Details for: SNRPD1

Gene ID: 6632

Symbol: SNRPD1

Ensembl ID: ENSG00000167088

Description: small nuclear ribonucleoprotein D1 polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.6071
    Cell Significance Index: -41.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 170.3129
    Cell Significance Index: -70.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.9065
    Cell Significance Index: -69.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 145.1644
    Cell Significance Index: -36.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 129.2805
    Cell Significance Index: -66.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.3632
    Cell Significance Index: -70.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.1008
    Cell Significance Index: -63.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.8994
    Cell Significance Index: -47.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.7063
    Cell Significance Index: -69.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7264
    Cell Significance Index: -42.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.6773
    Cell Significance Index: 61.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.6351
    Cell Significance Index: 150.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.3637
    Cell Significance Index: 91.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4969
    Cell Significance Index: 27.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0484
    Cell Significance Index: 105.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8830
    Cell Significance Index: 339.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8656
    Cell Significance Index: 75.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2106
    Cell Significance Index: 60.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1077
    Cell Significance Index: 1151.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0099
    Cell Significance Index: 142.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9641
    Cell Significance Index: 146.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9603
    Cell Significance Index: 253.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9426
    Cell Significance Index: 91.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8848
    Cell Significance Index: 121.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8747
    Cell Significance Index: 230.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7647
    Cell Significance Index: 780.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7520
    Cell Significance Index: 315.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6253
    Cell Significance Index: 47.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4771
    Cell Significance Index: 16.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4296
    Cell Significance Index: 196.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2677
    Cell Significance Index: 16.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2651
    Cell Significance Index: 65.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2226
    Cell Significance Index: 1103.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2136
    Cell Significance Index: 34.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.1963
    Cell Significance Index: 10.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1098
    Cell Significance Index: 10.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0228
    Cell Significance Index: 47.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0206
    Cell Significance Index: 23.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9906
    Cell Significance Index: 26.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8966
    Cell Significance Index: 177.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8546
    Cell Significance Index: 109.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7773
    Cell Significance Index: 13.7400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7468
    Cell Significance Index: 4.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5308
    Cell Significance Index: 11.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4844
    Cell Significance Index: 97.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4765
    Cell Significance Index: 13.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4621
    Cell Significance Index: 24.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3125
    Cell Significance Index: 21.6100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2477
    Cell Significance Index: 1.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2136
    Cell Significance Index: 13.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2047
    Cell Significance Index: 38.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1934
    Cell Significance Index: 31.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1930
    Cell Significance Index: 69.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1449
    Cell Significance Index: 109.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1350
    Cell Significance Index: 2.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1306
    Cell Significance Index: 12.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1034
    Cell Significance Index: 17.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0877
    Cell Significance Index: 2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0247
    Cell Significance Index: -46.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0396
    Cell Significance Index: -73.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0434
    Cell Significance Index: -4.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0476
    Cell Significance Index: -73.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0574
    Cell Significance Index: -78.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0639
    Cell Significance Index: -3.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0665
    Cell Significance Index: -2.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0735
    Cell Significance Index: -41.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0808
    Cell Significance Index: -51.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0957
    Cell Significance Index: -66.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0977
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1197
    Cell Significance Index: -25.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1325
    Cell Significance Index: -60.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1499
    Cell Significance Index: -3.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1517
    Cell Significance Index: -43.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1714
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1744
    Cell Significance Index: -20.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1948
    Cell Significance Index: -10.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3093
    Cell Significance Index: -35.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3176
    Cell Significance Index: -5.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4017
    Cell Significance Index: -58.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4758
    Cell Significance Index: -54.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4928
    Cell Significance Index: -5.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5651
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6035
    Cell Significance Index: -47.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6691
    Cell Significance Index: -30.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6762
    Cell Significance Index: -70.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7176
    Cell Significance Index: -55.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7994
    Cell Significance Index: -13.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8299
    Cell Significance Index: -55.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8752
    Cell Significance Index: -9.0600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.9018
    Cell Significance Index: -5.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9594
    Cell Significance Index: -58.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1158
    Cell Significance Index: -28.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1384
    Cell Significance Index: -33.5300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.1784
    Cell Significance Index: -7.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2624
    Cell Significance Index: -55.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.3000
    Cell Significance Index: -19.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Splicing:** SNRPD1 is involved in the catalytic step 2 spliceosome, a complex that recognizes and cleaves introns from pre-mRNA. 2. **Small Nuclear Ribonucleoprotein Complex (snRNP):** The Sm D1 protein is a key component of the snRNP complex, which assembles and disassembles to facilitate RNA splicing. 3. **7-Methylguanosine Cap Hypermethylation:** SNRPD1 is also involved in the hypermethylation of the 7-methylguanosine cap, a process that regulates mRNA stability and translation. 4. **Disease Association:** SNRPD1 has been linked to various diseases, including infectious diseases, cancer, and metabolic disorders. **Pathways and Functions:** 1. **RNA Splicing Pathway:** SNRPD1 is involved in the catalytic step 2 spliceosome, which recognizes and cleaves introns from pre-mRNA. 2. **Metabolism of Non-Coding RNA:** SNRPD1 is also involved in the metabolism of non-coding RNA, which plays a critical role in gene regulation. 3. **Viral Infection Pathways:** SNRPD1 has been implicated in the modulation of host translation machinery by SARS-CoV-2, a virus that causes COVID-19. 4. **Cellular Processes:** SNRPD1 is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of SNRPD1 has been implicated in several diseases, including: 1. **Infectious Diseases:** SNRPD1 has been linked to SARS-CoV-2 infection and modulation of host translation machinery. 2. **Cancer:** SNRPD1 has been implicated in cancer development and progression, particularly in hematological malignancies. 3. **Metabolic Disorders:** SNRPD1 has been linked to metabolic disorders, including diabetes and obesity. 4. **Neurological Disorders:** SNRPD1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SNRPD1 is a critical gene that plays a pivotal role in RNA splicing and various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the functions and pathogenesis of this gene.

Genular Protein ID: 492043516

Symbol: SMD1_HUMAN

Name: Small nuclear ribonucleoprotein Sm D1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3260384

Title: Molecular cloning of a cDNA encoding the human Sm-D autoantigen.

PubMed ID: 3260384

DOI: 10.1073/pnas.85.13.4832

PubMed ID: 2528429

Title: Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases.

PubMed ID: 2528429

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11747828

Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

PubMed ID: 11747828

DOI: 10.1016/s0960-9822(01)00592-9

PubMed ID: 11135666

Title: SMN tudor domain structure and its interaction with the Sm proteins.

PubMed ID: 11135666

DOI: 10.1038/83014

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17709427

Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.

PubMed ID: 17709427

DOI: 10.1083/jcb.200702147

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21113136

Title: Functional organization of the Sm core in the crystal structure of human U1 snRNP.

PubMed ID: 21113136

DOI: 10.1038/emboj.2010.295

PubMed ID: 21816274

Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.

PubMed ID: 21816274

DOI: 10.1016/j.cell.2011.06.043

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 31799625

Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.

PubMed ID: 31799625

DOI: 10.1093/nar/gkz1135

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 119
  • Mass: 13282
  • Checksum: 0C81C94BF98E0810
  • Sequence:
  • MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI 
    RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.