Details for: RIT1

Gene ID: 6016

Symbol: RIT1

Ensembl ID: ENSG00000143622

Description: Ras like without CAAX 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.5321
    Cell Significance Index: -24.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.4633
    Cell Significance Index: -23.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.6211
    Cell Significance Index: -26.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.6297
    Cell Significance Index: -24.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6171
    Cell Significance Index: -25.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1042
    Cell Significance Index: -21.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6193
    Cell Significance Index: -26.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5967
    Cell Significance Index: -17.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4468
    Cell Significance Index: 19.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9105
    Cell Significance Index: 99.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8954
    Cell Significance Index: 16.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8043
    Cell Significance Index: 41.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7536
    Cell Significance Index: 122.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6126
    Cell Significance Index: 16.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5568
    Cell Significance Index: 15.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5068
    Cell Significance Index: 50.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4996
    Cell Significance Index: 34.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4922
    Cell Significance Index: 31.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4749
    Cell Significance Index: 85.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4049
    Cell Significance Index: 49.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3641
    Cell Significance Index: 17.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3064
    Cell Significance Index: 167.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2940
    Cell Significance Index: 6.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2921
    Cell Significance Index: 13.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2694
    Cell Significance Index: 3.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2556
    Cell Significance Index: 113.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2400
    Cell Significance Index: 32.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2291
    Cell Significance Index: 2.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2232
    Cell Significance Index: 6.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1786
    Cell Significance Index: 4.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1701
    Cell Significance Index: 34.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1637
    Cell Significance Index: 4.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1528
    Cell Significance Index: 30.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1324
    Cell Significance Index: 16.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0969
    Cell Significance Index: 4.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0858
    Cell Significance Index: 16.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0590
    Cell Significance Index: 21.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0484
    Cell Significance Index: 1.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0455
    Cell Significance Index: 5.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0431
    Cell Significance Index: 29.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0141
    Cell Significance Index: 12.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0100
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0097
    Cell Significance Index: 18.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0069
    Cell Significance Index: 0.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0033
    Cell Significance Index: 0.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0128
    Cell Significance Index: -8.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0154
    Cell Significance Index: -1.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0271
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0309
    Cell Significance Index: -22.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0378
    Cell Significance Index: -5.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0378
    Cell Significance Index: -10.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0402
    Cell Significance Index: -22.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0454
    Cell Significance Index: -2.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0466
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0487
    Cell Significance Index: -30.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0586
    Cell Significance Index: -0.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0679
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0787
    Cell Significance Index: -9.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0791
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0856
    Cell Significance Index: -9.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0950
    Cell Significance Index: -5.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0964
    Cell Significance Index: -7.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1018
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1036
    Cell Significance Index: -17.6900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1072
    Cell Significance Index: -0.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1278
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1443
    Cell Significance Index: -30.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1620
    Cell Significance Index: -3.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1632
    Cell Significance Index: -9.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1998
    Cell Significance Index: -3.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2179
    Cell Significance Index: -22.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2540
    Cell Significance Index: -6.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2658
    Cell Significance Index: -21.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3085
    Cell Significance Index: -9.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3143
    Cell Significance Index: -16.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3300
    Cell Significance Index: -8.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3336
    Cell Significance Index: -22.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3463
    Cell Significance Index: -17.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4089
    Cell Significance Index: -3.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4405
    Cell Significance Index: -19.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4422
    Cell Significance Index: -27.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4578
    Cell Significance Index: -6.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4905
    Cell Significance Index: -12.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5145
    Cell Significance Index: -7.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5271
    Cell Significance Index: -19.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5331
    Cell Significance Index: -19.5700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5358
    Cell Significance Index: -7.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5563
    Cell Significance Index: -22.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5588
    Cell Significance Index: -16.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5662
    Cell Significance Index: -8.0600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6706
    Cell Significance Index: -11.0500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.6904
    Cell Significance Index: -9.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RIT1 is a GTP-binding protein that lacks the CAAX motif, a characteristic feature of Ras proteins. This difference in structure may have implications for its function and regulation. Despite the absence of the CAAX motif, RIT1 is involved in various signaling pathways, including those mediated by calmodulin, G protein activity, and receptor tyrosine kinases. Its expression in multiple cell types, including immune cells and epithelial cells, underscores its importance in cellular communication. **Pathways and Functions:** RIT1's involvement in signaling pathways is a key aspect of its function. The following pathways and functions have been identified: 1. **Calmodulin binding:** RIT1 interacts with calmodulin, a calcium-binding protein, which regulates its activity and localization. 2. **G protein activity:** RIT1 is involved in G protein-mediated signaling, which regulates cell growth, differentiation, and survival. 3. **GTPase activity:** RIT1 has GTPase activity, which regulates its GTP-binding and hydrolysis cycles, modulating its activity and localization. 4. **GTP binding:** RIT1 binds GTP, which regulates its activity and interaction with other proteins. 5. **Signaling by NTRK1 (TRKA):** RIT1 interacts with NTRK1, a receptor tyrosine kinase, to regulate cell growth and differentiation. 6. **Signaling by NTRKS:** RIT1 is involved in signaling by NTRK receptors, which regulate cell growth, differentiation, and survival. 7. **Signaling by receptor tyrosine kinases:** RIT1 interacts with receptor tyrosine kinases to regulate cell growth, differentiation, and survival. 8. **Signaling to ERKs:** RIT1 regulates signaling to ERKs, a family of transcription factors involved in cell growth and differentiation. 9. **Signaling to p38 via RIT and RIN:** RIT1 regulates signaling to p38, a MAPK involved in cell growth, differentiation, and survival. **Clinical Significance:** The clinical significance of RIT1's dysregulation is an area of ongoing research. Dysregulation of RIT1 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. The identification of RIT1 as a potential therapeutic target holds promise for the development of novel therapeutic strategies. Future research should focus on understanding the mechanisms by which RIT1 dysregulation contributes to disease and exploring its potential as a therapeutic target. In conclusion, RIT1 is a complex protein with multiple roles in cellular communication. Its involvement in various signaling pathways highlights its importance in maintaining cellular homeostasis. The clinical significance of RIT1's dysregulation underscores the need for further research into its role in disease and its potential as a therapeutic target.

Genular Protein ID: 3796384718

Symbol: RIT1_HUMAN

Name: GTP-binding protein Rit1

UniProtKB Accession Codes:

Q92963 B4DQE8 O00646 O00720 Q5VY89 Q5VY90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824319

Title: Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.

PubMed ID: 8824319

DOI: 10.1523/jneurosci.16-21-06784.1996

PubMed ID: 8918462

Title: RIC, a calmodulin-binding Ras-like GTPase.

PubMed ID: 8918462

DOI: 10.1002/j.1460-2075.1996.tb00971.x

PubMed ID: 10545207

Title: Biochemical characterization of the Ras-related GTPases Rit and Rin.

PubMed ID: 10545207

DOI: 10.1006/abbi.1999.1448

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632082

Title: Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.

PubMed ID: 15632082

DOI: 10.1128/mcb.25.2.830-846.2005

PubMed ID: 23791108

Title: Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome.

PubMed ID: 23791108

DOI: 10.1016/j.ajhg.2013.05.021

PubMed ID: 25959749

Title: Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype.

PubMed ID: 25959749

DOI: 10.1111/cge.12608

Sequence Information:

  • Length: 219
  • Mass: 25145
  • Checksum: 7F957871F836AE92
  • Sequence:
    • MDSGTRPVGS CCSSPAGLSR EYKLVMLGAG GVGKSAMTMQ FISHRFPEDH DPTIEDAYKI 
RIRIDDEPAN LDILDTAGQA EFTAMRDQYM RAGEGFIICY SITDRRSFHE VREFKQLIYR 
VRRTDDTPVV LVGNKSDLKQ LRQVTKEEGL ALAREFSCPF FETSAAYRYY IDDVFHALVR 
EIRRKEKEAV LAMEKKSKPK NSVWKRLKSP FRKKKDSVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.