Gene RPS15A - ENSG00000134419 | NCBI Gene ID: 6210

Details for: RPS15A

Gene ID: 6210

Symbol: RPS15A

Ensembl ID: ENSG00000134419

Description: ribosomal protein S15a

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Protein binding
(GO:0005515)
Response to virus
(GO:0009615)
Ribosomal small subunit biogenesis
(GO:0042274)
Rna binding
(GO:0003723)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 6.39
Marker Score: 3599
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.07
Marker Score: 29826
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.9
Marker Score: 4277.5
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.71
Marker Score: 2932
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.62
Marker Score: 11784
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.44
Marker Score: 15863
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.42
Marker Score: 7057
Cell Name: malignant cell (CL0001064)
Fold Change: 5.41
Marker Score: 72658
Cell Name: mature T cell (CL0002419)
Fold Change: 5.36
Marker Score: 53077
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.23
Marker Score: 2700
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.18
Marker Score: 8891
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 5.17
Marker Score: 4047
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.13
Marker Score: 1893
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.09
Marker Score: 4333
Cell Name: theca cell (CL0000503)
Fold Change: 5.08
Marker Score: 3640
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.04
Marker Score: 171633
Cell Name: naive B cell (CL0000788)
Fold Change: 4.88
Marker Score: 4359
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.88
Marker Score: 15395
Cell Name: memory T cell (CL0000813)
Fold Change: 4.87
Marker Score: 2093
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.78
Marker Score: 3610
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.78
Marker Score: 252641
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.74
Marker Score: 7297
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.73
Marker Score: 12032
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.69
Marker Score: 24675
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.6
Marker Score: 2452
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.55
Marker Score: 5059
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.53
Marker Score: 59689
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.51
Marker Score: 1466
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.5
Marker Score: 251668
Cell Name: blood cell (CL0000081)
Fold Change: 4.38
Marker Score: 50881
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.37
Marker Score: 2661
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.37
Marker Score: 26550
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.37
Marker Score: 1043
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.31
Marker Score: 11910
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.26
Marker Score: 11949
Cell Name: naive T cell (CL0000898)
Fold Change: 4.24
Marker Score: 2729
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.22
Marker Score: 10316
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.2
Marker Score: 4061
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.16
Marker Score: 2438
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.15
Marker Score: 9459
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 4.13
Marker Score: 2590
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.12
Marker Score: 10054
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.1
Marker Score: 3498
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.1
Marker Score: 30518
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.1
Marker Score: 6037
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.1
Marker Score: 17572
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.1
Marker Score: 2913
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.06
Marker Score: 3188
Cell Name: supporting cell (CL0000630)
Fold Change: 4.05
Marker Score: 7616
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.02
Marker Score: 26187
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.01
Marker Score: 3949
Cell Name: club cell (CL0000158)
Fold Change: 4
Marker Score: 4675
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.97
Marker Score: 4236
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.96
Marker Score: 10622.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.94
Marker Score: 4240
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.93
Marker Score: 25045
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.89
Marker Score: 13816
Cell Name: granulocyte (CL0000094)
Fold Change: 3.88
Marker Score: 1739
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.88
Marker Score: 1772
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.86
Marker Score: 3320
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.85
Marker Score: 3155
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.84
Marker Score: 3613
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.84
Marker Score: 3373
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.84
Marker Score: 4741
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.84
Marker Score: 880
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.82
Marker Score: 1258
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.81
Marker Score: 4218
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.81
Marker Score: 1974
Cell Name: papillary tips cell (CL1000597)
Fold Change: 3.79
Marker Score: 764
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.78
Marker Score: 996
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.78
Marker Score: 2087
Cell Name: reticular cell (CL0000432)
Fold Change: 3.78
Marker Score: 1380
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.77
Marker Score: 2533
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.76
Marker Score: 3352
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.76
Marker Score: 2162
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.75
Marker Score: 3335
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.75
Marker Score: 3305
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.74
Marker Score: 3109
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.74
Marker Score: 2503
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.74
Marker Score: 2831
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.73
Marker Score: 9297
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.73
Marker Score: 4263
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.72
Marker Score: 24199
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.71
Marker Score: 1045
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.7
Marker Score: 4457
Cell Name: memory B cell (CL0000787)
Fold Change: 3.7
Marker Score: 2797
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.67
Marker Score: 1043
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.67
Marker Score: 5842
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.67
Marker Score: 3721
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.67
Marker Score: 8324
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.66
Marker Score: 2254
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.66
Marker Score: 1261
Cell Name: immature B cell (CL0000816)
Fold Change: 3.65
Marker Score: 2417
Cell Name: microglial cell (CL0000129)
Fold Change: 3.64
Marker Score: 6634
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.63
Marker Score: 845
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.63
Marker Score: 961
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.63
Marker Score: 21508.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.62
Marker Score: 3415.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.62
Marker Score: 2120
Cell Name: paneth cell (CL0000510)
Fold Change: 3.62
Marker Score: 2516

Hover over a box to see details here...

**Key characteristics:** - The protein is a component of the ribosome, which is responsible for protein synthesis. - It is expressed in a variety of cell types, including epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, activated CD8+ T cells, natural T-regulatory cells, and malignant cells. - It is a highly conserved protein with a similar sequence in mammals and humans. **Pathways and functions:** - The protein is involved in the initiation, elongation, and termination of protein synthesis. - It is also involved in the processing and targeting of mRNA to the ribosome. - It is a key regulator of protein translation, and its expression is often linked to cell growth, differentiation, and apoptosis. **Clinical significance:** - Mutations in the RPS15A gene have been linked to several human diseases, including pancreatic cancer, breast cancer, and leukemia. - These mutations can lead to the overexpression of the protein, which can result in cell growth and cancer. - Targeting the RPS15A gene is a promising new approach for the treatment of these diseases. **Additional information:** - The gene is located on chromosome 15q21.1. - It is a member of the RPS15 family of ribosomal proteins. - It is involved in the regulation of gene expression through post-translational modifications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S15a

Genular Protein ID: 3619883915

Symbol: RS15A_HUMAN

Name: 40S ribosomal protein S15a

UniProtKB Accession Codes:

P62244 P39027 P39031 Q3MHD9 Q8C023 Q9BV24

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 8185605

Title: The primary structure of rat ribosomal protein S15a.

PubMed ID: 8185605

DOI: 10.1006/bbrc.1994.1620

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27909223

Title: Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.

PubMed ID: 27909223

DOI: 10.3324/haematol.2016.153932

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 130
Mass: 14840
Checksum: D4AC1E8864E3A184
Sequence:

MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK 
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH 
TGGKILGFFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS15A

Associated with

Cells (max top 100)

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

The primary structure of rat ribosomal protein S15a. PubMed ID: 8185605

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia. PubMed ID: 27909223

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797