Gene RPL6 - ENSG00000089009 | NCBI Gene ID: 6128

Details for: RPL6

Gene ID: 6128

Symbol: RPL6

Ensembl ID: ENSG00000089009

Description: ribosomal protein L6

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cadherin binding
(GO:0045296)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Dna binding
(GO:0003677)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Ribosomal large subunit assembly
(GO:0000027)
Rna binding
(GO:0003723)
Rough endoplasmic reticulum
(GO:0005791)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.02
Marker Score: 4709
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.9
Marker Score: 3325
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.75
Marker Score: 28243
Cell Name: malignant cell (CL0001064)
Fold Change: 5.61
Marker Score: 75414
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.61
Marker Score: 11763
Cell Name: mature T cell (CL0002419)
Fold Change: 5.3
Marker Score: 52504
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.25
Marker Score: 15324
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.11
Marker Score: 1883
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.1
Marker Score: 8744
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.02
Marker Score: 6539
Cell Name: theca cell (CL0000503)
Fold Change: 4.99
Marker Score: 3574
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.98
Marker Score: 3613.5
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.92
Marker Score: 2530
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.88
Marker Score: 165949
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.85
Marker Score: 15318
Cell Name: naive B cell (CL0000788)
Fold Change: 4.85
Marker Score: 4329
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.81
Marker Score: 7413.5
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.78
Marker Score: 2549
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.75
Marker Score: 2453
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.74
Marker Score: 250858
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.61
Marker Score: 3480
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.51
Marker Score: 3838
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.5
Marker Score: 59408
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.42
Marker Score: 4914
Cell Name: naive T cell (CL0000898)
Fold Change: 4.42
Marker Score: 2845
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.42
Marker Score: 246989
Cell Name: chondrocyte (CL0000138)
Fold Change: 4.39
Marker Score: 1977
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.38
Marker Score: 23012
Cell Name: blood cell (CL0000081)
Fold Change: 4.37
Marker Score: 50744.5
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.36
Marker Score: 1419
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.35
Marker Score: 2647
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.32
Marker Score: 1031
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.31
Marker Score: 26196
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.24
Marker Score: 11725
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.21
Marker Score: 11821
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.18
Marker Score: 4041
Cell Name: memory T cell (CL0000813)
Fold Change: 4.18
Marker Score: 1795
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.16
Marker Score: 10157.5
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.13
Marker Score: 30777
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.13
Marker Score: 9417
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.1
Marker Score: 3493
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.1
Marker Score: 2401
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17532
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.07
Marker Score: 5992
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.05
Marker Score: 9888
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.05
Marker Score: 3174.5
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.03
Marker Score: 10249
Cell Name: supporting cell (CL0000630)
Fold Change: 4.03
Marker Score: 7569.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4
Marker Score: 3941
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4
Marker Score: 10716
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.99
Marker Score: 4820
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.99
Marker Score: 4262
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.98
Marker Score: 3752
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.95
Marker Score: 25737
Cell Name: club cell (CL0000158)
Fold Change: 3.93
Marker Score: 4591
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.93
Marker Score: 13942
Cell Name: granulocyte (CL0000094)
Fold Change: 3.88
Marker Score: 1739.5
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.87
Marker Score: 3396
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.86
Marker Score: 1761.5
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.84
Marker Score: 3606
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.83
Marker Score: 2726.5
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.82
Marker Score: 2570
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.8
Marker Score: 1250
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.79
Marker Score: 3105
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.79
Marker Score: 868
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.78
Marker Score: 3948.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.78
Marker Score: 4666
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.78
Marker Score: 9407
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.75
Marker Score: 3362
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.74
Marker Score: 3329
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.72
Marker Score: 24200
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.71
Marker Score: 3079
Cell Name: memory B cell (CL0000787)
Fold Change: 3.71
Marker Score: 2804
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.7
Marker Score: 4097
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.7
Marker Score: 2126
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.69
Marker Score: 3256
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.69
Marker Score: 3290.5
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.68
Marker Score: 1006
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.68
Marker Score: 2030
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.68
Marker Score: 4205
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.67
Marker Score: 1042
Cell Name: immature B cell (CL0000816)
Fold Change: 3.66
Marker Score: 2426
Cell Name: reticular cell (CL0000432)
Fold Change: 3.65
Marker Score: 1333
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.63
Marker Score: 2127
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.62
Marker Score: 2424
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.62
Marker Score: 9129
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.61
Marker Score: 1018
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.61
Marker Score: 5921
Cell Name: microglial cell (CL0000129)
Fold Change: 3.61
Marker Score: 6567
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.59
Marker Score: 3022
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.59
Marker Score: 5705
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.57
Marker Score: 3842
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.57
Marker Score: 2346
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.56
Marker Score: 1143
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.55
Marker Score: 1841
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.55
Marker Score: 8062
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.54
Marker Score: 8552
Cell Name: basophil (CL0000767)
Fold Change: 3.54
Marker Score: 1683
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.54
Marker Score: 1009
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.53
Marker Score: 20944.5

Hover over a box to see details here...

**Key characteristics:** - RPL6 is a large protein with a molecular weight of approximately 110 kDa. - It is a member of the ribosomal protein L6 family. - RPL6 is involved in the initiation, elongation, and termination of protein translation. **Pathways and functions:** - RPL6 is involved in the initiation of protein translation by binding to the 5' cap of mRNA. - It is also involved in the elongation of protein translation by interacting with the ribosome. - RPL6 is involved in the termination of protein translation by binding to a stop codon on the mRNA. **Clinical significance:** - Mutations in RPL6 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - RPL6 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** - RPL6 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. - It is a well-characterized protein that has been extensively studied.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L6
Q8TBK5_HUMAN

Genular Protein ID: 898582045

Symbol: RL6_HUMAN

Name: 60S ribosomal protein L6

UniProtKB Accession Codes:

Q02878 Q2M3Q3 Q8WW97

Database IDs:

Citations:

PubMed ID: 8479925

Title: Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6.

PubMed ID: 8479925

DOI: 10.1093/nar/21.7.1673

PubMed ID: 8457378

Title: Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I.

PubMed ID: 8457378

DOI: 10.1089/aid.1993.9.115

PubMed ID: 11043511

Title: The human ribosomal protein L6 gene in a critical region for Noonan syndrome.

PubMed ID: 11043511

DOI: 10.1007/s100380070018

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8185817

Title: Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues.

PubMed ID: 8185817

DOI: 10.1677/jme.0.0120085

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 11823430

Title: Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.

PubMed ID: 11823430

DOI: 10.1093/emboj/21.3.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 288
Mass: 32728
Checksum: D24A6168C7D0ECBF
Sequence:

MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS 
AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 
VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 
LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 
EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

Genular Protein ID: 2722242587

Symbol: Q8TBK5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TBK5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 288
Mass: 32742
Checksum: 1495FF7BBFAE43A3
Sequence:

MAGEKVEKPD TKEKRPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGVGRYSRS 
AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 
VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 
LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 
EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPL6

Associated with

Cells (max top 100)

Other Information

Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6. PubMed ID: 8479925

Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. PubMed ID: 8457378

The human ribosomal protein L6 gene in a critical region for Noonan syndrome. PubMed ID: 11043511

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. PubMed ID: 8185817

Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. PubMed ID: 12962325

Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. PubMed ID: 11823430

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. PubMed ID: 17924679

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of actively translating human ribosomes. PubMed ID: 25957688

Structure of the human 80S ribosome. PubMed ID: 25901680

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 8479925

PubMed ID: 8457378

PubMed ID: 11043511

PubMed ID: 15489334

PubMed ID: 8185817

PubMed ID: 12962325

PubMed ID: 11823430

PubMed ID: 14654843

PubMed ID: 17924679

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 24524803

PubMed ID: 25944712

PubMed ID: 28112733

PubMed ID: 23636399

PubMed ID: 25957688

PubMed ID: 25901680

PubMed ID: 32669547

PubMed ID: 16959974

PubMed ID: 15489334