Details for: RPL34

Gene ID: 6164

Symbol: RPL34

Ensembl ID: ENSG00000109475

Description: ribosomal protein L34

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 844.9375
    Cell Significance Index: -348.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 771.3834
    Cell Significance Index: -313.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 683.5300
    Cell Significance Index: -322.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 661.6053
    Cell Significance Index: -340.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 483.1733
    Cell Significance Index: -324.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 52.7837
    Cell Significance Index: -141.4000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 25.0825
    Cell Significance Index: 147.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.1563
    Cell Significance Index: 463.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 18.0078
    Cell Significance Index: 1839.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 15.0612
    Cell Significance Index: 707.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 14.9683
    Cell Significance Index: 393.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.2208
    Cell Significance Index: 251.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.9118
    Cell Significance Index: 341.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.7794
    Cell Significance Index: 150.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.4652
    Cell Significance Index: 1481.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.0373
    Cell Significance Index: 295.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.4195
    Cell Significance Index: 118.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 10.4091
    Cell Significance Index: 217.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.3544
    Cell Significance Index: 359.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 10.0905
    Cell Significance Index: 186.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 10.0867
    Cell Significance Index: 751.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.9173
    Cell Significance Index: 1219.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.8757
    Cell Significance Index: 1780.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.6685
    Cell Significance Index: 1327.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 9.5297
    Cell Significance Index: 673.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.2735
    Cell Significance Index: 4100.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.1381
    Cell Significance Index: 56.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.0424
    Cell Significance Index: 208.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.4070
    Cell Significance Index: 1077.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 8.1680
    Cell Significance Index: 4460.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.0366
    Cell Significance Index: 421.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.8438
    Cell Significance Index: 925.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0617
    Cell Significance Index: 76.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.0640
    Cell Significance Index: 391.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8980
    Cell Significance Index: 160.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 5.5977
    Cell Significance Index: 4236.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2573
    Cell Significance Index: 245.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.8098
    Cell Significance Index: 111.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.3766
    Cell Significance Index: 26.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.2838
    Cell Significance Index: 2965.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6985
    Cell Significance Index: 24.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1295
    Cell Significance Index: 56.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.6656
    Cell Significance Index: 1221.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4419
    Cell Significance Index: 65.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.3908
    Cell Significance Index: 110.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3270
    Cell Significance Index: 252.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2464
    Cell Significance Index: 247.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0300
    Cell Significance Index: -56.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0390
    Cell Significance Index: -7.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1173
    Cell Significance Index: -8.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1547
    Cell Significance Index: -285.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1646
    Cell Significance Index: -59.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1884
    Cell Significance Index: -290.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2469
    Cell Significance Index: -5.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2597
    Cell Significance Index: -353.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3420
    Cell Significance Index: -217.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3427
    Cell Significance Index: -58.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.4192
    Cell Significance Index: -310.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4715
    Cell Significance Index: -24.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.5700
    Cell Significance Index: -321.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5952
    Cell Significance Index: -270.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.6455
    Cell Significance Index: -403.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9183
    Cell Significance Index: -51.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.9372
    Cell Significance Index: -92.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9720
    Cell Significance Index: -279.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1546
    Cell Significance Index: -70.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.1924
    Cell Significance Index: -193.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1967
    Cell Significance Index: -20.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4450
    Cell Significance Index: -165.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4468
    Cell Significance Index: -46.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9521
    Cell Significance Index: -283.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.9774
    Cell Significance Index: -416.5000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -2.4171
    Cell Significance Index: -6.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.4206
    Cell Significance Index: -152.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.6524
    Cell Significance Index: -44.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.6791
    Cell Significance Index: -66.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.8932
    Cell Significance Index: -17.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.1214
    Cell Significance Index: -325.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.3372
    Cell Significance Index: -57.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.7147
    Cell Significance Index: -31.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -4.0917
    Cell Significance Index: -245.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -4.1671
    Cell Significance Index: -62.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.1678
    Cell Significance Index: -319.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.5523
    Cell Significance Index: -279.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.6735
    Cell Significance Index: -101.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.6881
    Cell Significance Index: -315.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.7854
    Cell Significance Index: -65.2900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -5.4797
    Cell Significance Index: -29.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -6.0138
    Cell Significance Index: -313.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.0949
    Cell Significance Index: -175.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -6.3973
    Cell Significance Index: -282.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.4612
    Cell Significance Index: -190.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -7.3371
    Cell Significance Index: -143.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.8443
    Cell Significance Index: -287.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.8937
    Cell Significance Index: -298.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -8.4907
    Cell Significance Index: -298.3500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.5510
    Cell Significance Index: -110.1200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -9.2740
    Cell Significance Index: -42.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -9.3134
    Cell Significance Index: -304.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -9.3229
    Cell Significance Index: -96.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal Protein L34**: RPL34 is a 60S ribosomal protein that forms part of the large subunit of the ribosome, responsible for protein synthesis and translation. 2. **Cellular Expression**: RPL34 is highly expressed in epithelial cells of the exocrine pancreas, pancreatic acinar cells, and activated T-cells. 3. **Regulatory Mechanisms**: RPL34 expression is tightly regulated by various mechanisms, including transcriptional and post-transcriptional controls. 4. **Interactions with Other Proteins**: RPL34 interacts with other proteins, including translation initiation factors, to regulate protein synthesis and translation. **Pathways and Functions:** 1. **Translation Initiation**: RPL34 plays a crucial role in translation initiation, interacting with translation initiation factors to regulate protein synthesis. 2. **Cellular Responses to Stimuli**: RPL34 is involved in cellular responses to stimuli, including stress, starvation, and viral infection. 3. **Viral Infection**: RPL34 has been implicated in viral infection pathways, including influenza viral RNA transcription and replication. 4. **Axon Guidance**: RPL34 is involved in axon guidance, a critical process in neuronal development and function. 5. **Regulation of Expression**: RPL34 regulates the expression of other genes, including those involved in cellular responses to stimuli and viral infection. **Clinical Significance:** 1. **Cancer Research**: RPL34 has been identified as a potential biomarker for cancer diagnosis and prognosis. 2. **Infectious Diseases**: RPL34's involvement in viral infection pathways highlights its potential as a target for antiviral therapies. 3. **Neurological Disorders**: RPL34's role in axon guidance and neuronal development suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunology**: RPL34's expression in activated T-cells highlights its potential role in immune responses and immunotherapy. In conclusion, RPL34 is a multifaceted gene that plays a critical role in various cellular processes, including translation initiation, cellular responses to stimuli, and viral infection. Its clinical significance highlights the potential for RPL34 as a biomarker, therapeutic target, and diagnostic tool in various diseases. Further research is necessary to fully elucidate the mechanisms underlying RPL34's functions and to explore its therapeutic potential.

Genular Protein ID: 1334477984

Symbol: RL34_HUMAN

Name: 60S ribosomal protein L34

UniProtKB Accession Codes:

P49207 Q6FG66 Q9BUZ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DNASU 1 DisGeNET 1 EMBL 8 EMDB 70 Ensembl 5 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 85 PDBsum 85 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 117
  • Mass: 13293
  • Checksum: FC09D00B98CB770C
  • Sequence:
    • MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP GRLRGVRAVR 
PKVLMRLSKT KKHVSRAYGG SMCAKCVRDR IKRAFLIEEQ KIVVKVLKAQ AQSQKAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.