Details for: RPL9

Gene ID: 6133

Symbol: RPL9

Ensembl ID: ENSG00000163682

Description: ribosomal protein L9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 657.1467
    Cell Significance Index: -270.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 602.2787
    Cell Significance Index: -244.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 545.3032
    Cell Significance Index: -257.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 520.0966
    Cell Significance Index: -267.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 385.5163
    Cell Significance Index: -258.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 259.0855
    Cell Significance Index: -247.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.0476
    Cell Significance Index: -88.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.2536
    Cell Significance Index: 466.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.7665
    Cell Significance Index: 1712.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 15.2187
    Cell Significance Index: 407.0900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 12.8714
    Cell Significance Index: 75.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 12.8243
    Cell Significance Index: 602.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.7131
    Cell Significance Index: 206.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 11.6253
    Cell Significance Index: 403.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.2138
    Cell Significance Index: 321.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 10.5325
    Cell Significance Index: 276.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.2907
    Cell Significance Index: 131.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.0198
    Cell Significance Index: 209.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 9.5897
    Cell Significance Index: 1238.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.3765
    Cell Significance Index: 216.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.2309
    Cell Significance Index: 1267.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.0837
    Cell Significance Index: 642.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.9231
    Cell Significance Index: 101.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.5478
    Cell Significance Index: 1051.0400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.4186
    Cell Significance Index: 51.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.3972
    Cell Significance Index: 1513.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.3299
    Cell Significance Index: 620.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.2437
    Cell Significance Index: 89.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0250
    Cell Significance Index: 3548.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.1443
    Cell Significance Index: 333.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 7.0818
    Cell Significance Index: 130.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.9217
    Cell Significance Index: 446.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.8464
    Cell Significance Index: 3738.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.3266
    Cell Significance Index: 172.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.2064
    Cell Significance Index: 731.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.0636
    Cell Significance Index: 318.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.8533
    Cell Significance Index: 750.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.6769
    Cell Significance Index: 798.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.6451
    Cell Significance Index: 136.4200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.5427
    Cell Significance Index: 36.2700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.3675
    Cell Significance Index: 37.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0717
    Cell Significance Index: 37.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.4955
    Cell Significance Index: 2645.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.1953
    Cell Significance Index: 316.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.8359
    Cell Significance Index: 2560.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7466
    Cell Significance Index: 189.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8433
    Cell Significance Index: 53.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8164
    Cell Significance Index: 82.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.2136
    Cell Significance Index: 889.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0189
    Cell Significance Index: 80.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9461
    Cell Significance Index: 180.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9370
    Cell Significance Index: 25.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8586
    Cell Significance Index: 44.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0461
    Cell Significance Index: -86.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0896
    Cell Significance Index: -66.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1189
    Cell Significance Index: -219.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1208
    Cell Significance Index: -43.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1436
    Cell Significance Index: -89.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1487
    Cell Significance Index: -228.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2025
    Cell Significance Index: -114.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2034
    Cell Significance Index: -276.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2997
    Cell Significance Index: -190.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3806
    Cell Significance Index: -43.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4609
    Cell Significance Index: -97.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4718
    Cell Significance Index: -214.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4762
    Cell Significance Index: -26.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.7192
    Cell Significance Index: -142.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7222
    Cell Significance Index: -23.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.7247
    Cell Significance Index: -145.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7634
    Cell Significance Index: -13.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8116
    Cell Significance Index: -233.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9492
    Cell Significance Index: -49.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9936
    Cell Significance Index: -113.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0508
    Cell Significance Index: -66.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.2190
    Cell Significance Index: -198.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2568
    Cell Significance Index: -77.2500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.3208
    Cell Significance Index: -7.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4490
    Cell Significance Index: -24.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5429
    Cell Significance Index: -224.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8188
    Cell Significance Index: -45.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4271
    Cell Significance Index: -252.7200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.7125
    Cell Significance Index: -56.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.8029
    Cell Significance Index: -20.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -3.2444
    Cell Significance Index: -14.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.2877
    Cell Significance Index: -252.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.2960
    Cell Significance Index: -44.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.4392
    Cell Significance Index: -74.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.4527
    Cell Significance Index: -211.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.4697
    Cell Significance Index: -51.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.6859
    Cell Significance Index: -221.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.0055
    Cell Significance Index: -269.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.1318
    Cell Significance Index: -22.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -4.9715
    Cell Significance Index: -38.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.0621
    Cell Significance Index: -149.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -5.1509
    Cell Significance Index: -260.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -5.4668
    Cell Significance Index: -45.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -5.6898
    Cell Significance Index: -233.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7221
    Cell Significance Index: -253.1000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -5.8969
    Cell Significance Index: -36.6400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.2335
    Cell Significance Index: -80.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL9 is a 16-kDa protein that is structurally similar to other ribosomal proteins, with a conserved sequence and a specific binding site on the 60S ribosomal subunit. Its expression is highly regulated, with significant fluctuations in response to various cellular stimuli, such as amino acid availability and stress. RPL9 is also involved in the regulation of translation elongation, with its binding to the ribosome influencing the efficiency of protein synthesis. **Pathways and Functions:** RPL9 is involved in various cellular pathways, including: 1. **Translation elongation**: RPL9 plays a crucial role in the elongation phase of protein synthesis, facilitating the binding of aminoacyl-tRNA to the ribosome and promoting the translocation of the ribosome along the mRNA. 2. **Cap-dependent translation initiation**: RPL9 is involved in the initiation of translation, where it interacts with the 40S ribosomal subunit and the mRNA cap to facilitate the recruitment of the 60S subunit. 3. **Cytosolic translation**: RPL9 is also involved in cytosolic translation, where it regulates the translation of mRNAs in the cytosol. 4. **Regulation of protein synthesis**: RPL9 can regulate protein synthesis by modulating the binding of aminoacyl-tRNA to the ribosome and influencing the efficiency of translation elongation. **Clinical Significance:** RPL9 has been implicated in various diseases, including: 1. **Cancer**: RPL9 has been shown to be overexpressed in certain types of cancer, including breast and pancreatic cancer, suggesting its potential role as a diagnostic biomarker. 2. **Neurological disorders**: RPL9 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to the pathogenesis of these diseases. 3. **Infectious diseases**: RPL9 has been implicated in the regulation of translation during viral infections, such as influenza, where its dysregulation may contribute to the pathogenesis of these diseases. In conclusion, RPL9 is a multifaceted protein that plays a crucial role in various cellular processes, including translation elongation, cap-dependent translation initiation, and cytosolic translation. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully understand the mechanisms of RPL9 and its role in disease, with the goal of developing novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 2186048149

Symbol: RL9_HUMAN

Name: 60S ribosomal protein L9

UniProtKB Accession Codes:

P32969

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 2 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 78 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 3 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 93 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8415001

Title: A new human ribosomal protein sequence, homologue of rat L9.

PubMed ID: 8415001

DOI: 10.1093/nar/21.18.4395

PubMed ID: 8597601

Title: Structural organization and chromosomal localization of the human ribosomal protein L9 gene.

PubMed ID: 8597601

DOI: 10.1016/0167-4781(95)00201-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 192
  • Mass: 21863
  • Checksum: 0249E6CA12F77934
  • Sequence:
    • MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW 
WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE 
KYIRRVRMRP GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY 
VSEKGTVQQA DE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.