Details for: RPL13

Gene ID: 6137

Symbol: RPL13

Ensembl ID: ENSG00000167526

Description: ribosomal protein L13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 894.3613
    Cell Significance Index: -368.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 819.0872
    Cell Significance Index: -332.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 736.9272
    Cell Significance Index: -347.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 714.9894
    Cell Significance Index: -367.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 520.8472
    Cell Significance Index: -349.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 354.2734
    Cell Significance Index: -338.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.2355
    Cell Significance Index: -72.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 21.4761
    Cell Significance Index: 548.6500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 20.9650
    Cell Significance Index: 123.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 20.3265
    Cell Significance Index: 2076.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 18.0263
    Cell Significance Index: 482.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 16.2062
    Cell Significance Index: 761.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 14.6545
    Cell Significance Index: 385.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 13.6428
    Cell Significance Index: 474.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 13.5280
    Cell Significance Index: 387.7900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 13.0353
    Cell Significance Index: 34.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 12.7328
    Cell Significance Index: 294.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 12.3409
    Cell Significance Index: 218.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.0297
    Cell Significance Index: 154.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.8212
    Cell Significance Index: 1527.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 10.2506
    Cell Significance Index: 1407.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 10.1409
    Cell Significance Index: 1246.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 10.0307
    Cell Significance Index: 1808.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.8740
    Cell Significance Index: 698.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 9.5958
    Cell Significance Index: 715.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.5501
    Cell Significance Index: 199.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.5429
    Cell Significance Index: 4219.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.4786
    Cell Significance Index: 5176.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.1986
    Cell Significance Index: 104.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.7735
    Cell Significance Index: 1124.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.2676
    Cell Significance Index: 975.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 8.1308
    Cell Significance Index: 524.5600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.6655
    Cell Significance Index: 65.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.5151
    Cell Significance Index: 220.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.9989
    Cell Significance Index: 367.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.9050
    Cell Significance Index: 321.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 6.7328
    Cell Significance Index: 350.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.7103
    Cell Significance Index: 72.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.0991
    Cell Significance Index: 37.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.0178
    Cell Significance Index: 163.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.4847
    Cell Significance Index: 936.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.4229
    Cell Significance Index: 100.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.9526
    Cell Significance Index: 3748.7300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 4.4285
    Cell Significance Index: 92.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.3443
    Cell Significance Index: 116.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.3633
    Cell Significance Index: 667.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3233
    Cell Significance Index: 150.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9554
    Cell Significance Index: 27.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 2.5660
    Cell Significance Index: 203.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4864
    Cell Significance Index: 2244.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.2390
    Cell Significance Index: 1641.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3463
    Cell Significance Index: 256.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4096
    Cell Significance Index: 82.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3003
    Cell Significance Index: 18.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2889
    Cell Significance Index: 4.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2272
    Cell Significance Index: 11.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1978
    Cell Significance Index: 11.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0901
    Cell Significance Index: 32.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0693
    Cell Significance Index: -7.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1463
    Cell Significance Index: -269.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1496
    Cell Significance Index: -110.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1584
    Cell Significance Index: -10.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1752
    Cell Significance Index: -269.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2630
    Cell Significance Index: -357.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3143
    Cell Significance Index: -196.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3148
    Cell Significance Index: -177.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3636
    Cell Significance Index: -230.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3795
    Cell Significance Index: -3.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5817
    Cell Significance Index: -264.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6467
    Cell Significance Index: -105.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7394
    Cell Significance Index: -155.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7888
    Cell Significance Index: -78.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -1.0795
    Cell Significance Index: -310.6100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3783
    Cell Significance Index: -23.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.5657
    Cell Significance Index: -179.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9162
    Cell Significance Index: -278.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.5886
    Cell Significance Index: -15.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.7349
    Cell Significance Index: -172.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.1447
    Cell Significance Index: -327.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.3700
    Cell Significance Index: -84.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.4596
    Cell Significance Index: -110.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.4855
    Cell Significance Index: -100.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.7636
    Cell Significance Index: -288.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.9726
    Cell Significance Index: -238.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.1782
    Cell Significance Index: -280.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.3531
    Cell Significance Index: -74.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.9395
    Cell Significance Index: -302.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.4318
    Cell Significance Index: -74.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.4782
    Cell Significance Index: -82.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.6337
    Cell Significance Index: -197.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.0878
    Cell Significance Index: -72.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -6.8102
    Cell Significance Index: -48.9100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.8634
    Cell Significance Index: -37.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.9742
    Cell Significance Index: -205.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -7.5831
    Cell Significance Index: -148.0000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.7796
    Cell Significance Index: -35.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.1779
    Cell Significance Index: -361.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -8.5138
    Cell Significance Index: -184.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.5970
    Cell Significance Index: -315.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL13 is a 60S ribosomal protein, which is a subunit of the eukaryotic ribosome responsible for protein synthesis. It is composed of 147 amino acids and is highly conserved across species. RPL13 is a cytosolic protein, localized to the cytosolic large ribosomal subunit, where it interacts with other ribosomal proteins to facilitate protein synthesis. Its expression is highly regulated, with significant upregulation in response to cellular stress, starvation, and inflammation. **Pathways and Functions:** RPL13 is involved in numerous signaling pathways, including: 1. **Axon guidance**: RPL13 plays a crucial role in axon guidance, regulating the extension and retraction of axons during neural development. 2. **Blastocyst development**: RPL13 is involved in the development of the blastocyst, a critical stage in embryonic development. 3. **Bone development**: RPL13 regulates bone development and density, influencing the formation of osteoblasts and osteoclasts. 4. **Cellular responses to stimuli**: RPL13 is activated in response to cellular stress, starvation, and inflammation, regulating the expression of genes involved in cell survival and adaptation. 5. **Cytoplasmic translation**: RPL13 is involved in the translation of mRNAs into proteins, regulating the synthesis of key cellular proteins. 6. **Nonsense-mediated decay (NMD)**: RPL13 is involved in the NMD pathway, regulating the degradation of aberrant mRNAs. 7. **Selenocysteine synthesis**: RPL13 is required for the synthesis of selenocysteine, an essential amino acid involved in antioxidant defense. **Clinical Significance:** Dysregulation of RPL13 has been implicated in various diseases, including: 1. **Cancer**: RPL13 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: RPL13 is involved in the regulation of inflammatory responses, and its dysregulation has been linked to inflammatory disorders, such as rheumatoid arthritis and psoriasis. 3. **Neurodegenerative diseases**: RPL13 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: RPL13 is involved in the regulation of viral infections, including influenza and HIV. In conclusion, RPL13 is a multifaceted protein with a wide range of functions in cellular processes, including protein synthesis, cell growth, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in human health and disease. Further research is needed to elucidate the mechanisms underlying RPL13's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1507455680

Symbol: RL13_HUMAN

Name: 60S ribosomal protein L13

UniProtKB Accession Codes:

P26373 B4DLX3 F5H1S2 Q3KQT8 Q567Q8 Q9BPX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EMDB 78 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 93 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1301162

Title: Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours.

PubMed ID: 1301162

DOI: 10.1093/hmg/1.2.91

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31630789

Title: RPL13 variants cause spondyloepimetaphyseal dysplasia with severe short stature.

PubMed ID: 31630789

DOI: 10.1016/j.ajhg.2019.09.024

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 211
  • Mass: 24261
  • Checksum: DB9FC57768E6BEDE
  • Sequence:
    • MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP ASGPIRPIVR 
CPTVRYHTKV RAGRGFSLEE LRVAGIHKKV ARTIGISVDP RRRNKSTESL QANVQRLKEY 
RSKLILFPRK PSAPKKGDSS AEELKLATQL TGPVMPVRNV YKKEKARVIT EEEKNFKAFA 
SLRMARANAR LFGIRAKRAK EAAEQDVEKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.