Gene RPS27 - ENSG00000177954 | NCBI Gene ID: 6232

Details for: RPS27

Gene ID: 6232

Symbol: RPS27

Ensembl ID: ENSG00000177954

Description: ribosomal protein S27

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by robo receptors
(R-HSA-376176)
Signal transduction
(R-HSA-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Dna binding
(GO:0003677)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 8.71
Marker Score: 4911
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.29
Marker Score: 30874
Cell Name: malignant cell (CL0001064)
Fold Change: 5.99
Marker Score: 80464
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.96
Marker Score: 4327
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.78
Marker Score: 2970
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.62
Marker Score: 11772
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.61
Marker Score: 2896
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.52
Marker Score: 7189
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.5
Marker Score: 16056
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.37
Marker Score: 1980
Cell Name: mature T cell (CL0002419)
Fold Change: 5.37
Marker Score: 53147
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 5.24
Marker Score: 13326
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.2
Marker Score: 8928
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.17
Marker Score: 4404
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.15
Marker Score: 175337
Cell Name: theca cell (CL0000503)
Fold Change: 5.15
Marker Score: 3691
Cell Name: naive B cell (CL0000788)
Fold Change: 5.02
Marker Score: 4486.5
Cell Name: memory T cell (CL0000813)
Fold Change: 4.97
Marker Score: 2137
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.95
Marker Score: 26027
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.86
Marker Score: 15348
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.79
Marker Score: 253103
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.65
Marker Score: 5169
Cell Name: naive T cell (CL0000898)
Fold Change: 4.64
Marker Score: 2991
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.62
Marker Score: 1104
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.61
Marker Score: 1500
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.59
Marker Score: 7075
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.51
Marker Score: 59435
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.5
Marker Score: 251841
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 4.42
Marker Score: 3350
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.41
Marker Score: 2684
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.41
Marker Score: 26790
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.4
Marker Score: 11803
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.38
Marker Score: 27916
Cell Name: blood cell (CL0000081)
Fold Change: 4.34
Marker Score: 50477
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.34
Marker Score: 11982
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.33
Marker Score: 3078
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.26
Marker Score: 11964
Cell Name: acinar cell (CL0000622)
Fold Change: 4.25
Marker Score: 2997
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 4.24
Marker Score: 1761
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.22
Marker Score: 4082
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 4.22
Marker Score: 5087
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.22
Marker Score: 10312.5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.22
Marker Score: 2472
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.18
Marker Score: 5051
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.18
Marker Score: 9517
Cell Name: club cell (CL0000158)
Fold Change: 4.16
Marker Score: 4862
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.13
Marker Score: 14668.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.11
Marker Score: 3879
Cell Name: supporting cell (CL0000630)
Fold Change: 4.11
Marker Score: 7724
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.11
Marker Score: 10019
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.1
Marker Score: 6037
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.09
Marker Score: 4370
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.09
Marker Score: 17543
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.09
Marker Score: 3487
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.07
Marker Score: 933
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.06
Marker Score: 3184
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 4.06
Marker Score: 3491
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.06
Marker Score: 26437
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.05
Marker Score: 30182
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 4.03
Marker Score: 4333
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 4.02
Marker Score: 4959
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.01
Marker Score: 5807
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 4.01
Marker Score: 3947
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 4.01
Marker Score: 3562
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 4
Marker Score: 1828
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 4
Marker Score: 1052
Cell Name: fibroblast (CL0000057)
Fold Change: 3.99
Marker Score: 3857
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.97
Marker Score: 2997
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 3.97
Marker Score: 2487
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.96
Marker Score: 1115
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.94
Marker Score: 9803.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.93
Marker Score: 2034
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.92
Marker Score: 3978
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.91
Marker Score: 1111
Cell Name: paneth cell (CL0000510)
Fold Change: 3.91
Marker Score: 2723
Cell Name: reticular cell (CL0000432)
Fold Change: 3.91
Marker Score: 1426
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.9
Marker Score: 5661
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.89
Marker Score: 3189
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.89
Marker Score: 3417
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.88
Marker Score: 3425
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.88
Marker Score: 4291
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.86
Marker Score: 1056
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.86
Marker Score: 3629
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.86
Marker Score: 2219
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.83
Marker Score: 3419
Cell Name: granulocyte (CL0000094)
Fold Change: 3.83
Marker Score: 1715
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.82
Marker Score: 1257
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.82
Marker Score: 3421
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.82
Marker Score: 2567
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.81
Marker Score: 3165
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.81
Marker Score: 2031
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.8
Marker Score: 1083
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.78
Marker Score: 881
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.78
Marker Score: 2085
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.77
Marker Score: 999
Cell Name: memory B cell (CL0000787)
Fold Change: 3.75
Marker Score: 2840
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.75
Marker Score: 4290
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.75
Marker Score: 932
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.74
Marker Score: 5954
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.73
Marker Score: 1104

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## Summary RS27 is a ribosomal protein that plays a crucial role in eukaryotic translation elongation. It is involved in the initiation, elongation, and termination of translation. It is highly expressed in various cell types, including epithelial cells of the exocrine pancreas, myoepithelial cells of the mammary gland, malignant cells, activated CD8+ T cells, natural T-regulatory cells, and NKp46+ innate lymphoid cells. ## Key characteristics * RS27 is a 40S ribosomal protein. * It is a key component of the eukaryotic translation initiation complex. * It forms a complex with other ribosomal proteins, including RS27L and eIF4G. * It is involved in the recognition of the AUG start codon and the initiation of translation. * It is also involved in the termination of translation by interacting with release factors. ## Pathways and functions RS27 is involved in multiple pathways and functions, including: * **Cell cycle:** It is expressed in cells that are actively dividing. It is involved in the initiation of translation of mRNA that is being synthesized during cell cycle. * **Cell cycle checkpoints:** It is expressed in cells that are in G1 phase of the cell cycle. It is involved in the monitoring of cell cycle checkpoints and the initiation of cell cycle arrest or apoptosis if DNA damage is detected. * **Developmental biology:** It is expressed in cells during organogenesis. It is involved in the specification of cell fate and the development of tissues and organs. * **Disease:** RS27 is overexpressed in many human cancers. It is involved in the proliferation and survival of cancer cells. ## Clinical significance Mutations in RS27 have been linked to several human diseases, including cancer and neurodegenerative disorders. In cancer, RS27 mutations can lead to the activation of oncogenes, the inhibition of tumor suppressor genes, and the formation of tumors. In neurodegenerative disorders, RS27 mutations can lead to the accumulation of misfolded proteins, which can damage neurons and contribute to neurodegenerative diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S27

Genular Protein ID: 4260677873

Symbol: RS27_HUMAN

Name: 40S ribosomal protein S27

UniProtKB Accession Codes:

P42677 Q5T4L6

Database IDs:

Citations:

PubMed ID: 8407955

Title: A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure.

PubMed ID: 8407955

DOI: 10.1016/s0021-9258(19)36910-8

PubMed ID: 8908372

Title: Primary structures and sequence analysis of human ribosomal proteins L39 and S27.

PubMed ID: 8908372

DOI: 10.1080/15216549600201203

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25424902

Title: Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.

PubMed ID: 25424902

DOI: 10.1111/bjh.13229

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 84
Mass: 9461
Checksum: 242C4466AC8A8900
Sequence:

MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS 
TVLCQPTGGK ARLTEGCSFR RKQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS27

Associated with

Cells (max top 100)

Other Information

A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure. PubMed ID: 8407955

Primary structures and sequence analysis of human ribosomal proteins L39 and S27. PubMed ID: 8908372

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. PubMed ID: 25424902

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797