Details for: SELPLG
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 56.6395
Cell Significance Index: -8.8100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 26.4102
Cell Significance Index: -13.5900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 23.3004
Cell Significance Index: -5.9100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 22.1394
Cell Significance Index: -10.4500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.1860
Cell Significance Index: -8.8600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.6645
Cell Significance Index: 166.3600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.3921
Cell Significance Index: -13.4900 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.7726
Cell Significance Index: 8.4500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.3783
Cell Significance Index: -9.3900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.3348
Cell Significance Index: -5.1100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.2470
Cell Significance Index: 41.5300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 1.7059
Cell Significance Index: -4.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.2982
Cell Significance Index: 28.1300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1072
Cell Significance Index: 210.7200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8571
Cell Significance Index: 84.7900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7508
Cell Significance Index: 677.8900 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.7111
Cell Significance Index: 7.1300 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.4613
Cell Significance Index: 3.0600 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.3845
Cell Significance Index: 1.0300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3764
Cell Significance Index: 61.2200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3329
Cell Significance Index: 8.9100 - Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.3154
Cell Significance Index: 0.8100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3097
Cell Significance Index: 33.6900 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.2697
Cell Significance Index: 2.8700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2587
Cell Significance Index: 5.5100 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.1947
Cell Significance Index: 2.7900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1664
Cell Significance Index: 11.5100 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.0125
Cell Significance Index: 0.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0049
Cell Significance Index: 2.6700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0003
Cell Significance Index: 0.1200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0026
Cell Significance Index: -0.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0038
Cell Significance Index: -0.1100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0042
Cell Significance Index: -7.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0058
Cell Significance Index: -10.6400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0062
Cell Significance Index: -0.1600 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0064
Cell Significance Index: -0.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0069
Cell Significance Index: -10.5700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0070
Cell Significance Index: -0.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0079
Cell Significance Index: -10.7100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0097
Cell Significance Index: -7.3700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0123
Cell Significance Index: -0.7400 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0137
Cell Significance Index: -0.2000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0140
Cell Significance Index: -10.3400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0185
Cell Significance Index: -10.4600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0191
Cell Significance Index: -14.0300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0196
Cell Significance Index: -2.0000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0210
Cell Significance Index: -13.3300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0214
Cell Significance Index: -0.9700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0234
Cell Significance Index: -10.3300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0237
Cell Significance Index: -6.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0246
Cell Significance Index: -4.9400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0273
Cell Significance Index: -12.4000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0330
Cell Significance Index: -6.5500 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.0367
Cell Significance Index: -0.6300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0497
Cell Significance Index: -10.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0498
Cell Significance Index: -5.8000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0551
Cell Significance Index: -0.9500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0556
Cell Significance Index: -10.0300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0574
Cell Significance Index: -2.9000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0592
Cell Significance Index: -8.1300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0606
Cell Significance Index: -10.3500 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0665
Cell Significance Index: -0.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0671
Cell Significance Index: -4.1200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0683
Cell Significance Index: -2.8000 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.0694
Cell Significance Index: -0.5400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0770
Cell Significance Index: -9.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0821
Cell Significance Index: -10.1000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0842
Cell Significance Index: -12.2400 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0846
Cell Significance Index: -0.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0871
Cell Significance Index: -9.0700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0891
Cell Significance Index: -11.5100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0901
Cell Significance Index: -10.3300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0912
Cell Significance Index: -2.9200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1002
Cell Significance Index: -7.6900 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.1052
Cell Significance Index: -1.7900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1186
Cell Significance Index: -1.7900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1249
Cell Significance Index: -2.5900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1336
Cell Significance Index: -5.8100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1343
Cell Significance Index: -6.3100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1359
Cell Significance Index: -17.4200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1371
Cell Significance Index: -9.2200 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1414
Cell Significance Index: -1.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1456
Cell Significance Index: -10.8500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1528
Cell Significance Index: -9.8600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1553
Cell Significance Index: -10.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1574
Cell Significance Index: -9.9200 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.1584
Cell Significance Index: -1.4100 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.1619
Cell Significance Index: -2.3000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1623
Cell Significance Index: -8.4300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1666
Cell Significance Index: -10.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1762
Cell Significance Index: -4.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1825
Cell Significance Index: -10.2400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1958
Cell Significance Index: -10.2800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1975
Cell Significance Index: -6.9200 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1990
Cell Significance Index: -3.8900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2086
Cell Significance Index: -5.8300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2093
Cell Significance Index: -9.7600 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.2279
Cell Significance Index: -2.1900 - Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.2283
Cell Significance Index: -0.9500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2396
Cell Significance Index: -10.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2866111616
Symbol: SELPL_HUMAN
Name: P-selectin glycoprotein ligand 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7541799
Title: Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand.
PubMed ID: 7541799
PubMed ID: 7505206
Title: Expression cloning of a functional glycoprotein ligand for P-selectin.
PubMed ID: 7505206
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7521878
Title: The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.
PubMed ID: 7521878
PubMed ID: 7585949
Title: A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.
PubMed ID: 7585949
PubMed ID: 7585950
Title: PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.
PubMed ID: 7585950
PubMed ID: 7559387
Title: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.
PubMed ID: 7559387
PubMed ID: 8702529
Title: Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells.
PubMed ID: 8702529
PubMed ID: 10713099
Title: Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.
PubMed ID: 10713099
PubMed ID: 11566773
Title: Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin.
PubMed ID: 11566773
PubMed ID: 12387735
Title: ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.
PubMed ID: 12387735
PubMed ID: 12403782
Title: Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.
PubMed ID: 12403782
PubMed ID: 12736247
Title: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
PubMed ID: 12736247
PubMed ID: 17132726
Title: Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
PubMed ID: 17132726
PubMed ID: 18045383
Title: The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.
PubMed ID: 18045383
PubMed ID: 18196517
Title: SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.
PubMed ID: 18196517
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19543284
Title: Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.
PubMed ID: 19543284
DOI: 10.1038/nm.1961
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24703780
Title: TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.
PubMed ID: 24703780
PubMed ID: 11081633
Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
PubMed ID: 11081633
PubMed ID: 25102098
Title: A girl with West syndrome and autistic features harboring a de novo TBL1XR1 mutation.
PubMed ID: 25102098
DOI: 10.1038/jhg.2014.71
Sequence Information:
- Length: 412
- Mass: 43201
- Checksum: A92A2A902DC9963A
- Sequence:
MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.