Details for: RPS12

Gene ID: 6206

Symbol: RPS12

Ensembl ID: ENSG00000112306

Description: ribosomal protein S12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 864.7702
    Cell Significance Index: -356.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 720.7237
    Cell Significance Index: -340.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 693.8963
    Cell Significance Index: -356.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 509.1933
    Cell Significance Index: -341.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 50.5514
    Cell Significance Index: -135.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.8652
    Cell Significance Index: 507.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 18.3664
    Cell Significance Index: 491.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 15.5282
    Cell Significance Index: 729.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 14.7030
    Cell Significance Index: 1501.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 13.4613
    Cell Significance Index: 172.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 12.6609
    Cell Significance Index: 292.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.6381
    Cell Significance Index: 362.2800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 12.1674
    Cell Significance Index: 32.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.7188
    Cell Significance Index: 121.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.3197
    Cell Significance Index: 1333.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 10.0697
    Cell Significance Index: 712.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.9229
    Cell Significance Index: 1220.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.8267
    Cell Significance Index: 1771.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.5597
    Cell Significance Index: 1312.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 9.4679
    Cell Significance Index: 4185.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 9.1707
    Cell Significance Index: 6941.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.0201
    Cell Significance Index: 4926.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.9223
    Cell Significance Index: 234.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 8.7747
    Cell Significance Index: 1034.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7250
    Cell Significance Index: 650.2700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.3917
    Cell Significance Index: 72.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.3828
    Cell Significance Index: 291.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.3149
    Cell Significance Index: 146.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.7157
    Cell Significance Index: 226.6000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.7151
    Cell Significance Index: 47.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.6072
    Cell Significance Index: 159.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 7.4315
    Cell Significance Index: 952.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.1187
    Cell Significance Index: 459.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.2258
    Cell Significance Index: 115.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4046
    Cell Significance Index: 251.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.2468
    Cell Significance Index: 57.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0766
    Cell Significance Index: 138.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.9903
    Cell Significance Index: 262.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.7998
    Cell Significance Index: 819.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.7368
    Cell Significance Index: 43.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.4280
    Cell Significance Index: 155.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2609
    Cell Significance Index: 87.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.9322
    Cell Significance Index: 2647.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.3784
    Cell Significance Index: 1743.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3391
    Cell Significance Index: 464.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.9285
    Cell Significance Index: 152.7400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.7789
    Cell Significance Index: 37.1000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3277
    Cell Significance Index: 7.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2111
    Cell Significance Index: 230.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6363
    Cell Significance Index: 62.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2732
    Cell Significance Index: 78.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0449
    Cell Significance Index: -84.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0585
    Cell Significance Index: -6.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1157
    Cell Significance Index: -213.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1367
    Cell Significance Index: -101.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1592
    Cell Significance Index: -8.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1596
    Cell Significance Index: -245.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2423
    Cell Significance Index: -329.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2977
    Cell Significance Index: -167.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3039
    Cell Significance Index: -189.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3392
    Cell Significance Index: -215.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.5787
    Cell Significance Index: -207.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6333
    Cell Significance Index: -287.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7185
    Cell Significance Index: -151.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.7430
    Cell Significance Index: -149.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1680
    Cell Significance Index: -71.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.2127
    Cell Significance Index: -197.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4214
    Cell Significance Index: -162.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5169
    Cell Significance Index: -85.1200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5511
    Cell Significance Index: -26.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6632
    Cell Significance Index: -115.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9513
    Cell Significance Index: -283.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.3787
    Cell Significance Index: -39.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.7534
    Cell Significance Index: -173.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.0248
    Cell Significance Index: -181.5900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.0790
    Cell Significance Index: -18.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.2441
    Cell Significance Index: -337.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -3.3825
    Cell Significance Index: -108.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.5640
    Cell Significance Index: -89.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.1531
    Cell Significance Index: -318.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.6076
    Cell Significance Index: -282.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -4.6388
    Cell Significance Index: -37.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.8176
    Cell Significance Index: -65.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.9060
    Cell Significance Index: -329.8800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.9240
    Cell Significance Index: -26.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -5.6700
    Cell Significance Index: -84.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -6.3206
    Cell Significance Index: -182.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -6.6890
    Cell Significance Index: -197.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -6.8226
    Cell Significance Index: -239.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -6.9673
    Cell Significance Index: -150.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.0923
    Cell Significance Index: -313.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -7.1648
    Cell Significance Index: -107.9700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -7.3045
    Cell Significance Index: -52.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.9070
    Cell Significance Index: -211.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -8.0991
    Cell Significance Index: -104.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -8.1500
    Cell Significance Index: -299.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -8.3619
    Cell Significance Index: -163.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.6172
    Cell Significance Index: -326.3100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -9.1929
    Cell Significance Index: -57.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -9.4137
    Cell Significance Index: -72.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS12 is a highly conserved protein, with high sequence similarity across species, suggesting its essential role in ribosome function. The protein is composed of 106 amino acids and is part of the 40S subunit, which is responsible for the initiation and elongation phases of translation. RPS12 is also known as RS12_HUMAN and is encoded by the RPS12 gene (ENSG00000112306). **Pathways and Functions** RPS12 is involved in various cellular processes, including: 1. **Translation initiation**: RPS12 plays a crucial role in the binding of the cap-binding complex to mRNA, which is essential for the initiation of translation. 2. **Eukaryotic translation elongation**: RPS12 is involved in the elongation phase of translation, where it interacts with other ribosomal proteins to facilitate the assembly of the 40S subunit. 3. **Axon guidance**: RPS12 has been implicated in the regulation of axon guidance, a process critical for the development and maintenance of the nervous system. 4. **Cellular responses to stimuli**: RPS12 is involved in the regulation of cellular responses to various stimuli, including stress, starvation, and viral infections. **Clinical Significance** Dysregulation of RPS12 has been implicated in various diseases, including: 1. **Influenza infection**: RPS12 has been shown to be involved in the regulation of host translation machinery in response to influenza virus infection. 2. **SARS-CoV-2 infection**: Similar to influenza, RPS12 has been implicated in the modulation of host translation machinery in response to SARS-CoV-2 infection. 3. **Cancer**: RPS12 has been found to be overexpressed in various types of cancer, suggesting its potential role in tumorigenesis. 4. **Neurological disorders**: RPS12 has been implicated in the regulation of axon guidance and neuronal development, making it a potential target for the treatment of neurological disorders. In conclusion, RPS12 is a crucial component of the 40S small subunit of the ribosome, playing a vital role in the translation of mRNA into proteins. Its dysregulation has been implicated in various diseases, including influenza, SARS-CoV-2, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms by which RPS12 regulates cellular processes and to explore its potential as a therapeutic target. **Clinical Implications** 1. **Diagnostic biomarkers**: RPS12 may serve as a diagnostic biomarker for influenza and SARS-CoV-2 infections. 2. **Therapeutic targets**: RPS12 may be a potential target for the development of therapeutic agents against cancer, neurological disorders, and infectious diseases. 3. **Immunotherapy**: RPS12 may be used as a target for immunotherapy, exploiting its role in regulating host translation machinery in response to viral infections. In summary, RPS12 is a critical component of the ribosome, playing a vital role in the translation of mRNA into proteins. Its dysregulation has been implicated in various diseases, making it a promising target for the development of diagnostic biomarkers and therapeutic agents.

Genular Protein ID: 1334009087

Symbol: RS12_HUMAN

Name: 40S ribosomal protein S12

UniProtKB Accession Codes:

P25398 Q76M58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 73 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 82 PDBsum 82 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1861993

Title: cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17.

PubMed ID: 1861993

DOI: 10.1093/nar/19.14.4001

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 132
  • Mass: 14515
  • Checksum: 45AD1274D55FFA25
  • Sequence:
    • MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM 
YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP RKVVGCSCVV VKDYGKESQA 
KDVIEEYFKC KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.