Details for: SNRPD3

Gene ID: 6634

Symbol: SNRPD3

Ensembl ID: ENSG00000100028

Description: small nuclear ribonucleoprotein D3 polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.28
    Marker Score: 3419.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.69
    Marker Score: 93276
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.69
    Marker Score: 3228
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16877
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.52
    Marker Score: 33227
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.39
    Marker Score: 2891.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.38
    Marker Score: 3905
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.33
    Marker Score: 4869
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.32
    Marker Score: 3283
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.3
    Marker Score: 6268
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.29
    Marker Score: 6786
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.27
    Marker Score: 22797.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.24
    Marker Score: 8309
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.23
    Marker Score: 3888
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.21
    Marker Score: 2353
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.18
    Marker Score: 3498
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.17
    Marker Score: 3124
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.17
    Marker Score: 3346
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.17
    Marker Score: 2188
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.16
    Marker Score: 8827
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.15
    Marker Score: 16025
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.13
    Marker Score: 3627
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.13
    Marker Score: 1335.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.12
    Marker Score: 5346
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.12
    Marker Score: 23831
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.11
    Marker Score: 12515
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.1
    Marker Score: 28218
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1
    Marker Score: 8249
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.09
    Marker Score: 18039
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.09
    Marker Score: 1524
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.09
    Marker Score: 3321
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.08
    Marker Score: 2238
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.08
    Marker Score: 1952
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.07
    Marker Score: 20472
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.05
    Marker Score: 1371
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.04
    Marker Score: 3384
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.04
    Marker Score: 2156
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.01
    Marker Score: 20388
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2
    Marker Score: 2135.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2
    Marker Score: 5425
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.98
    Marker Score: 7650
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.98
    Marker Score: 977
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.98
    Marker Score: 2320
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.97
    Marker Score: 5286.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.96
    Marker Score: 1990
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.96
    Marker Score: 5416
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.96
    Marker Score: 12517
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.96
    Marker Score: 1477
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.96
    Marker Score: 928
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.94
    Marker Score: 1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.94
    Marker Score: 15124
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.93
    Marker Score: 8330
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.93
    Marker Score: 1062
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.92
    Marker Score: 107347
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.9
    Marker Score: 3705
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.89
    Marker Score: 2232
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.89
    Marker Score: 16406
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.88
    Marker Score: 6689.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.88
    Marker Score: 694
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.88
    Marker Score: 1078
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.86
    Marker Score: 4419
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.85
    Marker Score: 701
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.83
    Marker Score: 1768.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.83
    Marker Score: 1326
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.83
    Marker Score: 1719
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.82
    Marker Score: 8722
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.81
    Marker Score: 1515
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.8
    Marker Score: 5686.5
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.8
    Marker Score: 1321
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.79
    Marker Score: 4207.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.79
    Marker Score: 5609
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.79
    Marker Score: 571
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.78
    Marker Score: 979
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.77
    Marker Score: 569
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.77
    Marker Score: 3159
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.76
    Marker Score: 1870.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.76
    Marker Score: 45143
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.76
    Marker Score: 11469
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.75
    Marker Score: 418
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.74
    Marker Score: 620
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.74
    Marker Score: 11112
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.74
    Marker Score: 1556
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.74
    Marker Score: 850
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.73
    Marker Score: 1630
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.73
    Marker Score: 2449
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.73
    Marker Score: 3915
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.72
    Marker Score: 2011
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.71
    Marker Score: 3028
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.7
    Marker Score: 421
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.7
    Marker Score: 842
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.7
    Marker Score: 1131.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.7
    Marker Score: 399
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7
    Marker Score: 1328
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.68
    Marker Score: 589
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.68
    Marker Score: 2102
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.68
    Marker Score: 8806
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.67
    Marker Score: 1109
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.66
    Marker Score: 3022
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.66
    Marker Score: 3899
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.63
    Marker Score: 1718

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Other Information

**Key Characteristics:** SNRPD3 is a 93-kDa protein encoded by the U6 snRNA gene and is a component of the U6/U5 tri-snRNP complex, which is involved in the second catalytic step of RNA splicing. SNRPD3 shares sequence similarity with other Sm proteins and is characterized by a unique RNA-binding domain. The protein is predominantly expressed in cells of hematopoietic origin, including erythroid progenitor cells, myeloid leukocytes, and medullary thymic epithelial cells. **Pathways and Functions:** SNRPD3 is involved in various cellular processes, including: 1. **RNA Splicing:** SNRPD3 is a key component of the U6/U5 tri-snRNP complex, which is responsible for the second catalytic step of RNA splicing. This process involves the recognition and excision of introns from pre-mRNA, resulting in the generation of mature mRNA molecules. 2. **Immune Response:** SNRPD3 has been implicated in the regulation of immune responses, particularly in the context of viral infections. For example, SNRPD3 has been shown to modulate the host translation machinery in response to SARS-CoV-2 infection. 3. **Cell Differentiation:** SNRPD3 is expressed in cells of hematopoietic origin and is involved in the regulation of cell differentiation, particularly in the context of erythropoiesis. 4. **Disease Pathogenesis:** SNRPD3 has been implicated in the pathogenesis of various diseases, including cancer, where it is often overexpressed and associated with poor prognosis. **Clinical Significance:** SNRPD3 has significant clinical implications, particularly in the context of: 1. **Viral Infections:** SNRPD3 has been implicated in the regulation of immune responses to viral infections, including SARS-CoV-2. Its expression levels may serve as a biomarker for predicting disease severity and outcome. 2. **Cancer:** SNRPD3 overexpression has been observed in various types of cancer, including leukemia and lymphoma. Its role in cancer pathogenesis and prognosis warrants further investigation. 3. **Immune-Mediated Disorders:** SNRPD3 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. Its expression levels may serve as a biomarker for predicting disease activity and response to therapy. In conclusion, SNRPD3 is a critical component of the spliceosome complex and plays a pivotal role in RNA splicing, immune response, and cell differentiation. Its clinical significance is underscored by its involvement in various diseases, including viral infections, cancer, and immune-mediated disorders. Further research is warranted to fully elucidate the function and clinical significance of SNRPD3.

Genular Protein ID: 254494790

Symbol: SMD3_HUMAN

Name: Small nuclear ribonucleoprotein Sm D3

UniProtKB Accession Codes:

P62318 B4DJP7 B5BU13 P43331

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 EMDB 30 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 40 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7527560

Title: cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.

PubMed ID: 7527560

DOI: 10.1073/pnas.91.25.12317

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500148

Title: SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

PubMed ID: 10500148

DOI: 10.1073/pnas.96.20.11167

PubMed ID: 11747828

Title: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.

PubMed ID: 11747828

DOI: 10.1016/s0960-9822(01)00592-9

PubMed ID: 11135666

Title: SMN tudor domain structure and its interaction with the Sm proteins.

PubMed ID: 11135666

DOI: 10.1038/83014

PubMed ID: 11574479

Title: Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein.

PubMed ID: 11574479

DOI: 10.1093/emboj/20.19.5470

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12628254

Title: High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues.

PubMed ID: 12628254

DOI: 10.1016/s0022-2836(03)00148-7

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15146077

Title: The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

PubMed ID: 15146077

DOI: 10.1261/rna.7320604

PubMed ID: 16314521

Title: Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.

PubMed ID: 16314521

DOI: 10.1128/mcb.25.24.10989-11004.2005

PubMed ID: 17709427

Title: Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.

PubMed ID: 17709427

DOI: 10.1083/jcb.200702147

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10025403

Title: Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

PubMed ID: 10025403

DOI: 10.1016/s0092-8674(00)80550-4

PubMed ID: 19325628

Title: Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.

PubMed ID: 19325628

DOI: 10.1038/nature07851

PubMed ID: 21516107

Title: Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.

PubMed ID: 21516107

DOI: 10.1038/nature09956

PubMed ID: 25555158

Title: Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.

PubMed ID: 25555158

DOI: 10.7554/elife.04986

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 33509932

Title: Structure of the activated human minor spliceosome.

PubMed ID: 33509932

DOI: 10.1126/science.abg0879

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 126
  • Mass: 13916
  • Checksum: 59A6E78E860AA3E0
  • Sequence:
    • MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ 
VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN 
IFQKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.