Details for: RPL6

Gene ID: 6128

Symbol: RPL6

Ensembl ID: ENSG00000089009

Description: ribosomal protein L6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 694.0931
    Cell Significance Index: -285.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 628.2228
    Cell Significance Index: -255.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 577.6677
    Cell Significance Index: -272.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 543.5615
    Cell Significance Index: -279.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 408.3323
    Cell Significance Index: -274.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 272.1570
    Cell Significance Index: -259.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.9559
    Cell Significance Index: -74.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 17.1771
    Cell Significance Index: 438.8200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 16.8943
    Cell Significance Index: 179.5000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.0885
    Cell Significance Index: 94.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.6136
    Cell Significance Index: 1492.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.0891
    Cell Significance Index: 376.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.0517
    Cell Significance Index: 566.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.8950
    Cell Significance Index: 152.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.7751
    Cell Significance Index: 409.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 11.3283
    Cell Significance Index: 237.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.9871
    Cell Significance Index: 262.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 9.7421
    Cell Significance Index: 105.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.1149
    Cell Significance Index: 1177.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.0191
    Cell Significance Index: 637.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.9692
    Cell Significance Index: 207.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.8838
    Cell Significance Index: 1220.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.8419
    Cell Significance Index: 1087.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.7664
    Cell Significance Index: 99.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.5357
    Cell Significance Index: 1538.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.9284
    Cell Significance Index: 140.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.7658
    Cell Significance Index: 3433.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.6255
    Cell Significance Index: 218.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.4533
    Cell Significance Index: 878.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.0560
    Cell Significance Index: 3853.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.9875
    Cell Significance Index: 520.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.6758
    Cell Significance Index: 430.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.1907
    Cell Significance Index: 288.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.3573
    Cell Significance Index: 686.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.1038
    Cell Significance Index: 138.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.8698
    Cell Significance Index: 29.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.4819
    Cell Significance Index: 765.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2157
    Cell Significance Index: 221.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.8626
    Cell Significance Index: 30.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.7332
    Cell Significance Index: 69.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.6501
    Cell Significance Index: 107.2000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.4470
    Cell Significance Index: 29.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3376
    Cell Significance Index: 30.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.8078
    Cell Significance Index: 2125.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6764
    Cell Significance Index: 531.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3555
    Cell Significance Index: 62.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.3133
    Cell Significance Index: 120.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5145
    Cell Significance Index: 149.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.0829
    Cell Significance Index: 794.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0306
    Cell Significance Index: 81.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0111
    Cell Significance Index: 290.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9133
    Cell Significance Index: 824.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8477
    Cell Significance Index: 52.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6529
    Cell Significance Index: 18.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5513
    Cell Significance Index: 110.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3388
    Cell Significance Index: 19.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2637
    Cell Significance Index: 13.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2606
    Cell Significance Index: 49.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0741
    Cell Significance Index: 26.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0491
    Cell Significance Index: -92.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0939
    Cell Significance Index: -69.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1181
    Cell Significance Index: -217.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1468
    Cell Significance Index: -226.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2106
    Cell Significance Index: -286.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2108
    Cell Significance Index: -118.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2215
    Cell Significance Index: -138.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3320
    Cell Significance Index: -210.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3614
    Cell Significance Index: -16.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3931
    Cell Significance Index: -63.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5102
    Cell Significance Index: -231.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5156
    Cell Significance Index: -108.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0825
    Cell Significance Index: -124.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1301
    Cell Significance Index: -129.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.4082
    Cell Significance Index: -29.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4400
    Cell Significance Index: -90.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4999
    Cell Significance Index: -48.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.6270
    Cell Significance Index: -27.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.6365
    Cell Significance Index: -237.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8522
    Cell Significance Index: -31.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.1401
    Cell Significance Index: -12.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.5795
    Cell Significance Index: -268.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.1184
    Cell Significance Index: -239.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.2768
    Cell Significance Index: -226.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.6066
    Cell Significance Index: -242.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.9912
    Cell Significance Index: -244.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.1924
    Cell Significance Index: -57.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.5369
    Cell Significance Index: -77.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.6202
    Cell Significance Index: -69.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.2434
    Cell Significance Index: -154.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.4061
    Cell Significance Index: -45.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.5849
    Cell Significance Index: -66.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.6638
    Cell Significance Index: -250.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -6.3375
    Cell Significance Index: -151.9900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.4554
    Cell Significance Index: -35.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.6723
    Cell Significance Index: -244.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.8185
    Cell Significance Index: -258.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -6.9444
    Cell Significance Index: -227.3600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.9988
    Cell Significance Index: -90.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -7.1326
    Cell Significance Index: -249.8700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.3096
    Cell Significance Index: -33.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL6 is a 20-kDa protein that belongs to the ribosomal protein family. It is composed of two domains: a globular domain and a helical domain. The globular domain is responsible for binding to the ribosomal RNA (rRNA), while the helical domain interacts with other ribosomal proteins. RPL6 is highly conserved across species, suggesting its essential role in ribosome biogenesis and function. **Pathways and Functions:** RPL6 is involved in various cellular pathways, including: 1. **Translation initiation and elongation:** RPL6 plays a crucial role in the initiation and elongation phases of translation, interacting with other ribosomal proteins and RNA to facilitate the assembly of the 60S ribosomal subunit. 2. **Stress response and apoptosis:** RPL6 is induced in response to cellular stress, including DNA damage, hypoxia, and viral infections, and promotes apoptosis by regulating the expression of pro-apoptotic genes. 3. **Viral infection pathways:** RPL6 interacts with viral RNA and proteins to facilitate viral translation and replication. 4. **Cellular responses to stimuli:** RPL6 is involved in the regulation of cellular responses to stimuli, including cytokine signaling and immune responses. **Clinical Significance:** RPL6 has been implicated in various diseases, including: 1. **Cancer:** RPL6 is overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a prognostic biomarker. 2. **Autoimmune diseases:** RPL6 is involved in the regulation of immune responses and has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative diseases:** RPL6 has been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where it may play a role in the regulation of protein synthesis and clearance. 4. **Infectious diseases:** RPL6 has been shown to interact with viral RNA and proteins, suggesting its potential as a target for antiviral therapies. **Significantly Expressed Cells:** RPL6 is highly expressed in various cell types, including: 1. **Thyroid follicular cells:** RPL6 is essential for the regulation of thyroid hormone synthesis and release. 2. **Epithelial cells of exocrine pancreas:** RPL6 is involved in the regulation of pancreatic function and secretion. 3. **Myoepithelial cells of mammary gland:** RPL6 plays a role in the regulation of milk production and secretion. 4. **Malignant cells:** RPL6 is overexpressed in various types of cancer, suggesting its potential as a prognostic biomarker. In conclusion, RPL6 is a crucial protein that plays a vital role in ribosome biogenesis, translation regulation, and cellular responses to stimuli. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of RPL6 in normal and diseased states.

Genular Protein ID: 898582045

Symbol: RL6_HUMAN

Name: 60S ribosomal protein L6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8479925

Title: Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6.

PubMed ID: 8479925

DOI: 10.1093/nar/21.7.1673

PubMed ID: 8457378

Title: Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.

PubMed ID: 8457378

DOI: 10.1089/aid.1993.9.115

PubMed ID: 11043511

Title: The human ribosomal protein L6 gene in a critical region for Noonan syndrome.

PubMed ID: 11043511

DOI: 10.1007/s100380070018

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8185817

Title: Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues.

PubMed ID: 8185817

DOI: 10.1677/jme.0.0120085

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 11823430

Title: Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.

PubMed ID: 11823430

DOI: 10.1093/emboj/21.3.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 288
  • Mass: 32728
  • Checksum: D24A6168C7D0ECBF
  • Sequence:
  • MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS 
    AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 
    VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 
    LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 
    EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

Genular Protein ID: 2722242587

Symbol: Q8TBK5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 288
  • Mass: 32742
  • Checksum: 1495FF7BBFAE43A3
  • Sequence:
  • MAGEKVEKPD TKEKRPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGVGRYSRS 
    AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 
    VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 
    LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 
    EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.