Details for: SELPLG

Gene ID: 6404

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SELPLG

Ensembl ID: ENSG00000110876

Description: selectin P ligand

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmacytoid dendritic cell, human CL0001058
    CSI 84.79
    rCSI 59.2%
    PRS 24.29
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 78.35
    rCSI 60.37%
    PRS 21.26
  • activated type II NK T cell CL0000931
    CSI 25.4
    rCSI 28.58%
    PRS 36.09
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 21.81
    rCSI 14.54%
    PRS 51.9
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 12.91
    rCSI 25.74%
    PRS 37.83
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 12.46
    rCSI 8.4%
    PRS 28.19
  • plasmacytoid dendritic cell CL0000784
    CSI 11.37
    rCSI 11.52%
    PRS 76.33
  • double negative thymocyte CL0002489
    CSI 5.96
    rCSI 4.14%
    PRS 27.46
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 5.42
    rCSI 6.81%
    PRS 73.13
  • gamma-delta T cell CL0000798
    CSI 5.39
    rCSI 6.33%
    PRS 78.25
  • mature alpha-beta T cell CL0000791
    CSI 4.65
    rCSI 16.84%
    PRS 38.91
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.14
    rCSI 2.91%
    PRS 50.81
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 4.13
    rCSI 5.67%
    PRS 43.43
  • mature NK T cell CL0000814
    CSI 3.36
    rCSI 4.3%
    PRS 68.67
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3
    rCSI 2.4%
    PRS 40.29
  • T-helper 17 cell CL0000899
    CSI 2.95
    rCSI 2.34%
    PRS 40.47
  • non-classical monocyte CL0000875
    CSI 2.57
    rCSI 4.13%
    PRS 57.35
  • group 3 innate lymphoid cell CL0001071
    CSI 2.08
    rCSI 1.56%
    PRS 24.37
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.03
    rCSI 1.54%
    PRS 30.17
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.86
    rCSI 3.18%
    PRS 43.09
  • dendritic cell CL0000451
    CSI 1.85
    rCSI 2.28%
    PRS 59.3
  • mononuclear phagocyte CL0000113
    CSI 1.75
    rCSI 3.85%
    PRS 26.13
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 1.73
    rCSI 1.3%
    PRS 58.65
  • mature T cell CL0002419
    CSI 1.43
    rCSI 1.11%
    PRS 33.43
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.39
    rCSI 1.42%
    PRS 32.43
  • regulatory T cell CL0000815
    CSI 1.37
    rCSI 1.59%
    PRS 56.56
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 1.34
    rCSI 1.24%
    PRS 40.7
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.28
    rCSI 1.74%
    PRS 51.08
  • naive T cell CL0000898
    CSI 1.27
    rCSI 0.89%
    PRS 32.14
  • monocyte CL0000576
    CSI 1.17
    rCSI 2.11%
    PRS 53.73
  • CD4-positive helper T cell CL0000492
    CSI 1.17
    rCSI 0.88%
    PRS 31.24
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.13
    rCSI 5.69%
    PRS 30.11
  • inflammatory macrophage CL0000863
    CSI 1.09
    rCSI 1.87%
    PRS 45.38
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 1.08
    rCSI 0.77%
    PRS 31.48
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.07
    rCSI 1.4%
    PRS 32.48
  • alternatively activated macrophage CL0000890
    CSI 1.05
    rCSI 1.33%
    PRS 34.64
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 1
    rCSI 0.91%
    PRS 34.68
  • plasmablast CL0000980
    CSI 1
    rCSI 0.78%
    PRS 27.58
  • IgA plasma cell CL0000987
    CSI 0.99
    rCSI 1.01%
    PRS 40.78
  • CD14-positive monocyte CL0001054
    CSI 0.99
    rCSI 1.23%
    PRS 31.98
  • innate lymphoid cell CL0001065
    CSI 0.9
    rCSI 1.85%
    PRS 33.55
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 0.9
    rCSI 0.53%
    PRS 32.06
  • alveolar macrophage CL0000583
    CSI 0.89
    rCSI 1.46%
    PRS 26.91
  • lung macrophage CL1001603
    CSI 0.86
    rCSI 1.92%
    PRS 26.69
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 0.86
    rCSI 0.84%
    PRS 35.28
  • professional antigen presenting cell CL0000145
    CSI 0.8
    rCSI 2.76%
    PRS 63.38
  • memory T cell CL0000813
    CSI 0.76
    rCSI 1.47%
    PRS 50.38
  • erythrocyte CL0000232
    CSI 0.75
    rCSI 1.7%
    PRS 29.93
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 0.73
    rCSI 4.42%
    PRS 48.68
  • elicited macrophage CL0000861
    CSI 0.73
    rCSI 0.67%
    PRS 26.92
  • T follicular helper cell CL0002038
    CSI 0.72
    rCSI 0.54%
    PRS 35.72
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.66
    rCSI 0.81%
    PRS 27.82
  • granulocyte monocyte progenitor cell CL0000557
    CSI 0.64
    rCSI 0.55%
    PRS 25.61
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.63
    rCSI 1.81%
    PRS 34.26
  • early lymphoid progenitor CL0000936
    CSI 0.61
    rCSI 0.54%
    PRS 26.28
  • eosinophil CL0000771
    CSI 0.61
    rCSI 3.97%
    PRS 54.75
  • myeloid dendritic cell CL0000782
    CSI 0.6
    rCSI 0.88%
    PRS 34.48
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.6
    rCSI 0.72%
    PRS 39.26
  • double negative T regulatory cell CL0011024
    CSI 0.59
    rCSI 11.17%
    PRS 79.93
  • dendritic cell, human CL0001056
    CSI 0.58
    rCSI 0.89%
    PRS 27.35
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 0.46
    rCSI 1.2%
    PRS 55.87
  • group 2 innate lymphoid cell CL0001069
    CSI 0.38
    rCSI 2.06%
    PRS 66.06
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.37
    rCSI 0.45%
    PRS 27.56
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 0.33
    rCSI 0.29%
    PRS 20.62
  • megakaryocyte CL0000556
    CSI 0.29
    rCSI 1.25%
    PRS 38.85
  • common myeloid progenitor CL0000049
    CSI 0.27
    rCSI 0.22%
    PRS 22.88
  • alpha-beta T cell CL0000789
    CSI 0.26
    rCSI 0.31%
    PRS 31.77
  • intermediate monocyte CL0002393
    CSI 0.25
    rCSI 0.38%
    PRS 23.22
  • promonocyte CL0000559
    CSI 0.24
    rCSI 0.42%
    PRS 30.79
  • intraepithelial lymphocyte CL0002496
    CSI 0.2
    rCSI 0.55%
    PRS 69.99
  • helper T cell CL0000912
    CSI 0.2
    rCSI 0.28%
    PRS 31.85
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.18
    rCSI 2.12%
    PRS 69.99
  • promyelocyte CL0000836
    CSI 0.11
    rCSI 0.16%
    PRS 31.68
  • T-helper 1 cell CL0000545
    CSI 0.11
    rCSI 0.19%
    PRS 52.62
  • cytotoxic T cell CL0000910
    CSI 0.07
    rCSI 0.38%
    PRS 33.5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Color (Target Cell CSI, relative to current network):
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SELPLG](/details-gene/6404) (Selectin P Ligand) is a protein-coding gene located on chromosome 12 that encodes the well-characterized protein P-selectin glycoprotein ligand 1 (PSGL-1). This transmembrane protein is a crucial adhesion molecule expressed on the surface of leukocytes. Its primary function is to mediate the initial tethering and rolling of circulating immune cells on activated endothelium expressing selectins (P-selectin and E-selectin), a critical first step in leukocyte extravasation to sites of inflammation or injury. Expression data indicates that **Overall**, [SELPLG](/details-gene/6404) is a defining marker for myeloid-lineage cells, with exceptionally high significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), while also being prominently expressed across various T cell and natural killer cell subsets. Clinically, it is associated with an entry in the Online Mendelian Inheritance in Man (OMIM: [600738](https://omim.org/entry/600738)). ## Cellular Roles and Expression Landscape The expression profile of [SELPLG](/details-gene/6404) firmly establishes its identity as a key leukocyte surface protein, with a particularly dominant role in the myeloid compartment. **Overall**, the gene shows the highest significance in professional antigen-presenting cells and monocytes. It is the top marker for [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 84.79) and the closely related [plasmacytoid dendritic cell](/details-cell/CL0000784) (CSI: 11.37), suggesting a fundamental role in the function of this cell type, which is specialized in antiviral responses. Its significance is similarly pronounced in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 78.35), a subset known for patrolling the vasculature. Beyond the myeloid lineage, [SELPLG](/details-gene/6404) is also highly significant across a spectrum of lymphoid cells, indicating a broader role in immune surveillance and trafficking. It is prominently expressed in [activated type II NK T cell](/details-cell/CL0000931) (CSI: 25.40) and [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) (CSI: 21.81), cell types involved in rapid cytotoxic responses. Furthermore, its expression is notable in various alpha-beta T cell subsets, including [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 12.46) and multiple naive and cytotoxic populations. This widespread expression across diverse leukocyte populations underscores its general importance as a trafficking molecule that enables immune cells to exit circulation and enter tissues. ## Pathways and Molecular Function The functional annotations for [SELPLG](/details-gene/6404) are highly consistent with its role as the ligand for selectins. Its involvement in the Reactome pathway '[Cell surface interactions at the vascular wall](/details-pathway/R-HSA-202733)' directly describes its canonical function. This is further detailed by Gene Ontology (GO) terms for Biological Process, including '[Leukocyte tethering or rolling](/details-pathway/GO:0050901)', '[Leukocyte migration](/details-pathway/GO:0050900)', and '[Cell adhesion](/details-pathway/GO:0007155)'. These processes are essential for the recruitment of the high-expressing cell types, such as monocytes and lymphocytes, to sites of inflammation. At the molecular level, its functions include '[Protein binding](/details-pathway/GO:0005515)' and '[Signaling receptor binding](/details-pathway/GO:0005102)', reflecting its interaction with P-selectin and E-selectin on endothelial cells. Notably, post-translational modifications, such as tyrosine sulfation and the addition of specific O-glycans, are critical for high-affinity binding to selectins, as documented in several studies ([Link](https://doi.org/10.1016/0092-8674(95)90174-4), [Link](https://doi.org/10.1074/jbc.270.39.22677)). The annotation for '[Virus receptor activity](/details-pathway/GO:0001618)' also suggests a secondary role in pathogenesis, where viruses may co-opt this surface molecule for cellular entry. As a transmembrane protein, it is localized to the '[Plasma membrane](/details-pathway/GO:0005886)' and specialized structures like the '[Uropod](/details-pathway/GO:0001931)', the trailing edge of migrating leukocytes. ## Research Directions The well-established role of [SELPLG](/details-gene/6404) in leukocyte trafficking provides a strong foundation for further investigation into its cell-type-specific functions and therapeutic potential. **Testable Hypotheses:** 1. Given its exceptionally high significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and its annotated role in '[Symbiont entry into host cell](/details-pathway/GO:0046718)', it is hypothesized that beyond trafficking, [SELPLG](/details-gene/6404) functions as a co-receptor or signaling scaffold that modulates TLR-mediated antiviral responses and subsequent type I interferon production in these cells. 2. The high expression of [SELPLG](/details-gene/6404) on [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), which are known as "patrolling" monocytes, suggests that its interaction with endothelial selectins is not only for extravasation but is also critical for mediating their unique intravascular crawling and surveillance behavior, allowing for rapid detection of endothelial injury or inflammation. **Proposed Experiment:** To test the hypothesis that [SELPLG](/details-gene/6404) modulates pDC function (Hypothesis 1), a CRISPR-Cas9 knockout of [SELPLG](/details-gene/6404) could be performed in primary human CD34+ hematopoietic stem cells, followed by in vitro differentiation into [plasmacytoid dendritic cell, human](/details-cell/CL0001058). These knockout pDCs, alongside wild-type controls, would then be stimulated with a TLR9 agonist (e.g., CpG-A). The functional consequences would be assessed by measuring the secretion of IFN-alpha and other cytokines using ELISA and by profiling downstream signaling pathways (e.g., IRF7 phosphorylation) via Western blot. **Therapeutic Potential:** As a key initiator of leukocyte recruitment to inflamed tissues, the protein product of [SELPLG](/details-gene/6404), PSGL-1, is a well-recognized therapeutic target. Its function as a cell surface adhesion molecule makes it highly accessible to biologic drugs. Inhibition of the PSGL-1/selectin interaction represents a promising strategy for treating a wide range of inflammatory and autoimmune diseases characterized by excessive leukocyte infiltration, such as psoriasis, rheumatoid arthritis, or ischemia-reperfusion injury. A therapeutic approach would focus on inhibition, using monoclonal antibodies or small molecule antagonists to block the binding site, thereby preventing the initial step of leukocyte rolling and reducing inflammation.

Genular Protein ID: 2866111616

Symbol: SELPL_HUMAN

Name: P-selectin glycoprotein ligand 1

UniProtKB Accession Codes:

Q14242 A8K2Y0 B4DQC3 B7Z5C7 J3KMX6 Q12775 Q6GTW7 Q8N7J7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7541799

Title: Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand.

PubMed ID: 7541799

DOI: 10.1074/jbc.270.27.16470

PubMed ID: 7505206

Title: Expression cloning of a functional glycoprotein ligand for P-selectin.

PubMed ID: 7505206

DOI: 10.1016/0092-8674(93)90327-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7521878

Title: The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.

PubMed ID: 7521878

DOI: 10.1016/s0021-9258(17)31656-3

PubMed ID: 7585949

Title: A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.

PubMed ID: 7585949

DOI: 10.1016/0092-8674(95)90173-6

PubMed ID: 7585950

Title: PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.

PubMed ID: 7585950

DOI: 10.1016/0092-8674(95)90174-4

PubMed ID: 7559387

Title: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.

PubMed ID: 7559387

DOI: 10.1074/jbc.270.39.22677

PubMed ID: 8702529

Title: Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells.

PubMed ID: 8702529

DOI: 10.1074/jbc.271.31.18732

PubMed ID: 10713099

Title: Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.

PubMed ID: 10713099

DOI: 10.1074/jbc.275.11.7839

PubMed ID: 11566773

Title: Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin.

PubMed ID: 11566773

DOI: 10.1016/s0006-3495(01)75850-x

PubMed ID: 12387735

Title: ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

PubMed ID: 12387735

DOI: 10.1016/s1074-7613(02)00420-x

PubMed ID: 12403782

Title: Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.

PubMed ID: 12403782

DOI: 10.1074/jbc.m204360200

PubMed ID: 12736247

Title: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.

PubMed ID: 12736247

DOI: 10.1074/jbc.m303551200

PubMed ID: 17132726

Title: Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.

PubMed ID: 17132726

DOI: 10.1182/blood-2006-06-015461

PubMed ID: 18045383

Title: The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.

PubMed ID: 18045383

DOI: 10.1111/j.1365-2958.2007.05989.x

PubMed ID: 18196517

Title: SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.

PubMed ID: 18196517

DOI: 10.1002/eji.200737777

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19543284

Title: Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.

PubMed ID: 19543284

DOI: 10.1038/nm.1961

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24703780

Title: TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

PubMed ID: 24703780

DOI: 10.1016/j.immuni.2014.03.004

PubMed ID: 11081633

Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

PubMed ID: 11081633

DOI: 10.1016/s0092-8674(00)00138-0

PubMed ID: 25102098

Title: A girl with West syndrome and autistic features harboring a de novo TBL1XR1 mutation.

PubMed ID: 25102098

DOI: 10.1038/jhg.2014.71

Sequence Information:

  • Length: 412
  • Mass: 43201
  • Checksum: A92A2A902DC9963A
  • Sequence:
    • MPLQLLLLLI LLGPGNSLQL WDTWADEAEK ALGPLLARDR RQATEYEYLD YDFLPETEPP 
EMLRNSTDTT PLTGPGTPES TTVEPAARRS TGLDAGGAVT ELTTELANMG NLSTDSAAME 
IQTTQPAATE AQTTQPVPTE AQTTPLAATE AQTTRLTATE AQTTPLAATE AQTTPPAATE 
AQTTQPTGLE AQTTAPAAME AQTTAPAAME AQTTPPAAME AQTTQTTAME AQTTAPEATE 
AQTTQPTATE AQTTPLAAME ALSTEPSATE ALSMEPTTKR GLFIPFSVSS VTHKGIPMAA 
SNLSVNYPVG APDHISVKQC LLAILILALV ATIFFVCTVV LAVRLSRKGH MYPVRNYSPT 
EMVCISSLLP DGGEGPSATA NGGLSKAKSP GLTPEPREDR EGDDLTLHSF LP