Details for: SNRPD1

Gene ID: 6632

Symbol: SNRPD1

Ensembl ID: ENSG00000167088

Description: small nuclear ribonucleoprotein D1 polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 4.38
    Marker Score: 4569
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.25
    Marker Score: 2452
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.83
    Marker Score: 37383.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.74
    Marker Score: 1009
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.62
    Marker Score: 10726
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.59
    Marker Score: 6323
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.54
    Marker Score: 2716
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.53
    Marker Score: 2381
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.52
    Marker Score: 3888
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.51
    Marker Score: 5246
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.5
    Marker Score: 1570
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.39
    Marker Score: 82655
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.37
    Marker Score: 4035
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.35
    Marker Score: 6982
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.3
    Marker Score: 735
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.29
    Marker Score: 2450
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.29
    Marker Score: 14891
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.27
    Marker Score: 8737
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.27
    Marker Score: 2281
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.24
    Marker Score: 3219
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.24
    Marker Score: 1762
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.22
    Marker Score: 75410.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.21
    Marker Score: 8691
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2
    Marker Score: 9509
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.19
    Marker Score: 3107
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.17
    Marker Score: 16949.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.16
    Marker Score: 5094.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.16
    Marker Score: 2284.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.14
    Marker Score: 1301
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.12
    Marker Score: 28470
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.11
    Marker Score: 952
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.1
    Marker Score: 5716
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.1
    Marker Score: 2359
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.1
    Marker Score: 3376
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1
    Marker Score: 23615
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.09
    Marker Score: 7756
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.09
    Marker Score: 1397.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.08
    Marker Score: 2214
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.07
    Marker Score: 3300
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.07
    Marker Score: 24098
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.07
    Marker Score: 4921
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.05
    Marker Score: 5585
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 2.03
    Marker Score: 2549
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.03
    Marker Score: 3541
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.02
    Marker Score: 1473
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.01
    Marker Score: 17332
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.01
    Marker Score: 713
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2
    Marker Score: 1141.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.99
    Marker Score: 2143
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.99
    Marker Score: 20119
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.98
    Marker Score: 14741
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.97
    Marker Score: 2908.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.96
    Marker Score: 968
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.96
    Marker Score: 1183
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.95
    Marker Score: 1321
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.95
    Marker Score: 16907
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.94
    Marker Score: 3186.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.94
    Marker Score: 1223
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.93
    Marker Score: 912
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.93
    Marker Score: 19115.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.93
    Marker Score: 3514
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.92
    Marker Score: 12286
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.92
    Marker Score: 1056
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.89
    Marker Score: 48531.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.88
    Marker Score: 1363.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.88
    Marker Score: 921
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.88
    Marker Score: 9232
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.88
    Marker Score: 929
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.87
    Marker Score: 885
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.86
    Marker Score: 3712
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.85
    Marker Score: 656
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.85
    Marker Score: 1744
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.85
    Marker Score: 5098
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.84
    Marker Score: 3262
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.84
    Marker Score: 11727
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.83
    Marker Score: 4157
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.83
    Marker Score: 972
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.83
    Marker Score: 2131
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.82
    Marker Score: 10809
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.82
    Marker Score: 937
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.82
    Marker Score: 2417
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.81
    Marker Score: 18240
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.81
    Marker Score: 1778
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.79
    Marker Score: 1593
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.78
    Marker Score: 691
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.77
    Marker Score: 1657
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.76
    Marker Score: 617
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.76
    Marker Score: 419
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.76
    Marker Score: 579
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.75
    Marker Score: 418
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.75
    Marker Score: 587
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.74
    Marker Score: 590
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.74
    Marker Score: 1092
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.74
    Marker Score: 2888
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.74
    Marker Score: 558
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.7
    Marker Score: 547
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.69
    Marker Score: 1270
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.69
    Marker Score: 487
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.69
    Marker Score: 2181
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.69
    Marker Score: 635

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** 1. **RNA Splicing:** SNRPD1 is involved in the catalytic step 2 spliceosome, a complex that recognizes and cleaves introns from pre-mRNA. 2. **Small Nuclear Ribonucleoprotein Complex (snRNP):** The Sm D1 protein is a key component of the snRNP complex, which assembles and disassembles to facilitate RNA splicing. 3. **7-Methylguanosine Cap Hypermethylation:** SNRPD1 is also involved in the hypermethylation of the 7-methylguanosine cap, a process that regulates mRNA stability and translation. 4. **Disease Association:** SNRPD1 has been linked to various diseases, including infectious diseases, cancer, and metabolic disorders. **Pathways and Functions:** 1. **RNA Splicing Pathway:** SNRPD1 is involved in the catalytic step 2 spliceosome, which recognizes and cleaves introns from pre-mRNA. 2. **Metabolism of Non-Coding RNA:** SNRPD1 is also involved in the metabolism of non-coding RNA, which plays a critical role in gene regulation. 3. **Viral Infection Pathways:** SNRPD1 has been implicated in the modulation of host translation machinery by SARS-CoV-2, a virus that causes COVID-19. 4. **Cellular Processes:** SNRPD1 is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of SNRPD1 has been implicated in several diseases, including: 1. **Infectious Diseases:** SNRPD1 has been linked to SARS-CoV-2 infection and modulation of host translation machinery. 2. **Cancer:** SNRPD1 has been implicated in cancer development and progression, particularly in hematological malignancies. 3. **Metabolic Disorders:** SNRPD1 has been linked to metabolic disorders, including diabetes and obesity. 4. **Neurological Disorders:** SNRPD1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SNRPD1 is a critical gene that plays a pivotal role in RNA splicing and various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the functions and pathogenesis of this gene.

Genular Protein ID: 492043516

Symbol: SMD1_HUMAN

Name: Small nuclear ribonucleoprotein Sm D1

UniProtKB Accession Codes:

P62314 B5BTZ1 P13641

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 29 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 62 PDBsum 46 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3260384

Title: Molecular cloning of a cDNA encoding the human Sm-D autoantigen.

PubMed ID: 3260384

DOI: 10.1073/pnas.85.13.4832

PubMed ID: 2528429

Title: Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases.

PubMed ID: 2528429

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11747828

Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

PubMed ID: 11747828

DOI: 10.1016/s0960-9822(01)00592-9

PubMed ID: 11135666

Title: SMN tudor domain structure and its interaction with the Sm proteins.

PubMed ID: 11135666

DOI: 10.1038/83014

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17709427

Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.

PubMed ID: 17709427

DOI: 10.1083/jcb.200702147

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21113136

Title: Functional organization of the Sm core in the crystal structure of human U1 snRNP.

PubMed ID: 21113136

DOI: 10.1038/emboj.2010.295

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 119
  • Mass: 13282
  • Checksum: 0C81C94BF98E0810
  • Sequence:
    • MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI 
RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.