Details for: SUMO3

Gene ID: 6612

Symbol: SUMO3

Ensembl ID: ENSG00000184900

Description: small ubiquitin like modifier 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.8233
    Cell Significance Index: -37.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.1070
    Cell Significance Index: -37.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.6625
    Cell Significance Index: -54.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.2704
    Cell Significance Index: -53.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.0965
    Cell Significance Index: -45.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.1754
    Cell Significance Index: -50.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.8483
    Cell Significance Index: -53.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.8969
    Cell Significance Index: -52.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2092
    Cell Significance Index: -56.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.6364
    Cell Significance Index: -36.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0231
    Cell Significance Index: -40.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.7763
    Cell Significance Index: 451.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2184
    Cell Significance Index: 133.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.0328
    Cell Significance Index: 106.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8629
    Cell Significance Index: 54.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7283
    Cell Significance Index: 80.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6998
    Cell Significance Index: 35.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6968
    Cell Significance Index: 488.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3615
    Cell Significance Index: 37.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3131
    Cell Significance Index: 61.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2548
    Cell Significance Index: 172.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1901
    Cell Significance Index: 649.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1089
    Cell Significance Index: 136.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0952
    Cell Significance Index: 484.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0310
    Cell Significance Index: 101.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0185
    Cell Significance Index: 75.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9992
    Cell Significance Index: 117.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9953
    Cell Significance Index: 128.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9668
    Cell Significance Index: 10.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9163
    Cell Significance Index: 59.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9137
    Cell Significance Index: 10.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9076
    Cell Significance Index: 163.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7753
    Cell Significance Index: 54.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7473
    Cell Significance Index: 19.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7442
    Cell Significance Index: 25.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7248
    Cell Significance Index: 92.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6043
    Cell Significance Index: 31.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5895
    Cell Significance Index: 118.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5172
    Cell Significance Index: 9.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4518
    Cell Significance Index: 20.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3831
    Cell Significance Index: 8.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3642
    Cell Significance Index: 6.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3503
    Cell Significance Index: 22.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2848
    Cell Significance Index: 56.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2769
    Cell Significance Index: 52.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2548
    Cell Significance Index: 230.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2153
    Cell Significance Index: 77.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2030
    Cell Significance Index: 5.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0440
    Cell Significance Index: 33.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0293
    Cell Significance Index: 0.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0117
    Cell Significance Index: 0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0071
    Cell Significance Index: 0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0214
    Cell Significance Index: -40.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0320
    Cell Significance Index: -1.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0369
    Cell Significance Index: -67.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0434
    Cell Significance Index: -66.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0497
    Cell Significance Index: -67.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0551
    Cell Significance Index: -40.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0652
    Cell Significance Index: -41.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0810
    Cell Significance Index: -45.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1019
    Cell Significance Index: -63.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1036
    Cell Significance Index: -47.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1058
    Cell Significance Index: -18.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1132
    Cell Significance Index: -1.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2200
    Cell Significance Index: -5.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2391
    Cell Significance Index: -27.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2536
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2626
    Cell Significance Index: -30.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2710
    Cell Significance Index: -7.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2845
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2987
    Cell Significance Index: -62.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3157
    Cell Significance Index: -45.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3279
    Cell Significance Index: -9.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3514
    Cell Significance Index: -9.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4081
    Cell Significance Index: -13.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4361
    Cell Significance Index: -5.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4391
    Cell Significance Index: -34.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4842
    Cell Significance Index: -29.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5273
    Cell Significance Index: -4.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5370
    Cell Significance Index: -55.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5617
    Cell Significance Index: -16.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6379
    Cell Significance Index: -39.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6664
    Cell Significance Index: -51.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7907
    Cell Significance Index: -41.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8132
    Cell Significance Index: -5.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8382
    Cell Significance Index: -12.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8760
    Cell Significance Index: -49.1600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9401
    Cell Significance Index: -5.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9462
    Cell Significance Index: -9.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9534
    Cell Significance Index: -5.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9602
    Cell Significance Index: -42.4700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9620
    Cell Significance Index: -12.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0254
    Cell Significance Index: -27.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0447
    Cell Significance Index: -30.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0736
    Cell Significance Index: -39.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1734
    Cell Significance Index: -27.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1868
    Cell Significance Index: -44.9400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.3048
    Cell Significance Index: -8.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SUMO3 is a member of the SUMO family, which consists of four distinct proteins: SUMO1, SUMO2, SUMO3, and SUMO4. The SUMO3 protein is characterized by its ability to interact with specific SUMO E3 ligases, which are responsible for recognizing and targeting specific proteins for sumoylation. SUMO3 is also known to be involved in the regulation of protein localization to the nucleus, where it can modulate the activity of transcription factors and other nuclear proteins. **Pathways and Functions** The sumoylation pathway, in which SUMO3 plays a key role, is involved in various cellular processes, including: 1. **DNA Repair**: SUMO3 is involved in the regulation of DNA damage response and repair proteins, such as BRCA1 and BRCA2. 2. **Transcription Regulation**: SUMO3 can modulate the activity of transcription factors, such as p53 and NF-κB, which are involved in the regulation of gene expression. 3. **Immune Response**: SUMO3 is involved in the regulation of immune response proteins, such as cytokines and chemokines, which are essential for the proper functioning of the immune system. 4. **Cell Cycle Regulation**: SUMO3 can regulate the activity of cell cycle regulatory proteins, such as p21 and p27, which are involved in the control of cell proliferation. **Clinical Significance** Dysregulation of the sumoylation pathway, including SUMO3, has been implicated in various diseases, including: 1. **Cancer**: Altered sumoylation patterns have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: SUMO3 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Autoimmune Diseases**: SUMO3 is involved in the regulation of immune response proteins, and alterations in sumoylation patterns have been observed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, SUMO3 is a key component of the sumoylation pathway, which plays a crucial role in various cellular processes, including DNA repair, transcription regulation, and immune response. Dysregulation of SUMO3 has been implicated in various diseases, highlighting the importance of understanding the mechanisms of sumoylation and its role in human disease.

Genular Protein ID: 1419991373

Symbol: SUMO3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P55854 B2R5X4 B4DUW4 Q53HI9 Q6FGD4 Q9BWR4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119407

Title: SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.

PubMed ID: 9119407

DOI: 10.1006/geno.1996.4556

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10692421

Title: Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.

PubMed ID: 10692421

DOI: 10.1074/jbc.275.9.6252

PubMed ID: 11451954

Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

PubMed ID: 11451954

DOI: 10.1074/jbc.m104214200

PubMed ID: 12383504

Title: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.

PubMed ID: 12383504

DOI: 10.1016/s0378-1119(02)00843-0

PubMed ID: 12924945

Title: Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.

PubMed ID: 12924945

DOI: 10.1021/bi0345283

PubMed ID: 15296745

Title: A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.

PubMed ID: 15296745

DOI: 10.1016/j.str.2004.05.023

PubMed ID: 15487983

Title: Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.

PubMed ID: 15487983

DOI: 10.1042/bj20041210

PubMed ID: 16608850

Title: Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.

PubMed ID: 16608850

DOI: 10.1074/jbc.m511658200

PubMed ID: 18538659

Title: Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.

PubMed ID: 18538659

DOI: 10.1016/j.molcel.2008.03.021

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 24105744

Title: A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.

PubMed ID: 24105744

DOI: 10.1101/gad.224923.113

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15723523

Title: Solution structure of human SUMO-3 C47S and its binding surface for Ubc9.

PubMed ID: 15723523

DOI: 10.1021/bi0477586

PubMed ID: 16553580

Title: The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.

PubMed ID: 16553580

DOI: 10.1042/bj20052030

Sequence Information:

  • Length: 103
  • Mass: 11637
  • Checksum: E337E34CB5B3B187
  • Sequence:
    • MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR 
FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVPESSLAG HSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.