RPS15A | ENSG00000134419 | NCBI 6210

Details for: RPS15A

Gene ID: 6210

Symbol: RPS15A

Ensembl ID: ENSG00000134419

Description: ribosomal protein S15a

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Protein binding
(GO:0005515)
Response to virus
(GO:0009615)
Ribosomal small subunit biogenesis
(GO:0042274)
Rna binding
(GO:0003723)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 747.1096
Cell Significance Index: -307.7700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 689.8833
Cell Significance Index: -280.2700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 611.3771
Cell Significance Index: -288.6500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 601.3295
Cell Significance Index: -309.3200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 432.3106
Cell Significance Index: -290.0900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 298.2688
Cell Significance Index: -284.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.9859
Cell Significance Index: -99.0800
Cell Name: pro-T cell (CL0000827)
Fold Change: 19.4714
Cell Significance Index: 497.4300
Cell Name: theca cell (CL0000503)
Fold Change: 18.0357
Cell Significance Index: 105.9600
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 16.9567
Cell Significance Index: 45.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: 16.1662
Cell Significance Index: 1651.3800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 14.8299
Cell Significance Index: 396.6900
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 13.9392
Cell Significance Index: 178.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 13.1899
Cell Significance Index: 619.9100
Cell Name: granulosa cell (CL0000501)
Fold Change: 12.7431
Cell Significance Index: 335.0800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 12.6455
Cell Significance Index: 264.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 11.8605
Cell Significance Index: 339.9900
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 10.7318
Cell Significance Index: 189.6500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 10.0959
Cell Significance Index: 350.8300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 10.0005
Cell Significance Index: 113.6100
Cell Name: lactocyte (CL0002325)
Fold Change: 9.8985
Cell Significance Index: 1278.8200
Cell Name: peg cell (CL4033014)
Fold Change: 9.4419
Cell Significance Index: 218.1400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.3219
Cell Significance Index: 1280.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 9.2410
Cell Significance Index: 653.5600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 8.8989
Cell Significance Index: 1094.2000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.5931
Cell Significance Index: 1013.3900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 8.4841
Cell Significance Index: 1529.4100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.3964
Cell Significance Index: 91.2800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 8.3892
Cell Significance Index: 246.3800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.0822
Cell Significance Index: 602.3600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 8.0581
Cell Significance Index: 148.9400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 8.0402
Cell Significance Index: 3554.7600
Cell Name: cell in vitro (CL0001034)
Fold Change: 7.4035
Cell Significance Index: 4043.2400
Cell Name: odontoblast (CL0000060)
Fold Change: 6.8863
Cell Significance Index: 882.7800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.4991
Cell Significance Index: 419.2900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 6.0560
Cell Significance Index: 37.2700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.6922
Cell Significance Index: 218.7700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.1985
Cell Significance Index: 114.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.1029
Cell Significance Index: 700.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 3.7585
Cell Significance Index: 2844.8600
Cell Name: kidney cell (CL1000497)
Fold Change: 3.5952
Cell Significance Index: 28.7100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.9163
Cell Significance Index: 25.0600
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 2.7695
Cell Significance Index: 57.7600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.5878
Cell Significance Index: 2336.5500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3239
Cell Significance Index: 21.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.6332
Cell Significance Index: 85.7500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3434
Cell Significance Index: 35.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2517
Cell Significance Index: 65.2000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1186
Cell Significance Index: 212.8800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8369
Cell Significance Index: 37.9400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.7233
Cell Significance Index: 530.3000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1814
Cell Significance Index: 36.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1803
Cell Significance Index: 17.8400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1485
Cell Significance Index: 4.2800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1037
Cell Significance Index: -195.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1083
Cell Significance Index: -80.1900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1602
Cell Significance Index: -295.4900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1733
Cell Significance Index: -108.1900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1931
Cell Significance Index: -297.3200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2114
Cell Significance Index: -60.8300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.2427
Cell Significance Index: -330.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2453
Cell Significance Index: -138.3500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3017
Cell Significance Index: -15.6700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.3973
Cell Significance Index: -274.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.4098
Cell Significance Index: -260.2700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.4449
Cell Significance Index: -159.5900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5776
Cell Significance Index: -121.6600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.5935
Cell Significance Index: -269.3900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.7289
Cell Significance Index: -146.2200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8793
Cell Significance Index: -60.8100
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.9490
Cell Significance Index: -16.3600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.2069
Cell Significance Index: -137.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.2499
Cell Significance Index: -70.1400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2614
Cell Significance Index: -99.9000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.2816
Cell Significance Index: -146.8300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.3252
Cell Significance Index: -81.4600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -1.5095
Cell Significance Index: -245.5100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.5608
Cell Significance Index: -9.4300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.5861
Cell Significance Index: -26.5500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7731
Cell Significance Index: -56.7900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.9138
Cell Significance Index: -278.1900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.1480
Cell Significance Index: -135.3800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.3271
Cell Significance Index: -58.1700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -2.3606
Cell Significance Index: -141.7200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.8317
Cell Significance Index: -294.8500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -2.9945
Cell Significance Index: -45.1300
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -3.2167
Cell Significance Index: -17.5400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.5211
Cell Significance Index: -270.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.0539
Cell Significance Index: -248.5400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.3633
Cell Significance Index: -65.3800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -4.4574
Cell Significance Index: -299.7200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.6343
Cell Significance Index: -100.4000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -4.7745
Cell Significance Index: -167.7700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -4.8645
Cell Significance Index: -66.3700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.8762
Cell Significance Index: -173.0800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.1566
Cell Significance Index: -272.3200
Cell Name: perivascular cell (CL4033054)
Fold Change: -6.3653
Cell Significance Index: -29.3900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -6.3657
Cell Significance Index: -109.0900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -6.9281
Cell Significance Index: -254.3300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -7.3163
Cell Significance Index: -277.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RPS15A is a 15-kDa protein that belongs to the ribosomal protein S15 family. It is a structural component of the 40S small ribosomal subunit, which is responsible for the initiation of translation. RPS15A is characterized by its high degree of conservation across species, suggesting its essential role in eukaryotic translation. The protein exhibits a high degree of specificity for the mRNA cap-binding complex and eIFs, facilitating the recruitment of the 43S complex and the initiation of translation. **Pathways and Functions:** RPS15A is involved in several key pathways, including: 1. **Translation Initiation:** RPS15A plays a crucial role in the initiation of translation by binding to the mRNA cap-binding complex and eIFs, facilitating the recruitment of the 43S complex and the recognition of the start codon. 2. **Axon Guidance:** RPS15A is implicated in axon guidance, a critical process in the development of the nervous system. 3. **Cellular Responses to Stimuli:** RPS15A is involved in cellular responses to stimuli, including stress responses and responses to amino acid deficiency. 4. **Ribosomal Biogenesis:** RPS15A is involved in the biogenesis of the 40S small ribosomal subunit, which is essential for protein synthesis. **Clinical Significance:** RPS15A has been implicated in various diseases and disorders, including: 1. **Influenza Infections:** RPS15A has been shown to be a target of the influenza virus, which modulates host translation machinery to facilitate viral replication. 2. **SARS-CoV-1 and SARS-CoV-2 Infections:** RPS15A has been implicated in the modulation of host translation machinery by SARS-CoV-1 and SARS-CoV-2, which are responsible for severe respiratory illnesses. 3. **Cancer:** RPS15A has been shown to be overexpressed in various types of cancer, suggesting its potential role in tumorigenesis. In conclusion, RPS15A is a critical component of the 40S small ribosomal subunit in eukaryotic cells, playing a pivotal role in translation initiation and beyond. Its involvement in various cellular processes and its implication in disease suggests its potential as a therapeutic target for various diseases and disorders. Further research is necessary to fully elucidate the molecular mechanisms of RPS15A and its role in eukaryotic translation and beyond.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S15a

Genular Protein ID: 3619883915

Symbol: RS15A_HUMAN

Name: 40S ribosomal protein S15a

UniProtKB Accession Codes:

P62244 P39027 P39031 Q3MHD9 Q8C023 Q9BV24

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 8185605

Title: The primary structure of rat ribosomal protein S15a.

PubMed ID: 8185605

DOI: 10.1006/bbrc.1994.1620

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27909223

Title: Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.

PubMed ID: 27909223

DOI: 10.3324/haematol.2016.153932

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 130
Mass: 14840
Checksum: D4AC1E8864E3A184
Sequence:

MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK 
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH 
TGGKILGFFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS15A

Associated with

Cells (max top 100)

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

The primary structure of rat ribosomal protein S15a. PubMed ID: 8185605

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia. PubMed ID: 27909223

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797