Details for: RPL32

Gene ID: 6161

Symbol: RPL32

Ensembl ID: ENSG00000144713

Description: ribosomal protein L32

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 846.9524
    Cell Significance Index: -348.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 771.9003
    Cell Significance Index: -313.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 692.5531
    Cell Significance Index: -326.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 677.8771
    Cell Significance Index: -348.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 489.3579
    Cell Significance Index: -328.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 334.0585
    Cell Significance Index: -318.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.9672
    Cell Significance Index: -99.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.6248
    Cell Significance Index: 501.3500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.7574
    Cell Significance Index: 98.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 15.8897
    Cell Significance Index: 425.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.3933
    Cell Significance Index: 1572.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 14.7341
    Cell Significance Index: 692.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.3075
    Cell Significance Index: 349.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.8905
    Cell Significance Index: 165.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.4905
    Cell Significance Index: 358.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 12.3636
    Cell Significance Index: 218.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.7646
    Cell Significance Index: 1390.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.4968
    Cell Significance Index: 219.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 10.4565
    Cell Significance Index: 241.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.0119
    Cell Significance Index: 113.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.8562
    Cell Significance Index: 697.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.6346
    Cell Significance Index: 1323.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.1633
    Cell Significance Index: 1126.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.9994
    Cell Significance Index: 1622.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.9034
    Cell Significance Index: 663.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.8395
    Cell Significance Index: 3908.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.5385
    Cell Significance Index: 296.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.5185
    Cell Significance Index: 1004.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.4699
    Cell Significance Index: 4625.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.1352
    Cell Significance Index: 1042.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.0116
    Cell Significance Index: 148.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.9512
    Cell Significance Index: 86.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.1051
    Cell Significance Index: 458.3900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.5378
    Cell Significance Index: 40.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.2076
    Cell Significance Index: 182.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.4345
    Cell Significance Index: 285.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 5.2244
    Cell Significance Index: 3954.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.0747
    Cell Significance Index: 866.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0148
    Cell Significance Index: 136.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.9210
    Cell Significance Index: 229.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.6173
    Cell Significance Index: 163.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.2888
    Cell Significance Index: 325.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4596
    Cell Significance Index: 2220.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2486
    Cell Significance Index: 60.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1463
    Cell Significance Index: 19.7700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.7572
    Cell Significance Index: 15.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6631
    Cell Significance Index: 330.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5717
    Cell Significance Index: 81.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.2672
    Cell Significance Index: 929.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1366
    Cell Significance Index: 216.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7743
    Cell Significance Index: 222.7800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3528
    Cell Significance Index: 0.9500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2217
    Cell Significance Index: 1.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2034
    Cell Significance Index: 16.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1717
    Cell Significance Index: 34.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0881
    Cell Significance Index: -165.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1273
    Cell Significance Index: -94.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1824
    Cell Significance Index: -336.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2094
    Cell Significance Index: -10.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.2191
    Cell Significance Index: -337.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2228
    Cell Significance Index: -79.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2763
    Cell Significance Index: -375.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2773
    Cell Significance Index: -156.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3122
    Cell Significance Index: -194.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.4233
    Cell Significance Index: -268.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4513
    Cell Significance Index: -27.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6391
    Cell Significance Index: -290.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6739
    Cell Significance Index: -141.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.2441
    Cell Significance Index: -202.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3626
    Cell Significance Index: -23.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.3655
    Cell Significance Index: -155.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4067
    Cell Significance Index: -161.1600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.5607
    Cell Significance Index: -32.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5709
    Cell Significance Index: -50.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.0651
    Cell Significance Index: -300.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1370
    Cell Significance Index: -134.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1601
    Cell Significance Index: -121.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.2084
    Cell Significance Index: -36.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.9048
    Cell Significance Index: -17.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.1389
    Cell Significance Index: -326.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.3173
    Cell Significance Index: -229.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.4061
    Cell Significance Index: -204.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.0469
    Cell Significance Index: -310.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -4.0470
    Cell Significance Index: -101.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.4647
    Cell Significance Index: -300.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.5159
    Cell Significance Index: -276.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.5575
    Cell Significance Index: -68.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -4.6271
    Cell Significance Index: -162.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.1024
    Cell Significance Index: -87.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -5.1929
    Cell Significance Index: -70.8500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.4788
    Cell Significance Index: -29.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.5182
    Cell Significance Index: -119.5500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -5.6023
    Cell Significance Index: -40.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -5.7294
    Cell Significance Index: -165.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -6.3084
    Cell Significance Index: -75.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.3746
    Cell Significance Index: -187.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.3184
    Cell Significance Index: -323.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -7.8198
    Cell Significance Index: -65.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.8879
    Cell Significance Index: -289.5600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -8.0611
    Cell Significance Index: -37.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL32 is a 32-kilodalton protein that belongs to the ribosomal protein family, specifically the large subunit of the 60S ribosomal complex. Its structure consists of a conserved N-terminal domain and a C-terminal domain that interacts with other ribosomal proteins. RPL32 is highly conserved across species, suggesting its fundamental role in eukaryotic translation. The gene is expressed in various cell types, including epithelial cells, immune cells, and stem cells, highlighting its importance in multiple cellular processes. **Pathways and Functions** RPL32 is involved in several key cellular pathways, including: 1. **Translation**: RPL32 is a crucial component of the large ribosomal subunit, responsible for translating mRNA into proteins. It interacts with other ribosomal proteins to facilitate the assembly and function of ribosomes. 2. **Axon Guidance**: RPL32 has been implicated in axon guidance, a process critical for neuronal development and axon extension. Its involvement in this pathway suggests a role in regulating neuronal development and function. 3. **Cellular Responses to Stimuli**: RPL32 is involved in cellular responses to various stimuli, including amino acid deprivation, stress, and viral infections. Its expression in immune cells and stem cells highlights its role in regulating cellular responses to environmental cues. 4. **Viral Infection Pathways**: RPL32 has been identified as a target for viral proteins, suggesting its involvement in viral infection pathways. Its expression in epithelial cells and immune cells highlights its role in regulating viral replication and translation. **Clinical Significance** RPL32 has been implicated in various diseases and disorders, including: 1. **Influenza Infection**: RPL32 has been identified as a target for influenza viral proteins, suggesting its role in regulating viral replication and translation. 2. **Neurological Disorders**: RPL32's involvement in axon guidance and neuronal development highlights its potential role in neurological disorders, such as autism and schizophrenia. 3. **Cancer**: RPL32's expression in malignant cells suggests its potential role in cancer development and progression. 4. **Immune System Disorders**: RPL32's expression in immune cells highlights its potential role in regulating immune responses and immune system disorders, such as autoimmune diseases. In conclusion, RPL32 is a crucial component of the large ribosomal subunit, playing a vital role in protein synthesis and translation. Its involvement in multiple cellular pathways, including axon guidance, cellular responses to stimuli, and viral infection pathways, highlights its importance in maintaining cellular homeostasis and regulating protein synthesis. Further research is needed to fully elucidate the role of RPL32 in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2391067176

Symbol: RL32_HUMAN

Name: 60S ribosomal protein L32

UniProtKB Accession Codes:

P62910 B2R4Q3 P02433

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 80 Ensembl 4 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 95 PDBsum 95 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3866218

Title: A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family.

PubMed ID: 3866218

DOI: 10.1093/nar/13.24.8883

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 135
  • Mass: 15860
  • Checksum: EDEE48446483966E
  • Sequence:
    • MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK GQILMPNIGY 
GSNKKTKHML PSGFRKFLVH NVKELEVLLM CNKSYCAEIA HNVSSKNRKA IVERAAQLAI 
RVTNPNARLR SEENE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.