMKITDL RSISAKGAER VITLKMEIPG 
SMPPLIQEML ENSEGLDTLS GQPGGGGRDG GGLAPPPGSC SPSLSPSSNR SSPATHSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.