Details for: SNRPD1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 267.6071
Cell Significance Index: -41.6300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 170.3129
Cell Significance Index: -70.1600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 147.9065
Cell Significance Index: -69.8300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 145.1644
Cell Significance Index: -36.8200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 129.2805
Cell Significance Index: -66.5000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 104.3632
Cell Significance Index: -70.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 51.1008
Cell Significance Index: -63.0100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8994
Cell Significance Index: -47.9500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.7063
Cell Significance Index: -69.8700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.7264
Cell Significance Index: -42.1600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.6773
Cell Significance Index: 61.7200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 5.6351
Cell Significance Index: 150.7400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.3637
Cell Significance Index: 91.3400 - Cell Name: kidney cell (CL1000497)
Fold Change: 3.4969
Cell Significance Index: 27.9200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.0484
Cell Significance Index: 105.9300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.8830
Cell Significance Index: 339.9900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.8656
Cell Significance Index: 75.3500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.2106
Cell Significance Index: 60.1700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1077
Cell Significance Index: 1151.0500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.0099
Cell Significance Index: 142.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.9641
Cell Significance Index: 146.3800 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.9603
Cell Significance Index: 253.2600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.9426
Cell Significance Index: 91.3000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8848
Cell Significance Index: 121.6000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.8747
Cell Significance Index: 230.5100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.7647
Cell Significance Index: 780.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.7520
Cell Significance Index: 315.8300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.6253
Cell Significance Index: 47.7300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.4771
Cell Significance Index: 16.7800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4296
Cell Significance Index: 196.3300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.2677
Cell Significance Index: 16.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2651
Cell Significance Index: 65.7200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2226
Cell Significance Index: 1103.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2136
Cell Significance Index: 34.7900 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.1963
Cell Significance Index: 10.2800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.1098
Cell Significance Index: 10.2200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0228
Cell Significance Index: 47.6900 - Cell Name: peg cell (CL4033014)
Fold Change: 1.0206
Cell Significance Index: 23.5800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9906
Cell Significance Index: 26.4500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8966
Cell Significance Index: 177.9400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8546
Cell Significance Index: 109.5500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7773
Cell Significance Index: 13.7400 - Cell Name: sensory neuron (CL0000101)
Fold Change: 0.7468
Cell Significance Index: 4.2400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5308
Cell Significance Index: 11.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4844
Cell Significance Index: 97.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4765
Cell Significance Index: 13.7300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4621
Cell Significance Index: 24.2600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3125
Cell Significance Index: 21.6100 - Cell Name: germ cell (CL0000586)
Fold Change: 0.2477
Cell Significance Index: 1.8700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2136
Cell Significance Index: 13.4600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2047
Cell Significance Index: 38.9500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1934
Cell Significance Index: 31.4600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1930
Cell Significance Index: 69.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1449
Cell Significance Index: 109.6400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1350
Cell Significance Index: 2.2600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1306
Cell Significance Index: 12.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1034
Cell Significance Index: 17.6500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0877
Cell Significance Index: 2.4500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0492
Cell Significance Index: 1.7300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0042
Cell Significance Index: -3.1200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0106
Cell Significance Index: -7.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0131
Cell Significance Index: -8.2100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0247
Cell Significance Index: -46.5100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0396
Cell Significance Index: -73.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0434
Cell Significance Index: -4.4300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0476
Cell Significance Index: -73.3200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0574
Cell Significance Index: -78.0600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0639
Cell Significance Index: -3.9300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0665
Cell Significance Index: -2.1300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0735
Cell Significance Index: -41.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0808
Cell Significance Index: -51.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0957
Cell Significance Index: -66.1700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0977
Cell Significance Index: -0.5900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1197
Cell Significance Index: -25.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1325
Cell Significance Index: -60.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1499
Cell Significance Index: -3.8300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1517
Cell Significance Index: -43.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1714
Cell Significance Index: -3.6500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1744
Cell Significance Index: -20.3300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1948
Cell Significance Index: -10.9300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3093
Cell Significance Index: -35.4400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3176
Cell Significance Index: -5.8700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4017
Cell Significance Index: -58.3900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4758
Cell Significance Index: -54.3100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4928
Cell Significance Index: -5.8800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5651
Cell Significance Index: -7.7100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6035
Cell Significance Index: -47.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.6691
Cell Significance Index: -30.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6762
Cell Significance Index: -70.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7176
Cell Significance Index: -55.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7994
Cell Significance Index: -13.7000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8299
Cell Significance Index: -55.8000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.8752
Cell Significance Index: -9.0600 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.9018
Cell Significance Index: -5.5500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9594
Cell Significance Index: -58.8200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1158
Cell Significance Index: -28.6800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1384
Cell Significance Index: -33.5300 - Cell Name: glioblast (CL0000030)
Fold Change: -1.1784
Cell Significance Index: -7.4000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2624
Cell Significance Index: -55.8400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.3000
Cell Significance Index: -19.4800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 492043516
Symbol: SMD1_HUMAN
Name: Small nuclear ribonucleoprotein Sm D1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3260384
Title: Molecular cloning of a cDNA encoding the human Sm-D autoantigen.
PubMed ID: 3260384
PubMed ID: 2528429
Title: Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases.
PubMed ID: 2528429
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10500148
Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.
PubMed ID: 10500148
PubMed ID: 11747828
Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.
PubMed ID: 11747828
PubMed ID: 11135666
Title: SMN tudor domain structure and its interaction with the Sm proteins.
PubMed ID: 11135666
DOI: 10.1038/83014
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 15146077
Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
PubMed ID: 15146077
DOI: 10.1261/rna.7320604
PubMed ID: 16314521
Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.
PubMed ID: 16314521
PubMed ID: 17709427
Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.
PubMed ID: 17709427
PubMed ID: 18984161
Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.
PubMed ID: 18984161
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 10025403
Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
PubMed ID: 10025403
PubMed ID: 19325628
Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
PubMed ID: 19325628
DOI: 10.1038/nature07851
PubMed ID: 21113136
Title: Functional organization of the Sm core in the crystal structure of human U1 snRNP.
PubMed ID: 21113136
PubMed ID: 21816274
Title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.
PubMed ID: 21816274
PubMed ID: 21516107
Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
PubMed ID: 21516107
DOI: 10.1038/nature09956
PubMed ID: 23333303
Title: Structural basis of assembly chaperone-mediated snRNP formation.
PubMed ID: 23333303
PubMed ID: 25555158
Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
PubMed ID: 25555158
DOI: 10.7554/elife.04986
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 31799625
Title: Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly.
PubMed ID: 31799625
DOI: 10.1093/nar/gkz1135
PubMed ID: 32494006
Title: Molecular architecture of the human 17S U2 snRNP.
PubMed ID: 32494006
PubMed ID: 33509932
Title: Structure of the activated human minor spliceosome.
PubMed ID: 33509932
PubMed ID: 36797247
Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
PubMed ID: 36797247
Sequence Information:
- Length: 119
- Mass: 13282
- Checksum: 0C81C94BF98E0810
- Sequence:
MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.