Details for: SNRPD3

Gene ID: 6634

Symbol: SNRPD3

Ensembl ID: ENSG00000100028

Description: small nuclear ribonucleoprotein D3 polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 251.1167
    Cell Significance Index: -39.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.1427
    Cell Significance Index: -38.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.6874
    Cell Significance Index: -56.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.1118
    Cell Significance Index: -48.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.7885
    Cell Significance Index: -53.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.4451
    Cell Significance Index: -53.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.9005
    Cell Significance Index: -53.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.0873
    Cell Significance Index: -49.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.5725
    Cell Significance Index: -52.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1686
    Cell Significance Index: -55.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1334
    Cell Significance Index: -43.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0279
    Cell Significance Index: -34.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3312
    Cell Significance Index: -16.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.8526
    Cell Significance Index: 30.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.6434
    Cell Significance Index: 46.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.1266
    Cell Significance Index: 33.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6099
    Cell Significance Index: 307.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5271
    Cell Significance Index: 1380.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3744
    Cell Significance Index: 49.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1208
    Cell Significance Index: 291.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0855
    Cell Significance Index: 61.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0685
    Cell Significance Index: 133.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.0578
    Cell Significance Index: 54.1100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.9349
    Cell Significance Index: 14.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9048
    Cell Significance Index: 66.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8079
    Cell Significance Index: 84.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7471
    Cell Significance Index: 772.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6557
    Cell Significance Index: 117.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5985
    Cell Significance Index: 196.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5708
    Cell Significance Index: 117.0700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.4233
    Cell Significance Index: 8.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3953
    Cell Significance Index: 401.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3670
    Cell Significance Index: 37.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3426
    Cell Significance Index: 62.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2478
    Cell Significance Index: 247.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2352
    Cell Significance Index: 11.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1895
    Cell Significance Index: 214.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0451
    Cell Significance Index: 54.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9632
    Cell Significance Index: 60.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8663
    Cell Significance Index: 111.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7915
    Cell Significance Index: 102.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6991
    Cell Significance Index: 31.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6698
    Cell Significance Index: 12.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5889
    Cell Significance Index: 30.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5292
    Cell Significance Index: 57.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5105
    Cell Significance Index: 5.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3133
    Cell Significance Index: 59.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2699
    Cell Significance Index: 54.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2477
    Cell Significance Index: 42.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2473
    Cell Significance Index: 24.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2065
    Cell Significance Index: 33.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1974
    Cell Significance Index: 4.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1844
    Cell Significance Index: 1.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1821
    Cell Significance Index: 5.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1817
    Cell Significance Index: 11.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1309
    Cell Significance Index: 99.0900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1292
    Cell Significance Index: 1.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1204
    Cell Significance Index: 2.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1041
    Cell Significance Index: 2.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0895
    Cell Significance Index: 65.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0677
    Cell Significance Index: 24.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0255
    Cell Significance Index: -2.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0267
    Cell Significance Index: -50.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0290
    Cell Significance Index: -53.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0351
    Cell Significance Index: -54.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0416
    Cell Significance Index: -56.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0470
    Cell Significance Index: -2.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0577
    Cell Significance Index: -32.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0660
    Cell Significance Index: -0.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0798
    Cell Significance Index: -50.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0904
    Cell Significance Index: -1.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1059
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1084
    Cell Significance Index: -22.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1145
    Cell Significance Index: -51.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1240
    Cell Significance Index: -14.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1311
    Cell Significance Index: -4.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1492
    Cell Significance Index: -8.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1797
    Cell Significance Index: -4.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2043
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2160
    Cell Significance Index: -17.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3166
    Cell Significance Index: -36.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3193
    Cell Significance Index: -6.8000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3427
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3526
    Cell Significance Index: -51.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3585
    Cell Significance Index: -6.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3995
    Cell Significance Index: -10.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4307
    Cell Significance Index: -24.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4318
    Cell Significance Index: -49.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5119
    Cell Significance Index: -39.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5410
    Cell Significance Index: -56.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5901
    Cell Significance Index: -17.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6549
    Cell Significance Index: -6.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6841
    Cell Significance Index: -14.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7988
    Cell Significance Index: -6.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8124
    Cell Significance Index: -21.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.8175
    Cell Significance Index: -5.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8474
    Cell Significance Index: -56.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8818
    Cell Significance Index: -54.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNRPD3 is a 93-kDa protein encoded by the U6 snRNA gene and is a component of the U6/U5 tri-snRNP complex, which is involved in the second catalytic step of RNA splicing. SNRPD3 shares sequence similarity with other Sm proteins and is characterized by a unique RNA-binding domain. The protein is predominantly expressed in cells of hematopoietic origin, including erythroid progenitor cells, myeloid leukocytes, and medullary thymic epithelial cells. **Pathways and Functions:** SNRPD3 is involved in various cellular processes, including: 1. **RNA Splicing:** SNRPD3 is a key component of the U6/U5 tri-snRNP complex, which is responsible for the second catalytic step of RNA splicing. This process involves the recognition and excision of introns from pre-mRNA, resulting in the generation of mature mRNA molecules. 2. **Immune Response:** SNRPD3 has been implicated in the regulation of immune responses, particularly in the context of viral infections. For example, SNRPD3 has been shown to modulate the host translation machinery in response to SARS-CoV-2 infection. 3. **Cell Differentiation:** SNRPD3 is expressed in cells of hematopoietic origin and is involved in the regulation of cell differentiation, particularly in the context of erythropoiesis. 4. **Disease Pathogenesis:** SNRPD3 has been implicated in the pathogenesis of various diseases, including cancer, where it is often overexpressed and associated with poor prognosis. **Clinical Significance:** SNRPD3 has significant clinical implications, particularly in the context of: 1. **Viral Infections:** SNRPD3 has been implicated in the regulation of immune responses to viral infections, including SARS-CoV-2. Its expression levels may serve as a biomarker for predicting disease severity and outcome. 2. **Cancer:** SNRPD3 overexpression has been observed in various types of cancer, including leukemia and lymphoma. Its role in cancer pathogenesis and prognosis warrants further investigation. 3. **Immune-Mediated Disorders:** SNRPD3 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. Its expression levels may serve as a biomarker for predicting disease activity and response to therapy. In conclusion, SNRPD3 is a critical component of the spliceosome complex and plays a pivotal role in RNA splicing, immune response, and cell differentiation. Its clinical significance is underscored by its involvement in various diseases, including viral infections, cancer, and immune-mediated disorders. Further research is warranted to fully elucidate the function and clinical significance of SNRPD3.

Genular Protein ID: 254494790

Symbol: SMD3_HUMAN

Name: Small nuclear ribonucleoprotein Sm D3

UniProtKB Accession Codes:

P62318 B4DJP7 B5BU13 P43331

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 EMDB 50 Ensembl 2 EvolutionaryTrace 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7527560

Title: cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

PubMed ID: 7527560

DOI: 10.1073/pnas.91.25.12317

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11747828

Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

PubMed ID: 11747828

DOI: 10.1016/s0960-9822(01)00592-9

PubMed ID: 11135666

Title: SMN tudor domain structure and its interaction with the Sm proteins.

PubMed ID: 11135666

DOI: 10.1038/83014

PubMed ID: 11574479

Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

PubMed ID: 11574479

DOI: 10.1093/emboj/20.19.5470

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12628254

Title: High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues.

PubMed ID: 12628254

DOI: 10.1016/s0022-2836(03)00148-7

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17709427

Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.

PubMed ID: 17709427

DOI: 10.1083/jcb.200702147

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 126
  • Mass: 13916
  • Checksum: 59A6E78E860AA3E0
  • Sequence:
    • MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ 
VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN 
IFQKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.