Details for: SNRPB

Gene ID: 6628

Symbol: SNRPB

Ensembl ID: ENSG00000125835

Description: small nuclear ribonucleoprotein polypeptides B and B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 308.3348
    Cell Significance Index: -47.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.1559
    Cell Significance Index: -49.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 191.9662
    Cell Significance Index: -79.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 164.5017
    Cell Significance Index: -66.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 159.5666
    Cell Significance Index: -75.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 145.0275
    Cell Significance Index: -74.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 112.2839
    Cell Significance Index: -75.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.6214
    Cell Significance Index: -68.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.5203
    Cell Significance Index: -70.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.5284
    Cell Significance Index: -77.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.2073
    Cell Significance Index: -49.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2225
    Cell Significance Index: -38.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 9.2353
    Cell Significance Index: 1076.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.9099
    Cell Significance Index: -19.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.1108
    Cell Significance Index: 163.4600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.4932
    Cell Significance Index: 32.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.9583
    Cell Significance Index: 137.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.9296
    Cell Significance Index: 42.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5968
    Cell Significance Index: 63.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.5729
    Cell Significance Index: 102.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.4691
    Cell Significance Index: 29.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.2611
    Cell Significance Index: 85.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2287
    Cell Significance Index: 380.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2204
    Cell Significance Index: 240.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2057
    Cell Significance Index: 150.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8021
    Cell Significance Index: 362.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7416
    Cell Significance Index: 176.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.7022
    Cell Significance Index: 23.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6295
    Cell Significance Index: 21.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5144
    Cell Significance Index: 68.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.4506
    Cell Significance Index: 71.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4481
    Cell Significance Index: 301.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3958
    Cell Significance Index: 169.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3853
    Cell Significance Index: 1302.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2933
    Cell Significance Index: 413.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2779
    Cell Significance Index: 1007.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.1660
    Cell Significance Index: 13.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1241
    Cell Significance Index: 44.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1232
    Cell Significance Index: 24.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8797
    Cell Significance Index: 258.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7120
    Cell Significance Index: 15.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5698
    Cell Significance Index: 81.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5640
    Cell Significance Index: 72.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2887
    Cell Significance Index: 89.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2039
    Cell Significance Index: 238.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0568
    Cell Significance Index: 54.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9389
    Cell Significance Index: 92.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8115
    Cell Significance Index: 131.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7974
    Cell Significance Index: 102.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7670
    Cell Significance Index: 20.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7580
    Cell Significance Index: 684.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6194
    Cell Significance Index: 14.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4757
    Cell Significance Index: 13.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4750
    Cell Significance Index: 8.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3700
    Cell Significance Index: 22.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1404
    Cell Significance Index: 2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1401
    Cell Significance Index: 23.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1200
    Cell Significance Index: 24.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0858
    Cell Significance Index: 64.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0215
    Cell Significance Index: 0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0117
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0154
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0240
    Cell Significance Index: -4.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0304
    Cell Significance Index: -57.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0389
    Cell Significance Index: -3.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0485
    Cell Significance Index: -89.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0570
    Cell Significance Index: -87.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0663
    Cell Significance Index: -23.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0665
    Cell Significance Index: -90.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0756
    Cell Significance Index: -52.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0883
    Cell Significance Index: -49.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0944
    Cell Significance Index: -59.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1288
    Cell Significance Index: -3.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1454
    Cell Significance Index: -65.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1479
    Cell Significance Index: -31.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1519
    Cell Significance Index: -3.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1862
    Cell Significance Index: -4.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2099
    Cell Significance Index: -7.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2250
    Cell Significance Index: -64.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2379
    Cell Significance Index: -7.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2409
    Cell Significance Index: -27.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2442
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2759
    Cell Significance Index: -31.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3003
    Cell Significance Index: -18.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3487
    Cell Significance Index: -18.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3653
    Cell Significance Index: -20.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4379
    Cell Significance Index: -19.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4408
    Cell Significance Index: -64.0700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5328
    Cell Significance Index: -2.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5526
    Cell Significance Index: -7.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5640
    Cell Significance Index: -12.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6966
    Cell Significance Index: -55.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7502
    Cell Significance Index: -78.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9108
    Cell Significance Index: -55.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9439
    Cell Significance Index: -72.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0596
    Cell Significance Index: -71.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.1061
    Cell Significance Index: -14.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1251
    Cell Significance Index: -68.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1301
    Cell Significance Index: -57.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location**: The SNRPB gene is located on chromosome 19q13.4, which is a region known for its involvement in various genetic disorders. 2. **Expression**: SNRPB is expressed in a wide range of cell types, including fibroblasts, epithelial cells, immune cells, and progenitor cells. 3. **Function**: The SNRPB gene encodes two polypeptides, B and B1, which are involved in the assembly and function of the snRNP complex. 4. **Pathways**: SNRPB is involved in various cellular pathways, including RNA splicing, histone pre-mRNA processing, and protein binding. 5. **Disease Association**: SNRPB has been implicated in several diseases, including SARS-CoV-2 infection, which highlights its role in viral infections and host translation machinery modulation. **Pathways and Functions** 1. **RNA Splicing**: SNRPB plays a crucial role in the splicing of pre-mRNA, which is a process that removes introns and joins exons to form mature mRNA. 2. **Histone Pre-mRNA Processing**: SNRPB is involved in the processing of histone pre-mRNAs, which is essential for chromatin assembly and gene regulation. 3. **Protein Binding**: SNRPB polypeptides B and B1 interact with various proteins, including RNA-binding proteins and histone-modifying enzymes. 4. **Cellular Regulation**: SNRPB regulates various cellular processes, including gene expression, cell proliferation, and differentiation. 5. **Immune Response**: SNRPB has been implicated in the immune response, particularly in the regulation of immune cell function and cytokine production. **Clinical Significance** 1. **SARS-CoV-2 Infection**: SNRPB has been implicated in the modulation of host translation machinery by SARS-CoV-2, which highlights its role in viral infections. 2. **Cancer**: SNRPB has been associated with various types of cancer, including lung, breast, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders**: SNRPB has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegeneration. 4. **Immune-Mediated Diseases**: SNRPB has been associated with various immune-mediated diseases, including rheumatoid arthritis and lupus, suggesting its potential role in autoimmune responses. 5. **Therapeutic Targeting**: SNRPB has been identified as a potential therapeutic target for various diseases, including cancer and viral infections, highlighting its potential as a therapeutic agent. In conclusion, the SNRPB gene plays a crucial role in various cellular processes, including RNA metabolism, gene expression, and protein interactions. Its involvement in various diseases and viral infections highlights its potential as a therapeutic target and underscores the importance of further research into its functions and mechanisms of action.

Genular Protein ID: 3217170740

Symbol: RSMB_HUMAN

Name: Small nuclear ribonucleoprotein-associated proteins B and B'

UniProtKB Accession Codes:

P14678 Q15490 Q6IB35 Q9UIS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EMDB 49 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 56 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2531083

Title: Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part.

PubMed ID: 2531083

DOI: 10.1002/j.1460-2075.1989.tb08563.x

PubMed ID: 2522186

Title: A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'.

PubMed ID: 2522186

DOI: 10.1093/nar/17.4.1733

PubMed ID: 2524838

Title: Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles.

PubMed ID: 2524838

DOI: 10.1073/pnas.86.11.4249

PubMed ID: 10556313

Title: Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.

PubMed ID: 10556313

DOI: 10.1093/nar/27.23.4577

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 1694885

Title: Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction.

PubMed ID: 1694885

PubMed ID: 1825643

Title: The small nuclear ribonucleoproteins, SmB and B', are products of a single gene.

PubMed ID: 1825643

DOI: 10.1016/0378-1119(91)90069-n

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11574479

Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

PubMed ID: 11574479

DOI: 10.1093/emboj/20.19.5470

PubMed ID: 12095920

Title: SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

PubMed ID: 12095920

DOI: 10.1093/hmg/11.15.1785

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12975319

Title: Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.

PubMed ID: 12975319

DOI: 10.1101/gad.274403

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 15955813

Title: Tudor domains bind symmetrical dimethylated arginines.

PubMed ID: 15955813

DOI: 10.1074/jbc.m414328200

PubMed ID: 16087681

Title: Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

PubMed ID: 16087681

DOI: 10.1074/jbc.m505077200

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25047197

Title: Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro-costo-mandibular syndrome.

PubMed ID: 25047197

DOI: 10.1038/ncomms5483

PubMed ID: 25504470

Title: Mutations in SNRPB, encoding components of the core splicing machinery, cause cerebro-costo-mandibular syndrome.

PubMed ID: 25504470

DOI: 10.1002/humu.22729

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 240
  • Mass: 24610
  • Checksum: F2E1D5E11A601170
  • Sequence:
    • MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNSKQAE 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGIGRAA GRGIPAGVPM 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAAAATAS IAGAPTQYPP GRGGPPPPMG 
RGAPPPGMMG PPPGMRPPMG PPMGIPPGRG TPMGMPPPGM RPPPPGMRGP PPPGMRPPRP

Genular Protein ID: 1109669817

Symbol: Q66K91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q66K91

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 ExpressionAtlas 1 GO 14 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PIRNR 1 PIRSF 1 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33446560

Title: Structure of a transcribing RNA polymerase II-U1 snRNP complex.

PubMed ID: 33446560

DOI: 10.1126/science.abf1870

Sequence Information:

  • Length: 231
  • Mass: 23656
  • Checksum: 5CB0BB2E75B93D4A
  • Sequence:
    • MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNSKQAE 
REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGIGRAA GRGIPAGVPM 
PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAAAATAS IAGAPTQYPP GRGGPPPPMG 
RGAPPPGMMG PPPGMRPPMG PPMGIPPGRG TPMGMPPPGM RPPPPGMRGL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.