Details for: RPL5

Gene ID: 6125

Symbol: RPL5

Ensembl ID: ENSG00000122406

Description: ribosomal protein L5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 651.6363
    Cell Significance Index: -268.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 589.9158
    Cell Significance Index: -239.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 541.7448
    Cell Significance Index: -255.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 520.0382
    Cell Significance Index: -267.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 383.2064
    Cell Significance Index: -257.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 256.1056
    Cell Significance Index: -244.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 38.8486
    Cell Significance Index: -104.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.3881
    Cell Significance Index: 444.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 15.8386
    Cell Significance Index: 202.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 13.6914
    Cell Significance Index: 475.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 13.4566
    Cell Significance Index: 1374.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 11.8787
    Cell Significance Index: 558.2900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.4876
    Cell Significance Index: 67.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.8691
    Cell Significance Index: 311.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.3891
    Cell Significance Index: 273.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.3328
    Cell Significance Index: 195.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.1510
    Cell Significance Index: 211.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.0129
    Cell Significance Index: 1237.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.9605
    Cell Significance Index: 1157.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.6578
    Cell Significance Index: 1064.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.6445
    Cell Significance Index: 152.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.5997
    Cell Significance Index: 93.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.5981
    Cell Significance Index: 608.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.3694
    Cell Significance Index: 95.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.2365
    Cell Significance Index: 1484.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.5358
    Cell Significance Index: 3331.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.4224
    Cell Significance Index: 4053.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2636
    Cell Significance Index: 541.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0589
    Cell Significance Index: 832.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.9105
    Cell Significance Index: 445.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.9728
    Cell Significance Index: 278.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8782
    Cell Significance Index: 160.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.4408
    Cell Significance Index: 697.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.3944
    Cell Significance Index: 43.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.0730
    Cell Significance Index: 866.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.1143
    Cell Significance Index: 25.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.0839
    Cell Significance Index: 119.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.8635
    Cell Significance Index: 35.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.8044
    Cell Significance Index: 198.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2027
    Cell Significance Index: 168.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0594
    Cell Significance Index: 607.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5437
    Cell Significance Index: 67.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.1045
    Cell Significance Index: 1592.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4516
    Cell Significance Index: 26.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4327
    Cell Significance Index: 1293.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.1430
    Cell Significance Index: 838.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8821
    Cell Significance Index: 176.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.7972
    Cell Significance Index: 63.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3942
    Cell Significance Index: 75.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3201
    Cell Significance Index: 36.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2752
    Cell Significance Index: 15.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2138
    Cell Significance Index: 9.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2050
    Cell Significance Index: 10.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1251
    Cell Significance Index: 44.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0982
    Cell Significance Index: 9.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0471
    Cell Significance Index: 88.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0643
    Cell Significance Index: -118.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0891
    Cell Significance Index: -137.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0952
    Cell Significance Index: -70.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1792
    Cell Significance Index: -243.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2068
    Cell Significance Index: -12.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2119
    Cell Significance Index: -119.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2148
    Cell Significance Index: -134.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2904
    Cell Significance Index: -184.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4241
    Cell Significance Index: -192.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4250
    Cell Significance Index: -69.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5008
    Cell Significance Index: -105.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8112
    Cell Significance Index: -233.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9769
    Cell Significance Index: -111.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4675
    Cell Significance Index: -24.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.4835
    Cell Significance Index: -215.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6962
    Cell Significance Index: -29.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7263
    Cell Significance Index: -55.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9357
    Cell Significance Index: -11.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0606
    Cell Significance Index: -129.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.0735
    Cell Significance Index: -72.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.2978
    Cell Significance Index: -239.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.6394
    Cell Significance Index: -202.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.7148
    Cell Significance Index: -187.7400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -3.0126
    Cell Significance Index: -13.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.1938
    Cell Significance Index: -214.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.7294
    Cell Significance Index: -228.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.8583
    Cell Significance Index: -83.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.0569
    Cell Significance Index: -108.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.0678
    Cell Significance Index: -55.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.6548
    Cell Significance Index: -79.7700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -5.0010
    Cell Significance Index: -104.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.0387
    Cell Significance Index: -75.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -5.0611
    Cell Significance Index: -43.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.1505
    Cell Significance Index: -138.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.3018
    Cell Significance Index: -28.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.3188
    Cell Significance Index: -156.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.3692
    Cell Significance Index: -45.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -5.3960
    Cell Significance Index: -81.3200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -5.5498
    Cell Significance Index: -41.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -5.5918
    Cell Significance Index: -139.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7024
    Cell Significance Index: -252.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.2848
    Cell Significance Index: -80.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.3910
    Cell Significance Index: -234.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -6.8204
    Cell Significance Index: -223.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL5 is a 14-kDa protein that is highly conserved across species, with a high degree of sequence similarity to other ribosomal proteins. It is a component of the 60S ribosomal subunit, which is responsible for protein synthesis and translation. RPL5 exhibits a unique structure, consisting of a β-barrel domain and a C-terminal tail, allowing it to interact with other ribosomal proteins and RNA molecules. **Pathways and Functions:** RPL5 is involved in multiple signaling pathways, including: 1. **Cap-dependent translation initiation**: RPL5 plays a crucial role in the initiation of protein synthesis, interacting with eIF4E and eIF4A to regulate translation. 2. **Cytoplasmic translation**: RPL5 is essential for the assembly of the 60S ribosomal subunit, facilitating the translation of mRNAs. 3. **Cellular responses to stimuli**: RPL5 modulates cellular responses to stress, starvation, and amino acid deficiency by regulating the expression of genes involved in cell survival and adaptation. 4. **Viral infection pathways**: RPL5 interacts with viral RNA molecules, influencing the translation of viral mRNAs and modulating the host cell's response to viral infection. 5. **Signaling by Robo receptors**: RPL5 is involved in the regulation of signaling by Robo receptors, which play a crucial role in axon guidance and neuronal development. **Clinical Significance:** RPL5 is significantly expressed in various cell types, including epithelial cells, myoepithelial cells, and stem cells. Alterations in RPL5 expression or function have been implicated in several diseases, including: 1. **Cancer**: RPL5 is overexpressed in various types of cancer, including pancreatic cancer, lung cancer, and breast cancer. 2. **Neurological disorders**: RPL5 has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: RPL5 plays a role in the regulation of viral infection pathways, including influenza and HIV-1. 4. **Metabolic disorders**: RPL5 is involved in the regulation of protein synthesis and metabolism, which is disrupted in metabolic disorders, such as diabetes and obesity. In conclusion, RPL5 is a multifunctional protein that plays a critical role in various cellular processes, including protein synthesis, translation, and signaling pathways. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and clinical significance of RPL5.

Genular Protein ID: 3733615456

Symbol: RL5_HUMAN

Name: 60S ribosomal protein L5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 8806611

Title: Interaction of the beta subunit of casein kinase II with the ribosomal protein L5.

PubMed ID: 8806611

DOI: 10.1006/bbrc.1996.1330

PubMed ID: 7937132

Title: U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals.

PubMed ID: 7937132

DOI: 10.1093/nar/22.20.4073

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15469983

Title: NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.

PubMed ID: 15469983

DOI: 10.1091/mbc.e04-08-0692

PubMed ID: 19061985

Title: Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients.

PubMed ID: 19061985

DOI: 10.1016/j.ajhg.2008.11.004

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 19191325

Title: Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia.

PubMed ID: 19191325

DOI: 10.1002/humu.20874

Sequence Information:

  • Length: 297
  • Mass: 34363
  • Checksum: 07CA9FBA842BD2A3
  • Sequence:
  • MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI 
    ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE 
    GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF 
    PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNS VTPDMMEEMY 
    KKAHAAIREN PVYEKKPKKE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.