Details for: RPL18A

Gene ID: 6142

Symbol: RPL18A

Ensembl ID: ENSG00000105640

Description: ribosomal protein L18a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 748.0442
    Cell Significance Index: -308.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 703.6677
    Cell Significance Index: -285.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 623.3550
    Cell Significance Index: -294.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 602.9236
    Cell Significance Index: -310.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 440.5667
    Cell Significance Index: -295.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.2886
    Cell Significance Index: -78.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 20.5416
    Cell Significance Index: 524.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 20.1615
    Cell Significance Index: 306.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 17.9301
    Cell Significance Index: 105.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 16.5866
    Cell Significance Index: 1694.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.8231
    Cell Significance Index: 396.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.0843
    Cell Significance Index: 661.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.2486
    Cell Significance Index: 348.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.2437
    Cell Significance Index: 144.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 10.8558
    Cell Significance Index: 191.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.4456
    Cell Significance Index: 299.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.4401
    Cell Significance Index: 1348.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.2422
    Cell Significance Index: 214.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.6860
    Cell Significance Index: 336.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.6229
    Cell Significance Index: 109.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.1410
    Cell Significance Index: 646.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.9728
    Cell Significance Index: 1232.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.8186
    Cell Significance Index: 95.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.8141
    Cell Significance Index: 1083.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.6584
    Cell Significance Index: 1560.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.6208
    Cell Significance Index: 1016.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.2118
    Cell Significance Index: 612.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.1377
    Cell Significance Index: 4444.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.9471
    Cell Significance Index: 3513.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.8166
    Cell Significance Index: 180.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.6519
    Cell Significance Index: 356.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.3381
    Cell Significance Index: 473.4200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.2396
    Cell Significance Index: 62.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.1652
    Cell Significance Index: 210.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.5159
    Cell Significance Index: 40.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.7524
    Cell Significance Index: 737.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.7778
    Cell Significance Index: 815.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.4728
    Cell Significance Index: 3385.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2022
    Cell Significance Index: 220.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8315
    Cell Significance Index: 104.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4218
    Cell Significance Index: 31.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3588
    Cell Significance Index: 62.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.1803
    Cell Significance Index: 2871.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7949
    Cell Significance Index: 22.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3736
    Cell Significance Index: 234.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9645
    Cell Significance Index: 183.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6827
    Cell Significance Index: 18.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6108
    Cell Significance Index: 447.8100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1642
    Cell Significance Index: 0.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0966
    Cell Significance Index: 5.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0048
    Cell Significance Index: 1.3900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0877
    Cell Significance Index: -1.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0991
    Cell Significance Index: -186.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1182
    Cell Significance Index: -87.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1700
    Cell Significance Index: -313.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2007
    Cell Significance Index: -9.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2084
    Cell Significance Index: -320.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2631
    Cell Significance Index: -148.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2645
    Cell Significance Index: -359.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3197
    Cell Significance Index: -199.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3602
    Cell Significance Index: -129.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3878
    Cell Significance Index: -246.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4007
    Cell Significance Index: -65.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6036
    Cell Significance Index: -37.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6098
    Cell Significance Index: -276.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6634
    Cell Significance Index: -139.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.7404
    Cell Significance Index: -146.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0500
    Cell Significance Index: -18.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -1.1210
    Cell Significance Index: -224.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1548
    Cell Significance Index: -91.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3322
    Cell Significance Index: -152.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3588
    Cell Significance Index: -76.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4871
    Cell Significance Index: -47.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6161
    Cell Significance Index: -101.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.8818
    Cell Significance Index: -273.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.9672
    Cell Significance Index: -224.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.0561
    Cell Significance Index: -34.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.4009
    Cell Significance Index: -166.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.8784
    Cell Significance Index: -299.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.4029
    Cell Significance Index: -20.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.6792
    Cell Significance Index: -91.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.9057
    Cell Significance Index: -299.7200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -4.0129
    Cell Significance Index: -28.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.0630
    Cell Significance Index: -60.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.1025
    Cell Significance Index: -251.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.5233
    Cell Significance Index: -61.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.6960
    Cell Significance Index: -315.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.7203
    Cell Significance Index: -283.3800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.9827
    Cell Significance Index: -27.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.3299
    Cell Significance Index: -115.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -5.4770
    Cell Significance Index: -285.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7496
    Cell Significance Index: -169.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -5.8461
    Cell Significance Index: -205.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.7194
    Cell Significance Index: -193.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.8782
    Cell Significance Index: -304.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.1009
    Cell Significance Index: -260.6700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -7.5384
    Cell Significance Index: -97.0800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -7.5781
    Cell Significance Index: -34.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.6799
    Cell Significance Index: -64.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.0264
    Cell Significance Index: -303.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL18A shares high sequence identity with other ribosomal proteins, particularly those in the 60S large ribosomal subunit. The protein exhibits a conserved structure, with a single polypeptide chain that folds into a globular domain. RPL18A has been shown to interact with other ribosomal proteins, including L10A, L11, and L13A, to form a stable complex that is essential for ribosome biogenesis and function. The protein's expression is tightly regulated, with studies suggesting that RPL18A is involved in the response to amino acid starvation and stress. **Pathways and Functions** RPL18A is involved in several critical cellular pathways, including: 1. **Translation**: RPL18A is a component of the 60S large ribosomal subunit, which is responsible for the elongation phase of translation. The protein plays a crucial role in the assembly of the ribosome and the regulation of translation initiation. 2. **Cell Growth and Proliferation**: RPL18A is involved in the regulation of cell growth and proliferation, particularly in response to amino acid starvation. The protein's expression is upregulated in response to growth factors, such as insulin-like growth factor-1 (IGF-1), and is downregulated in response to stress. 3. **Stress Response**: RPL18A is involved in the cellular response to stress, including amino acid starvation, hypoxia, and oxidative stress. The protein's expression is upregulated in response to stress, and it helps to regulate the expression of other genes involved in stress response. 4. **Immune Response**: RPL18A is expressed in immune cells, including CD8-positive T cells and natural T-regulatory cells, and plays a role in the regulation of immune responses. The protein's expression is upregulated in response to viral infections, such as influenza. **Clinical Significance** RPL18A has been implicated in various diseases, including: 1. **Cancer**: RPL18A is overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer. The protein's expression is associated with poor prognosis and increased tumor aggressiveness. 2. **Neurological Disorders**: RPL18A has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The protein's expression is altered in the brains of patients with these diseases. 3. **Viral Infections**: RPL18A is involved in the regulation of viral infections, including influenza and HIV-1. The protein's expression is altered in response to viral infections, and it helps to regulate the expression of other genes involved in viral replication. In conclusion, RPL18A is a crucial component of the 60S large ribosomal subunit in eukaryotic cells, and its expression is tightly regulated in response to various cellular and environmental cues. The protein's involvement in translation, cell growth, and stress response pathways makes it an important target for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1604774245

Symbol: RL18A_HUMAN

Name: 60S ribosomal protein L18a

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11823430

Title: Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.

PubMed ID: 11823430

DOI: 10.1093/emboj/21.3.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 176
  • Mass: 20762
  • Checksum: 5E501C6D835BE580
  • Sequence:
  • MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE 
    IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL TTAGAVTQCY RDMGARHRAR 
    AHSIQIMKVE EIAASKCRRP AVKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.