Details for: SARS1

Gene ID: 6301

Symbol: SARS1

Ensembl ID: ENSG00000031698

Description: seryl-tRNA synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 316.3067
    Cell Significance Index: -49.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 210.8275
    Cell Significance Index: -53.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.3260
    Cell Significance Index: -57.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.0054
    Cell Significance Index: -59.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.6994
    Cell Significance Index: -49.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 111.4923
    Cell Significance Index: -57.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.8045
    Cell Significance Index: -49.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.7380
    Cell Significance Index: -55.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4904
    Cell Significance Index: -57.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.7701
    Cell Significance Index: -33.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0743
    Cell Significance Index: -19.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2736
    Cell Significance Index: 87.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9745
    Cell Significance Index: 103.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6398
    Cell Significance Index: 44.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5860
    Cell Significance Index: 195.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3736
    Cell Significance Index: 247.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2989
    Cell Significance Index: 178.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2915
    Cell Significance Index: 259.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0891
    Cell Significance Index: 31.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0773
    Cell Significance Index: 50.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0239
    Cell Significance Index: 76.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0230
    Cell Significance Index: 70.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9825
    Cell Significance Index: 434.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9317
    Cell Significance Index: 43.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9271
    Cell Significance Index: 65.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9121
    Cell Significance Index: 498.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8817
    Cell Significance Index: 113.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8668
    Cell Significance Index: 111.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8004
    Cell Significance Index: 41.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6456
    Cell Significance Index: 231.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6425
    Cell Significance Index: 127.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6424
    Cell Significance Index: 29.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5717
    Cell Significance Index: 5.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5677
    Cell Significance Index: 29.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5551
    Cell Significance Index: 11.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5414
    Cell Significance Index: 11.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5029
    Cell Significance Index: 13.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4563
    Cell Significance Index: 74.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4441
    Cell Significance Index: 400.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3763
    Cell Significance Index: 24.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3233
    Cell Significance Index: 223.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3108
    Cell Significance Index: 36.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3102
    Cell Significance Index: 30.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2603
    Cell Significance Index: 49.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2587
    Cell Significance Index: 13.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2566
    Cell Significance Index: 16.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1516
    Cell Significance Index: 114.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0981
    Cell Significance Index: 16.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0547
    Cell Significance Index: 103.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0518
    Cell Significance Index: 1.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0233
    Cell Significance Index: 0.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0164
    Cell Significance Index: 30.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0146
    Cell Significance Index: 22.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0033
    Cell Significance Index: 4.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0270
    Cell Significance Index: -17.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0580
    Cell Significance Index: -26.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0624
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0633
    Cell Significance Index: -46.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0848
    Cell Significance Index: -6.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0853
    Cell Significance Index: -48.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1003
    Cell Significance Index: -1.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1047
    Cell Significance Index: -2.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1096
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1109
    Cell Significance Index: -69.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1129
    Cell Significance Index: -1.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1591
    Cell Significance Index: -45.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1595
    Cell Significance Index: -18.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1867
    Cell Significance Index: -1.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2080
    Cell Significance Index: -2.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2130
    Cell Significance Index: -14.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2174
    Cell Significance Index: -13.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2252
    Cell Significance Index: -32.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2335
    Cell Significance Index: -1.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2416
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2931
    Cell Significance Index: -61.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3095
    Cell Significance Index: -1.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3598
    Cell Significance Index: -20.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4178
    Cell Significance Index: -7.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4225
    Cell Significance Index: -10.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4537
    Cell Significance Index: -6.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4792
    Cell Significance Index: -49.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5179
    Cell Significance Index: -41.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5218
    Cell Significance Index: -13.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5317
    Cell Significance Index: -15.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5604
    Cell Significance Index: -22.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6467
    Cell Significance Index: -9.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6507
    Cell Significance Index: -28.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7012
    Cell Significance Index: -42.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7163
    Cell Significance Index: -13.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7334
    Cell Significance Index: -6.1600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.7730
    Cell Significance Index: -5.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7838
    Cell Significance Index: -29.6800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.7840
    Cell Significance Index: -3.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7886
    Cell Significance Index: -18.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8179
    Cell Significance Index: -6.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9673
    Cell Significance Index: -20.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9707
    Cell Significance Index: -26.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine-tRNA Synthetase Activity:** SARS1 is a cytoplasmic enzyme that catalyzes the attachment of serine to its corresponding tRNA molecule, enabling its incorporation into proteins. 2. **Aminoacyl-tRNA Synthetase Family:** As a member of this family, SARS1 shares a common structural and functional framework with other aminoacyl-tRNA synthetases, which are essential for protein synthesis. 3. **Serine Metabolism:** SARS1 plays a critical role in serine metabolism, influencing the availability of serine for protein synthesis, angiogenesis, and other cellular processes. 4. **Interconnected Metabolic Pathways:** SARS1's involvement in serine metabolism intersects with other metabolic pathways, including protein synthesis, angiogenesis, and vascular endothelial growth factor production. **Pathways and Functions:** 1. **Serine Metabolism:** SARS1 is involved in the biosynthesis of serine, which is a non-essential amino acid essential for various cellular processes, including protein synthesis and angiogenesis. 2. **Protein Synthesis:** SARS1's activity enables the incorporation of serine into proteins, which is crucial for maintaining protein structure and function. 3. **Angiogenesis:** SARS1's role in serine metabolism influences angiogenesis, a process essential for tissue growth and development. 4. **Vascular Endothelial Growth Factor (VEGF) Production:** SARS1's activity is also linked to the regulation of VEGF production, a key regulator of angiogenesis. 5. **Cell Signaling and Regulation:** SARS1's involvement in serine metabolism and protein synthesis influences cell signaling and regulation, including the negative regulation of transcription by RNA polymerase II and the negative regulation of vascular endothelial growth factor production. **Clinical Significance:** 1. **Serine Deficiency:** Abnormalities in SARS1 activity or expression may lead to serine deficiency, which can result in various clinical manifestations, including growth retardation, developmental delays, and increased risk of infections. 2. **Cancer and Angiogenesis:** Altered SARS1 activity or expression may contribute to cancer progression and angiogenesis, highlighting the potential of SARS1 as a therapeutic target. 3. **Neurological Disorders:** SARS1's involvement in serine metabolism and protein synthesis may also influence the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Pregnancy and Fetal Development:** SARS1's expression in placental villous trophoblasts highlights its importance in fetal development and pregnancy outcomes. In conclusion, SARS1 is a multifunctional enzyme that plays a critical role in serine metabolism, protein synthesis, and angiogenesis. Its involvement in various cellular processes underscores its importance in maintaining cellular homeostasis and function. Further research on SARS1 is necessary to elucidate its mechanisms of action and its role in various diseases, ultimately paving the way for the development of novel therapeutic strategies.

Genular Protein ID: 3661051730

Symbol: SYSC_HUMAN

Name: Serine--tRNA ligase, cytoplasmic

UniProtKB Accession Codes:

P49591 B2R6Y9 Q5T5C8 Q9NSE3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9431993

Title: Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase.

PubMed ID: 9431993

DOI: 10.1111/j.1432-1033.1997.00077.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19423848

Title: Noncanonical activity of seryl-tRNA synthetase is involved in vascular development.

PubMed ID: 19423848

DOI: 10.1161/circresaha.108.191189

PubMed ID: 19423847

Title: Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development.

PubMed ID: 19423847

DOI: 10.1161/circresaha.108.191718

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24940000

Title: tRNA synthetase counteracts c-Myc to develop functional vasculature.

PubMed ID: 24940000

DOI: 10.7554/elife.02349

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28655767

Title: Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.

PubMed ID: 28655767

DOI: 10.1074/jbc.m117.798298

PubMed ID: 34268557

Title: Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.

PubMed ID: 34268557

DOI: 10.1093/nar/gkab603

PubMed ID: 22353712

Title: Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.

PubMed ID: 22353712

DOI: 10.1038/ncomms1686

PubMed ID: 24095058

Title: Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes.

PubMed ID: 24095058

DOI: 10.1016/j.str.2013.08.021

PubMed ID: 26433229

Title: SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis.

PubMed ID: 26433229

DOI: 10.1093/nar/gkv996

PubMed ID: 28236339

Title: Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the aetiology of autosomal recessive intellectual disability.

PubMed ID: 28236339

DOI: 10.1002/humu.23205

PubMed ID: 34570399

Title: A bi-allelic loss-of-function SARS1 variant in children with neurodevelopmental delay, deafness, cardiomyopathy, and decompensation during fever.

PubMed ID: 34570399

DOI: 10.1002/humu.24285

PubMed ID: 35790048

Title: WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly.

PubMed ID: 35790048

DOI: 10.1002/humu.24430

PubMed ID: 36041817

Title: Loss of seryl-tRNA synthetase (SARS1) causes complex spastic paraplegia and cellular senescence.

PubMed ID: 36041817

DOI: 10.1136/jmg-2022-108529

Sequence Information:

  • Length: 514
  • Mass: 58777
  • Checksum: F59DA8E55F193ACB
  • Sequence:
    • MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC 
SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE 
RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF 
EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL 
SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC 
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH 
IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV 
EFVHMLNATM CATTRTICAI LENYQTEKGI TVPEKLKEFM PPGLQELIPF VKPAPIEQEP 
SKKQKKQHEG SKKKAAARDV TLENRLQNME VTDA

Genular Protein ID: 3323427564

Symbol: Q5T5C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T5C7

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 SAM 1 SMR 1 SUPFAM 2 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 536
  • Mass: 61313
  • Checksum: 8ADA07F1F6E88A04
  • Sequence:
    • MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC 
SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE 
RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF 
EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL 
SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC 
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH 
IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKR 
KNNLHLSTQN KLEASLFSPK KVEFVHMLNA TMCATTRTIC AILENYQTEK GITVPEKLKE 
FMPPGLQELI PFVKPAPIEQ EPSKKQKKQH EGSKKKAAAR DVTLENRLQN MEVTDA

Genular Protein ID: 4143985308

Symbol: Q0VGA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0VGA5

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 21 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 5 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMR 1 SUPFAM 2 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 511
  • Mass: 58407
  • Checksum: 9169FB4B37CD4DEF
  • Sequence:
    • MVLDLDLFRV DKGGDPALIR ETQEKRFKDP GLVDQLVKAD SEWRRCRFRA DNLNKLKNLC 
SKTIGEKMKK KEPVGDDESV PENVLSFDDL TADALANLKV SQIKKVRLLI DEAILKCDAE 
RIKLEAERFE NLREIGNLLH PSVPISNDED VDNKVERIWG DCTVRKKYSH VDLVVMVDGF 
EGEKGAVVAG SRGYFLKGVL VFLEQALIQY ALRTLGSRGY IPIYTPFFMR KEVMQEVAQL 
SQFDEELYKV IGKGSEKSDD NSYDEKYLIA TSEQPIAALH RDEWLRPEDL PIKYAGLSTC 
FRQEVGSHGR DTRGIFRVHQ FEKIEQFVYS SPHDNKSWEM FEEMITTAEE FYQSLGIPYH 
IVNIVSGSLN HAASKKLDLE AWFPGSGAFR ELVSCSNCTD YQARRLRIRY GQTKKMMDKV 
EFVHMLNATM CATTRTICAI LENYQTEKGI TVPEKFMPPG LQELIPFVKP APIEQEPSKK 
QKKQHEGSKK KAAARDVTLE NRLQNMEVTD A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.