Details for: SELPLG

Gene ID: 6404

Symbol: SELPLG

Ensembl ID: ENSG00000110876

Description: selectin P ligand

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.6395
    Cell Significance Index: -8.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.4102
    Cell Significance Index: -13.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.3004
    Cell Significance Index: -5.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.1394
    Cell Significance Index: -10.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.1860
    Cell Significance Index: -8.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6645
    Cell Significance Index: 166.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3921
    Cell Significance Index: -13.4900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.7726
    Cell Significance Index: 8.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3783
    Cell Significance Index: -9.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3348
    Cell Significance Index: -5.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2470
    Cell Significance Index: 41.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7059
    Cell Significance Index: -4.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2982
    Cell Significance Index: 28.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1072
    Cell Significance Index: 210.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8571
    Cell Significance Index: 84.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7508
    Cell Significance Index: 677.8900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7111
    Cell Significance Index: 7.1300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4613
    Cell Significance Index: 3.0600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3845
    Cell Significance Index: 1.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3764
    Cell Significance Index: 61.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3329
    Cell Significance Index: 8.9100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.3154
    Cell Significance Index: 0.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3097
    Cell Significance Index: 33.6900
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2697
    Cell Significance Index: 2.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2587
    Cell Significance Index: 5.5100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1947
    Cell Significance Index: 2.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1664
    Cell Significance Index: 11.5100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0125
    Cell Significance Index: 0.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0049
    Cell Significance Index: 2.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0058
    Cell Significance Index: -10.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0062
    Cell Significance Index: -0.1600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0064
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0070
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0123
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0191
    Cell Significance Index: -14.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0210
    Cell Significance Index: -13.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0214
    Cell Significance Index: -0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0234
    Cell Significance Index: -10.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0237
    Cell Significance Index: -6.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0246
    Cell Significance Index: -4.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0330
    Cell Significance Index: -6.5500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0367
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0497
    Cell Significance Index: -10.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0498
    Cell Significance Index: -5.8000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0551
    Cell Significance Index: -0.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0556
    Cell Significance Index: -10.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0574
    Cell Significance Index: -2.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0592
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0606
    Cell Significance Index: -10.3500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0665
    Cell Significance Index: -0.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0671
    Cell Significance Index: -4.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0683
    Cell Significance Index: -2.8000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0694
    Cell Significance Index: -0.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0770
    Cell Significance Index: -9.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0821
    Cell Significance Index: -10.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0842
    Cell Significance Index: -12.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0846
    Cell Significance Index: -0.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0871
    Cell Significance Index: -9.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0891
    Cell Significance Index: -11.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0901
    Cell Significance Index: -10.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0912
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1002
    Cell Significance Index: -7.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1052
    Cell Significance Index: -1.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1186
    Cell Significance Index: -1.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1249
    Cell Significance Index: -2.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1336
    Cell Significance Index: -5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1343
    Cell Significance Index: -6.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1359
    Cell Significance Index: -17.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1371
    Cell Significance Index: -9.2200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1414
    Cell Significance Index: -1.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1456
    Cell Significance Index: -10.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1528
    Cell Significance Index: -9.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1553
    Cell Significance Index: -10.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1574
    Cell Significance Index: -9.9200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1584
    Cell Significance Index: -1.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1619
    Cell Significance Index: -2.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1623
    Cell Significance Index: -8.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1666
    Cell Significance Index: -10.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1762
    Cell Significance Index: -4.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1825
    Cell Significance Index: -10.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1958
    Cell Significance Index: -10.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1975
    Cell Significance Index: -6.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1990
    Cell Significance Index: -3.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2086
    Cell Significance Index: -5.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2093
    Cell Significance Index: -9.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2279
    Cell Significance Index: -2.1900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2283
    Cell Significance Index: -0.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2396
    Cell Significance Index: -10.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SELPLG is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, characterized by its ability to bind sialic acid residues on cell surfaces. This interaction plays a pivotal role in modulating immune responses, including leukocyte activation, migration, and adhesion. SELPLG is expressed on various immune cells, such as T cells, monocytes, and dendritic cells, and is involved in the regulation of immune cell interactions with the vascular wall and other cells. **Pathways and Functions:** SELPLG is implicated in multiple signaling pathways, including: 1. **Leukocyte adhesion and migration:** SELPLG interacts with selectins on endothelial cells, facilitating the rolling and subsequent migration of leukocytes through the vascular wall. 2. **Cell surface interactions:** SELPLG binding to sialic acid residues on cell surfaces modulates cell adhesion, migration, and activation of immune cells. 3. **Immunoregulation:** SELPLG expression on immune cells, such as T cells and dendritic cells, regulates T cell activation, proliferation, and differentiation. 4. **Hemostasis:** SELPLG is involved in the regulation of platelet activation and aggregation, which is essential for maintaining vascular homeostasis. **Clinical Significance:** Understanding the role of SELPLG in immune response and its clinical implications is crucial for the development of novel therapeutic strategies. Alterations in SELPLG expression or function have been implicated in various diseases, including: 1. **Autoimmune disorders:** SELPLG has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where immune cell dysregulation plays a key role. 2. **Cancer:** SELPLG expression has been found to be altered in various cancers, including leukemia and lymphoma, where immune cell infiltration and tumor microenvironment modulation are critical. 3. **Infectious diseases:** SELPLG has been implicated in the regulation of immune responses to infections, such as influenza and tuberculosis, where immune cell activation and migration are essential for clearance of pathogens. In conclusion, SELPLG plays a vital role in immune response and beyond, influencing various cellular processes, including cell adhesion, migration, and immunoregulation. Further research on SELPLG is essential for the development of novel therapeutic strategies and a deeper understanding of its clinical significance in various diseases.

Genular Protein ID: 2866111616

Symbol: SELPL_HUMAN

Name: P-selectin glycoprotein ligand 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7541799

Title: Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand.

PubMed ID: 7541799

DOI: 10.1074/jbc.270.27.16470

PubMed ID: 7505206

Title: Expression cloning of a functional glycoprotein ligand for P-selectin.

PubMed ID: 7505206

DOI: 10.1016/0092-8674(93)90327-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7521878

Title: The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.

PubMed ID: 7521878

DOI: 10.1016/s0021-9258(17)31656-3

PubMed ID: 7585949

Title: A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.

PubMed ID: 7585949

DOI: 10.1016/0092-8674(95)90173-6

PubMed ID: 7585950

Title: PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.

PubMed ID: 7585950

DOI: 10.1016/0092-8674(95)90174-4

PubMed ID: 7559387

Title: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.

PubMed ID: 7559387

DOI: 10.1074/jbc.270.39.22677

PubMed ID: 8702529

Title: Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells.

PubMed ID: 8702529

DOI: 10.1074/jbc.271.31.18732

PubMed ID: 10713099

Title: Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.

PubMed ID: 10713099

DOI: 10.1074/jbc.275.11.7839

PubMed ID: 11566773

Title: Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin.

PubMed ID: 11566773

DOI: 10.1016/s0006-3495(01)75850-x

PubMed ID: 12387735

Title: ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

PubMed ID: 12387735

DOI: 10.1016/s1074-7613(02)00420-x

PubMed ID: 12403782

Title: Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.

PubMed ID: 12403782

DOI: 10.1074/jbc.m204360200

PubMed ID: 12736247

Title: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.

PubMed ID: 12736247

DOI: 10.1074/jbc.m303551200

PubMed ID: 17132726

Title: Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.

PubMed ID: 17132726

DOI: 10.1182/blood-2006-06-015461

PubMed ID: 18045383

Title: The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.

PubMed ID: 18045383

DOI: 10.1111/j.1365-2958.2007.05989.x

PubMed ID: 18196517

Title: SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.

PubMed ID: 18196517

DOI: 10.1002/eji.200737777

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19543284

Title: Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.

PubMed ID: 19543284

DOI: 10.1038/nm.1961

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24703780

Title: TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

PubMed ID: 24703780

DOI: 10.1016/j.immuni.2014.03.004

PubMed ID: 11081633

Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

PubMed ID: 11081633

DOI: 10.1016/s0092-8674(00)00138-0

PubMed ID: 25102098

Title: A girl with West syndrome and autistic features harboring a de novo TBL1XR1 mutation.

PubMed ID: 25102098

DOI: 10.1038/jhg.2014.71

Sequence Information:

  • Length: 412
  • Mass: 43201
  • Checksum: A92A2A902DC9963A
  • Sequence:
  • MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP 
    EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME 
    IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE 
    AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE 
    AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA 
    SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT 
    EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.