Details for: RLN1

Gene ID: 6013

Symbol: RLN1

Ensembl ID: ENSG00000107018

Description: relaxin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.8942
    Cell Significance Index: -3.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.7094
    Cell Significance Index: -2.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.6765
    Cell Significance Index: -3.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1738
    Cell Significance Index: 47.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7184
    Cell Significance Index: 136.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4880
    Cell Significance Index: 48.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4815
    Cell Significance Index: 10.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3939
    Cell Significance Index: 355.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3058
    Cell Significance Index: 33.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2802
    Cell Significance Index: 45.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2418
    Cell Significance Index: 14.5200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2251
    Cell Significance Index: 3.7100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1835
    Cell Significance Index: 1.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1557
    Cell Significance Index: 10.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1022
    Cell Significance Index: 6.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0792
    Cell Significance Index: 0.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0762
    Cell Significance Index: 1.0400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0495
    Cell Significance Index: 0.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0335
    Cell Significance Index: 0.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0264
    Cell Significance Index: 0.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0225
    Cell Significance Index: 1.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0190
    Cell Significance Index: 10.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0164
    Cell Significance Index: 1.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0121
    Cell Significance Index: 0.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0097
    Cell Significance Index: 0.3100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0052
    Cell Significance Index: 2.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0039
    Cell Significance Index: 0.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0032
    Cell Significance Index: 0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0029
    Cell Significance Index: 0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.9300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0033
    Cell Significance Index: -2.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0048
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0061
    Cell Significance Index: -1.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0065
    Cell Significance Index: -1.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0075
    Cell Significance Index: -0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0090
    Cell Significance Index: -1.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0091
    Cell Significance Index: -0.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0119
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0138
    Cell Significance Index: -2.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0140
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0183
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0189
    Cell Significance Index: -3.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0190
    Cell Significance Index: -2.6100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0191
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0203
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0205
    Cell Significance Index: -4.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0213
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0298
    Cell Significance Index: -2.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0299
    Cell Significance Index: -0.4200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0303
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0314
    Cell Significance Index: -3.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0324
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0362
    Cell Significance Index: -0.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0369
    Cell Significance Index: -4.7700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0386
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0401
    Cell Significance Index: -0.8400
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0415
    Cell Significance Index: -0.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0420
    Cell Significance Index: -0.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0434
    Cell Significance Index: -2.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0444
    Cell Significance Index: -3.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0446
    Cell Significance Index: -3.0000
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0452
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0467
    Cell Significance Index: -2.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0484
    Cell Significance Index: -3.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0490
    Cell Significance Index: -2.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0522
    Cell Significance Index: -2.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0531
    Cell Significance Index: -1.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0545
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0547
    Cell Significance Index: -1.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0549
    Cell Significance Index: -0.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0570
    Cell Significance Index: -0.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0609
    Cell Significance Index: -2.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0644
    Cell Significance Index: -1.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0645
    Cell Significance Index: -3.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0662
    Cell Significance Index: -1.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0664
    Cell Significance Index: -1.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0668
    Cell Significance Index: -2.3200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0669
    Cell Significance Index: -0.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0685
    Cell Significance Index: -1.6600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0711
    Cell Significance Index: -0.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0722
    Cell Significance Index: -1.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0733
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0736
    Cell Significance Index: -2.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RLN1 is a secreted protein that belongs to the relaxin family, which is known for its ability to modulate various physiological processes. It is primarily expressed in the reproductive system, particularly in the ovaries and placenta during pregnancy. However, its expression is not limited to these tissues, as it is also found in immune cells and other tissues, including the large intestine, small intestine, and brain. **Pathways and Functions:** RLN1's functions are closely linked to its ability to interact with various signaling pathways, including those involved in stress response, immune regulation, and hormone activity. The protein's primary function is to modulate the heat shock response, which is essential for protecting cells against stress and damage. RLN1 achieves this by binding to heat shock factor 1 (HSF1), a transcription factor that regulates the expression of heat shock proteins. Additionally, RLN1 has been shown to interact with other signaling pathways, including the extracellular signal-regulated kinase (ERK) pathway, which is involved in cellular responses to stimuli and stress. **Clinical Significance:** RLN1's role in immune regulation and stress response has significant implications for various clinical contexts. For example: 1. **Autoimmune Diseases:** RLN1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the regulation of immune responses and tissue damage. 2. **Inflammatory Disorders:** RLN1's anti-inflammatory properties may be beneficial in treating inflammatory disorders, such as inflammatory bowel disease and asthma. 3. **Cancer:** RLN1's role in regulating stress response pathways may also be relevant in cancer, where it may influence tumor growth and metastasis. 4. **Neurological Disorders:** RLN1's expression in the brain and its interaction with signaling pathways involved in neuronal development and function may have implications for neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells:** RLN1's expression is widespread, with significant levels found in: 1. Enterocytes of the large intestine and small intestine 2. Colon goblet cells and intestinal crypt stem cells 3. Early T lineage precursors and granulocyte monocyte progenitor cells 4. Cerebral cortex GABAergic interneurons and forebrain radial glial cells 5. Tuft cells of the colon and absorptive cells **Proteins:** The primary protein associated with RLN1 is REL1_HUMAN, also known as prorelaxin H1, which is the precursor to the mature relaxin protein. In conclusion, RLN1's multifaceted role in immune regulation, stress response, and development highlights its importance in various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which RLN1 exerts its effects and to explore its therapeutic potential in different clinical contexts.

Genular Protein ID: 3630498532

Symbol: REL1_HUMAN

Name: Prorelaxin H1

UniProtKB Accession Codes:

P04808 Q99936 Q9UQJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6548702

Title: Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.

PubMed ID: 6548702

DOI: 10.1002/j.1460-2075.1984.tb02135.x

PubMed ID: 6298628

Title: Structure of a genomic clone encoding biologically active human relaxin.

PubMed ID: 6298628

DOI: 10.1038/301628a0

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8735594

Title: Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species.

PubMed ID: 8735594

DOI: 10.1016/0303-7207(96)03770-7

PubMed ID: 10601981

Title: Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping.

PubMed ID: 10601981

DOI: 10.1677/jme.0.0230355

Sequence Information:

  • Length: 185
  • Mass: 21146
  • Checksum: B318628ABFEC7142
  • Sequence:
    • MPRLFLFHLL EFCLLLNQFS RAVAAKWKDD VIKLCGRELV RAQIAICGMS TWSKRSLSQE 
DAPQTPRPVA EIVPSFINKD TETIIIMLEF IANLPPELKA ALSERQPSLP ELQQYVPALK 
DSNLSFEEFK KLIRNRQSEA ADSNPSELKY LGLDTHSQKK RRPYVALFEK CCLIGCTKRS 
LAKYC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.